메뉴 건너뛰기




Volumn 44, Issue 4, 2012, Pages 490-498

Pattern recognition receptors in equine endotoxaemia and sepsis

Author keywords

Endotoxaemia; Horse; Innate immunity; Pathogen recognition receptor; Pathogen associated molecular pattern; Sepsis

Indexed keywords

PATTERN RECOGNITION RECEPTOR;

EID: 84862009345     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2012.00574.x     Document Type: Review
Times cited : (18)

References (184)
  • 2
    • 35948948662 scopus 로고    scopus 로고
    • Sepsis: definition, epidemiology, and diagnosis
    • Lever, A. and Mackenzie, I. (2007) Sepsis: definition, epidemiology, and diagnosis. BMJ 335, 879-883.
    • (2007) BMJ , vol.335 , pp. 879-883
    • Lever, A.1    Mackenzie, I.2
  • 3
    • 0032977569 scopus 로고    scopus 로고
    • Microbiologic findings and correlations with serum tumor necrosis factor-α in patients with severe sepsis and septic shock
    • Cohen, J. and Abraham, E. (1999) Microbiologic findings and correlations with serum tumor necrosis factor-α in patients with severe sepsis and septic shock. J. Infect. Dis. 180, 116-121.
    • (1999) J. Infect. Dis. , vol.180 , pp. 116-121
    • Cohen, J.1    Abraham, E.2
  • 4
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin, G.S., Mannino, D.M., Eaton, S. and Moss, M. (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348, 1546-1554.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 5
    • 33646116564 scopus 로고    scopus 로고
    • Peptidoglycan - an endotoxin in its own right?
    • Myhre, A.E., Aasen, A.O., Thiemermann, C. and Wang, J.E. (2006) Peptidoglycan - an endotoxin in its own right? Shock 25, 227-235.
    • (2006) Shock , vol.25 , pp. 227-235
    • Myhre, A.E.1    Aasen, A.O.2    Thiemermann, C.3    Wang, J.E.4
  • 7
    • 68949135791 scopus 로고    scopus 로고
    • Detection of bloodstream infection in neonatal foals with suspected sepsis using real-time PCR
    • Pusterla, N., Mapes, S., Byrne, B.A. and Magdesian, K.G. (2009) Detection of bloodstream infection in neonatal foals with suspected sepsis using real-time PCR. Vet. Rec. 165, 114-117.
    • (2009) Vet. Rec. , vol.165 , pp. 114-117
    • Pusterla, N.1    Mapes, S.2    Byrne, B.A.3    Magdesian, K.G.4
  • 8
    • 47249091885 scopus 로고    scopus 로고
    • Blood culture isolates and antimicrobial sensitivities from 427 critically ill neonatal foals
    • Russell, C.M., Axon, J.E., Blishen, A. and Begg, A.P. (2008) Blood culture isolates and antimicrobial sensitivities from 427 critically ill neonatal foals. Aust. Vet. J. 86, 266-271.
    • (2008) Aust. Vet. J. , vol.86 , pp. 266-271
    • Russell, C.M.1    Axon, J.E.2    Blishen, A.3    Begg, A.P.4
  • 9
    • 33845997767 scopus 로고    scopus 로고
    • Bacteraemia in neonatal foals: clinicopathological differences between Gram-positive and Gram-negative infections, and single organism and mixed infections
    • Corley, K.T.T., Pearce, G., Magdesian, K.G. and Wilson, W.D. (2007) Bacteraemia in neonatal foals: clinicopathological differences between Gram-positive and Gram-negative infections, and single organism and mixed infections. Equine Vet. J. 39, 84-89.
    • (2007) Equine Vet. J. , vol.39 , pp. 84-89
    • Corley, K.T.T.1    Pearce, G.2    Magdesian, K.G.3    Wilson, W.D.4
  • 10
    • 66349123933 scopus 로고    scopus 로고
    • Blood culture status in mature horses with diarrhoea: a possible association with survival
    • Johns, I., Tennent-Brown, B., Schaer, B.D., Southwood, L., Boston, R. and Wilkins, P. (2009) Blood culture status in mature horses with diarrhoea: a possible association with survival. Equine Vet. J. 41, 160-164.
    • (2009) Equine Vet. J. , vol.41 , pp. 160-164
    • Johns, I.1    Tennent-Brown, B.2    Schaer, B.D.3    Southwood, L.4    Boston, R.5    Wilkins, P.6
  • 11
    • 52649094327 scopus 로고    scopus 로고
    • Bacteremia in equine neonatal diarrhea: a retrospective study (1990-2007)
    • Hollis, A.R., Wilkins, P.A., Palmer, J.E. and Boston, R.C. (2008) Bacteremia in equine neonatal diarrhea: a retrospective study (1990-2007). J. Vet. Intern. Med. 22, 1203-1209.
    • (2008) J. Vet. Intern. Med. , vol.22 , pp. 1203-1209
    • Hollis, A.R.1    Wilkins, P.A.2    Palmer, J.E.3    Boston, R.C.4
  • 12
    • 70350356853 scopus 로고    scopus 로고
    • Activating immunity: lessons from the TLRs and NLRs
    • Monie, T.P., Bryant, C.E. and Gay, N.J. (2009) Activating immunity: lessons from the TLRs and NLRs. Trends Biochem. Sci. 34, 553-561.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 553-561
    • Monie, T.P.1    Bryant, C.E.2    Gay, N.J.3
  • 13
    • 67649422321 scopus 로고    scopus 로고
    • Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    • O'Neill, L., Bryant, C. and Doyle, S. (2009) Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol. Rev. 61, 177-197.
