A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection

Infection and Immunity

Volumn 68, Issue 11, 2000, Pages 6398-6401

  Lorenz, E ^a   Mira, J P ^a   Cornish, K L ^a   Arbour, N C ^a   Schwartz, D A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN; RECEPTOR PROTEIN; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BORRELIA BURGDORFERI; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; GENE MUTATION; HUMAN; HUMAN CELL; MISSENSE MUTATION; MYCOPLASMA HOMINIS; OPEN READING FRAME; PRIORITY JOURNAL; SEPTIC SHOCK; SINGLE STRAND CONFORMATION POLYMORPHISM; STAPHYLOCOCCUS INFECTION; TREPONEMA PALLIDUM;

AMINO ACID SEQUENCE; ANIMAL; HUMAN; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMORPHISM (GENETICS); RECEPTORS, CELL SURFACE; SHOCK, SEPTIC; STAPHYLOCOCCAL INFECTIONS; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

BORRELIA BURGDORFERI; MYCOPLASMA FERMENTANS; TREPONEMA PALLIDUM;

EID: 0033794461     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.11.6398-6401.2000     Document Type: Article

References (17)

1. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
2. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
3. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
4. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
5. Cutting edge: Cells that carry a null allele for toll-like receptor 2 are capable of responding to endotoxin
6. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
7. Multiple systems organ failures: Epidemiology and prognosis
8. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
9. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
10. Innate immunity: Impact on the adaptive immune response
11. Association of TNF2, a TNF-α promoter polymorphism, with septic shock susceptibility and mortality
12. Defective LPS signaling in C3H/Hej and C57BL/10ScCr mice: Mutations in Tlr4 gene
13. Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins
14. MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4
15. The IL-1 receptor and Rho directly associate to drive cell activation in inflammation
16. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
17. Detection of mutations by single-strand conformation polymorphism (SSCP) analysis and SSCP-hybrid methods