-
1
-
-
0037312020
-
How does calorie restriction work?
-
Koubova J., and Guarente L. How does calorie restriction work?. Genes Dev. 17 (2003) 313-321
-
(2003)
Genes Dev.
, vol.17
, pp. 313-321
-
-
Koubova, J.1
Guarente, L.2
-
2
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273 (2000) 793-798
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
4
-
-
0004760134
-
Life span of individual yeast cells
-
Mortimer R.K., and Johnston J.R. Life span of individual yeast cells. Nature 183 (1959) 1751-1752
-
(1959)
Nature
, vol.183
, pp. 1751-1752
-
-
Mortimer, R.K.1
Johnston, J.R.2
-
5
-
-
0242585476
-
Asymmetric inheritance of oxidatively damaged proteins during cytokinesis
-
Aguilaniu H., Gustafsson L., Rigoulet M., and Nystrom T. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299 (2003) 1751-1753
-
(2003)
Science
, vol.299
, pp. 1751-1753
-
-
Aguilaniu, H.1
Gustafsson, L.2
Rigoulet, M.3
Nystrom, T.4
-
6
-
-
67149099680
-
Histone H4 lysine 16 acetylation regulates cellular lifespan
-
Dang W., Steffen K.K., Perry R., Dorsey J.A., Johnson F.B., Shilatifard A., Kaeberlein M., Kennedy B.K., and Berger S.L. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459 (2009) 802-807
-
(2009)
Nature
, vol.459
, pp. 802-807
-
-
Dang, W.1
Steffen, K.K.2
Perry, R.3
Dorsey, J.A.4
Johnson, F.B.5
Shilatifard, A.6
Kaeberlein, M.7
Kennedy, B.K.8
Berger, S.L.9
-
7
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M., McVey M., and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 (1999) 2570-2580
-
(1999)
Genes Dev.
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
8
-
-
0031459980
-
Extrachromosomal rDNA circles-a cause of aging in yeast
-
Sinclair D.A., and Guarente L. Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91 (1997) 1033-1042
-
(1997)
Cell
, vol.91
, pp. 1033-1042
-
-
Sinclair, D.A.1
Guarente, L.2
-
9
-
-
0018892091
-
Calendar life span versus budding life span of Saccharomyces cerevisiae
-
Muller I., Zimmermann M., Becker D., and Flomer M. Calendar life span versus budding life span of Saccharomyces cerevisiae. Mech. Ageing Dev. 12 (1980) 47-52
-
(1980)
Mech. Ageing Dev.
, vol.12
, pp. 47-52
-
-
Muller, I.1
Zimmermann, M.2
Becker, D.3
Flomer, M.4
-
10
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin S.J., Defossez P.A., and Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289 (2000) 2126-2128
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
11
-
-
24944559665
-
HST2 mediates SIR2-independent life-span extension by calorie restriction
-
Lamming D.W., Latorre-Esteves M., Medvedik O., Wong S.N., Tsang F.A., Wang C., Lin S.J., and Sinclair D.A. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309 (2005) 1861-1864
-
(2005)
Science
, vol.309
, pp. 1861-1864
-
-
Lamming, D.W.1
Latorre-Esteves, M.2
Medvedik, O.3
Wong, S.N.4
Tsang, F.A.5
Wang, C.6
Lin, S.J.7
Sinclair, D.A.8
-
12
-
-
0042422247
-
The chronological life span of Saccharomyces cerevisiae
-
Fabrizio P., and Longo V.D. The chronological life span of Saccharomyces cerevisiae. Aging Cell. 2 (2003) 73-81
-
(2003)
Aging Cell.