    • (2009) Pharmacol. Rev. , vol.61 , pp. 177-197
    • O'Neill, L.1    Bryant, C.2    Doyle, S.3
  • 14
    • 34548459868 scopus 로고    scopus 로고
    • Structure and function of Toll receptors and their ligands
    • Gay, N.J. and Gangloff, M. (2007) Structure and function of Toll receptors and their ligands. Annu. Rev. Biochem. 76, 141-165.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 141-165
    • Gay, N.J.1    Gangloff, M.2
  • 15
  • 16
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • Jin, M.S., Kim, S.E., Heo, J.Y., Lee, M.E., Kim, H.M., Paik, S.G., Lee, H. and Lee, J.O. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071-1082.
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.G.6    Lee, H.7    Lee, J.O.8
  • 18
    • 35448968699 scopus 로고    scopus 로고
    • The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist
    • Lohmann, K.L., Vandenplas, M.L., Barton, M.H., Bryant, C.E. and Moore, J.N. (2007) The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist. J. Endotoxin Res. 13, 235-242.
    • (2007) J. Endotoxin Res. , vol.13 , pp. 235-242
    • Lohmann, K.L.1    Vandenplas, M.L.2    Barton, M.H.3    Bryant, C.E.4    Moore, J.N.5
  • 19
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park, B.S., Song, D.H., Kim, H.M., Choi, B.S., Lee, H. and Lee, J.O. (2009) The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458, 1191-1195.
    • (2009) Nature , vol.458 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.S.4    Lee, H.5    Lee, J.O.6
  • 20
    • 0022462376 scopus 로고
    • Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum
    • Tobias, P.S., Soldau, K. and Ulevitch, R.J. (1986) Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J. Exp. Med. 164, 777-793.
    • (1986) J. Exp. Med. , vol.164 , pp. 777-793
    • Tobias, P.S.1    Soldau, K.2    Ulevitch, R.J.3
  • 21
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J. and Mathison, J.C. (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 22
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K. and Kimoto, M. (1999) MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189, 1777-1782.
    • (1999) J. Exp. Med. , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 23
    • 0025193891 scopus 로고
    • Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo
    • Kovach, N.L., Yee, E., Munford, R.S., Raetz, C.R. and Harlan, J.M. (1990) Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo. J. Exp. Med. 172, 77-84.
    • (1990) J. Exp. Med. , vol.172 , pp. 77-84
    • Kovach, N.L.1    Yee, E.2    Munford, R.S.3    Raetz, C.R.4    Harlan, J.M.5
  • 25
    • 0021351151 scopus 로고
    • In vitro stimulation of C3H/HeJ spleen cells and macrophages by a lipid A precursor molecule derived from Salmonella typhimurium
    • Vogel, S.N., Madonna, G.S., Wahl, L.M. and Rick, P.D. (1984) In vitro stimulation of C3H/HeJ spleen cells and macrophages by a lipid A precursor molecule derived from Salmonella typhimurium. J. Immunol. 132, 347-353.
    • (1984) J. Immunol. , vol.132 , pp. 347-353
    • Vogel, S.N.1    Madonna, G.S.2    Wahl, L.M.3    Rick, P.D.4
  • 26
    • 0026088437 scopus 로고
    • Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes
    • Golenbock, D.T., Hampton, R.Y., Qureshi, N., Takayama, K. and Raetz, C.R. (1991) Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J. Biol. Chem. 266, 19490-19498.
    • (1991) J. Biol. Chem. , vol.266 , pp. 19490-19498
    • Golenbock, D.T.1    Hampton, R.Y.2    Qureshi, N.3    Takayama, K.4    Raetz, C.R.5
  • 27
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S., Uematsu, S. and Takeuchi, O. (2006) Pathogen recognition and innate immunity. Cell 124, 783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 28
    • 80051471930 scopus 로고    scopus 로고
    • Plasma endotoxin in horses presented to an equine referral hospital: correlation to selected clinical parameters and outcomes
    • Senior, J.M., Proudman, C.J., Leuwer, M. and Carter, S.D. (2011) Plasma endotoxin in horses presented to an equine referral hospital: correlation to selected clinical parameters and outcomes. Equine Vet. J. 43, 585-591.
    • (2011) Equine Vet. J. , vol.43 , pp. 585-591
    • Senior, J.M.1    Proudman, C.J.2    Leuwer, M.3    Carter, S.D.4
  • 30
    • 0022745351 scopus 로고
    • Incidence, diagnosis and treatment of postoperative complications in colic cases
    • Hunt, J.M., Edwards, G.B. and Clarke, K.W. (1986) Incidence, diagnosis and treatment of postoperative complications in colic cases. Equine Vet. J. 18, 264-270.
    • (1986) Equine Vet. J. , vol.18 , pp. 264-270
    • Hunt, J.M.1    Edwards, G.B.2    Clarke, K.W.3
  • 32
    • 0037501031 scopus 로고    scopus 로고
    • Effects on plasma endotoxin and eicosanoid concentrations and serum cytokine activities in horses competing in a 48-, 83-, or 159-km endurance ride under similar terrain and weather conditions
    • Barton, M.H., Williamson, L., Jacks, S. and Norton, N. (2003) Effects on plasma endotoxin and eicosanoid concentrations and serum cytokine activities in horses competing in a 48-, 83-, or 159-km endurance ride under similar terrain and weather conditions. Am. J. Vet. Res. 64, 754-761.
    • (2003) Am. J. Vet. Res. , vol.64 , pp. 754-761
    • Barton, M.H.1    Williamson, L.2    Jacks, S.3    Norton, N.4
  • 33
    • 0031608148 scopus 로고    scopus 로고
    • Hemostatic and fibrinolytic indices in neonatal foals with presumed septicemia
    • Barton, M.H., Morris, D.D., Norton, N. and Prasse, K.W. (1998) Hemostatic and fibrinolytic indices in neonatal foals with presumed septicemia. J. Vet. Intern. Med. 12, 26-35.
