-
1
-
-
55749084738
-
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
-
Ahn B.H., Kim H.S., Song S., Lee I.H., Liu J., Vassilopoulos A., Deng C.X., Finkel T. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:14447-14452.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
Kim, H.S.2
Song, S.3
Lee, I.H.4
Liu, J.5
Vassilopoulos, A.6
Deng, C.X.7
Finkel, T.8
-
2
-
-
36349030394
-
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
-
Ahuja N., Schwer B., Carobbio S., Waltregny D., North B.J., Castronovo V., Maechler P., Verdin E. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J. Biol. Chem. 2007, 282:33583-33592.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 33583-33592
-
-
Ahuja, N.1
Schwer, B.2
Carobbio, S.3
Waltregny, D.4
North, B.J.5
Castronovo, V.6
Maechler, P.7
Verdin, E.8
-
4
-
-
79953799195
-
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer
-
Alhazzazi T.Y., Kamarajan P., Joo N., Huang J.Y., Verdin E., D'Silva N.J., Kapila Y.L. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer 2011, 117:1670-1687.
-
(2011)
Cancer
, vol.117
, pp. 1670-1687
-
-
Alhazzazi, T.Y.1
Kamarajan, P.2
Joo, N.3
Huang, J.Y.4
Verdin, E.5
D'Silva, N.J.6
Kapila, Y.L.7
-
5
-
-
36849002444
-
SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways
-
Allison S.J., Milner J. SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways. Cell Cycle 2007, 6:2669-2677.
-
(2007)
Cell Cycle
, vol.6
, pp. 2669-2677
-
-
Allison, S.J.1
Milner, J.2
-
6
-
-
77954353059
-
Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
-
Aquilano K., Vigilanza P., Baldelli S., Pagliei B., Rotilio G., Ciriolo M.R. Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J. Biol. Chem. 2010, 285:21590-21599.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 21590-21599
-
-
Aquilano, K.1
Vigilanza, P.2
Baldelli, S.3
Pagliei, B.4
Rotilio, G.5
Ciriolo, M.R.6
-
7
-
-
33748199578
-
Insulin secretion: SIRT4 gets in on the act
-
Argmann C., Auwerx J. Insulin secretion: SIRT4 gets in on the act. Cell 2006, 126:837-839.
-
(2006)
Cell
, vol.126
, pp. 837-839
-
-
Argmann, C.1
Auwerx, J.2
-
8
-
-
33750212896
-
Altered sirtuin expression is associated with node-positive breast cancer
-
Ashraf N., Zino S., Macintyre A., Kingsmore D., Payne A.P., George W.D., Shiels P.G. Altered sirtuin expression is associated with node-positive breast cancer. Br. J. Cancer 2006, 95:1056-1061.
-
(2006)
Br. J. Cancer
, vol.95
, pp. 1056-1061
-
-
Ashraf, N.1
Zino, S.2
Macintyre, A.3
Kingsmore, D.4
Payne, A.P.5
George, W.D.6
Shiels, P.G.7
-
9
-
-
3943054839
-
The Sir2 family of protein deacetylases
-
Blander G., Guarente L. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 2004, 73:417-435.
-
(2004)
Annu. Rev. Biochem.
, vol.73
, pp. 417-435
-
-
Blander, G.1
Guarente, L.2
-
10
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
-
Bordone L., Motta M.C., Picard F., Robinson A., Jhala U.S., Apfeld J., McDonagh T., Lemieux M., McBurney M., Szilvasi A., Easlon E.J., Lin S.J., Guarente L. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 2006, 4:e31.
-
(2006)
PLoS Biol.
, vol.4
-
-
Bordone, L.1
Motta, M.C.2
Picard, F.3
Robinson, A.4
Jhala, U.S.5
Apfeld, J.6
McDonagh, T.7
Lemieux, M.8
McBurney, M.9
Szilvasi, A.10
Easlon, E.J.11
Lin, S.J.12
Guarente, L.13
-
11
-
-
36248975293
-
SIRT1 transgenic mice show phenotypes resembling calorie restriction
-
Bordone L., Cohen D., Robinson A., Motta M.C., van Veen E., Czopik A., Steele A.D., Crowe H., Marmor S., Luo J., Gu W., Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007, 6:759-767.
-
(2007)
Aging Cell
, vol.6
, pp. 759-767
-
-
Bordone, L.1
Cohen, D.2
Robinson, A.3
Motta, M.C.4
van Veen, E.5
Czopik, A.6
Steele, A.D.7
Crowe, H.8
Marmor, S.9
Luo, J.10
Gu, W.11
Guarente, L.12
-
12
-
-
20444444649
-
Mechanism of human SIRT1 activation by resveratrol
-
Borra M.T., Smith B.C., Denu J.M. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 2005, 280:17187-17195.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17187-17195
-
-
Borra, M.T.1
Smith, B.C.2
Denu, J.M.3
-
13
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., Hu L.S., Cheng H.L., Jedrychowski M.P., Gygi S.P., Sinclair D.A., Alt F.W., Greenberg M.E. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303:2011-2015.
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
Hu, L.S.11
Cheng, H.L.12
Jedrychowski, M.P.13
Gygi, S.P.14
Sinclair, D.A.15
Alt, F.W.16
Greenberg, M.E.17
-
14
-
-
66149173551
-
Aging and cancer cell biology, 2009
-
Campisi J., Yaswen P. Aging and cancer cell biology, 2009. Aging Cell 2009, 8:221-225.
-
(2009)
Aging Cell
, vol.8
, pp. 221-225
-
-
Campisi, J.1
Yaswen, P.2
-
15
-
-
69849107217
-
Caloric restriction, SIRT1 and longevity
-
Canto C., Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol. Metab. 2009, 20:325-331.
-
(2009)
Trends Endocrinol. Metab.
, vol.20
, pp. 325-331
-
-
Canto, C.1
Auwerx, J.2
-
16
-
-
77249156847
-
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
Canto C., Jiang L.Q., Deshmukh A.S., Mataki C., Coste A., Lagouge M., Zierath J.R., Auwerx J. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 2010, 11:213-219.
-
(2010)
Cell Metab.
, vol.11
, pp. 213-219
-
-
Canto, C.1
Jiang, L.Q.2
Deshmukh, A.S.3
Mataki, C.4
Coste, A.5
Lagouge, M.6
Zierath, J.R.7
Auwerx, J.8
-
17
-
-
73449125908
-
Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
-
Chabi B., Adhihetty P.J., O'Leary M.F., Menzies K.J., Hood D.A. Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse. J. Appl. Physiol. 2009, 107:1730-1735.
-
(2009)
J. Appl. Physiol.
, vol.107
, pp. 1730-1735
-
-
Chabi, B.1
Adhihetty, P.J.2
O'Leary, M.F.3
Menzies, K.J.4
Hood, D.A.5
-
18
-
-
28844469898
-
Increase in activity during calorie restriction requires Sirt1
-
Chen D., Steele A.D., Lindquist S., Guarente L. Increase in activity during calorie restriction requires Sirt1. Science 2005, 310:1641.