, vol.2
, pp. 73-81
-
-
Fabrizio, P.1
Longo, V.D.2
-
13
-
-
63549145905
-
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
-
Jimenez-Hidalgo M., Santos-Ocana C., Padilla S., Villalba J.M., Lopez-Lluch G., Martin-Montalvo A., Minor R.K., Sinclair D.A., de Cabo R., and Navas P. NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8 (2009) 140-151
-
(2009)
Aging Cell
, vol.8
, pp. 140-151
-
-
Jimenez-Hidalgo, M.1
Santos-Ocana, C.2
Padilla, S.3
Villalba, J.M.4
Lopez-Lluch, G.5
Martin-Montalvo, A.6
Minor, R.K.7
Sinclair, D.A.8
de Cabo, R.9
Navas, P.10
-
14
-
-
34548615053
-
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
-
Smith Jr. D.L., McClure J.M., Matecic M., and Smith J.S. Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 6 (2007) 649-662
-
(2007)
Aging Cell
, vol.6
, pp. 649-662
-
-
Smith Jr., D.L.1
McClure, J.M.2
Matecic, M.3
Smith, J.S.4
-
15
-
-
27744554550
-
The enigmatic role of Sir2 in aging
-
Kennedy B.K., Smith E.D., and Kaeberlein M. The enigmatic role of Sir2 in aging. Cell 123 (2005) 548-550
-
(2005)
Cell
, vol.123
, pp. 548-550
-
-
Kennedy, B.K.1
Smith, E.D.2
Kaeberlein, M.3
-
16
-
-
34249882777
-
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
-
Miyamoto K., Araki K.Y., Naka K., Arai F., Takubo K., Yamazaki S., Matsuoka S., Miyamoto T., Ito K., Ohmura M., Chen C., Hosokawa K., Nakauchi H., Nakayama K., Nakayama K.I., Harada M., Motoyama N., Suda T., and Hirao A. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1 (2007) 101-112
-
(2007)
Cell Stem Cell
, vol.1
, pp. 101-112
-
-
Miyamoto, K.1
Araki, K.Y.2
Naka, K.3
Arai, F.4
Takubo, K.5
Yamazaki, S.6
Matsuoka, S.7
Miyamoto, T.8
Ito, K.9
Ohmura, M.10
Chen, C.11
Hosokawa, K.12
Nakauchi, H.13
Nakayama, K.14
Nakayama, K.I.15
Harada, M.16
Motoyama, N.17
Suda, T.18
Hirao, A.19
-
17
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz O.H., Valdez R., Theisen B.K., Guo W., Ferguson D.O., Wu H., and Morrison S.J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441 (2006) 475-482
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
18
-
-
3242815537
-
Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells
-
Kim Y.A., Choi B.T., Lee Y.T., Park D.I., Rhee S.H., Park K.Y., and Choi Y.H. Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol. Rep. 11 (2004) 441-446
-
(2004)
Oncol. Rep.
, vol.11
, pp. 441-446
-
-
Kim, Y.A.1
Choi, B.T.2
Lee, Y.T.3
Park, D.I.4
Rhee, S.H.5
Park, K.Y.6
Choi, Y.H.7
-
19
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (2001) 227-230
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
20
-
-
27644585190
-
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
-
Viswanathan M., Kim S.K., Berdichevsky A., and Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9 (2005) 605-615
-
(2005)
Dev. Cell
, vol.9
, pp. 605-615
-
-
Viswanathan, M.1
Kim, S.K.2
Berdichevsky, A.3
Guarente, L.4
-
21
-
-
0347128279
-
Calorie restriction extends yeast life span by lowering the level of NADH
-
Lin S.J., Ford E., Haigis M., Liszt G., and Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 18 (2004) 12-16
-
(2004)
Genes Dev.
, vol.18
, pp. 12-16
-
-
Lin, S.J.1
Ford, E.2
Haigis, M.3
Liszt, G.4
Guarente, L.5
-
22
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
Lin S.J., Kaeberlein M., Andalis A.A., Sturtz L.A., Defossez P.A., Culotta V.C., Fink G.R., and Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418 (2002) 344-348
-
(2002)
Nature
, vol.418
, pp. 344-348
-
-
Lin, S.J.1
Kaeberlein, M.2
Andalis, A.A.3
Sturtz, L.A.4
Defossez, P.A.5
Culotta, V.C.6
Fink, G.R.7
Guarente, L.8
-
23
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson R.M., Bitterman K.J., Wood J.G., Medvedik O., and Sinclair D.A. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423 (2003) 181-185
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
24
-
-
27744596999
-
Sir2 blocks extreme life-span extension
-
Fabrizio P., Gattazzo C., Battistella L., Wei M., Cheng C., McGrew K., and Longo V.D. Sir2 blocks extreme life-span extension. Cell 123 (2005) 655-667
-
(2005)
Cell
, vol.123
, pp. 655-667
-
-
Fabrizio, P.1
Gattazzo, C.2
Battistella, L.3
Wei, M.4
Cheng, C.5
McGrew, K.6
Longo, V.D.7
-
25
-
-
29244489494
-
Increased life span due to calorie restriction in respiratory-deficient yeast
-
Kaeberlein M., Hu D., Kerr E.O., Tsuchiya M., Westman E.A., Dang N., Fields S., and Kennedy B.K. Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet. 1 (2005) e69
-
(2005)
PLoS Genet.