    • (1998) J. Vet. Intern. Med. , vol.12 , pp. 26-35
    • Barton, M.H.1    Morris, D.D.2    Norton, N.3    Prasse, K.W.4
  • 34
    • 33646851430 scopus 로고    scopus 로고
    • Prognostic value of clinicopathologic variables obtained at admission and effect of antiendotoxin plasma on survival in septic and critically ill foals
    • Peek, S.F., Semrad, S., McGuirk, S.M., Riseberg, A., Ann Slack, J., Marques, F., Coombs, D., Lien, L., Keuler, N. and Darien, B.J. (2006) Prognostic value of clinicopathologic variables obtained at admission and effect of antiendotoxin plasma on survival in septic and critically ill foals. J. Vet. Intern. Med. 20, 569-574.
    • (2006) J. Vet. Intern. Med. , vol.20 , pp. 569-574
    • Peek, S.F.1    Semrad, S.2    McGuirk, S.M.3    Riseberg, A.4    Ann Slack, J.5    Marques, F.6    Coombs, D.7    Lien, L.8    Keuler, N.9    Darien, B.J.10
  • 35
    • 0037903424 scopus 로고    scopus 로고
    • Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust-induced asthma)
    • Pirie, R.S., Collie, D.D.S., Dixon, P.M. and McGorum, B.C. (2003) Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust-induced asthma). Clin. Exp. Allergy 33, 676-683.
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 676-683
    • Pirie, R.S.1    Collie, D.D.S.2    Dixon, P.M.3    McGorum, B.C.4
  • 36
    • 14844310311 scopus 로고    scopus 로고
    • Dose responses to inhalation of endotoxin, hay dust suspension and Aspergillus fumigatus extract in horses as measured by levels and activation of matrix metalloproteinase-9
    • Simonen-Jokinen, T., Pirie, R.S., McGorum, B. and Maisi, P. (2005) Dose responses to inhalation of endotoxin, hay dust suspension and Aspergillus fumigatus extract in horses as measured by levels and activation of matrix metalloproteinase-9. Equine Vet. J. 37, 155-160.
    • (2005) Equine Vet. J. , vol.37 , pp. 155-160
    • Simonen-Jokinen, T.1    Pirie, R.S.2    McGorum, B.3    Maisi, P.4
  • 37
    • 34247237701 scopus 로고    scopus 로고
    • Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction
    • Berndt, A., Derksen, F.J., Venta, P.J., Ewart, S., Yuzbasiyan-Gurkan, V. and Robinson, N.E. (2007) Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction. Am. J. Physiol. Lung Cell. Mol. Physiol. 292, L936-L943.
    • (2007) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.292
    • Berndt, A.1    Derksen, F.J.2    Venta, P.J.3    Ewart, S.4    Yuzbasiyan-Gurkan, V.5    Robinson, N.E.6
  • 40
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K. and Akira, S. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 41
    • 0033794461 scopus 로고    scopus 로고
    • A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection
    • Lorenz, E., Mira, J.P., Cornish, K.L., Arbour, N.C. and Schwartz, D.A. (2000) A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect. Immun. 68, 6398-6401.
    • (2000) Infect. Immun. , vol.68 , pp. 6398-6401
    • Lorenz, E.1    Mira, J.P.2    Cornish, K.L.3    Arbour, N.C.4    Schwartz, D.A.5
  • 42
    • 0345798148 scopus 로고    scopus 로고
    • TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase
    • Fan, J., Frey, R.S. and Malik, A.B. (2003) TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J. Clin. Invest. 112, 1234-1243.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1234-1243
    • Fan, J.1    Frey, R.S.2    Malik, A.B.3
  • 44
    • 0034656222 scopus 로고    scopus 로고
    • Inactivation of the flagellin gene of Salmonella enterica serotype enteritidis strongly reduces invasion into differentiated Caco-2 cells
    • Van Asten, F.J., Hendriks, H.G., Koninkx, J.F., Van der Zeijst, B.A. and Gaastra, W. (2000) Inactivation of the flagellin gene of Salmonella enterica serotype enteritidis strongly reduces invasion into differentiated Caco-2 cells. FEMS Microbiol. Lett. 185, 175-179.
    • (2000) FEMS Microbiol. Lett. , vol.185 , pp. 175-179
    • Van Asten, F.J.1    Hendriks, H.G.2    Koninkx, J.F.3    Van der Zeijst, B.A.4    Gaastra, W.5
  • 48
  • 49
    • 0036735155 scopus 로고    scopus 로고
    • Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines
    • Applequist, S.E., Wallin, R.P. and Ljunggren, H.G. (2002) Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines. Int. Immunol. 14, 1065-1074.
    • (2002) Int. Immunol. , vol.14 , pp. 1065-1074
    • Applequist, S.E.1    Wallin, R.P.2    Ljunggren, H.G.3
  • 50
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdörfer, B., Giese, T., Endres, S. and Hartmann, G. (2002) Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168, 4531-4537.
    • (2002) J. Immunol. , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdörfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 51
    • 37349057372 scopus 로고    scopus 로고
    • Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin
    • Keestra, A.M., de Zoete, M.R., van Aubel, R.A. and van Putten, J.P. (2008) Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin. Mol. Immunol. 45, 1298-1307.