-
(2005)
Science
, vol.310
, pp. 1641
-
-
Chen, D.1
Steele, A.D.2
Lindquist, S.3
Guarente, L.4
-
19
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen D., Bruno J., Easlon E., Lin S.J., Cheng H.L., Alt F.W., Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 2008, 22:1753-1757.
-
(2008)
Genes Dev.
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
Bruno, J.2
Easlon, E.3
Lin, S.J.4
Cheng, H.L.5
Alt, F.W.6
Guarente, L.7
-
20
-
-
79952117379
-
Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
-
Chen Y.R., Fang S.R., Fu Y.C., Zhou X.H., Xu M.Y., Xu W.C. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. Biochem. Cell Biol. 2010, 88:715-722.
-
(2010)
Biochem. Cell Biol.
, vol.88
, pp. 715-722
-
-
Chen, Y.R.1
Fang, S.R.2
Fu, Y.C.3
Zhou, X.H.4
Xu, M.Y.5
Xu, W.C.6
-
21
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
Olsen, J.V.7
Mann, M.8
-
22
-
-
75349111140
-
Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria
-
Cimen H., Han M.J., Yang Y., Tong Q., Koc H., Koc E.C. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Biochemistry 2010, 49:304-311.
-
(2010)
Biochemistry
, vol.49
, pp. 304-311
-
-
Cimen, H.1
Han, M.J.2
Yang, Y.3
Tong, Q.4
Koc, H.5
Koc, E.C.6
-
23
-
-
25144496904
-
The Sir 2 family of protein deacetylases
-
Denu J.M. The Sir 2 family of protein deacetylases. Curr. Opin. Chem. Biol. 2005, 9:431-440.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 431-440
-
-
Denu, J.M.1
-
24
-
-
77953257025
-
Aging and disease: connections to sirtuins
-
Donmez G., Guarente L. Aging and disease: connections to sirtuins. Aging Cell 2010, 9:285-290.
-
(2010)
Aging Cell
, vol.9
, pp. 285-290
-
-
Donmez, G.1
Guarente, L.2
-
25
-
-
0037405043
-
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
-
Dryden S.C., Nahhas F.A., Nowak J.E., Goustin A.S., Tainsky M.A. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol. Cell. Biol. 2003, 23:3173-3185.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 3173-3185
-
-
Dryden, S.C.1
Nahhas, F.A.2
Nowak, J.E.3
Goustin, A.S.4
Tainsky, M.A.5
-
27
-
-
54849425547
-
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
-
Feige J.N., Lagouge M., Canto C., Strehle A., Houten S.M., Milne J.C., Lambert P.D., Mataki C., Elliott P.J., Auwerx J. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008, 8:347-358.
-
(2008)
Cell Metab.
, vol.8
, pp. 347-358
-
-
Feige, J.N.1
Lagouge, M.2
Canto, C.3
Strehle, A.4
Houten, S.M.5
Milne, J.C.6
Lambert, P.D.7
Mataki, C.8
Elliott, P.J.9
Auwerx, J.10
-
28
-
-
67949102053
-
Recent progress in the biology and physiology of sirtuins
-
Finkel T., Deng C.X., Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009, 460:587-591.
-
(2009)
Nature
, vol.460
, pp. 587-591
-
-
Finkel, T.1
Deng, C.X.2
Mostoslavsky, R.3
-
29
-
-
28544444366
-
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
-
Ford J., Jiang M., Milner J. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res. 2005, 65:10457-10463.
-
(2005)
Cancer Res.
, vol.65
, pp. 10457-10463
-
-
Ford, J.1
Jiang, M.2
Milner, J.3
-
30
-
-
33744466971
-
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
-
Ford E., Voit R., Liszt G., Magin C., Grummt I., Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 2006, 20:1075-1080.
-
(2006)
Genes Dev.
, vol.20
, pp. 1075-1080
-
-
Ford, E.1
Voit, R.2
Liszt, G.3
Magin, C.4
Grummt, I.5
Guarente, L.6
-
31
-
-
20144365700
-
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
-
Frescas D., Valenti L., Accili D. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J. Biol. Chem. 2005, 280:20589-20595.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20589-20595
-
-
Frescas, D.1
Valenti, L.2
Accili, D.3
-
32
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 2000, 273:793-798.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
33
-
-
0043244921
-
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
-
Fulco M., Schiltz R.L., Iezzi S., King M.T., Zhao P., Kashiwaya Y., Hoffman E., Veech R.L., Sartorelli V. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 2003, 12:51-62.
-
(2003)
Mol. Cell
, vol.12
, pp. 51-62
-
-
Fulco, M.1
Schiltz, R.L.2
Iezzi, S.3
King, M.T.4
Zhao, P.5
Kashiwaya, Y.6
Hoffman, E.7
Veech, R.L.8
Sartorelli, V.9
-
34
-
-
41549136422
-
Paths of convergence: sirtuins in aging and neurodegeneration
-
Gan L., Mucke L. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron 2008, 58:10-14.
-
(2008)
Neuron
, vol.58
, pp. 10-14
-
-
Gan, L.1
Mucke, L.2
-
36
-
-
77953285831
-
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia
-
Gertz M., Steegborn C. Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia. Biochim. Biophys. Acta 2010, 1804:1658-1665.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1658-1665
-
-
Gertz, M.1
Steegborn, C.2
-
38
-
-
79551584971
-
Regulation of intermediary metabolism by protein acetylation
-
Guan K.L., Xiong Y. Regulation of intermediary metabolism by protein acetylation. Trends Biochem. Sci. 2011, 36:108-116.
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 108-116
-
-
Guan, K.L.1
Xiong, Y.2
-
39
-
-
33845868198
-
Sirtuins as potential targets for metabolic syndrome
-
Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature 2006, 444:868-874.
-
(2006)
Nature
, vol.444
, pp. 868-874
-
-
Guarente, L.1
-
41
-
-
38649132337
-
Mitochondria-a nexus for aging, calorie restriction, and sirtuins?
-
Guarente L. Mitochondria-a nexus for aging, calorie restriction, and sirtuins?. Cell 2008, 132:171-176.
-
(2008)
Cell
, vol.132
, pp. 171-176
-
-
Guarente, L.1
-
42
-
-
77951225449
-
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
-
Guo X., Williams J.G., Schug T.T., Li X. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 2010, 285:13223-13232.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 13223-13232
-
-
Guo, X.1
Williams, J.G.2
Schug, T.T.3
Li, X.4
-
43
-
-
79952266729
-
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
-
Hafner A.V., Dai J., Gomes A.P., Xiao C.Y., Palmeira C.M., Rosenzweig A., Sinclair D.A. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging 2010, 2:914-923.
-
(2010)
Aging
, vol.2
, pp. 914-923
-
-
Hafner, A.V.1
Dai, J.2
Gomes, A.P.3
Xiao, C.Y.4
Palmeira, C.M.5
Rosenzweig, A.6
Sinclair, D.A.7
-
44
-
-
33751113602
-
Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
-
Haigis M.C., Guarente L.P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006, 20:2913-2921.