, vol.1
-
-
Kaeberlein, M.1
Hu, D.2
Kerr, E.O.3
Tsuchiya, M.4
Westman, E.A.5
Dang, N.6
Fields, S.7
Kennedy, B.K.8
-
26
-
-
34347354447
-
Sir2 and calorie restriction in yeast: a skeptical perspective
-
Kaeberlein M., and Powers III R.W. Sir2 and calorie restriction in yeast: a skeptical perspective. Ageing Res. Rev. 6 (2007) 128-140
-
(2007)
Ageing Res. Rev.
, vol.6
, pp. 128-140
-
-
Kaeberlein, M.1
Powers III, R.W.2
-
27
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B., and Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 15998-16003
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
28
-
-
18744416824
-
Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction
-
Rogina B., Helfand S.L., and Frankel S. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science 298 (2002) 1745
-
(2002)
Science
, vol.298
, pp. 1745
-
-
Rogina, B.1
Helfand, S.L.2
Frankel, S.3
-
29
-
-
22344443522
-
A systematic RNAi screen for longevity genes in C. elegans
-
Hamilton B., Dong Y., Shindo M., Liu W., Odell I., Ruvkun G., and Lee S.S. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19 (2005) 1544-1555
-
(2005)
Genes Dev.
, vol.19
, pp. 1544-1555
-
-
Hamilton, B.1
Dong, Y.2
Shindo, M.3
Liu, W.4
Odell, I.5
Ruvkun, G.6
Lee, S.S.7
-
30
-
-
28244475950
-
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
-
Wang Y., and Tissenbaum H.A. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech. Ageing Dev. 127 (2006) 48-56
-
(2006)
Mech. Ageing Dev.
, vol.127
, pp. 48-56
-
-
Wang, Y.1
Tissenbaum, H.A.2
-
31
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen M., Taubert S., Crawford D., Libina N., Lee S.J., and Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6 (2007) 95-110
-
(2007)
Aging Cell
, vol.6
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.J.5
Kenyon, C.6
-
32
-
-
33751250243
-
Lifespan extension in Caenorhabditis elegans by complete removal of food
-
Kaeberlein T.L., Smith E.D., Tsuchiya M., Welton K.L., Thomas J.H., Fields S., Kennedy B.K., and Kaeberlein M. Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5 (2006) 487-494
-
(2006)
Aging Cell
, vol.5
, pp. 487-494
-
-
Kaeberlein, T.L.1
Smith, E.D.2
Tsuchiya, M.3
Welton, K.L.4
Thomas, J.H.5
Fields, S.6
Kennedy, B.K.7
Kaeberlein, M.8
-
33
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz T.J., Zarse K., Voigt A., Urban N., Birringer M., and Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell. Metab. 6 (2007) 280-293
-
(2007)
Cell. Metab.
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
Urban, N.4
Birringer, M.5
Ristow, M.6
-
34
-
-
33751113602
-
Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
-
Haigis M.C., and Guarente L.P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20 (2006) 2913-2921
-
(2006)
Genes Dev.
, vol.20
, pp. 2913-2921
-
-
Haigis, M.C.1
Guarente, L.P.2
-
35
-
-
19944433088
-
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
-
Bellizzi D., Rose G., Cavalcante P., Covello G., Dato S., De Rango F., Greco V., Maggiolini M., Feraco E., Mari V., Franceschi C., Passarino G., and De Benedictis G. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85 (2005) 258-263
-
(2005)
Genomics
, vol.85
, pp. 258-263
-
-
Bellizzi, D.1
Rose, G.2
Cavalcante, P.3
Covello, G.4
Dato, S.5
De Rango, F.6
Greco, V.7
Maggiolini, M.8
Feraco, E.9
Mari, V.10
Franceschi, C.11
Passarino, G.12
De Benedictis, G.13
-
36
-
-
70350365059
-
Human longevity and 11p15.5: a study in 1321 centenarians
-
[April 15, Electronic publication ahead of print]
-
Lescai F., Blanche H., Nebel A., Beekman M., Sahbatou M., Flachsbart F., Slagboom E., Schreiber S., Sorbi S., Passarino G., and Franceschi C. Human longevity and 11p15.5: a study in 1321 centenarians. Eur. J. Hum. Genet. (2009) [April 15, Electronic publication ahead of print]
-
(2009)
Eur. J. Hum. Genet.
