The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

Journal of Biological Chemistry

Volumn 275, Issue 8, 2000, Pages 5600-5605

  Graves, Paul R ^a   Yu, Lijia ^a   Schwarz, Julie K ^a   Gales, Janis ^a   Sausville, Edward A ^b   O'Connor, Patrick M ^a,c   Piwnica Worms, Helen ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; NOCODAZOLE; PROTEIN KINASE;

ARTICLE; CELL CYCLE G2 PHASE; DNA DAMAGE; DNA FLANKING REGION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HELA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; MITOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; TUMOR SUPPRESSOR GENE;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CLONING, MOLECULAR; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; G2 PHASE; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PLASMIDS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SERINE; STAUROSPORINE; TIME FACTORS;

EID: 0034053130     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.8.5600     Document Type: Article

References (66)

1. Wang, O., Fan, S., Eastman, A., Worland, P. J., Sausville, E. A., and O'Connor, P. M. (1996) J. Natl. Cancer Inst. 88, 956-965
2. Bunch, R. T., and Eastman, A. (1996) Clin. Cancer Res. 2, 791-797
3. Shao, R. G., Cao, C. X., Shimizu, T., O'Connor, P. M., Kohn, K. W., and Pommier, Y (1997) Cancer Res. 57, 4029-4035
4. Yu, L., Orlandi, L., Wang, P., Orr, M. S., Senderowicz, A. M., Sausville, E. A., Silvestrini, R., Watanabe, N., Piwnica-Worms, H., and O'Connor, P. M. (1998) J. Biol. Chem. 273, 33455-33464
5. Atherton-Fessler, S., Hannig, G., and Piwnica-Worms, H. (1993) Semin. Cell Biol. 4, 433-442
6. Morgan, D. O. (1997) Annu. Rev. Cell Dev. Biol. 13, 261-291
7. Yang, J., and Kornbluth, S. (1999) Trends Cell Biol. 9, 201-210
8. Draetta, G., and Beach, D. (1988) Cell 54, 17-26
9. Draetta, G., Piwnica-Worms, H., Morrison, D., Druker, B., Roberts, T., and Beach, D. (1988) Nature 336, 738-744
10. Morla, A. O., Draetta, G., Beach, D., and Wang, J. Y. J. (1989) Cell 58, 193-203
11. Krek, W., and Nigg, E. A. (1991) EMBO J. 10, 305-316
12. Gould, K. L., and Nurse, P. (1989) Nature 342, 39-45
13. Norbury, C., Blow, J., and Nurse, P. (1991) EMBO J. 10, 3321-3329
14. Solomon, M. J., Lee, T., and Kirschner, M. W. (1992) Mol. Biol. Cell 3, 13-27
15. Parker, L. L., Atherton-Fessler, S., and Piwnica-Worms, H. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 2917-2921
16. Liu, F., Stanton, J. J., Wu, Z., and Piwnica-Worms, H. (1997) Mol. Cell. Biol. 17, 571-583
17. Honda, R., Ohba, Y., and Yasuda, H. (1992) Biochem. Biophys. Res. Commun. 186, 1333-1338
18. Igarashi, M., Nagata, A., Jinno, S., Suto, K., and Okayama, H. (1991) Nature 353, 80-83
19. McGowan, C. H., and Russell, P. (1993) EMBO J. 12, 75-85
20. McGowan, C. H., and Russell, P. (1995) EMBO J. 14, 2166-2175
21. Parker, L. L., Sylvestre, P. J., Byrnes, M. J., III, Liu, F., and Piwnica-Worms, H. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9638-9642
22. Parker, L. L., and Piwnica-Worms, H. (1992) Science 257, 1955-1957
23. Watanabe, N., Broome, M., and Hunter, T. (1995) EMBO J. 14, 1878-1891
24. Mueller, P. R., Coleman, T. R., and Dunphy, W. G. (1995) Mol. Biol. Cell 6, 119-134
25. Mueller, P. R., Coleman, T. R., Kumagai, A., and Dunphy, W. G. (1995) Science 270, 86-90
26. Booher, R. N., Holman, P. S., and Fattaey, A. (1997) J. Biol. Chem. 272, 22300-22306
27. Lee, M. S., Ogg, S., Xu, M., Parker, L. L., Donoghue, D. J., Maller, J. L., and Piwnica-Worms, H. (1992) Mol. Biol. Cell 3, 73-84
28. Dunphy, W. G., and Kumagai, A. (1991) Cell 67, 189-196
29. Gautier, J., Solomon, M. J., Booher, R. N., Bazan, J. F., and Kirschner, M. W. (1991) Cell 67, 197-211
30. Strausfeld, U., Labbe, J. C., Fesquet, D., Cavadore, J. C., Picard, A., Sadhu, K., Russell, P., and Doree, M. (1991) Nature 351, 242-245