    • (2008) Mol. Immunol. , vol.45 , pp. 1298-1307
    • Keestra, A.M.1    de Zoete, M.R.2    van Aubel, R.A.3    van Putten, J.P.4
  • 52
    • 79958073597 scopus 로고    scopus 로고
    • Disparities in TLR5 expression and responsiveness to flagellin in equine neutrophils and mononuclear phagocytes
    • Kwon, S., Gewirtz, A.T., Hurley, D.J., Robertson, T.P., Moore, J.N. and Vandenplas, M.L. (2011) Disparities in TLR5 expression and responsiveness to flagellin in equine neutrophils and mononuclear phagocytes. J. Immunol. 186, 6263-6270.
    • (2011) J. Immunol. , vol.186 , pp. 6263-6270
    • Kwon, S.1    Gewirtz, A.T.2    Hurley, D.J.3    Robertson, T.P.4    Moore, J.N.5    Vandenplas, M.L.6
  • 53
    • 67349097405 scopus 로고    scopus 로고
    • Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma
    • Lun, S.W., Wong, C.K., Ko, F.W., Hui, D.S. and Lam, C.W. (2009) Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma. J. Clin. Immunol. 29, 330-342.
    • (2009) J. Clin. Immunol. , vol.29 , pp. 330-342
    • Lun, S.W.1    Wong, C.K.2    Ko, F.W.3    Hui, D.S.4    Lam, C.W.5
  • 56
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J. and Steinman, R.M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 57
    • 79953679912 scopus 로고    scopus 로고
    • Single molecule in vivo analysis of Toll-like receptor 9 and CpG DNA interaction
    • Chen, J., Nag, S., Vidi, P.A. and Irudayaraj, J. (2011) Single molecule in vivo analysis of Toll-like receptor 9 and CpG DNA interaction. PLoS One 6, e17991.
    • (2011) PLoS One , vol.6
    • Chen, J.1    Nag, S.2    Vidi, P.A.3    Irudayaraj, J.4
  • 58
    • 79955743119 scopus 로고    scopus 로고
    • Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
    • Ewald, S.E., Engel, A., Lee, J., Wang, M., Bogyo, M. and Barton, G.M. (2011) Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J. Exp. Med. 208, 643-651.
    • (2011) J. Exp. Med. , vol.208 , pp. 643-651
    • Ewald, S.E.1    Engel, A.2    Lee, J.3    Wang, M.4    Bogyo, M.5    Barton, G.M.6
  • 59
    • 80053145718 scopus 로고    scopus 로고
    • Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9
    • Avalos, A.M. and Ploegh, H.L. (2011) Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9. Eur. J. Immunol. 41, 2820-2827.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 2820-2827
    • Avalos, A.M.1    Ploegh, H.L.2
  • 60
    • 0034457684 scopus 로고    scopus 로고
    • Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9
    • Chuang, T.H. and Ulevitch, R.J. (2000) Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 11, 372-378.
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 372-378
    • Chuang, T.H.1    Ulevitch, R.J.2
  • 61
    • 33746312334 scopus 로고    scopus 로고
    • Full-length sequence and expression analysis of Toll-like receptor 9 in the gilthead seabream (Sparus aurata L.)
    • Franch, R., Cardazzo, B., Antonello, J., Castagnaro, M., Patarnello, T. and Bargelloni, L. (2006) Full-length sequence and expression analysis of Toll-like receptor 9 in the gilthead seabream (Sparus aurata L.). Gene 378, 42-51.
    • (2006) Gene , vol.378 , pp. 42-51
    • Franch, R.1    Cardazzo, B.2    Antonello, J.3    Castagnaro, M.4    Patarnello, T.5    Bargelloni, L.6
  • 62
    • 84954358619 scopus 로고    scopus 로고
    • Cloning and expression analysis of two alternative splicing toll-like receptor 9 isoforms A and B in large yellow croaker, Pseudosciaena crocea
    • Yao, C.L., Kong, P., Wang, Z.Y., Ji, P.F., Cai, M.Y., Liu, X.D. and Han, X.Z. (2008) Cloning and expression analysis of two alternative splicing toll-like receptor 9 isoforms A and B in large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol. 25, 648-656.
    • (2008) Fish Shellfish Immunol. , vol.25 , pp. 648-656
    • Yao, C.L.1    Kong, P.2    Wang, Z.Y.3    Ji, P.F.4    Cai, M.Y.5    Liu, X.D.6    Han, X.Z.7
  • 63
    • 79151479087 scopus 로고    scopus 로고
    • Cell-specific expression of TLR9 isoforms in inflammation
    • McKelvey, K.J., Highton, J. and Hessian, P.A. (2011) Cell-specific expression of TLR9 isoforms in inflammation. J. Autoimmun. 36, 76-86.
    • (2011) J. Autoimmun. , vol.36 , pp. 76-86
    • McKelvey, K.J.1    Highton, J.2    Hessian, P.A.3
  • 66
    • 79952143793 scopus 로고    scopus 로고
    • Expression of Toll-like receptors 2, 3, 4, 6, 9, and MD-2 in the normal equine cornea, limbus, and conjunctiva
    • Gornik, K., Moore, P. and Figueiredo, M. (2011) Expression of Toll-like receptors 2, 3, 4, 6, 9, and MD-2 in the normal equine cornea, limbus, and conjunctiva. Vet. Ophthalmol. 14, 80-85.
    • (2011) Vet. Ophthalmol. , vol.14 , pp. 80-85
    • Gornik, K.1    Moore, P.2    Figueiredo, M.3
  • 67
    • 70350026654 scopus 로고    scopus 로고
    • Activation of foal neutrophils at different ages by CpG oligodeoxynucleotides and Rhodococcus equi
    • Liu, M., Liu, T., Bordin, A., Nerren, J. and Cohen, N. (2009) Activation of foal neutrophils at different ages by CpG oligodeoxynucleotides and Rhodococcus equi. Cytokine 48, 280-289.