-
-
Lescai, F.1
Blanche, H.2
Nebel, A.3
Beekman, M.4
Sahbatou, M.5
Flachsbart, F.6
Slagboom, E.7
Schreiber, S.8
Sorbi, S.9
Passarino, G.10
Franceschi, C.11
-
37
-
-
28844469898
-
Increase in activity during calorie restriction requires Sirt1
-
Chen D., Steele A.D., Lindquist S., and Guarente L. Increase in activity during calorie restriction requires Sirt1. Science 310 (2005) 1641
-
(2005)
Science
, vol.310
, pp. 1641
-
-
Chen, D.1
Steele, A.D.2
Lindquist, S.3
Guarente, L.4
-
38
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C. elegans
-
Bishop N.A., and Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447 (2007) 545-549
-
(2007)
Nature
, vol.447
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
39
-
-
13944253348
-
Calorie restriction-the SIR2 connection
-
Guarente L., and Picard F. Calorie restriction-the SIR2 connection. Cell 120 (2005) 473-482
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
40
-
-
26844558334
-
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
-
Nisoli E., Tonello C., Cardile A., Cozzi V., Bracale R., Tedesco L., Falcone S., Valerio A., Cantoni O., Clementi E., Moncada S., and Carruba M.O. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310 (2005) 314-317
-
(2005)
Science
, vol.310
, pp. 314-317
-
-
Nisoli, E.1
Tonello, C.2
Cardile, A.3
Cozzi, V.4
Bracale, R.5
Tedesco, L.6
Falcone, S.7
Valerio, A.8
Cantoni, O.9
Clementi, E.10
Moncada, S.11
Carruba, M.O.12
-
41
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., and Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 (2004) 771-776
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
Machado De Oliveira, R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
42
-
-
34247259630
-
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
-
Gerhart-Hines Z., Rodgers J.T., Bare O., Lerin C., Kim S.H., Mostoslavsky R., Alt F.W., Wu Z., and Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26 (2007) 1913-1923
-
(2007)
EMBO J.
, vol.26
, pp. 1913-1923
-
-
Gerhart-Hines, Z.1
Rodgers, J.T.2
Bare, O.3
Lerin, C.4
Kim, S.H.5
Mostoslavsky, R.6
Alt, F.W.7
Wu, Z.8
Puigserver, P.9
-
43
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen D., Bruno J., Easlon E., Lin S.J., Cheng H.L., Alt F.W., and Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22 (2008) 1753-1757
-
(2008)
Genes Dev.
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
Bruno, J.2
Easlon, E.3
Lin, S.J.4
Cheng, H.L.5
Alt, F.W.6
Guarente, L.7
-
44
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
-
Bordone L., Motta M.C., Picard F., Robinson A., Jhala U.S., Apfeld J., McDonagh T., Lemieux M., McBurney M., Szilvasi A., Easlon E.J., Lin S.J., and Guarente L. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 4 (2006) e31
-
(2006)
PLoS Biol.
, vol.4
-
-
Bordone, L.1
Motta, M.C.2
Picard, F.3
Robinson, A.4
Jhala, U.S.5
Apfeld, J.6
McDonagh, T.7
Lemieux, M.8
McBurney, M.9
Szilvasi, A.10
Easlon, E.J.11
Lin, S.J.12
Guarente, L.13
-
45
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan K.A., Grimm A.A., Plueger M.M., Bernal-Mizrachi E., Ford E., Cras-Meneur C., Permutt M.A., and Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell. Metab. 2 (2005) 105-117
-
(2005)
Cell. Metab.
, vol.2
, pp. 105-117
-
-
Moynihan, K.A.1
Grimm, A.A.2
Plueger, M.M.3
Bernal-Mizrachi, E.4
Ford, E.5
Cras-Meneur, C.6
Permutt, M.A.7
Imai, S.8
-
46
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 (2005) 113-118
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
47
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
-
Liu Y., Dentin R., Chen D., Hedrick S., Ravnskjaer K., Schenk S., Milne J., Meyers D.J., Cole P., Yates III J., Olefsky J., Guarente L., and Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456 (2008) 269-273
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
Dentin, R.2
Chen, D.3
Hedrick, S.4
Ravnskjaer, K.5
Schenk, S.6
Milne, J.7
Meyers, D.J.8
Cole, P.9
Yates III, J.10
Olefsky, J.11
Guarente, L.12
Montminy, M.13
-
48
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
-
Yoon J.C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C.R., Granner D.K., Newgard C.B., and Spiegelman B.M. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413 (2001) 131-138
-
(2001)
Nature
, vol.413
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
Donovan, J.4
Wu, Z.5
Rhee, J.6
Adelmant, G.7
Stafford, J.8
Kahn, C.R.9
Granner, D.K.10
Newgard, C.B.11
Spiegelman, B.M.12
-
49
-
-
0028051314
-
Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver
-
Grasl-Kraupp B., Bursch W., Ruttkay-Nedecky B., Wagner A., Lauer B., and Schulte-Hermann R. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 9995-9999
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 9995-9999
-
-
Grasl-Kraupp, B.1
Bursch, W.2
Ruttkay-Nedecky, B.3
Wagner, A.4
Lauer, B.5
Schulte-Hermann, R.6
-
50
-
-
0031967803
-
Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging
-
James S.J., Muskhelishvili L., Gaylor D.W., Turturro A., and Hart R. Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging. Environ. Health Perspect. 106 Suppl. 1 (1998) 307-312
-
(1998)
Environ. Health Perspect.
