Molecular cloning and characterization of equine Toll-like receptor 9

Veterinary Immunology and Immunopathology

Volumn 124, Issue 3-4, 2008, Pages 209-219

  Zhang, Yuwen W ^a   Davis, Elizabeth G ^a   Blecha, Frank ^a   Wilkerson, Melinda J ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Equine TLR9; PMBC; PMN

Indexed keywords

MONOCLONAL ANTIBODY; MRNA EXP; TOLL LIKE RECEPTOR 9;

ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE AMPLIFICATION; GENE SEQUENCE; HORSE; INNATE IMMUNITY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CLONING, MOLECULAR; FLOW CYTOMETRY; HORSES; IMMUNITY, NATURAL; PHYLOGENY; RANDOM AMPLIFIED POLYMORPHIC DNA TECHNIQUE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SEQUENCE ANALYSIS, DNA; TOLL-LIKE RECEPTOR 9;

BACTERIA (MICROORGANISMS); BOVINAE; EQUIDAE; FELIDAE; OVIS; SUS;

EID: 47049095772     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.03.005     Document Type: Article

References (61)

1. Akira S., and Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4 (2004) 499-511
2. Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
3. Anders H.J. A Toll for lupus. Lupus 14 (2005) 417-422
4. Bafica A., Scanga C.A., Feng C.G., Leifer C., Cheever A., and Sher A. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J. Exp. Med. 202 (2005) 1715-1724
5. Bafica A., Santiago H.C., Goldszmid R., Ropert C., Gazzinelli R.T., and Sher A. Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection. J. Immunol. 177 (2006) 3515-3519
6. Barton G.M., Kagan J.C., and Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7 (2006) 49-56
7. Bauer S., Kirschning C.J., Hacker H., Redecke V., Hausmann S., Akira S., Wagner H., and Lipford G.B. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 9237-9242
8. Bowie A., and O'Neill L.A. The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J. Leukoc. Biol. 67 (2000) 508-514
9. Bowles K.S., Beadle R.E., Mouch S., Pourciau S.S., Littlefield-Chabaud M.A., Le B.C., Mistric L., Fermaglich D., and Horohov D.W. A novel model for equine recurrent airway obstruction. Vet. Immunol. Immunopathol. 87 (2002) 385-389
10. Chuang T.H., and Ulevitch R.J. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 11 (2000) 372-378
11. Cordeau M.E., Joubert P., Dewachi O., Hamid Q., and Lavoie J.P. IL-4, IL-5 and IFN-gamma mRNA expression in pulmonary lymphocytes in equine heaves. Vet. Immunol. Immunopathol. 97 (2004) 87-96
12. Cornelie S., Hoebeke J., Schacht A.M., Bertin B., Vicogne J., Capron M., and Riveau G. Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosine-phosphate-guanine motif recognition. J. Biol. Chem. 279 (2004) 15124-15129
13. Dewachi O., Joubert P., Hamid Q., and Lavoie J.P. Expression of interleukin (IL)-5 and IL-9 receptors on neutrophils of horses with heaves. Vet. Immunol. Immunopathol. 109 (2006) 31-36
14. Flaminio M.J., Borges A.S., Nydam D.V., Horohov D.W., Hecker R., and Matychak M.B. The effect of CpG-ODN on antigen presenting cells of the foal. J. Immun. Based Ther. Vaccines 5 (2007) 1
15. Fransson M., Benson M., Erjefalt J.S., Jansson L., Uddman R., Bjornsson S., Cardell L.O., and Adner M. Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis. Respir. Res. 8 (2007) 17
16. Giguere S., Viel L., Lee E., MacKay R.J., Hernandez J., and Franchini M. Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet. Immunol. Immunopathol. 85 (2002) 147-158
17. Griebel P.J., Brownlie R., Manuja A., Nichani A., Mookherjee N., Popowych Y., Mutwiri G., Hecker R., and Babiuk L.A. Bovine toll-like receptor 9: a comparative analysis of molecular structure, function and expression. Vet. Immunol. Immunopathol. 108 (2005) 11-16
18. Hasan U.A., Bates E., Takeshita F., Biliato A., Accardi R., Bouvard V., Mansour M., Vincent I., Gissmann L., Iftner T., Sideri M., Stubenrauch F., and Tommasino M. TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16. J. Immunol. 178 (2007) 3186-3197