    • (2009) Cytokine , vol.48 , pp. 280-289
    • Liu, M.1    Liu, T.2    Bordin, A.3    Nerren, J.4    Cohen, N.5
  • 70
    • 80052175401 scopus 로고    scopus 로고
    • Intracellular sensing of microbes and danger signals by the inflammasomes
    • Horvath, G.L., Schrum, J.E., De Nardo, C.M. and Latz, E. (2011) Intracellular sensing of microbes and danger signals by the inflammasomes. Immunol. Rev. 243, 119-135.
    • (2011) Immunol. Rev. , vol.243 , pp. 119-135
    • Horvath, G.L.1    Schrum, J.E.2    De Nardo, C.M.3    Latz, E.4
  • 71
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β
    • Martinon, F., Burns, K. and Tschopp, J. (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417-426.
    • (2002) Mol. Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 73
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • Kanneganti, T.D., Lamkanfi, M. and Núñez, G. (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27, 549-559.
    • (2007) Immunity , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Núñez, G.3
  • 74
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
    • Ogura, Y., Inohara, N., Benito, A., Chen, F.F., Yamaoka, S. and Nunez, G. (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276, 4812-4818.
    • (2001) J. Biol. Chem. , vol.276 , pp. 4812-4818
    • Ogura, Y.1    Inohara, N.2    Benito, A.3    Chen, F.F.4    Yamaoka, S.5    Nunez, G.6
  • 76
    • 76249120134 scopus 로고    scopus 로고
    • Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
    • Clarke, T.B., Davis, K.M., Lysenko, E.S., Zhou, A.Y., Yu, Y. and Weiser, J.N. (2010) Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat. Med. 16, 228-231.
    • (2010) Nat. Med. , vol.16 , pp. 228-231
    • Clarke, T.B.1    Davis, K.M.2    Lysenko, E.S.3    Zhou, A.Y.4    Yu, Y.5    Weiser, J.N.6
  • 77
    • 80051596812 scopus 로고    scopus 로고
    • Comparison of genomic and proteomic data in recurrent airway obstruction affected horses using ingenuity pathway analysis®
    • Racine, J., Gerber, V., Miskovic Feutz, M., Riley, C.P., Adamec, J., Swinburne, J.E. and Couetil, L.L. (2011) Comparison of genomic and proteomic data in recurrent airway obstruction affected horses using ingenuity pathway analysis®. BMC Vet. Res. 7, 48.
    • (2011) BMC Vet. Res. , vol.7 , pp. 48
    • Racine, J.1    Gerber, V.2    Miskovic Feutz, M.3    Riley, C.P.4    Adamec, J.5    Swinburne, J.E.6    Couetil, L.L.7
  • 78
    • 57149102672 scopus 로고    scopus 로고
    • NLRC4/IPAF: a CARD carrying member of the NLR family
    • Sutterwala, F.S. and Flavell, R. (2009) NLRC4/IPAF: a CARD carrying member of the NLR family. Clin. Immunol. 130, 2-6.
    • (2009) Clin. Immunol. , vol.130 , pp. 2-6
    • Sutterwala, F.S.1    Flavell, R.2
  • 89
    • 77955390094 scopus 로고    scopus 로고
    • Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
    • Broz, P., Newton, K., Lamkanfi, M., Mariathasan, S., Dixit, V.M. and Monack, D.M. (2010) Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J. Exp. Med. 207, 1745-1755.
    • (2010) J. Exp. Med. , vol.207 , pp. 1745-1755
    • Broz, P.1    Newton, K.2    Lamkanfi, M.3    Mariathasan, S.4    Dixit, V.M.5    Monack, D.M.6
  • 90
    • 69549119940 scopus 로고    scopus 로고
    • Molecular mechanisms involved in inflammasome activation
    • Bryant, C. and Fitzgerald, K.A. (2009) Molecular mechanisms involved in inflammasome activation. Trends Cell Biol. 19, 455-464.
    • (2009) Trends Cell Biol. , vol.19 , pp. 455-464
    • Bryant, C.1    Fitzgerald, K.A.2
  • 93
    • 0034716983 scopus 로고    scopus 로고
    • Cytoplasmic localization of the interferon-inducible protein that is encoded by the AIM2 (absent in melanoma) gene from the 200-gene family
    • Choubey, D., Walter, S., Geng, Y. and Xin, H. (2000) Cytoplasmic localization of the interferon-inducible protein that is encoded by the AIM2 (absent in melanoma) gene from the 200-gene family. FEBS Lett. 474, 38-42.
    • (2000) FEBS Lett. , vol.474 , pp. 38-42
    • Choubey, D.1    Walter, S.2    Geng, Y.3    Xin, H.4
  • 97
    • 0037226464 scopus 로고    scopus 로고
    • Lipopolysaccharide from Rhodobacter sphaeroides is an agonist in equine cells
    • Lohmann, K.L., Vandenplas, M., Barton, M.H. and Moore, J.N. (2003) Lipopolysaccharide from Rhodobacter sphaeroides is an agonist in equine cells. J. Endotoxin Res. 9, 33-37.
    • (2003) J. Endotoxin Res. , vol.9 , pp. 33-37
    • Lohmann, K.L.1    Vandenplas, M.2    Barton, M.H.3    Moore, J.N.4
  • 101
    • 0036954040 scopus 로고    scopus 로고
    • Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue
    • Rossignol, D.P. and Lynn, M. (2002) Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue. J. Endotoxin Res. 8, 483-488.
