-
2
-
-
0033601346
-
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
-
Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DCR, Shannon KE et al. (1999). Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286: 2528-2531.
-
(1999)
Science
, vol.286
, pp. 2528-2531
-
-
Bell, D.W.1
Varley, J.M.2
Szydlo, T.E.3
Kang, D.H.4
Wahrer, D.C.R.5
Shannon, K.E.6
-
3
-
-
0035819038
-
Inhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice
-
Beneke R, Moroy T. (2001). Inhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice. Oncogene 20: 8136-8141.
-
(2001)
Oncogene
, vol.20
, pp. 8136-8141
-
-
Beneke, R.1
Moroy, T.2
-
4
-
-
0030005453
-
Poly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer
-
Bieche I, de Murcia G, Lidereau R. (1996). Poly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer. Clin Cancer Res 2: 1163-1167.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1163-1167
-
-
Bieche, I.1
de Murcia, G.2
Lidereau, R.3
-
5
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E et al. (2005). Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434: 913-917.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
-
6
-
-
0034696279
-
The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting
-
Cardiff RD, Anver MR, Gusterson BA, Hennighausen L, Jensen RA, Merino MJ et al. (2000). The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 19: 968-988.
-
(2000)
Oncogene
, vol.19
, pp. 968-988
-
-
Cardiff, R.D.1
Anver, M.R.2
Gusterson, B.A.3
Hennighausen, L.4
Jensen, R.A.5
Merino, M.J.6
-
7
-
-
0034710870
-
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
-
Chao C, Saito S, Anderson CW, Appella E, Xu Y. (2000). Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci USA 97: 11936-11941.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11936-11941
-
-
Chao, C.1
Saito, S.2
Anderson, C.W.3
Appella, E.4
Xu, Y.5
-
8
-
-
0033527717
-
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
-
Cortez D, Wang Y, Qin J, Elledge SJ. (1999). Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286: 1162-1166.
-
(1999)
Science
, vol.286
, pp. 1162-1166
-
-
Cortez, D.1
Wang, Y.2
Qin, J.3
Elledge, S.J.4
-
9
-
-
0033055841
-
Mammary tumor formation in p53- and BRCA1-deficient mice
-
Cressman VL, Backlund DC, Hicks EM, Gowen LC, Godfrey V, Koller BH. (1999). Mammary tumor formation in p53- and BRCA1-deficient mice. Cell Growth Differ 10: 1-10.
-
(1999)
Cell Growth Differ
, vol.10
, pp. 1-10
-
-
Cressman, V.L.1
Backlund, D.C.2
Hicks, E.M.3
Gowen, L.C.4
Godfrey, V.5
Koller, B.H.6
-
10
-
-
0030860404
-
p53 mutations in BRCA1-associated familial breast cancer
-
Crook T, Crossland S, Crompton MR, Osin P, Gusterson BA. (1997). p53 mutations in BRCA1-associated familial breast cancer. Lancet 350: 638-639.
-
(1997)
Lancet
, vol.350
, pp. 638-639
-
-
Crook, T.1
Crossland, S.2
Crompton, M.R.3
Osin, P.4
Gusterson, B.A.5
-
11
-
-
33749316516
-
PARP-1 inhibitors: Are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?
-
De Soto JA, Deng CX. (2006). PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? Int J Med Sci 3: 117-123.
-
(2006)
Int J Med Sci
, vol.3
, pp. 117-123
-
-
De Soto, J.A.1
Deng, C.X.2
-
12
-
-
33745867950
-
The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors
-
De Soto JA, Wang X, Tominaga Y, Wang RH, Cao L, Skoumbourdis AP et al. (2006). The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors. Int J Biol Sci 2: 179-185.
-
(2006)
Int J Biol Sci
, vol.2
, pp. 179-185
-
-
De Soto, J.A.1
Wang, X.2
Tominaga, Y.3
Wang, R.H.4
Cao, L.5
Skoumbourdis, A.P.6
-
13
-
-
0037048290
-
Role of BRCA1 in centrosome duplication
-
Deng CX. (2002). Role of BRCA1 in centrosome duplication. Oncogene 21: 6222-6227.
