Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase I DNA damage response axis in colon cancers

Genes Chromosomes and Cancer

Volumn 46, Issue 12, 2007, Pages 1061-1068

  Lewis, Kriste A ^a   Bakkum Gamez, Jamie ^a   Loewen, Ralitsa ^a   French, Amy J ^a   Thibodeau, Stephen N ^a   Cliby, William A ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; MICROSATELLITE DNA; NUCLEOTIDE;

ADULT; AGED; ARTICLE; ATR GENE; CANCER RECURRENCE; CANCER STAGING; CELL CYCLE ARREST; CHEKI GENE; CLINICAL ARTICLE; COLON CANCER; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DISEASE FREE SURVIVAL; DNA DAMAGE; DNA REPAIR; EXON; FEMALE; GENE; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC SCREENING; HUMAN; HUMAN TISSUE; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; UNIVARIATE ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; CELL CYCLE PROTEINS; COLONIC NEOPLASMS; DNA DAMAGE; FEMALE; HUMANS; MALE; MICROSATELLITE INSTABILITY; MICROSATELLITE REPEATS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES;

ATAXIA TELANGIECTASIA;

EID: 35348970340     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20486     Document Type: Article

References (25)

1. Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zeiger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J. 2005. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864-870.
2. Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG. 2006. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444:633-637.
3. Bertoni F, Codegoni AM, Furlan D, Tibiletti MG, Capella C, Broggini M. 1999. CHEK1 frameshift mutations in genetically unstable colorectal and endometrial cancers. Genes Chromosomes Cancer 26:176-180.
4. Canman CE. 2001. Replication checkpoint: Preventing mitotic catastrophe. Curr Biol 11:R121-R124.
5. Chung KY, Nam-gyun K, Long SL, Haeryoung K, Kim H, Nam CM, Kim H, Shin DH. 2003. Clinicopathologic characteristics related to the high variability of coding mononucleotide repeat sequences in tumors with high-microsatellite instability. Oncol Rep 10:439-444.
6. Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. 1998. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. The EMBO J 17:159-169.
7. Cliby WA, Lewis KA, Lilly KK, Kaufmann SH. 2002. S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function. J Biol Chem 277:1599-1606.
8. Fang Y, Tsao C-C, Goodman BK, Furumai R, Tirado CA, Abraham RT, Wang X-F. 2004. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J 23:3164-3174.
9. Furlan D, Casati B, Cerutti R, Facco C, Terracciano L, Capella C, Chiaravalli AM. 2002. Genetic progression in sporadic endome-trial and gastrointestinal cancers with high microsatellite instability. J Pathol 197:603-609.
10. Kumar K, Rahman Q, Schipper H, Matschegewski C, Schiffman D, Papp T. 2005. Mutational analysis of 9 different tumour-associated genes in human malignant mesothelioma cell lines. Oncol Rep 14:743-750.
11. Lewis KA, Mullany S, Thomas B, Chien J, Loewen R, Shridhar V, Cliby WA. 2005. Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance. Cancer Res 65:7091-7095.
12. Li LS, Kim N-G, Kim SH, Park C, Kim H, Kang HJ, Koh KH, Kim SN, Kim WH, Kim NK, Kim H. 2003. Chromosomal imbalances in the colorectal carcinomas with microsatellite instability. Am J Pathol 163:1429-1436.
13. Liu Q, Guntuku S, Cui X-S, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Doehower LA, Elledge SJ. 2000. CHEK1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. 2000. Genes Dev 14:1448-1459.
14. Liu W, Smith D, Rechtzigel K, Thibodeau S, James C. 1998. Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations. Nucleic Acids Res 26:1396-1400.
15. Menoyo A, Alazzouzi H, Espin E, Armengol M, Yamamoto H, Schwartz S, Jr. 2001. Somatic mutations in the DNA damage-response genes ATR and CHEK1 in sporadic stomach tumors with microsatellite instability. Cancer Res 61:7727-7730.
16. Miquel C, Jacob S, Grandjouan S, Aime A, Viguier J, Sabourin JC, Sarasin A, Duval A, Praz F. 2007. Frequent alteration of DNA damage signaling and repair pathways in human colorectal cancers with microsatellite instability. Oncogene.Epub ahead of print.
17. Nghiem P, Park PK, Kim Y-S, Vaziri C, Schreiber SL. 2001. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci USA 98:9092-9097.
18. O'Connell MJ, Walworth NC, Carr AM. 2000. The G2-phase DNA-damage checkpoint. Trends Cell Biol 10:296-303.
19. Rhind N, Russell P. 2000. CHEK1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways. J Cell Sci 113:3889-3896.
20. Semba S, Ouyang H, Han S-Y, Kato Y, Hor A, II. 2000. Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium. Int J Oncol 16:731-737.
21. Sinicrope FA, Rego RL, Halling KC, Foster N, Sargent DJ, La Plant B, French AJ, Laurie JA, Goldberg RM, Thibodeau SN, Witzig TE. 2006. Prognostic impact of microsatellite instability and DNA poidy in human colon carcinoma patients. Gastroenterology 131:729-737.
22. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. 1993. Science 260:816-819.
23. Underhill PA, Jin L, Lin AA, Mehdi SQ, Jenkins T, Vollrath D, Davis RW, Cavalli-Sforza LL, Oefner PJ. 1997. Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography. Genome Res 7:996-1005.
24. Vassileva V, Millar A, Briollais L, Chapman W, Bapat B. 2002. Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability. Cancer Res 62:4095-4099.
25. Zhao H, Piwnica-Worms H. 2001. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 21:4129-4139.