, vol.106
, Issue.SUPPL. 1
, pp. 307-312
-
-
James, S.J.1
Muskhelishvili, L.2
Gaylor, D.W.3
Turturro, A.4
Hart, R.5
-
51
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., and Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 (2001) 137-148
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
52
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., and Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 (2001) 149-159
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
53
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., Hu L.S., Cheng H.L., Jedrychowski M.P., Gygi S.P., Sinclair D.A., Alt F.W., and Greenberg M.E. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 (2004) 2011-2015
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
Hu, L.S.11
Cheng, H.L.12
Jedrychowski, M.P.13
Gygi, S.P.14
Sinclair, D.A.15
Alt, F.W.16
Greenberg, M.E.17
-
54
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., Bultsma Y., McBurney M., and Guarente L. Mammalian SIRT1 represses forkhead transcription factors. Cell 116 (2004) 551-563
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
Bultsma, Y.7
McBurney, M.8
Guarente, L.9
-
55
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., de Cabo R., and Sinclair D.A. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305 (2004) 390-392
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
de Cabo, R.9
Sinclair, D.A.10
-
56
-
-
33748200050
-
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
-
Wang C., Chen L., Hou X., Li Z., Kabra N., Ma Y., Nemoto S., Finkel T., Gu W., Cress W.D., and Chen J. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat. Cell Biol. 8 9 (2006) 1025-1031
-
(2006)
Nat. Cell Biol.
, vol.8
, Issue.9
, pp. 1025-1031
-
-
Wang, C.1
Chen, L.2
Hou, X.3
Li, Z.4
Kabra, N.5
Ma, Y.6
Nemoto, S.7
Finkel, T.8
Gu, W.9
Cress, W.D.10
Chen, J.11
-
57
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., Pistell P.J., Poosala S., Becker K.G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K.W., Spencer R.G., Lakatta E.G., Le Couteur D., Shaw R.J., Navas P., Puigserver P., Ingram D.K., de Cabo R., and Sinclair D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 (2006) 337-342
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
de Cabo, R.26
Sinclair, D.A.27
more..
-
58
-
-
33846505019
-
Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
-
Zhang Q., Wang S.Y., Fleuriel C., Leprince D., Rocheleau J.V., Piston D.W., and Goodman R.H. Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 829-833
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 829-833
-
-
Zhang, Q.1
Wang, S.Y.2
Fleuriel, C.3
Leprince, D.4
Rocheleau, J.V.5
Piston, D.W.6
Goodman, R.H.7
-
59
-
-
52749091816
-
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
-
Banks A.S., Kon N., Knight C., Matsumoto M., Gutierrez-Juarez R., Rossetti L., Gu W., and Accili D. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell. Metab. 8 (2008) 333-341
-
(2008)
Cell. Metab.
, vol.8
, pp. 333-341
-
-
Banks, A.S.1
Kon, N.2
Knight, C.3
Matsumoto, M.4
Gutierrez-Juarez, R.5
Rossetti, L.6
Gu, W.7
Accili, D.8
-
60
-
-
36248975293
-
SIRT1 transgenic mice show phenotypes resembling calorie restriction
-
Bordone L., Cohen D., Robinson A., Motta M.C., van Veen E., Czopik A., Steele A.D., Crowe H., Marmor S., Luo J., Gu W., and Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6 (2007) 759-767
-
(2007)
Aging Cell
, vol.6
, pp. 759-767
-
-
Bordone, L.1
Cohen, D.2
Robinson, A.3
Motta, M.C.4
van Veen, E.5
Czopik, A.6
Steele, A.D.7
Crowe, H.8
Marmor, S.9
Luo, J.10
Gu, W.11
Guarente, L.12
-
61
-
-
47749128879
-
Sirt1 protects against high-fat diet-induced metabolic damage
-
Pfluger P.T., Herranz D., Velasco-Miguel S., Serrano M., and Tschop M.H. Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 9793-9798
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 9793-9798
-
-
Pfluger, P.T.1
Herranz, D.2
Velasco-Miguel, S.3
Serrano, M.4
Tschop, M.H.5
-
62
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., and Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127 (2006) 1109-1122
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
63
-
-
33745962138
-
Therapeutic potential of resveratrol: the in vivo evidence
-
Baur J.A., and Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev., Drug Discov. 5 (2006) 493-506
-
(2006)
Nat. Rev., Drug Discov.