-
(2006)
Genes Dev
, vol.20
, pp. 2913-2921
-
-
Haigis, M.C.1
Guarente, L.P.2
-
45
-
-
33748316536
-
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
-
Haigis M.C., Mostoslavsky R., Haigis K.M., Fahie K., Christodoulou D.C., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., Karow M., Blander G., Wolberger C., Prolla T.A., Weindruch R., Alt F.W., Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006, 126:941-954.
-
(2006)
Cell
, vol.126
, pp. 941-954
-
-
Haigis, M.C.1
Mostoslavsky, R.2
Haigis, K.M.3
Fahie, K.4
Christodoulou, D.C.5
Murphy, A.J.6
Valenzuela, D.M.7
Yancopoulos, G.D.8
Karow, M.9
Blander, G.10
Wolberger, C.11
Prolla, T.A.12
Weindruch, R.13
Alt, F.W.14
Guarente, L.15
-
46
-
-
33745931074
-
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
-
Hallows W.C., Lee S., Denu J.M. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:10230-10235.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 10230-10235
-
-
Hallows, W.C.1
Lee, S.2
Denu, J.M.3
-
48
-
-
78651468707
-
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
-
Hallows W.C., Yu W., Smith B.C., Devires M.K., Ellinger J.J., Someya S., Shortreed M.R., Prolla T., Markley J.L., Smith L.M., Zhao S., Guan K.L., Denu J.M. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol. Cell 2011, 41:139-149.
-
(2011)
Mol. Cell
, vol.41
, pp. 139-149
-
-
Hallows, W.C.1
Yu, W.2
Smith, B.C.3
Devires, M.K.4
Ellinger, J.J.5
Someya, S.6
Shortreed, M.R.7
Prolla, T.8
Markley, J.L.9
Smith, L.M.10
Zhao, S.11
Guan, K.L.12
Denu, J.M.13
-
49
-
-
77049308856
-
Aging: a theory based on free radical and radiation chemistry
-
Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11:298-300.
-
(1956)
J. Gerontol.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
50
-
-
77149172855
-
SIRT2-mediated protein deacetylation: an emerging key regulator in brain physiology and pathology
-
Harting K., Knoll B. SIRT2-mediated protein deacetylation: an emerging key regulator in brain physiology and pathology. Eur. J. Cell Biol. 2010, 89:262-269.
-
(2010)
Eur. J. Cell Biol.
, vol.89
, pp. 262-269
-
-
Harting, K.1
Knoll, B.2
-
51
-
-
0041829415
-
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene
-
Hiratsuka M., Inoue T., Toda T., Kimura N., Shirayoshi Y., Kamitani H., Watanabe T., Ohama E., Tahimic C.G., Kurimasa A., Oshimura M. Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem. Biophys. Res. Commun. 2003, 309:558-566.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.309
, pp. 558-566
-
-
Hiratsuka, M.1
Inoue, T.2
Toda, T.3
Kimura, N.4
Shirayoshi, Y.5
Kamitani, H.6
Watanabe, T.7
Ohama, E.8
Tahimic, C.G.9
Kurimasa, A.10
Oshimura, M.11
-
52
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
-
Hirschey M.D., Shimazu T., Goetzman E., Jing E., Schwer B., Lombard D.B., Grueter C.A., Harris C., Biddinger S., Ilkayeva O.R., Stevens R.D., Li Y., Saha A.K., Ruderman N.B., Bain J.R., Newgard C.B., Farese R.V., Alt F.W., Kahn C.R., Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010, 464:121-125.
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
Jing, E.4
Schwer, B.5
Lombard, D.B.6
Grueter, C.A.7
Harris, C.8
Biddinger, S.9
Ilkayeva, O.R.10
Stevens, R.D.11
Li, Y.12
Saha, A.K.13
Ruderman, N.B.14
Bain, J.R.15
Newgard, C.B.16
Farese, R.V.17
Alt, F.W.18
Kahn, C.R.19
Verdin, E.20
more..
-
53
-
-
77953287165
-
Mitochondrial sirtuins
-
Huang J.Y., Hirschey M.D., Shimazu T., Ho L., Verdin E. Mitochondrial sirtuins. Biochim. Biophys. Acta 2010, 1804:1645-1651.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1645-1651
-
-
Huang, J.Y.1
Hirschey, M.D.2
Shimazu, T.3
Ho, L.4
Verdin, E.5
-
54
-
-
51449083112
-
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression
-
Jacobs K.M., Pennington J.D., Bisht K.S., Aykin-Burns N., Kim H.S., Mishra M., Sun L., Nguyen P., Ahn B.H., Leclerc J., Deng C.X., Spitz D.R., Gius D. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int. J. Biol. Sci. 2008, 4:291-299.
-
(2008)
Int. J. Biol. Sci.
, vol.4
, pp. 291-299
-
-
Jacobs, K.M.1
Pennington, J.D.2
Bisht, K.S.3
Aykin-Burns, N.4
Kim, H.S.5
Mishra, M.6
Sun, L.7
Nguyen, P.8
Ahn, B.H.9
Leclerc, J.10
Deng, C.X.11
Spitz, D.R.12
Gius, D.13
-
55
-
-
39649100868
-
Regulation of SIRT6 protein levels by nutrient availability
-
Kanfi Y., Shalman R., Peshti V., Pilosof S.N., Gozlan Y.M., Pearson K.J., Lerrer B., Moazed D., Marine J.C., de Cabo R., Cohen H.Y. Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett. 2008, 582:543-548.
-
(2008)
FEBS Lett.
, vol.582
, pp. 543-548
-
-
Kanfi, Y.1
Shalman, R.2
Peshti, V.3
Pilosof, S.N.4
Gozlan, Y.M.5
Pearson, K.J.6
Lerrer, B.7
Moazed, D.8
Marine, J.C.9
de Cabo, R.10
Cohen, H.Y.11
-
56
-
-
58149090925
-
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
-
Kawahara T.L., Michishita E., Adler A.S., Damian M., Berber E., Lin M., McCord R.A., Ongaigui K.C., Boxer L.D., Chang H.Y., Chua K.F. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009, 136:62-74.
-
(2009)
Cell
, vol.136
, pp. 62-74
-
-
Kawahara, T.L.1
Michishita, E.2
Adler, A.S.3
Damian, M.4
Berber, E.5
Lin, M.6
McCord, R.A.7
Ongaigui, K.C.8
Boxer, L.D.9
Chang, H.Y.10
Chua, K.F.11
-
57
-
-
77955287479
-
Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest
-
Kawamura Y., Uchijima Y., Horike N., Tonami K., Nishiyama K., Amano T., Asano T., Kurihara Y., Kurihara H. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J. Clin. Invest. 2010, 120:2817-2828.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2817-2828
-
-
Kawamura, Y.1
Uchijima, Y.2
Horike, N.3
Tonami, K.4
Nishiyama, K.5
Amano, T.6
Asano, T.7
Kurihara, Y.8
Kurihara, H.9
-
58
-
-
78751513117
-
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
-
Kendrick A.A., Choudhury M., Rahman S.M., McCurdy C.E., Friederich M., Van Hove J.L., Watson P.A., Birdsey N., Bao J., Gius D., Sack M.N., Jing E., Kahn C.R., Friedman J.E., Jonscher K.R. Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem. J. 2011, 433:505-514.