    • (2002) J. Endotoxin Res. , vol.8 , pp. 483-488
    • Rossignol, D.P.1    Lynn, M.2
  • 103
    • 45949103247 scopus 로고    scopus 로고
    • Effects of the second-generation synthetic lipid A analogue E5564 on responses to endotoxin in [corrected] equine whole blood and monocytes
    • Figueiredo, M.D., Moore, J.N., Vandenplas, M.L., Sun, W. and Murray, T.F. (2008) Effects of the second-generation synthetic lipid A analogue E5564 on responses to endotoxin in [corrected] equine whole blood and monocytes. Am. J. Vet. Res. 69, 796-803.
    • (2008) Am. J. Vet. Res. , vol.69 , pp. 796-803
    • Figueiredo, M.D.1    Moore, J.N.2    Vandenplas, M.L.3    Sun, W.4    Murray, T.F.5
  • 104
    • 80052968260 scopus 로고    scopus 로고
    • Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis
    • Kalil, A.C., LaRosa, S.P., Gogate, J., Lynn, M. and Opal, S.M. (2011) Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis. Shock 36, 327-331.
    • (2011) Shock , vol.36 , pp. 327-331
    • Kalil, A.C.1    LaRosa, S.P.2    Gogate, J.3    Lynn, M.4    Opal, S.M.5
  • 105
    • 80052756634 scopus 로고    scopus 로고
    • Eritoran trial reaches unfortunate conclusion
    • Ed: L. Davenport, MediFore Limited, Brussels
    • Opal, S.M. (2011) Eritoran trial reaches unfortunate conclusion. In: ISICEM News, Ed: L. Davenport, MediFore Limited, Brussels. pp 8-9.
    • (2011) ISICEM News , pp. 8-9
    • Opal, S.M.1
  • 107
    • 27644533352 scopus 로고    scopus 로고
    • Toll-like receptor 2 antagonists. Part 1: preliminary SAR investigation of novel synthetic phospholipids
    • Spyvee, M.R., Zhang, H., Hawkins, L.D. and Chow, J.C. (2005) Toll-like receptor 2 antagonists. Part 1: preliminary SAR investigation of novel synthetic phospholipids. Bioorg. Med. Chem. Lett. 15, 5494-5498.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 5494-5498
    • Spyvee, M.R.1    Zhang, H.2    Hawkins, L.D.3    Chow, J.C.4
  • 111
  • 112
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R.L. and Akira, S. (2002) Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169, 10-14.
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Takeda, K.5    Dong, Z.6    Modlin, R.L.7    Akira, S.8
  • 116
    • 0037083638 scopus 로고    scopus 로고
    • Cutting edge: immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent
    • Massari, P., Henneke, P., Ho, Y., Latz, E., Golenbock, D.T. and Wetzler, L.M. (2002) Cutting edge: immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J. Immunol. 168, 1533-1537.
    • (2002) J. Immunol. , vol.168 , pp. 1533-1537
    • Massari, P.1    Henneke, P.2    Ho, Y.3    Latz, E.4    Golenbock, D.T.5    Wetzler, L.M.6
  • 120
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner, R., Dziarski, R., Wesche, H., Rothe, M. and Kirschning, C.J. (1999) Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274, 17406-17409.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17406-17409
    • Schwandner, R.1    Dziarski, R.2    Wesche, H.3    Rothe, M.4    Kirschning, C.J.5
  • 121
    • 0033458799 scopus 로고    scopus 로고
    • Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
    • Underhill, D.M., Ozinsky, A., Smith, K.D. and Aderem, A. (1999) Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc. Natl. Acad. Sci. U.S.A. 96, 14459-14463.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 14459-14463
    • Underhill, D.M.1    Ozinsky, A.2    Smith, K.D.3    Aderem, A.4
  • 122
    • 0037200040 scopus 로고    scopus 로고
    • A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production
    • Garton, N.J., Gilleron, M., Brando, T., Dan, H.H., Giguere, S., Puzo, G., Prescott, J.F. and Sutcliffe, I.C. (2002) A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production. J. Biol. Chem. 277, 31722-31733.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31722-31733
    • Garton, N.J.1    Gilleron, M.2    Brando, T.3    Dan, H.H.4    Giguere, S.5    Puzo, G.6    Prescott, J.F.7    Sutcliffe, I.C.8
  • 125
    • 0035165287 scopus 로고    scopus 로고
    • Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    • Hajjar, A.M., O'Mahony, D.S., Ozinsky, A., Underhill, D.M., Aderem, A., Klebanoff, S.J. and Wilson, C.B. (2001) Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J. Immunol. 166, 15-19.
    • (2001) J. Immunol. , vol.166 , pp. 15-19
    • Hajjar, A.M.1    O'Mahony, D.S.2    Ozinsky, A.3    Underhill, D.M.4    Aderem, A.5    Klebanoff, S.J.6    Wilson, C.B.7
  • 130
    • 0035903158 scopus 로고    scopus 로고
    • Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
    • Vabulas, R.M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C.J., Hacker, H. and Wagner, H. (2001) Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J. Biol. Chem. 276, 31332-31339.
    • (2001) J. Biol. Chem. , vol.276 , pp. 31332-31339
    • Vabulas, R.M.1    Ahmad-Nejad, P.2    da Costa, C.3    Miethke, T.4    Kirschning, C.J.5    Hacker, H.6    Wagner, H.7
  • 131
    • 0037177825 scopus 로고    scopus 로고
    • Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4
    • Asea, A., Rehli, M., Kabingu, E., Boch, J.A., Bare, O., Auron, P.E., Stevenson, M.A. and Calderwood, S.K. (2002) Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 277, 15028-15034.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15028-15034
    • Asea, A.1    Rehli, M.2    Kabingu, E.3    Boch, J.A.4    Bare, O.5    Auron, P.E.6    Stevenson, M.A.7    Calderwood, S.K.8
  • 135
    • 49649127951 scopus 로고    scopus 로고
    • Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of β-defensin 2 via TLR2 and TLR4
    • Gariboldi, S., Palazzo, M., Zanobbio, L., Selleri, S., Sommariva, M., Sfondrini, L., Cavicchini, S., Balsari, A. and Rumio, C. (2008) Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of β-defensin 2 via TLR2 and TLR4. J. Immunol. 181, 2103-2110.