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
64
-
-
54849425547
-
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
-
Feige J.N., Lagouge M., Canto C., Strehle A., Houten S.M., Milne J.C., Lambert P.D., Mataki C., Elliott P.J., and Auwerx J. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell. Metab. 8 (2008) 347-358
-
(2008)
Cell. Metab.
, vol.8
, pp. 347-358
-
-
Feige, J.N.1
Lagouge, M.2
Canto, C.3
Strehle, A.4
Houten, S.M.5
Milne, J.C.6
Lambert, P.D.7
Mataki, C.8
Elliott, P.J.9
Auwerx, J.10
-
65
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne J., Lambert P., Westphal C., Milne J., Lambert P., Schenk S., Carney D., Smith J., Gagne D., Jin L., Boss O., Perni R., Vu C., Bemis J., Xie R., Disch J., Ng P., Nunes J., Lynch A., Yang H., Galonek H., Israelian K., Choy W., Iffland A., Lavu S., Medvedik O., Sinclair D., Olefsky J., Jirousek M., Elliott P., and Westphal C. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450 (2007) 712-716
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.1
Lambert, P.2
Westphal, C.3
Milne, J.4
Lambert, P.5
Schenk, S.6
Carney, D.7
Smith, J.8
Gagne, D.9
Jin, L.10
Boss, O.11
Perni, R.12
Vu, C.13
Bemis, J.14
Xie, R.15
Disch, J.16
Ng, P.17
Nunes, J.18
Lynch, A.19
Yang, H.20
Galonek, H.21
Israelian, K.22
Choy, W.23
Iffland, A.24
Lavu, S.25
Medvedik, O.26
Sinclair, D.27
Olefsky, J.28
Jirousek, M.29
Elliott, P.30
Westphal, C.31
more..
-
66
-
-
0037102256
-
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
-
Lin J., Wu H., Tarr P.T., Zhang C.Y., Wu Z., Boss O., Michael L.F., Puigserver P., Isotani E., Olson E.N., Lowell B.B., Bassel-Duby R., and Spiegelman B.M. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418 (2002) 797-801
-
(2002)
Nature
, vol.418
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
Zhang, C.Y.4
Wu, Z.5
Boss, O.6
Michael, L.F.7
Puigserver, P.8
Isotani, E.9
Olson, E.N.10
Lowell, B.B.11
Bassel-Duby, R.12
Spiegelman, B.M.13
-
67
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R.C., and Spiegelman B.M. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 (1999) 115-124
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
Zhang, C.4
Adelmant, G.5
Mootha, V.6
Troy, A.7
Cinti, S.8
Lowell, B.9
Scarpulla, R.C.10
Spiegelman, B.M.11
-
68
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.J., and Zhao Y. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell 23 (2006) 607-618
-
(2006)
Mol. Cell
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
Cheng, T.7
Kho, Y.8
Xiao, H.9
Xiao, L.10
Grishin, N.V.11
White, M.12
Yang, X.J.13
Zhao, Y.14
-
69
-
-
37549002891
-
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
-
Lombard D.B., Alt F.W., Cheng H.L., Bunkenborg J., Streeper R.S., Mostoslavsky R., Kim J., Yancopoulos G., Valenzuela D., Murphy A., Yang Y., Chen Y., Hirschey M.D., Bronson R.T., Haigis M., Guarente L.P., Farese Jr. R.V., Weissman S., Verdin E., and Schwer B. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27 (2007) 8807-8814
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
Alt, F.W.2
Cheng, H.L.3
Bunkenborg, J.4
Streeper, R.S.5
Mostoslavsky, R.6
Kim, J.7
Yancopoulos, G.8
Valenzuela, D.9
Murphy, A.10
Yang, Y.11
Chen, Y.12
Hirschey, M.D.13
Bronson, R.T.14
Haigis, M.15
Guarente, L.P.16
Farese Jr., R.V.17
Weissman, S.18
Verdin, E.19
Schwer, B.20
more..