19. Hashimoto C., Hudson K.L., and Anderson K.V. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52 (1988) 269-279
20. Hashimoto M., Asahina Y., Sano J., Kano R., Moritomo T., and Hasegawa A. Cloning of canine toll-like receptor 9 and its expression in dog tissues. Vet. Immunol. Immunopathol. 106 (2005) 159-163
21. Hayashi T., and Raz E. TLR9-based immunotherapy for allergic disease. Am. J. Med. 119 (2006) 897-906
22. Hayashi F., Means T.K., and Luster A.D. Toll-like receptors stimulate human neutrophil function. Blood 102 (2003) 2660-2669
23. Heil F., hmad-Nejad P., Hemmi H., Hochrein H., Ampenberger F., Gellert T., Dietrich H., Lipford G., Takeda K., Akira S., Wagner H., and Bauer S. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur. J. Immunol. 33 (2003) 2987-2997
24. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., and Bauer S. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303 (2004) 1526-1529
25. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., and Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
26. Hines S.A., Stone D.M., Hines M.T., Alperin D.C., Knowles D.P., Norton L.K., Hamilton M.J., Davis W.C., and McGuire T.C. Clearance of virulent but not avirulent Rhodococcus equi from the lungs of adult horses is associated with intracytoplasmic gamma interferon production by CD4+ and CD8+ T lymphocytes. Clin. Diagn. Lab Immunol. 10 (2003) 208-215
27. Hoene V., Peiser M., and Wanner R. Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19. J. Leukoc. Biol. 80 (2006) 1328-1336
28. Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T., Endres S., and Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168 (2002) 4531-4537
29. Ignacio G., Nordone S., Howard K.E., and Dean G.A. Toll-like receptor expression in feline lymphoid tissues. Vet. Immunol. Immunopathol. 106 (2005) 229-237
30. Janeway Jr. C.A., and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 20 (2002) 197-216
31. Kalis C., Gumenscheimer M., Freudenberg N., Tchaptchet S., Fejer G., Heit A., Akira S., Galanos C., and Freudenberg M.A. Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes. J. Immunol. 174 (2005) 4295-4300
32. Khvalevsky E., Rivkin L., Rachmilewitz J., Galun E., and Giladi H. TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. J. Cell Biochem. 100 (2007) 1301-1312
33. Kohler A.K., Stone D.M., Hines M.T., Byrne B.A., Alperin D.C., Norton L.K., and Hines S.A. Rhodococcus equi secreted antigens are immunogenic and stimulate a type 1 recall response in the lungs of horses immune to R. equi infection. Infect. Immun. 71 (2003) 6329-6337
34. Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 5 (2006) 471-484
35. Krieg A.M. Development of TLR9 agonists for cancer therapy. J. Clin. Invest. 117 (2007) 1184-1194
36. Krug A., French A.R., Barchet W., Fischer J.A., Dzionek A., Pingel J.T., Orihuela M.M., Akira S., Yokoyama W.M., and Colonna M. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21 (2004) 107-119
37. Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., Lien E., Nilsen N.J., Espevik T., and Golenbock D.T. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5 (2004) 190-198
38. Lavoie J.P., Maghni K., Desnoyers M., Taha R., Martin J.G., and Hamid Q.A. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile. Am. J. Respir. Crit. Care Med. 164 (2001) 1410-1413
39. Leifer C.A., Kennedy M.N., Mazzoni A., Lee C., Kruhlak M.J., and Segal D.M. TLR9 is localized in the endoplasmic reticulum prior to stimulation. J. Immunol. 173 (2004) 1179-1183
40. Leifer C.A., Brooks J.C., Hoelzer K., Lopez J., Kennedy M.N., Mazzoni A., and Segal D.M. Cytoplasmic targeting motifs control localization of toll-like receptor 9. J. Biol. Chem. 281 (2006) 35585-35592
41. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., and Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 (1996) 973-983
42. Lopez A.M., Hecker R., Mutwiri G., van Drunen Littel-van den Hurk S., Babiuk L.A., and Townsend H.G. Formulation with CpG ODN enhances antibody responses to an equine influenza virus vaccine. Vet. Immunol. Immunopathol. 114 (2006) 103-110
43. Lund J., Sato A., Akira S., Medzhitov R., and Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198 (2003) 513-520
44. Marchler-Bauer A., Anderson J.B., Derbyshire M.K., Weese-Scott C., Gonzales N.R., Gwadz M., Hao L., He S., Hurwitz D.I., Jackson J.D., Ke Z., Krylov D., Lanczycki C.J., Liebert C.A., Liu C., Lu F., Lu S., Marchler G.H., Mullokandov M., Song J.S., Thanki N., Yamashita R.A., Yin J.J., Zhang D., and Bryant S.H. CDD: a conserved domain database for interactive domain family analysis. Nucl. Acids Res. 35 (2007) D237-D240
45. Page R.D. TreeView: an application to display phylogenetic trees on personal computers. Comput. Appl. Biosci. 12 (1996) 357-358
46. Paillot R., Daly J.M., Juillard V., Minke J.M., Hannant D., and Kydd J.H. Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1. Vaccine 23 (2005) 4541-4551
47. Parker L.C., Whyte M.K., Dower S.K., and Sabroe I. The expression and roles of Toll-like receptors in the biology of the human neutrophil. J. Leukoc. Biol. 77 (2005) 886-892
48. Pasare C., and Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Microbes Infect. 6 (2004) 1382-1387
49. Patton K.M., McGuire T.C., Fraser D.G., and Hines S.A. Rhodococcus equi-infected macrophages are recognized and killed by CD8+ T lymphocytes in a major histocompatibility complex class I-unrestricted fashion. Infect. Immun. 72 (2004) 7073-7083
50. Patton K.M., McGuire T.C., Hines M.T., Mealey R.H., and Hines S.A. Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals. Infect. Immun. 73 (2005) 2083-2093
51. Rahman A.H., and Eisenberg R.A. The role of toll-like receptors in systemic lupus erythematosus. Springer Semin. Immunopathol. 28 (2006) 131-143
52. Ramakers C., Ruijter J.M., Deprez R.H., and Moorman A.F. Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci. Lett. 339 (2003) 62-66
53. Schefe J.H., Lehmann K.E., Buschmann I.R., Unger T., and Funke-Kaiser H. Quantitative real-time RT-PCR data analysis: current concepts and the novel "gene expression's CT difference" formula. J. Mol. Med. 84 (2006) 901-910
54. Shimosato T., Kitazawa H., Katoh S., Tomioka Y., Karima R., Ueha S., Kawai Y., Hishinuma T., Matsushima K., and Saito T. Swine Toll-like receptor 9(1) recognizes CpG motifs of human cell stimulant. Biochim. Biophys. Acta 1627 (2003) 56-61
55. Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., and Beutler B. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 3516-3521
56. Takeda K., Kaisho T., and Akira S. Toll-like receptors. Annu. Rev. Immunol. 21 (2003) 335-376
57. Trevani A.S., Chorny A., Salamone G., Vermeulen M., Gamberale R., Schettini J., Raiden S., and Geffner J. Bacterial DNA activates human neutrophils by a CpG-independent pathway. Eur. J. Immunol. 33 (2003) 3164-3174
58. Tumas D.B., Brassfield A.L., Travenor A.S., Hines M.T., Davis W.C., and McGuire T.C. Monoclonal antibodies to the equine CD2 T lymphocyte marker, to a pan-granulocyte/monocyte marker and to a unique pan-B lymphocyte marker. Immunobiology 192 (1994) 48-64
59. Uchijima M., Nagata T., Aoshi T., and Koide Y. IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA. Immunol. Cell Biol. 83 (2005) 92-95
60. Wattrang E., Berg M., and Magnusson M. Immunostimulatory DNA activates production of type I interferons and interleukin-6 in equine peripheral blood mononuclear cells in vitro. Vet. Immunol. Immunopathol. 107 (2005) 265-279
61. Werling D., and Jungi T.W. TOLL-like receptors linking innate and adaptive immune response. Vet. Immunol. Immunopathol. 91 (2003) 1-12