    • (2008) J. Immunol. , vol.181 , pp. 2103-2110
    • Gariboldi, S.1    Palazzo, M.2    Zanobbio, L.3    Selleri, S.4    Sommariva, M.5    Sfondrini, L.6    Cavicchini, S.7    Balsari, A.8    Rumio, C.9
  • 138
    • 0345505220 scopus 로고    scopus 로고
    • Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2
    • Compton, T., Kurt-Jones, E.A., Boehme, K.W., Belko, J., Latz, E., Golenbock, D.T. and Finberg, R.W. (2003) Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J. Virol. 77, 4588-4596.
    • (2003) J. Virol. , vol.77 , pp. 4588-4596
    • Compton, T.1    Kurt-Jones, E.A.2    Boehme, K.W.3    Belko, J.4    Latz, E.5    Golenbock, D.T.6    Finberg, R.W.7
  • 140
    • 15844389172 scopus 로고    scopus 로고
    • MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection
    • Zhou, S., Kurt-Jones, E.A., Mandell, L., Cerny, A., Chan, M., Golenbock, D.T. and Finberg, R.W. (2005) MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection. Eur. J. Immunol. 35, 822-830.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 822-830
    • Zhou, S.1    Kurt-Jones, E.A.2    Mandell, L.3    Cerny, A.4    Chan, M.5    Golenbock, D.T.6    Finberg, R.W.7
  • 142
    • 0034651729 scopus 로고    scopus 로고
    • Human Toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
    • Flo, T.H., Halaas, O., Lien, E., Ryan, L., Teti, G., Golenbock, D.T., Sundan, A. and Espevik, T. (2000) Human Toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J. Immunol. 164, 2064-2069.
    • (2000) J. Immunol. , vol.164 , pp. 2064-2069
    • Flo, T.H.1    Halaas, O.2    Lien, E.3    Ryan, L.4    Teti, G.5    Golenbock, D.T.6    Sundan, A.7    Espevik, T.8
  • 143
    • 67349224644 scopus 로고    scopus 로고
    • SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-κB pathway in human monocyte macrophages in vitro
    • Dosch, S.F., Mahajan, S.D. and Collins, A.R. (2009) SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-κB pathway in human monocyte macrophages in vitro. Virus Res. 142, 19-27.
    • (2009) Virus Res. , vol.142 , pp. 19-27
    • Dosch, S.F.1    Mahajan, S.D.2    Collins, A.R.3
  • 145
    • 0035313274 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates intracellular signaling without TNF-α release in response to Cryptococcus neoformans polysaccharide capsule
    • Shoham, S., Huang, C., Chen, J.M., Golenbock, D.T. and Levitz, S.M. (2001) Toll-like receptor 4 mediates intracellular signaling without TNF-α release in response to Cryptococcus neoformans polysaccharide capsule. J. Immunol. 166, 4620-4626.
    • (2001) J. Immunol. , vol.166 , pp. 4620-4626
    • Shoham, S.1    Huang, C.2    Chen, J.M.3    Golenbock, D.T.4    Levitz, S.M.5
  • 147
    • 67650394363 scopus 로고    scopus 로고
    • Requirement of TLR4 and CD14 in dendritic cell activation by Hemagglutinin B from Porphyromonas gingivalis
    • Gaddis, D.E., Michalek, S.M. and Katz, J. (2009) Requirement of TLR4 and CD14 in dendritic cell activation by Hemagglutinin B from Porphyromonas gingivalis. Mol. Immunol. 46, 2493-2504.
    • (2009) Mol. Immunol. , vol.46 , pp. 2493-2504
    • Gaddis, D.E.1    Michalek, S.M.2    Katz, J.3
  • 148
    • 0037087255 scopus 로고    scopus 로고
    • Toll-like receptor 4-MD-2 complex mediates the signal transduction induced by flavolipin, an amino acid-containing lipid unique to Flavobacterium meningosepticum
    • Gomi, K., Kawasaki, K., Kawai, Y., Shiozaki, M. and Nishijima, M. (2002) Toll-like receptor 4-MD-2 complex mediates the signal transduction induced by flavolipin, an amino acid-containing lipid unique to Flavobacterium meningosepticum. J. Immunol. 168, 2939-2943.
    • (2002) J. Immunol. , vol.168 , pp. 2939-2943
    • Gomi, K.1    Kawasaki, K.2    Kawai, Y.3    Shiozaki, M.4    Nishijima, M.5
  • 149
    • 37349033531 scopus 로고    scopus 로고
    • Synthetic Toll-like receptor 4 agonist enhances vaccine efficacy in an experimental model of toxic shock syndrome
    • Morefield, G.L., Hawkins, L.D., Ishizaka, S.T., Kissner, T.L. and Ulrich, R.G. (2007) Synthetic Toll-like receptor 4 agonist enhances vaccine efficacy in an experimental model of toxic shock syndrome. Clin. Vaccine Immunol. 14, 1499-1504.
    • (2007) Clin. Vaccine Immunol. , vol.14 , pp. 1499-1504
    • Morefield, G.L.1    Hawkins, L.D.2    Ishizaka, S.T.3    Kissner, T.L.4    Ulrich, R.G.5
  • 150
    • 0034723186 scopus 로고    scopus 로고
    • Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol
    • Kawasaki, K., Akashi, S., Shimazu, R., Yoshida, T., Miyake, K. and Nishijima, M. (2000) Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J. Biol. Chem. 275, 2251-2254.