-
70
-
-
33745931074
-
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
-
Hallows W.C., Lee S., and Denu J.M. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 10230-10235
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 10230-10235
-
-
Hallows, W.C.1
Lee, S.2
Denu, J.M.3
-
71
-
-
33745889628
-
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
-
Schwer B., Bunkenborg J., Verdin R.O., Andersen J.S., and Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 10224-10229
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 10224-10229
-
-
Schwer, B.1
Bunkenborg, J.2
Verdin, R.O.3
Andersen, J.S.4
Verdin, E.5
-
72
-
-
17144424946
-
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
-
Shi T., Wang F., Stieren E., and Tong Q. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J. Biol. Chem. 280 (2005) 13560-13567
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 13560-13567
-
-
Shi, T.1
Wang, F.2
Stieren, E.3
Tong, Q.4
-
73
-
-
55749084738
-
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
-
Ahn B.H., Kim H.S., Song S., Lee I.H., Liu J., Vassilopoulos A., Deng C.X., and Finkel T. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 14447-14452
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
Kim, H.S.2
Song, S.3
Lee, I.H.4
Liu, J.5
Vassilopoulos, A.6
Deng, C.X.7
Finkel, T.8
-
74
-
-
65249087389
-
SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
Nakagawa T., Lomb D.J., Haigis M.C., and Guarente L. SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137 (2009) 560-570
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
75
-
-
33748316536
-
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
-
Haigis M.C., Mostoslavsky R., Haigis K.M., Fahie K., Christodoulou D.C., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., Karow M., Blander G., Wolberger C., Prolla T.A., Weindruch R., Alt F.W., and Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 (2006) 941-954
-
(2006)
Cell
, vol.126
, pp. 941-954
-
-
Haigis, M.C.1
Mostoslavsky, R.2
Haigis, K.M.3
Fahie, K.4
Christodoulou, D.C.5
Murphy, A.J.6
Valenzuela, D.M.7
Yancopoulos, G.D.8
Karow, M.9
Blander, G.10
Wolberger, C.11
Prolla, T.A.12
Weindruch, R.13
Alt, F.W.14
Guarente, L.15
-
76
-
-
34548627517
-
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
-
Yang H., Yang T., Baur J.A., Perez E., Matsui T., Carmona J.J., Lamming D.W., Souza-Pinto N.C., Bohr V.A., Rosenzweig A., de Cabo R., Sauve A.A., and Sinclair D.A. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130 (2007) 1095-1107
-
(2007)
Cell
, vol.130
, pp. 1095-1107
-
-
Yang, H.1
Yang, T.2
Baur, J.A.3
Perez, E.4
Matsui, T.5
Carmona, J.J.6
Lamming, D.W.7
Souza-Pinto, N.C.8
Bohr, V.A.9
Rosenzweig, A.10
de Cabo, R.11
Sauve, A.A.12
Sinclair, D.A.13
-
77
-
-
3343024449
-
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases
-
Borra M.T., Langer M.R., Slama J.T., and Denu J.M. Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. Biochemistry 43 (2004) 9877-9887
-
(2004)
Biochemistry
, vol.43
, pp. 9877-9887
-
-
Borra, M.T.1
Langer, M.R.2
Slama, J.T.3
Denu, J.M.4
-
78
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., and Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 (2003) 191-196
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.L.10
Scherer, B.11
Sinclair, D.A.12
-
79
-
-
4544243684
-
Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation
-
Schmidt M.T., Smith B.C., Jackson M.D., and Denu J.M. Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation. J. Biol. Chem. 279 (2004) 40122-40129
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 40122-40129
-
-
Schmidt, M.T.1
Smith, B.C.2
Jackson, M.D.3
Denu, J.M.4
-
80
-
-
10844236451
-
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
-
Nemoto S., Fergusson M.M., and Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306 (2004) 2105-2108
-
(2004)
Science
, vol.306
, pp. 2105-2108
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
81
-
-
58149202185
-
Phosphorylation regulates SIRT1 function
-
Sasaki T., Maier B., Koclega K.D., Chruszcz M., Gluba W., Stukenberg P.T., Minor W., and Scrable H. Phosphorylation regulates SIRT1 function. PLoS One 3 (2008) e4020
-
(2008)
PLoS One
, vol.3
-
-
Sasaki, T.1
Maier, B.2
Koclega, K.D.3
Chruszcz, M.4
Gluba, W.5
Stukenberg, P.T.6
Minor, W.7
Scrable, H.8
-
82
-
-
35748962613
-