-
(2002)
Oncogene
, vol.21
, pp. 6222-6227
-
-
Deng, C.X.1
-
14
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery Jr CA, Butel JS et al. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery Jr, C.A.5
Butel, J.S.6
-
16
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB et al. (2005). Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434: 917-921.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.4
Johnson, D.A.5
Richardson, T.B.6
-
17
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. (2000). The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
18
-
-
3042614143
-
Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma
-
Hao B, Wang H, Zhou K, Li Y, Chen X, Zhou G et al. (2004). Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. Cancer Res 64: 4378-4384.
-
(2004)
Cancer Res
, vol.64
, pp. 4378-4384
-
-
Hao, B.1
Wang, H.2
Zhou, K.3
Li, Y.4
Chen, X.5
Zhou, G.6
-
19
-
-
25444471892
-
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
-
Helleday T, Bryant HE, Schultz N. (2005). Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle 4: 1176-1178.
-
(2005)
Cell Cycle
, vol.4
, pp. 1176-1178
-
-
Helleday, T.1
Bryant, H.E.2
Schultz, N.3
-
20
-
-
0033003004
-
Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis
-
Herceg Z, Wang ZQ. (1999). Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Mol Cell Biol 19: 5124-5133.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5124-5133
-
-
Herceg, Z.1
Wang, Z.Q.2
-
21
-
-
0030797430
-
Poly(ADP-ribose) polymerase in human breast cancer: A case-control analysis
-
Hu JJ, Roush GC, Dubin N, BerwickM, Roses DF, HarrisMN. (1997). Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis. Pharmacogenetics 7: 309-316.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 309-316
-
-
Hu, J.J.1
Roush, G.C.2
Dubin, N.3
Berwick, M.4
Roses, D.F.5
Harris, M.N.6
-
22
-
-
0035734285
-
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
-
Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. (2001). Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet 29: 418-425.
-
(2001)
Nat Genet
, vol.29
, pp. 418-425
-
-
Jonkers, J.1
Meuwissen, R.2
van der Gulden, H.3
Peterse, H.4
van der Valk, M.5
Berns, A.6
-
23
-
-
0037379179
-
Involvement of poly(ADP-ribose) polymerase-1 and poly(ADP-ribosyl)ation in regulation of centrosome function
-
Kanai M, Tong WM, Sugihara E, Wang ZQ, Fukasawa K, Miwa M. (2003). Involvement of poly(ADP-ribose) polymerase-1 and poly(ADP-ribosyl)ation in regulation of centrosome function. Mol Cell Biol 23: 2451-2462.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2451-2462
-
-
Kanai, M.1
Tong, W.M.2
Sugihara, E.3
Wang, Z.Q.4
Fukasawa, K.5
Miwa, M.6
-
24
-
-
24344454692
-
Poly(ADP-ribosyl)-ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal
-
Kim MY, Zhang T, Kraus WL. (2005). Poly(ADP-ribosyl)-ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. Genes Dev 19: 1951-1967.
-
(2005)
Genes Dev
, vol.19
, pp. 1951-1967
-
-
Kim, M.Y.1
Zhang, T.2
Kraus, W.L.3
-
25
-
-
0242585417
-
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
-
Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R. (2003). Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am J Pathol 162: 1559-1569.
-
(2003)
Am J Pathol
, vol.162
, pp. 1559-1569
-
-
Lebel, M.1
Lavoie, J.2
Gaudreault, I.3
Bronsard, M.4
Drouin, R.5
-
26
-
-
0034644220
-
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
-
Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y et al. (2000). Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406: 210-215.
-
(2000)
Nature
, vol.406
, pp. 210-215
-
-
Li, S.1
Ting, N.S.2
Zheng, L.3
Chen, P.L.4
Ziv, Y.5
Shiloh, Y.6
-
27
-
-
4344646721
-
The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function
-
Lockett KL, Hall MC, Xu J, Zheng SL, Berwick M, Chuang SC et al. (2004). The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function. Cancer Res 64: 6344-6348.