-
(2011)
Biochem. J.
, vol.433
, pp. 505-514
-
-
Kendrick, A.A.1
Choudhury, M.2
Rahman, S.M.3
McCurdy, C.E.4
Friederich, M.5
Van Hove, J.L.6
Watson, P.A.7
Birdsey, N.8
Bao, J.9
Gius, D.10
Sack, M.N.11
Jing, E.12
Kahn, C.R.13
Friedman, J.E.14
Jonscher, K.R.15
-
59
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.J., Zhao Y. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell 2006, 23:607-618.
-
(2006)
Mol. Cell
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
Cheng, T.7
Kho, Y.8
Xiao, H.9
Xiao, L.10
Grishin, N.V.11
White, M.12
Yang, X.J.13
Zhao, Y.14
-
60
-
-
74049094817
-
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
-
Kim H.S., Patel K., Muldoon-Jacobs K., Bisht K.S., Aykin-Burns N., Pennington J.D., van der Meer R., Nguyen P., Savage J., Owens K.M., Vassilopoulos A., Ozden O., Park S.H., Singh K.K., Abdulkadir S.A., Spitz D.R., Deng C.X., Gius D. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010, 17:41-52.
-
(2010)
Cancer Cell
, vol.17
, pp. 41-52
-
-
Kim, H.S.1
Patel, K.2
Muldoon-Jacobs, K.3
Bisht, K.S.4
Aykin-Burns, N.5
Pennington, J.D.6
van der Meer, R.7
Nguyen, P.8
Savage, J.9
Owens, K.M.10
Vassilopoulos, A.11
Ozden, O.12
Park, S.H.13
Singh, K.K.14
Abdulkadir, S.A.15
Spitz, D.R.16
Deng, C.X.17
Gius, D.18
-
61
-
-
77955347446
-
Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis
-
Kong X., Wang R., Xue Y., Liu X., Zhang H., Chen Y., Fang F., Chang Y. Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One 2010, 5:e11707.
-
(2010)
PLoS One
, vol.5
-
-
Kong, X.1
Wang, R.2
Xue, Y.3
Liu, X.4
Zhang, H.5
Chen, Y.6
Fang, F.7
Chang, Y.8
-
62
-
-
33745166337
-
Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
-
Kume S., Haneda M., Kanasaki K., Sugimoto T., Araki S., Isono M., Isshiki K., Uzu T., Kashiwagi A., Koya D. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free Radic. Biol. Med. 2006, 40:2175-2182.
-
(2006)
Free Radic. Biol. Med.
, vol.40
, pp. 2175-2182
-
-
Kume, S.1
Haneda, M.2
Kanasaki, K.3
Sugimoto, T.4
Araki, S.5
Isono, M.6
Isshiki, K.7
Uzu, T.8
Kashiwagi, A.9
Koya, D.10
-
63
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127:1109-1122.
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
64
-
-
79952590211
-
A role for SIRT1 in the hypoxic response
-
Leiser S.F., Kaeberlein M. A role for SIRT1 in the hypoxic response. Mol. Cell 2010, 38:779-780.
-
(2010)
Mol. Cell
, vol.38
, pp. 779-780
-
-
Leiser, S.F.1
Kaeberlein, M.2
-
65
-
-
34948883324
-
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
-
Li X., Zhang S., Blander G., Tse J.G., Krieger M., Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell 2007, 28:91-106.
-
(2007)
Mol. Cell
, vol.28
, pp. 91-106
-
-
Li, X.1
Zhang, S.2
Blander, G.3
Tse, J.G.4
Krieger, M.5
Guarente, L.6
-
66
-
-
77956295588
-
P53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase
-
Li S., Banck M., Mujtaba S., Zhou M.M., Sugrue M.M., Walsh M.J. p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One 2010, 5:e10486.
-
(2010)
PLoS One
, vol.5
-
-
Li, S.1
Banck, M.2
Mujtaba, S.3
Zhou, M.M.4
Sugrue, M.M.5
Walsh, M.J.6
-
68
-
-
46049084164
-
Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function
-
Lieber C.S., Leo M.A., Wang X., Decarli L.M. Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function. Biochem. Biophys. Res. Commun. 2008, 373:246-252.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.373
, pp. 246-252
-
-
Lieber, C.S.1
Leo, M.A.2
Wang, X.3
Decarli, L.M.4
-
70
-
-
37549002891
-
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
-
Lombard D.B., Alt F.W., Cheng H.L., Bunkenborg J., Streeper R.S., Mostoslavsky R., Kim J., Yancopoulos G., Valenzuela D., Murphy A., Yang Y., Chen Y., Hirschey M.D., Bronson R.T., Haigis M., Guarente L.P., Farese R.V., Weissman S., Verdin E., Schwer B. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 2007, 27:8807-8814.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
Alt, F.W.2
Cheng, H.L.3
Bunkenborg, J.4
Streeper, R.S.5
Mostoslavsky, R.6
Kim, J.7
Yancopoulos, G.8
Valenzuela, D.9
Murphy, A.10
Yang, Y.11
Chen, Y.12
Hirschey, M.D.13
Bronson, R.T.14
Haigis, M.15
Guarente, L.P.16
Farese, R.V.17
Weissman, S.18
Verdin, E.19
Schwer, B.20
more..
-
71
-
-
32944479897
-
Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization
-
Mahlknecht U., Ho A.D., Letzel S., Voelter-Mahlknecht S. Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization. Cytogenet. Genome Res. 2006, 112:208-212.
-
(2006)
Cytogenet. Genome Res.
, vol.112
, pp. 208-212
-
-
Mahlknecht, U.1
Ho, A.D.2
Letzel, S.3
Voelter-Mahlknecht, S.4
-
72
-
-
39049184073
-
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene
-
Mahlknecht U., Ho A.D., Voelter-Mahlknecht S. Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene. Int. J. Oncol. 2006, 28:447-456.
-
(2006)
Int. J. Oncol.
, vol.28
, pp. 447-456
-
-
Mahlknecht, U.1
Ho, A.D.2
Voelter-Mahlknecht, S.3
-
73
-
-
33747692275
-
Regulation of murine TGFbeta2 by Pax3 during early embryonic development
-
Mayanil C.S., Pool A., Nakazaki H., Reddy A.C., Mania-Farnell B., Yun B., George D., McLone D.G., Bremer E.G. Regulation of murine TGFbeta2 by Pax3 during early embryonic development. J. Biol. Chem. 2006, 281:24544-24552.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 24544-24552
-
-
Mayanil, C.S.1
Pool, A.2
Nakazaki, H.3
Reddy, A.C.4
Mania-Farnell, B.5
Yun, B.6
George, D.7
McLone, D.G.8
Bremer, E.G.9
-
74
-
-
66049150672
-
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
-
McCord R.A., Michishita E., Hong T., Berber E., Boxer L.D., Kusumoto R., Guan S., Shi X., Gozani O., Burlingame A.L., Bohr V.A., Chua K.F. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) 2009, 1:109-121.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 109-121
-
-
McCord, R.A.1
Michishita, E.2
Hong, T.3
Berber, E.4
Boxer, L.D.5
Kusumoto, R.6
Guan, S.7
Shi, X.8
Gozani, O.9
Burlingame, A.L.10
Bohr, V.A.11
Chua, K.F.12
-
75
-
-
34249083199
-
Sirtuins in mammals: insights into their biological function
-
Michan S., Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem. J. 2007, 404:1-13.
