Plasma endotoxin in horses presented to an equine referral hospital: Correlation to selected clinical parameters and outcomes

Equine Veterinary Journal

Volumn 43, Issue 5, 2011, Pages 585-591

  Senior, J M ^a   Proudman, C J ^a   Leuwer, M ^b   Carter, S D ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Perioperative Medicine and Pain'   (United Kingdom)

Author keywords

Assay; Colic; Endotoxaemia; Endotoxin; Horse; Plasma

Indexed keywords

LIPOPOLYSACCHARIDE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; COLIC; ENDOTOXEMIA; FEMALE; HORSE; HORSE DISEASE; MALE; MORTALITY; PATHOLOGY; RISK; RISK FACTOR;

ANIMALS; COLIC; ENDOTOXEMIA; FEMALE; HORSE DISEASES; HORSES; LIPOPOLYSACCHARIDES; MALE; ODDS RATIO; RISK FACTORS;

EQUIDAE; LIMULUS; LIMULUS AMOEBOCYTE;

EID: 80051471930     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2010.00328.x     Document Type: Article

References (28)

1. Barton, M.H., Parviainen, A. and Norton, N. (2004) Polymyxin B protects horses against induced endotoxaemia in vivo. Equine vet. J. 36, 397-401.
2. Danner, R.L., Joiner, K.A., Rubin, M., Patterson, W.H., Johnson, N., Ayers, K.M. and Parrillo, J.E. (1989) Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob. Agents Chemother. 33, 1428-1434.
3. Donovan, D.C., Jackson, C.A., Colahan, P.T., Norton, N. and Hurley, D.J. (2007) Exercise-induced alterations in pro-inflammatory cytokines and prostaglandin F2 alpha in horses. Vet. Immunol. Immunopathol. 118, 263-269.
4. Fan, H.K. and Cook, J.A. (2004) Molecular mechanisms of endotoxin tolerance. J. Endotoxin Res. 10, 71-84.
5. Fessler, J.F., Bottoms, G.D., Coppoc, G.L., Gimarc, S., Latshaw, H.S. and Noble, J.K. (1989) Plasma endotoxin concentrations in experimental and clinical equine subjects. Equine vet. J., Suppl. 7, 24-28.
6. Figueiredo, M.D., Vandenplas, M.L., Hurley, D.J. and Moore, J.N. (2009) Differential induction of MyD88- and TRIF-dependent pathways in equine monocytes by Toll-like receptor agonists. Vet. Immunol. Immunopathol. 127, 125-134.
7. French, N.P., Smith, J., Edwards, G.B. and Proudman, C.J. (2002) Equine surgical colic: Risk factors for postoperative complications. Equine vet. J. 34, 444-449.
8. Geraghty, T., Love, S., Taylor, D., Heller, J., Mellor, D.J. and Hughes, K.J. (2008) Ultrasonographic and microbiological assessment of sub-clinical catheter-related venous disease in horses and associated risk factors. In: Proceedings of the 9th International Colic Research Symposium. pp 113-114.
9. King, J.N. and Gerring, E.L. (1988) Detection of endotoxin in cases of equine colic. Vet. Rec. 123, 269-271.
10. Leise, B.S., Yin, C., Pettigrew, A. and Belknap, J.K. (2010) Proinflammatory cytokine responses of cultured equine keratinocytes to bacterial pathogen-associated molecular pattern motifs. Equine vet J. 42, 294-303.
11. Levin, J. and Bang, F.B. (1964) Role of endotoxin in extracellular coagulation of Limulus blood. Bull. Johns Hopkins Hosp. 115, 265-274.
12. Mathison, J.C. and Ulevitch, R.J. (1979) The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits. J. Immunol. 123, 2133-2143.
13. Menzies-Gow, N.J., Bailey, S.R., Katz, L.M., Marr, C.M. and Elliott, J. (2004) Endotoxin-induced digital vasoconstriction in horses: Associated changes in plasma concentrations of vasoconstrictor mediators. Equine vet. J. 36, 273-278.
14. Moore, J.N. (1988) Recognition and treatment of endotoxaemia. Vet. Clin. N. Am.: Equine Pract. 4, 105-113.
15. Moore, J.N., Norton, N., Barton, M.H., Hurley, D.J., Reber, A.J., Donovan, D.C., Vandenplas, M.L., Parker, T.S. and Levine, D.M. (2007) Rapid infusion of a phospholipid emulsion attenuates the effects of endotoxaemia in horses. Equine vet. J. 39, 243-248.
16. Netea, M.G., van der Graaf, C., van der Meer, J.W. and Kullberg, B.J. (2004) Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system. J. Leukoc. Biol. 75, 749-755.
17. Parviainen, A.K., Barton, M.H. and Norton, N.N. (2001) Evaluation of polymyxin B in an ex vivo model of endotoxemia in horses. Am. J. vet. Res. 62, 72-76.
18. Peek, S.F., Borah, S., Semrad, S., McGuirk, S., Slack, J.A., Patton, E., Coombs, D., Lien, L. and Darien, B.J. (2004) Plasma endotoxin concentration in horses: A methods study. Vet. Clin. Path. 33, 29-31.
19. Proudman, C.J., Edwards, G.B., Barnes, J. and French, N.P. (2005a) Factors affecting long-term survival of horses recovering from surgery of the small intestine. Equine vet. J. 37, 360-365.
20. Proudman, C.J., Edwards, G.B., Barnes, J. and French, N.P. (2005b) Modelling long-term survival of horses following surgery for large intestinal disease. Equine vet. J. 37, 366-370.
21. Proudman, C.J., Smith, J.E., Edwards, G.B. and French, N.P. (2002) Long-term survival of equine surgical colic cases. Part 1: patterns of mortality and morbidity. Equine vet. J. 34, 432-437.
22. Senior, J.M. (2009) Complement and Endotoxins in Equine Colic. PhD Thesis, University of Liverpool. pp 137-170.
23. Sprouse, R.F., Garner, H.E. and Green, E.M. (1987) Plasma endotoxin levels in horses subjected to carbohydrate induced laminitis. Equine vet. J. 19, 25-28.
24. Steverink, P., Salden, H.J.M., Sturk, A., Klein, W.R., van der Velden, M.A. and Németh, F. (1994) Laboratory and clinical evaluation of a chromogenic endotoxin assay for horses with acute intestinal disorders. Vet. Quart. 16, S117-S121.
25. Steverink, P., Sturk, A., Rutten, V., Wagenaarhilbers, J., Klein, W.R., van der Velden, M.A. and Németh, F. (1995) Endotoxin, interleukin-6 and tumor-necrosis-factor concentrations in equine acute abdominal disease- relation to clinical outcome. J. Endotox. Res. 2, 289-299.
26. Sykes, B.W. and Furr, M. (2005) Equine endotoxaemia - a state-of-the art review of therapy. Aust. vet. J. 83, 45-50.
27. Tachiyama, G., Sakon, M., Kambayashi, J., Ohshiro, T. and Mori, T. (1986) Chromogenic assay of endotoxin in platelet poor or rich plasma. Thromb. Res. 41, 309-317.
28. Werners, A.H., Bull, S. and Fink-Gremmels, J. (2005) Endotoxaemia: a review with implications for the horse. Equine vet. J. 37, 371-383.