-
(2004)
Cancer Res
, vol.64
, pp. 6344-6348
-
-
Lockett, K.L.1
Hall, M.C.2
Xu, J.3
Zheng, S.L.4
Berwick, M.5
Chuang, S.C.6
-
28
-
-
0035811590
-
Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice
-
Ludwig T, Fisher P, Murty V, Efstratiadis A. (2001). Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene 20: 3937-3948.
-
(2001)
Oncogene
, vol.20
, pp. 3937-3948
-
-
Ludwig, T.1
Fisher, P.2
Murty, V.3
Efstratiadis, A.4
-
31
-
-
27744568392
-
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-Ribose) polymerase: An issue of potency
-
McCabe N, Lord CJ, Tutt AN, Martin NM, Smith GC, Ashworth A. (2005). BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther 4: 934-936.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 934-936
-
-
McCabe, N.1
Lord, C.J.2
Tutt, A.N.3
Martin, N.M.4
Smith, G.C.5
Ashworth, A.6
-
32
-
-
0030679762
-
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
-
Morrison C, Smith GC, Stingl L, Jackson SP, Wagner EF, Wang ZQ. (1997). Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat Genet 17: 479-482.
-
(1997)
Nat Genet
, vol.17
, pp. 479-482
-
-
Morrison, C.1
Smith, G.C.2
Stingl, L.3
Jackson, S.P.4
Wagner, E.F.5
Wang, Z.Q.6
-
33
-
-
0038640934
-
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane
-
Nozaki T, Fujihara H,WatanabeM, Tsutsumi M, Nakamoto K, Kusuoka O et al. (2003). Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. Cancer Sci 94: 497-500.
-
(2003)
Cancer Sci
, vol.94
, pp. 497-500
-
-
Nozaki, T.1
Fujihara, H.2
Watanabe, M.3
Tsutsumi, M.4
Nakamoto, K.5
Kusuoka, O.6
-
34
-
-
0343280013
-
A critical role for histone H2Ax in recruitment of repair factors to nuclear foci after DNA damage
-
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. (2000). A critical role for histone H2Ax in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10: 886-895.
-
(2000)
Curr Biol
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
35
-
-
0037051674
-
Reduced poly(ADP-ribosyl) ation in lymphocytes of laryngeal cancer patients: Results of a case-control study
-
Rajaee-Behbahani N, Schmezer P, Ramroth H, Burkle A, Bartsch H, Dietz A et al. (2002). Reduced poly(ADP-ribosyl) ation in lymphocytes of laryngeal cancer patients: results of a case-control study. Int J Cancer 98: 780-784.
-
(2002)
Int J Cancer
, vol.98
, pp. 780-784
-
-
Rajaee-Behbahani, N.1
Schmezer, P.2
Ramroth, H.3
Burkle, A.4
Bartsch, H.5
Dietz, A.6
-
36
-
-
20044369162
-
Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent
-
Shibata A, Kamada N, Masumura K, Nohmi T, Kobayashi S, Teraoka H et al. (2005). Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent. Oncogene 24: 1328-13237.
-
(2005)
Oncogene
, vol.24
, pp. 1328-13237
-
-
Shibata, A.1
Kamada, N.2
Masumura, K.3
Nohmi, T.4
Kobayashi, S.5
Teraoka, H.6
-
37
-
-
15044344581
-
Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors
-
Shiokawa M, Masutani M, Fujihara H, Ueki K, Nishikawa R, Sugimura T et al. (2005). Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. Jpn J Clin Oncol 35: 97-102.
-
(2005)
Jpn J Clin Oncol
, vol.35
, pp. 97-102
-
-
Shiokawa, M.1
Masutani, M.2
Fujihara, H.3
Ueki, K.4
Nishikawa, R.5
Sugimura, T.6
-
38
-
-
34249932323
-
Breast Cancer
-
Stewart BW, Kleihues P ed, IARC Press: Lyon
-
Stewart BW, Kleihues P (ed). (2003). Breast Cancer: World Cancer Report. IARC Press: Lyon.
-
(2003)
World Cancer Report
-
-
-
39
-
-
0036894745
-
Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation
-
Tong WM, Cortes U, Hande MP, Ohgaki H, Cavalli LR, Lansdorp PM et al. (2002). Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res 62: 6990-6996.