-
(2007)
Biochem. J.
, vol.404
, pp. 1-13
-
-
Michan, S.1
Sinclair, D.2
-
76
-
-
26244436281
-
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
-
Michishita E., Park J.Y., Burneskis J.M., Barrett J.C., Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 2005, 16:4623-4635.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4623-4635
-
-
Michishita, E.1
Park, J.Y.2
Burneskis, J.M.3
Barrett, J.C.4
Horikawa, I.5
-
77
-
-
41349090663
-
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
Michishita E., McCord R.A., Berber E., Kioi M., Padilla-Nash H., Damian M., Cheung P., Kusumoto R., Kawahara T.L., Barrett J.C., Chang H.Y., Bohr V.A., Ried T., Gozani O., Chua K.F. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008, 452:492-496.
-
(2008)
Nature
, vol.452
, pp. 492-496
-
-
Michishita, E.1
McCord, R.A.2
Berber, E.3
Kioi, M.4
Padilla-Nash, H.5
Damian, M.6
Cheung, P.7
Kusumoto, R.8
Kawahara, T.L.9
Barrett, J.C.10
Chang, H.Y.11
Bohr, V.A.12
Ried, T.13
Gozani, O.14
Chua, K.F.15
-
78
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky R., Chua K.F., Lombard D.B., Pang W.W., Fischer M.R., Gellon L., Liu P., Mostoslavsky G., Franco S., Murphy M.M., Mills K.D., Patel P., Hsu J.T., Hong A.L., Ford E., Cheng H.L., Kennedy C., Nunez N., Bronson R., Frendewey D., Auerbach W., Valenzuela D., Karow M., Hottiger M.O., Hursting S., Barrett J.C., Guarente L., Mulligan R., Demple B., Yancopoulos G.D., Alt F.W. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006, 124:315-329.
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
Liu, P.7
Mostoslavsky, G.8
Franco, S.9
Murphy, M.M.10
Mills, K.D.11
Patel, P.12
Hsu, J.T.13
Hong, A.L.14
Ford, E.15
Cheng, H.L.16
Kennedy, C.17
Nunez, N.18
Bronson, R.19
Frendewey, D.20
Auerbach, W.21
Valenzuela, D.22
Karow, M.23
Hottiger, M.O.24
Hursting, S.25
Barrett, J.C.26
Guarente, L.27
Mulligan, R.28
Demple, B.29
Yancopoulos, G.D.30
Alt, F.W.31
more..
-
79
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., Bultsma Y., McBurney M., Guarente L. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004, 116:551-563.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
Bultsma, Y.7
McBurney, M.8
Guarente, L.9
-
80
-
-
34547920351
-
Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin
-
Nahhas F., Dryden S.C., Abrams J., Tainsky M.A. Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin. Mol. Cell. Biochem. 2007, 303:221-230.
-
(2007)
Mol. Cell. Biochem.
, vol.303
, pp. 221-230
-
-
Nahhas, F.1
Dryden, S.C.2
Abrams, J.3
Tainsky, M.A.4
-
81
-
-
77953933813
-
Urea cycle regulation by mitochondrial sirtuin, SIRT5
-
Nakagawa T., Guarente L. Urea cycle regulation by mitochondrial sirtuin, SIRT5. Aging (Albany NY) 2009, 1:578-581.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 578-581
-
-
Nakagawa, T.1
Guarente, L.2
-
82
-
-
65249087389
-
SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
Nakagawa T., Lomb D.J., Haigis M.C., Guarente L. SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 2009, 137:560-570.
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
83
-
-
37549026223
-
Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5
-
Nakamura Y., Ogura M., Tanaka D., Inagaki N. Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem. Biophys. Res. Commun. 2008, 366:174-179.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.366
, pp. 174-179
-
-
Nakamura, Y.1
Ogura, M.2
Tanaka, D.3
Inagaki, N.4
-
84
-
-
77957762687
-
SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells
-
Nasrin N., Wu X., Fortier E., Feng Y., Bare O.C., Chen S., Ren X., Wu Z., Streeper R.S., Bordone L. SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. J. Biol. Chem. 2010, 285:1995-2002.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 1995-2002
-
-
Nasrin, N.1
Wu, X.2
Fortier, E.3
Feng, Y.4
Bare, O.C.5
Chen, S.6
Ren, X.7
Wu, Z.8
Streeper, R.S.9
Bordone, L.10
-
85
-
-
26844558334
-
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
-
Nisoli E., Tonello C., Cardile A., Cozzi V., Bracale R., Tedesco L., Falcone S., Valerio A., Cantoni O., Clementi E., Moncada S., Carruba M.O. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005, 310:314-317.
-
(2005)
Science
, vol.310
, pp. 314-317
-
-
Nisoli, E.1
Tonello, C.2
Cardile, A.3
Cozzi, V.4
Bracale, R.5
Tedesco, L.6
Falcone, S.7
Valerio, A.8
Cantoni, O.9
Clementi, E.10
Moncada, S.11
Carruba, M.O.12
-
86
-
-
33845933657
-
Sirtuins: a conserved key unlocking AceCS activity
-
North B.J., Sinclair D.A. Sirtuins: a conserved key unlocking AceCS activity. Trends Biochem. Sci. 2007, 32:1-4.
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 1-4
-
-
North, B.J.1
Sinclair, D.A.2
-
87
-
-
77952940043
-
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
-
Palacios O.M., Carmona J.J., Michan S., Chen K.Y., Manabe Y., Ward J.L., Goodyear L.J., Tong Q. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany NY) 2009, 1:771-783.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 771-783
-
-
Palacios, O.M.1
Carmona, J.J.2
Michan, S.3
Chen, K.Y.4
Manabe, Y.5
Ward, J.L.6
Goodyear, L.J.7
Tong, Q.8
-
88
-
-
53249114029
-
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
-
Pallos J., Bodai L., Lukacsovich T., Purcell J.M., Steffan J.S., Thompson L.M., Marsh J.L. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum. Mol. Genet. 2008, 17:3767-3775.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 3767-3775
-
-
Pallos, J.1
Bodai, L.2
Lukacsovich, T.3
Purcell, J.M.4
Steffan, J.S.5
Thompson, L.M.6
Marsh, J.L.7
-
89
-
-
63249131066
-
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
-
Pereira C.V., Moreira A.C., Pereira S.P., Machado N.G., Carvalho F.S., Sardao V.A., Oliveira P.J. Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?. Curr. Drug Saf. 2009, 4:34-54.