    • (2000) J. Biol. Chem. , vol.275 , pp. 2251-2254
    • Kawasaki, K.1    Akashi, S.2    Shimazu, R.3    Yoshida, T.4    Miyake, K.5    Nishijima, M.6
  • 154
    • 0037094084 scopus 로고    scopus 로고
    • Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
    • Johnson, G.B., Brunn, G.J., Kodaira, Y. and Platt, J.L. (2002) Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J. Immunol. 168, 5233-5239.
    • (2002) J. Immunol. , vol.168 , pp. 5233-5239
    • Johnson, G.B.1    Brunn, G.J.2    Kodaira, Y.3    Platt, J.L.4
  • 155
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley, S.T., King, J.A. and Hancock, W.W. (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J. Immunol. 167, 2887-2894.
    • (2001) J. Immunol. , vol.167 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 158
    • 0035892911 scopus 로고    scopus 로고
    • Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein
    • Eaves-Pyles, T.D., Wong, H.R., Odoms, K. and Pyles, R.B. (2001) Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein. J. Immunol. 167, 7009-7016.
    • (2001) J. Immunol. , vol.167 , pp. 7009-7016
    • Eaves-Pyles, T.D.1    Wong, H.R.2    Odoms, K.3    Pyles, R.B.4
  • 161
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund, J., Sato, A., Akira, S., Medzhitov, R. and Iwasaki, A. (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198, 513-520.
    • (2003) J. Exp. Med. , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 162
    • 0037460116 scopus 로고    scopus 로고
    • Recognition of pathogen-associated molecular patterns by TLR family
    • Akira, S. and Hemmi, H. (2003) Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 85, 85-95.
    • (2003) Immunol. Lett. , vol.85 , pp. 85-95
    • Akira, S.1    Hemmi, H.2
  • 166
    • 28444471235 scopus 로고    scopus 로고
    • Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells
    • Tada, H., Aiba, S., Shibata, K., Ohteki, T. and Takada, H. (2005) Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect. Immun. 73, 7967-7976.
    • (2005) Infect. Immun. , vol.73 , pp. 7967-7976
    • Tada, H.1    Aiba, S.2    Shibata, K.3    Ohteki, T.4    Takada, H.5
  • 167
    • 79955370281 scopus 로고    scopus 로고
    • The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection
    • Rajan, J.V., Rodriguez, D., Miao, E.A. and Aderem, A. (2011) The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection. J. Virol. 85, 4167-4172.
    • (2011) J. Virol. , vol.85 , pp. 4167-4172
    • Rajan, J.V.1    Rodriguez, D.2    Miao, E.A.3    Aderem, A.4
  • 169
    • 65549154784 scopus 로고    scopus 로고
    • An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans
    • Hise, A.G., Tomalka, J., Ganesan, S., Patel, K., Hall, B.A., Brown, G.D. and Fitzgerald, K.A. (2009) An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe 5, 487-497.
    • (2009) Cell Host Microbe , vol.5 , pp. 487-497
    • Hise, A.G.1    Tomalka, J.2    Ganesan, S.3    Patel, K.4    Hall, B.A.5    Brown, G.D.6    Fitzgerald, K.A.7
  • 170
    • 77954958602 scopus 로고    scopus 로고
    • Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase
    • Said-Sadier, N., Padilla, E., Langsley, G. and Ojcius, D.M. (2010) Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase. PLoS One 5, e10008.
    • (2010) PLoS One , vol.5
    • Said-Sadier, N.1    Padilla, E.2    Langsley, G.3    Ojcius, D.M.4
  • 172
    • 7944232105 scopus 로고    scopus 로고
    • Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
    • Martinon, F., Agostini, L., Meylan, E. and Tschopp, J. (2004) Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 14, 1929-1934.
    • (2004) Curr. Biol. , vol.14 , pp. 1929-1934
    • Martinon, F.1    Agostini, L.2    Meylan, E.3    Tschopp, J.4
  • 174
    • 0028989337 scopus 로고
    • Potassium-inhibited processing of IL-1 beta in human monocytes
    • Walev, I., Reske, K., Palmer, M., Valeva, A. and Bhakdi, S. (1995) Potassium-inhibited processing of IL-1 beta in human monocytes. EMBO J. 14, 1607-1614.
    • (1995) EMBO J. , vol.14 , pp. 1607-1614
    • Walev, I.1    Reske, K.2    Palmer, M.3    Valeva, A.4    Bhakdi, S.5
  • 175
    • 33748598700 scopus 로고    scopus 로고
    • Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    • Gurcel, L., Abrami, L., Girardin, S., Tschopp, J. and van der Goot, F.G. (2006) Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 126, 1135-1145.
    • (2006) Cell , vol.126 , pp. 1135-1145
    • Gurcel, L.1    Abrami, L.2    Girardin, S.3    Tschopp, J.4    van der Goot, F.G.5
  • 177
    • 47249095738 scopus 로고    scopus 로고
    • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection
    • Warren, S.E., Mao, D.P., Rodriguez, A.E., Miao, E.A. and Aderem, A. (2008) Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J. Immunol. 180, 7558-7564.
    • (2008) J. Immunol. , vol.180 , pp. 7558-7564
    • Warren, S.E.1    Mao, D.P.2    Rodriguez, A.E.3    Miao, E.A.4    Aderem, A.5
  • 179
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. and Tschopp, J. (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 180
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • Dostert, C., Petrilli, V., Van Bruggen, R., Steele, C., Mossman, B.T. and Tschopp, J. (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674-677.
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Petrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.