-
(2002)
Cancer Res
, vol.62
, pp. 6990-6996
-
-
Tong, W.M.1
Cortes, U.2
Hande, M.P.3
Ohgaki, H.4
Cavalli, L.R.5
Lansdorp, P.M.6
-
40
-
-
0035977206
-
Poly(ADP-ribose) polymerase: A guardian angel protecting genome and suppressing tumorigenesis
-
Tong WM, Cortes U, Wang ZQ. (2001a). Poly(ADP-ribose) polymerase: a guardian angel protecting genome and suppressing tumorigenesis. Biochim Biophys Acta-Rev on Cancer 1552: 27-37.
-
(2001)
Biochim Biophys Acta-Rev on Cancer
, vol.1552
, pp. 27-37
-
-
Tong, W.M.1
Cortes, U.2
Wang, Z.Q.3
-
41
-
-
0035012606
-
DNA-strand break-sensing molecule PARP cooperates with p53 in telomere function, chromosomal stability and tumor suppression
-
Tong WM, Hande MP, Lansdorp PM, Wang ZQ. (2001b). DNA-strand break-sensing molecule PARP cooperates with p53 in telomere function, chromosomal stability and tumor suppression. Mol Cell Biol 21: 4046-4054.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4046-4054
-
-
Tong, W.M.1
Hande, M.P.2
Lansdorp, P.M.3
Wang, Z.Q.4
-
42
-
-
0037219382
-
Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53-/- mice
-
Tong WM, Ohgaki H, Huang H, Granier C, Kleihues P, Wang ZQ. (2003). Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53-/- mice. Am J Pathol 162: 343-352.
-
(2003)
Am J Pathol
, vol.162
, pp. 343-352
-
-
Tong, W.M.1
Ohgaki, H.2
Huang, H.3
Granier, C.4
Kleihues, P.5
Wang, Z.Q.6
-
43
-
-
0035132977
-
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity
-
Tsutsumi M, Masutani M, Nozaki T, Kusuoka O, Tsujiuchi T, Nakagama H et al. (2001). Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity. Carcinogenesis 22: 1-3.
-
(2001)
Carcinogenesis
, vol.22
, pp. 1-3
-
-
Tsutsumi, M.1
Masutani, M.2
Nozaki, T.3
Kusuoka, O.4
Tsujiuchi, T.5
Nakagama, H.6
-
44
-
-
10344264478
-
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation
-
Turner JM, Aprelikova O, Xu X, Wang R, Kim S, Chandramouli GV et al. (2004). BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol 14: 2135-2142.
-
(2004)
Curr Biol
, vol.14
, pp. 2135-2142
-
-
Turner, J.M.1
Aprelikova, O.2
Xu, X.3
Wang, R.4
Kim, S.5
Chandramouli, G.V.6
-
45
-
-
0037169354
-
Cancer susceptibility and the functions of BRCA1 and BRCA2
-
Venkitaraman AR. (2002). Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108: 171-182.
-
(2002)
Cell
, vol.108
, pp. 171-182
-
-
Venkitaraman, A.R.1
-
46
-
-
0028922462
-
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
-
Wang ZQ, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M et al. (1995). Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev 9: 509-520.
-
(1995)
Genes Dev
, vol.9
, pp. 509-520
-
-
Wang, Z.Q.1
Auer, B.2
Stingl, L.3
Berghammer, H.4
Haidacher, D.5
Schweiger, M.6
-
47
-
-
0032587877
-
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
-
Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T et al. (1999). Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet 22: 37-43.
-
(1999)
Nat Genet
, vol.22
, pp. 37-43
-
-
Xu, X.1
Wagner, K.U.2
Larson, D.3
Weaver, Z.4
Li, C.5
Ried, T.6
-
48
-
-
13444306156
-
Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer
-
Zhang X, Miao X, Liang G, Hao B, Wang Y, Tan W et al. (2005). Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Cancer Res 65: 722-726.
-
(2005)
Cancer Res
, vol.65
, pp. 722-726
-
-
Zhang, X.1
Miao, X.2
Liang, G.3
Hao, B.4
Wang, Y.5
Tan, W.6
|