-
(2009)
Curr. Drug Saf.
, vol.4
, pp. 34-54
-
-
Pereira, C.V.1
Moreira, A.C.2
Pereira, S.P.3
Machado, N.G.4
Carvalho, F.S.5
Sardao, V.A.6
Oliveira, P.J.7
-
90
-
-
70449604749
-
Can drug safety be predicted and animal experiments reduced by using isolated mitochondrial fractions?
-
Pereira S.P., Pereira G.C., Moreno A.J., Oliveira P.J. Can drug safety be predicted and animal experiments reduced by using isolated mitochondrial fractions?. Altern. Lab. Anim. 2009, 37:355-365.
-
(2009)
Altern. Lab. Anim.
, vol.37
, pp. 355-365
-
-
Pereira, S.P.1
Pereira, G.C.2
Moreno, A.J.3
Oliveira, P.J.4
-
91
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004, 429:771-776.
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
Machado De Oliveira, R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
92
-
-
77956570054
-
Mitochondrial SIRT3 and heart disease
-
Pillai V.B., Sundaresan N.R., Jeevanandam V., Gupta M.P. Mitochondrial SIRT3 and heart disease. Cardiovasc. Res. 2010, 88:250-256.
-
(2010)
Cardiovasc. Res.
, vol.88
, pp. 250-256
-
-
Pillai, V.B.1
Sundaresan, N.R.2
Jeevanandam, V.3
Gupta, M.P.4
-
93
-
-
78649521247
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
-
Qiu X., Brown K., Hirschey M.D., Verdin E., Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 2010, 12:662-667.
-
(2010)
Cell Metab.
, vol.12
, pp. 662-667
-
-
Qiu, X.1
Brown, K.2
Hirschey, M.D.3
Verdin, E.4
Chen, D.5
-
94
-
-
77953293520
-
Sirtuin regulation in calorie restriction
-
Qiu X., Brown K.V., Moran Y., Chen D. Sirtuin regulation in calorie restriction. Biochim. Biophys. Acta 2010, 1804:1576-1583.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1576-1583
-
-
Qiu, X.1
Brown, K.V.2
Moran, Y.3
Chen, D.4
-
95
-
-
34547906123
-
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
-
Rodgers J.T., Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:12861-12866.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 12861-12866
-
-
Rodgers, J.T.1
Puigserver, P.2
-
96
-
-
10744232772
-
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
-
Rose G., Dato S., Altomare K., Bellizzi D., Garasto S., Greco V., Passarino G., Feraco E., Mari V., Barbi C., BonaFe M., Franceschi C., Tan Q., Boiko S., Yashin A.I., De Benedictis G. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp. Gerontol. 2003, 38:1065-1070.
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 1065-1070
-
-
Rose, G.1
Dato, S.2
Altomare, K.3
Bellizzi, D.4
Garasto, S.5
Greco, V.6
Passarino, G.7
Feraco, E.8
Mari, V.9
Barbi, C.10
BonaFe, M.11
Franceschi, C.12
Tan, Q.13
Boiko, S.14
Yashin, A.I.15
De Benedictis, G.16
-
97
-
-
41349119625
-
Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury
-
Sardao V.A., Pereira S.L., Oliveira P.J. Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury. Expert Opin. Drug Saf. 2008, 7:129-146.
-
(2008)
Expert Opin. Drug Saf.
, vol.7
, pp. 129-146
-
-
Sardao, V.A.1
Pereira, S.L.2
Oliveira, P.J.3
-
98
-
-
78650843340
-
MiRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
-
Saunders L.R., Sharma A.D., Tawney J., Nakagawa M., Okita K., Yamanaka S., Willenbring H., Verdin E. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) 2010, 2:415-431.
-
(2010)
Aging (Albany NY)
, vol.2
, pp. 415-431
-
-
Saunders, L.R.1
Sharma, A.D.2
Tawney, J.3
Nakagawa, M.4
Okita, K.5
Yamanaka, S.6
Willenbring, H.7
Verdin, E.8
-
99
-
-
77953291365
-
Sirtuin chemical mechanisms
-
Sauve A.A. Sirtuin chemical mechanisms. Biochim. Biophys. Acta 2010, 1804:1591-1603.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1591-1603
-
-
Sauve, A.A.1
-
100
-
-
33745203038
-
The biochemistry of sirtuins
-
Sauve A.A., Wolberger C., Schramm V.L., Boeke J.D. The biochemistry of sirtuins. Annu. Rev. Biochem. 2006, 75:435-465.
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 435-465
-
-
Sauve, A.A.1
Wolberger, C.2
Schramm, V.L.3
Boeke, J.D.4
-
101
-
-
34247271282
-
+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
-
+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev. 2007, 21:920-928.
-
(2007)
Genes Dev.
, vol.21
, pp. 920-928
-
-
Scher, M.B.1
Vaquero, A.2
Reinberg, D.3
-
102
-
-
50149103440
-
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
-
Schlicker C., Gertz M., Papatheodorou P., Kachholz B., Becker C.F., Steegborn C. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J. Mol. Biol. 2008, 382:790-801.
-
(2008)
J. Mol. Biol.
, vol.382
, pp. 790-801
-
-
Schlicker, C.1
Gertz, M.2
Papatheodorou, P.3
Kachholz, B.4
Becker, C.F.5
Steegborn, C.6
-
103
-
-
38649123072
-
Conserved metabolic regulatory functions of sirtuins
-
Schwer B., Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008, 7:104-112.
-
(2008)
Cell Metab.
, vol.7
, pp. 104-112
-
-
Schwer, B.1
Verdin, E.2
-
104
-
-
0037135972
-
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
-
Schwer B., North B.J., Frye R.A., Ott M., Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J. Cell Biol. 2002, 158:647-657.
-
(2002)
J. Cell Biol.
, vol.158
, pp. 647-657
-
-
Schwer, B.1
North, B.J.2
Frye, R.A.3
Ott, M.4
Verdin, E.5
-
105
-
-
73949123433
-
Calorie restriction alters mitochondrial protein acetylation
-
Schwer B., Eckersdorff M., Li Y., Silva J.C., Fermin D., Kurtev M.V., Giallourakis C., Comb M.J., Alt F.W., Lombard D.B. Calorie restriction alters mitochondrial protein acetylation. Aging Cell 2009, 8:604-606.
-
(2009)
Aging Cell
, vol.8
, pp. 604-606
-
-
Schwer, B.1
Eckersdorff, M.2
Li, Y.3
Silva, J.C.4
Fermin, D.5
Kurtev, M.V.6
Giallourakis, C.7
Comb, M.J.8
Alt, F.W.9
Lombard, D.B.10
-
106
-
-
78650724968
-
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
-
Schwer B., Schumacher B., Lombard D.B., Xiao C., Kurtev M.V., Gao J., Schneider J.I., Chai H., Bronson R.T., Tsai L.H., Deng C.X., Alt F.W. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:21790-21794.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 21790-21794
-
-
Schwer, B.1
Schumacher, B.2
Lombard, D.B.3
Xiao, C.4
Kurtev, M.V.5
Gao, J.6
Schneider, J.I.7
Chai, H.8
Bronson, R.T.9
Tsai, L.H.10
Deng, C.X.11
Alt, F.W.12
-
107
-
-
40149101710
-
FoxO transcription factors in oxidative stress response and ageing-a new fork on the way to longevity?