31. Sebastian, B., Kakizuka, A., and Hunter, T. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 3521-3524
32. Toyoshima, F., Moriguchi, T., Wada, A., Fukuda, M., and Nishida, E. (1998) EMBO J. 17, 2728-2735
33. Yang, J., Bardes, E. S. G., Moore, J. D., Brennan, J., Powers, M. A., and Kornbluth, S. (1998) Genes Dev. 12, 2131-2143
34. Hagting, A., Karlsson, C., Clute, P., Jackman, M., and Pines, J. (1998) EMBO J. 17, 4127-4138
35. Pines, J., and Hunter, T. (1994) EMBO J. 13, 3772-3781
36. Li, J., Meyer, A. N., and Donoghue, D. J. (1995) Mol. Biol. Cell 6, 1111-1124
37. Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A., and Piwnica-Worms, H. (1997) Science 277, 1501-1505
38. Liu, Y.-C., Liu, Y., Elly, C., Yoshida, H., Lipkowitz, S., and Altman, A. (1997) J. Biol. Chem. 272, 9979-9985
39. Liu, F., Oviatt-Rothblum, C., Ryan, C. E., and Piwnica-Worms, H. (1999) Mol. Cell. Biol. 19, 5113-5123
40. O'Connor, P. M., Ferris, D. K., Hoffmann, I., Jackman, J., Draetta, G., and Kohn, K. W. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9480-9484
41. Hoffmann, I., Clarke, P. R., Marcote, M. J., Karsenti, E., and Draetta, G. (1993) EMBO J. 12, 53-63
42. Lopez-Girona, A., Furnari, B., Mondesert, O., and Russell, P. (1999) Nature 397, 172-175
43. Zeng, Y., and Piwnica-Worms, H. (1999) Mol. Cell. Biol. 19, 7410-7419
44. Yang, J., Wonkler, K., Yoshida, M., and Kornbluth, S. (1999) EMBO J. 18, 2174-2183
45. Kumagai, A., and Dunphy, W. G. (1999) Genes Dev. 13, 1067-1072
46. Dalal, S. N., Schweitzer, C. M., Gan, J., and Decaprio, J. (1999) Mol. Cell. Biol. 19, 4465-4479
47. Kumagai, A., and Dunphy, W. G. (1992) Cell 70, 139-151
48. Izumi, T., Walker, D. H., and Maller, J. M. (1992) Mol. Biol. Cell 3, 927-939
49. Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., and Elledge, S. J. (1997) Science 277, 1497-1501
50. Brown, A., Lee, C.-H., Schwarz, J. K., Mitiku, N., Griffith, D., Piwnica-Worms, H., and Chung, J. H. (1999) Proc. Natl. Acad. Sci. U. S. A 96, 3745-3750
51. Matsuoka, S., Huang, M., and Elledge, S. J. (1998) Science 282, 1893-1897
52. Blasina, A., Van de Weyer, I., Laus, M. C., Luyten, W. H. M. L., Parker, A. E., and McGowan, C. H. (1998) Curr. Biol. 9, 1-10
53. Chaturvedi, P., Eng, W. K., Zhu, Y., Mattern, M. R., Mishra, R., Hurle, M. R., Zhang, X., Annan, R. S., Lu, Q., Faucette, L. F., Scott, G. F., Li, X., Carr, S. A, Johnson, R. K., Winkler, J. D., and Zhou, B.-B. S. (1999) Oncogene 18, 4047-4054
54. Zeng, Y., Forbes, K. C., Wu, Z., Moreno, S., Piwnica-Worms, H., and Enoch, T. (1998) Nature 395, 507-510
55. Kumagai, A., Yakowec, P. S., and Dunphy, W. G. (1998) Mol. Biol. Cell 9, 345-354
56. Walworth, N., Davey, S., and Beach, D. (1993) Nature 363, 368-371
57. Al-Khodairy, F., Fotou, E., Sheldrick, K. S., Griffiths, D. J. F., Lehmann, A. R., and Carr, A. M. (1994) Mol. Biol. Cell 5, 147-160
58. Lindsay, H. D., Griffiths, D. J. F., Edwards, R., Murray, J. M., Christensen, P. U., Murray, J. M., Osman, F., Walworth, N., and Carr, A. M. (1998) Genes Dev. 12, 382-395
59. Boddy, M. N., Furnari, B., Mondesert, O., and Russell, P. (1998) Science 280, 909-912
60. O'Connell, M. J., Raleigh, J. M., Verkade, H. M., and Nurse, P. (1997) EMBO J. 16, 545-554
61. Hartwell, L. H., and Kastan, M. B. (1994) Science 266, 1821-1828
62. O'Connor, P. M. (1997) Cancer Surv. 29, 151-182
63. Matsoka, S., Huang, M., and Elledge, S. J. (1998) Science 282, 1893-1897
64. Fan, S., Smith, M. L., Rivet, D. J., Duba, D., Zhan, Q., Kohn, K. W., Fornace, A. J., and O'Connor, P. M. (1995) Cancer Res. 55, 1649-1654
65. Bunz, F., Dutriaux, C., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., and Vogelstein, B. (1998) Science 282, 1497-1501
66. Atherton-Fessler, S., Liu, F., Gabrielli, B., Lee, M. S., Peng, C.-Y., and Piwnica-Worms, H. (1994) Mol. Biol. Cell 5, 989-1001