-
Sedding D.G. FoxO transcription factors in oxidative stress response and ageing-a new fork on the way to longevity?. Biol. Chem. 2008, 389:279-283.
-
(2008)
Biol. Chem.
, vol.389
, pp. 279-283
-
-
Sedding, D.G.1
-
108
-
-
76349125988
-
SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells
-
Shi T., Fan G.Q., Xiao S.D. SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells. J. Dig. Dis. 2010, 11:55-62.
-
(2010)
J. Dig. Dis.
, vol.11
, pp. 55-62
-
-
Shi, T.1
Fan, G.Q.2
Xiao, S.D.3
-
109
-
-
78649509214
-
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
-
Shimazu T., Hirschey M.D., Hua L., Dittenhafer-Reed K.E., Schwer B., Lombard D.B., Li Y., Bunkenborg J., Alt F.W., Denu J.M., Jacobson M.P., Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010, 12:654-661.
-
(2010)
Cell Metab.
, vol.12
, pp. 654-661
-
-
Shimazu, T.1
Hirschey, M.D.2
Hua, L.3
Dittenhafer-Reed, K.E.4
Schwer, B.5
Lombard, D.B.6
Li, Y.7
Bunkenborg, J.8
Alt, F.W.9
Denu, J.M.10
Jacobson, M.P.11
Verdin, E.12
-
110
-
-
65549090598
-
Function of sirtuins in biological tissues
-
Shoba B., Lwin Z.M., Ling L.S., Bay B.H., Yip G.W., Kumar S.D. Function of sirtuins in biological tissues. Anat. Rec. (Hoboken) 2009, 292:536-543.
-
(2009)
Anat. Rec. (Hoboken)
, vol.292
, pp. 536-543
-
-
Shoba, B.1
Lwin, Z.M.2
Ling, L.S.3
Bay, B.H.4
Yip, G.W.5
Kumar, S.D.6
-
111
-
-
77951176793
-
Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
-
Shulga N., Wilson-Smith R., Pastorino J.G. Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. J. Cell. Sci. 2010, 123:894-902.
-
(2010)
J. Cell. Sci.
, vol.123
, pp. 894-902
-
-
Shulga, N.1
Wilson-Smith, R.2
Pastorino, J.G.3
-
112
-
-
12944283150
-
+-dependent protein deacetylase activity in the Sir2 protein family
-
+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:6658-6663.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6658-6663
-
-
Smith, J.S.1
Brachmann, C.B.2
Celic, I.3
Kenna, M.A.4
Muhammad, S.5
Starai, V.J.6
Avalos, J.L.7
Escalante-Semerena, J.C.8
Grubmeyer, C.9
Wolberger, C.10
Boeke, J.D.11
-
113
-
-
0036279988
-
SIR2 family of NAD(+)-dependent protein deacetylases
-
Smith J.S., Avalos J., Celic I., Muhammad S., Wolberger C., Boeke J.D. SIR2 family of NAD(+)-dependent protein deacetylases. Methods Enzymol. 2002, 353:282-300.
-
(2002)
Methods Enzymol.
, vol.353
, pp. 282-300
-
-
Smith, J.S.1
Avalos, J.2
Celic, I.3
Muhammad, S.4
Wolberger, C.5
Boeke, J.D.6
-
114
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya S., Yu W., Hallows W.C., Xu J., Vann J.M., Leeuwenburgh C., Tanokura M., Denu J.M., Prolla T.A. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010, 143:802-812.
-
(2010)
Cell
, vol.143
, pp. 802-812
-
-
Someya, S.1
Yu, W.2
Hallows, W.C.3
Xu, J.4
Vann, J.M.5
Leeuwenburgh, C.6
Tanokura, M.7
Denu, J.M.8
Prolla, T.A.9
-
115
-
-
33846930889
-
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
-
Southwood C.M., Peppi M., Dryden S., Tainsky M.A., Gow A. Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem. Res. 2007, 32:187-195.
-
(2007)
Neurochem. Res.
, vol.32
, pp. 187-195
-
-
Southwood, C.M.1
Peppi, M.2
Dryden, S.3
Tainsky, M.A.4
Gow, A.5
-
117
-
-
75149118997
-
Role of oxidative stress in the progression of Alzheimer's disease
-
Sultana R., Butterfield D.A. Role of oxidative stress in the progression of Alzheimer's disease. J. Alzheimers Dis. 2010, 19:341-353.
-
(2010)
J. Alzheimers Dis.
, vol.19
, pp. 341-353
-
-
Sultana, R.1
Butterfield, D.A.2
-
118
-
-
53549105529
-
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
-
Sundaresan N.R., Samant S.A., Pillai V.B., Rajamohan S.B., Gupta M.P. SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol. Cell. Biol. 2008, 28:6384-6401.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 6384-6401
-
-
Sundaresan, N.R.1
Samant, S.A.2
Pillai, V.B.3
Rajamohan, S.B.4
Gupta, M.P.5
-
119
-
-
70349208608
-
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
-
Sundaresan N.R., Gupta M., Kim G., Rajamohan S.B., Isbatan A., Gupta M.P. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J. Clin. Invest. 2009, 119:2758-2771.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 2758-2771
-
-
Sundaresan, N.R.1
Gupta, M.2
Kim, G.3
Rajamohan, S.B.4
Isbatan, A.5
Gupta, M.P.6
-
120
-
-
40049093522
-
SIRT2, tubulin deacetylation, and oligodendroglia differentiation
-
Tang B.L., Chua C.E. SIRT2, tubulin deacetylation, and oligodendroglia differentiation. Cell Motil. Cytoskeleton 2008, 65:179-182.
-
(2008)
Cell Motil. Cytoskeleton
, vol.65
, pp. 179-182
-
-
Tang, B.L.1
Chua, C.E.2
-
121
-
-
0033598942
-
An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
-
Tanny J.C., Dowd G.J., Huang J., Hilz H., Moazed D. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 1999, 99:735-745.
-
(1999)
Cell
, vol.99
, pp. 735-745
-
-
Tanny, J.C.1
Dowd, G.J.2
Huang, J.3
Hilz, H.4
Moazed, D.5
-
122
-
-
78650248160
-
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
-
Tao R., Coleman M.C., Pennington J.D., Ozden O., Park S.H., Jiang H., Kim H.S., Flynn C.R., Hill S., Hayes McDonald W., Olivier A.K., Spitz D.R., Gius D. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol. cell 2010, 40:893-904.
-
(2010)
Mol. cell
, vol.40
, pp. 893-904
-
-
Tao, R.1
Coleman, M.C.2
Pennington, J.D.3
Ozden, O.4
Park, S.H.5
Jiang, H.6
Kim, H.S.7
Flynn, C.R.8
Hill, S.9
Hayes McDonald, W.10
Olivier, A.K.11
Spitz, D.R.12
Gius, D.13
-
123
-
-
41449083867
-
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
-
Vakhrusheva O., Smolka C., Gajawada P., Kostin S., Boettger T., Kubin T., Braun T., Bober E. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 2008, 102:703-710.
-
(2008)
Circ. Res.
, vol.102
, pp. 703-710
-
-
Vakhrusheva, O.1
Smolka, C.2
Gajawada, P.3
Kostin, S.4
Boettger, T.5
Kubin, T.6
Braun, T.7
Bober, E.8
-
124
-
-
59649117804
-
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
-
Van Gool F., Galli M., Gueydan C., Kruys V., Prevot P.P., Bedalov A., Mostoslavsky R., Alt F.W., De Smedt T., Leo O. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat. Med. 2009, 15:206-210.
-
(2009)
Nat. Med.
, vol.15
, pp. 206-210
-
-
Van Gool, F.1
Galli, M.2
Gueydan, C.3
Kruys, V.4
Prevot, P.P.5
Bedalov, A.6
Mostoslavsky, R.7
Alt, F.W.8
De Smedt, T.9
Leo, O.10
-
125
-
-
70349138701
-
The conserved role of sirtuins in chromatin regulation
-
Vaquero A. The conserved role of sirtuins in chromatin regulation. Int. J. Dev. Biol. 2009, 53:303-322.
-
(2009)
Int. J. Dev. Biol.
, vol.53
, pp. 303-322
-
-
Vaquero, A.1
-
126
-
-
34547875013
-
+-dependent deacetylation of H4 lysine 16 by class III HDACs
-
+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene 2007, 26:5505-5520.
-
(2007)
Oncogene
, vol.26
, pp. 5505-5520
-
-
Vaquero, A.1
Sternglanz, R.2
Reinberg, D.3
-
127
-
-
78649328799
-
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
-
Verdin E., Hirschey M.D., Finley L.W., Haigis M.C. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem. Sci. 2010.
-
(2010)
Trends Biochem. Sci.
-
-
Verdin, E.1
Hirschey, M.D.2
Finley, L.W.3
Haigis, M.C.4
-
128
-
-
33744735005
-
Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene
-
Voelter-Mahlknecht S., Letzel S., Mahlknecht U. Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene. Int. J. Oncol. 2006, 28:899-908.
-
(2006)
Int. J. Oncol.
, vol.28
, pp. 899-908
-
-
Voelter-Mahlknecht, S.1
Letzel, S.2
Mahlknecht, U.3
-
129
-
-
34447626095
-
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
-
Wang F., Nguyen M., Qin F.X., Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007, 6:505-514.
-
(2007)
Aging Cell
, vol.6
, pp. 505-514
-
-
Wang, F.1
Nguyen, M.2
Qin, F.X.3
Tong, Q.4
-
130
-
-
77953357982
-
Impaired quality control of mitochondria: aging from a new perspective
-
Weber T.A., Reichert A.S. Impaired quality control of mitochondria: aging from a new perspective. Exp. Gerontol. 2010, 45:503-511.
-
(2010)
Exp. Gerontol.
, vol.45
, pp. 503-511
-
-
Weber, T.A.1
Reichert, A.S.2
-
131
-
-
77954450977
-
Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1
-
Wu F., Schweizer C., Rudinskiy N., Taylor D.M., Kazantsev A., Luthi-Carter R., Fraering P.C. Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1. FASEB J. 2010, 24:2464-2474.
-
(2010)
FASEB J.
, vol.24
, pp. 2464-2474
-
-
Wu, F.1
Schweizer, C.2
Rudinskiy, N.3
Taylor, D.M.4
Kazantsev, A.5
Luthi-Carter, R.6
Fraering, P.C.7
-
133
-
-
34548627517
-
+ levels dictate cell survival
-
+ levels dictate cell survival. Cell 2007, 130:1095-1107.
-
(2007)
Cell
, vol.130
, pp. 1095-1107
-
-
Yang, H.1
Yang, T.2
Baur, J.A.3
Perez, E.4
Matsui, T.5
Carmona, J.J.6
Lamming, D.W.7
Souza-Pinto, N.C.8
Bohr, V.A.9
Rosenzweig, A.10
de Cabo, R.11
Sauve, A.A.12
Sinclair, D.A.13
-
134
-
-
77953292238
-
SIRT1 and p53, effect on cancer, senescence and beyond
-
Yi J., Luo J. SIRT1 and p53, effect on cancer, senescence and beyond. Biochim. Biophys. Acta 2010, 1804:1684-1689.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1684-1689
-
-
Yi, J.1
Luo, J.2
-
135
-
-
70350441907
-
The role of sirtuins in the control of metabolic homeostasis
-
Yu J., Auwerx J. The role of sirtuins in the control of metabolic homeostasis. Ann. N. Y. Acad. Sci. 2009, 1173(Suppl. 1):E10-E19.
-
(2009)
Ann. N. Y. Acad. Sci.
, vol.1173
, Issue.SUPPL. 1
-
-
Yu, J.1
Auwerx, J.2
-
136
-
-
77952876986
-
Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation
-
Yu J., Auwerx J. Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation. Pharmacol. Res. 2010, 62:35-41.
-
(2010)
Pharmacol. Res.
, vol.62
, pp. 35-41
-
-
Yu, J.1
Auwerx, J.2
-
137
-
-
77953290752
-
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions
-
Zhang T., Kraus W.L. SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim. Biophys. Acta 2010, 1804:1666-1675.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1666-1675
-
-
Zhang, T.1
Kraus, W.L.2
-
138
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
-
Zhong L., D'Urso A., Toiber D., Sebastian C., Henry R.E., Vadysirisack D.D., Guimaraes A., Marinelli B., Wikstrom J.D., Nir T., Clish C.B., Vaitheesvaran B., Iliopoulos O., Kurland I., Dor Y., Weissleder R., Shirihai O.S., Ellisen L.W., Espinosa J.M., Mostoslavsky R. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 2010, 140:280-293.
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
D'Urso, A.2
Toiber, D.3
Sebastian, C.4
Henry, R.E.5
Vadysirisack, D.D.6
Guimaraes, A.7
Marinelli, B.8
Wikstrom, J.D.9
Nir, T.10
Clish, C.B.11
Vaitheesvaran, B.12
Iliopoulos, O.13
Kurland, I.14
Dor, Y.15
Weissleder, R.16
Shirihai, O.S.17
Ellisen, L.W.18
Espinosa, J.M.19
Mostoslavsky, R.20
more..
-
139
-
-
77956213267
-
Mitochondrial dysfunction in Parkinson's disease
-
Zhu J., Chu C.T. Mitochondrial dysfunction in Parkinson's disease. J. Alzheimers Dis. 2010, 20(Suppl. 2):S325-S334.
-
(2010)
J. Alzheimers Dis.
, vol.20
, Issue.SUPPL. 2
-
-
Zhu, J.1
Chu, C.T.2
|