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
-
Yang Y., Fu W., Chen J., Olashaw N., Zhang X., Nicosia S.V., Bhalla K., and Bai W. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat. Cell Biol. 9 (2007) 1253-1262
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1253-1262
-
-
Yang, Y.1
Fu, W.2
Chen, J.3
Olashaw, N.4
Zhang, X.5
Nicosia, S.V.6
Bhalla, K.7
Bai, W.8
-
83
-
-
35349011726
-
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
-
Kim E.J., Kho J.H., Kang M.R., and Um S.J. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol. Cell 28 (2007) 277-290
-
(2007)
Mol. Cell
, vol.28
, pp. 277-290
-
-
Kim, E.J.1
Kho, J.H.2
Kang, M.R.3
Um, S.J.4
-
84
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
Zhao W., Kruse J.P., Tang Y., Jung S.Y., Qin J., and Gu W. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451 (2008) 587-590
-
(2008)
Nature
, vol.451
, pp. 587-590
-
-
Zhao, W.1
Kruse, J.P.2
Tang, Y.3
Jung, S.Y.4
Qin, J.5
Gu, W.6
-
85
-
-
27544434763
-
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
-
Chen W.Y., Wang D.H., Yen R.C., Luo J., Gu W., and Baylin S.B. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123 (2005) 437-448
-
(2005)
Cell
, vol.123
, pp. 437-448
-
-
Chen, W.Y.1
Wang, D.H.2
Yen, R.C.3
Luo, J.4
Gu, W.5
Baylin, S.B.6
-
86
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng H.L., Mostoslavsky R., Saito S., Manis J.P., Gu Y., Patel P., Bronson R., Appella E., Alt F.W., and Chua K.F. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 10794-10799
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
87
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang R.H., Sengupta K., Li C., Kim H.S., Cao L., Xiao C., Kim S., Xu X., Zheng Y., Chilton B., Jia R., Zheng Z.M., Appella E., Wang X.W., Ried T., and Deng C.X. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14 (2008) 312-323
-
(2008)
Cancer Cell
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
Sengupta, K.2
Li, C.3
Kim, H.S.4
Cao, L.5
Xiao, C.6
Kim, S.7
Xu, X.8
Zheng, Y.9
Chilton, B.10
Jia, R.11
Zheng, Z.M.12
Appella, E.13
Wang, X.W.14
Ried, T.15
Deng, C.X.16
-
88
-
-
53149144656
-
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
-
Wang R.H., Zheng Y., Kim H.S., Xu X., Cao L., Luhasen T., Lee M.H., Xiao C., Vassilopoulos A., Chen W., Gardner K., Man Y.G., Hung M.C., Finkel T., and Deng C.X. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol. Cell 32 (2008) 11-20
-
(2008)
Mol. Cell
, vol.32
, pp. 11-20
-
-
Wang, R.H.1
Zheng, Y.2
Kim, H.S.3
Xu, X.4
Cao, L.5
Luhasen, T.6
Lee, M.H.7
Xiao, C.8
Vassilopoulos, A.9
Chen, W.10
Gardner, K.11
Man, Y.G.12
Hung, M.C.13
Finkel, T.14
Deng, C.X.15
-
89
-
-
44849096876
-
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
Firestein R., Blander G., Michan S., Oberdoerffer P., Ogino S., Campbell J., Bhimavarapu A., Luikenhuis S., de Cabo R., Fuchs C., Hahn W.C., Guarente L.P., and Sinclair D.A. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3 (2008) e2020
-
(2008)
PLoS One
, vol.3
-
-
Firestein, R.1
Blander, G.2
Michan, S.3
Oberdoerffer, P.4
Ogino, S.5
Campbell, J.6
Bhimavarapu, A.7
Luikenhuis, S.8
de Cabo, R.9
Fuchs, C.10
Hahn, W.C.11
Guarente, L.P.12
Sinclair, D.A.13
-
90
-
-
65549113750
-
CBP/p300-mediated acetylation of histone H3 on lysine 56
-
Das C., Lucia M.S., Hansen K.C., and Tyler J.K. CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 459 (2009) 113-117
-
(2009)
Nature
, vol.459
, pp. 113-117
-
-
Das, C.1
Lucia, M.S.2
Hansen, K.C.3
Tyler, J.K.4
-
91
-
-
56749156405
-
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
-
Oberdoerffer P., Michan S., McVay M., Mostoslavsky R., Vann J., Park S.K., Hartlerode A., Stegmuller J., Hafner A., Loerch P., Wright S.M., Mills K.D., Bonni A., Yankner B.A., Scully R., Prolla T.A., Alt F.W., and Sinclair D.A. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135 (2008) 907-918
-
(2008)
Cell
, vol.135
, pp. 907-918
-
-
Oberdoerffer, P.1
Michan, S.2
McVay, M.3
Mostoslavsky, R.4
Vann, J.5
Park, S.K.6
Hartlerode, A.7
Stegmuller, J.8
Hafner, A.9
Loerch, P.10
Wright, S.M.11
Mills, K.D.12
Bonni, A.13
Yankner, B.A.14
Scully, R.15
Prolla, T.A.16
Alt, F.W.17
Sinclair, D.A.18
-
92
-
-
34250897968
-
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
-
Yuan Z., Zhang X., Sengupta N., Lane W.S., and Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27 (2007) 149-162
-
(2007)
Mol. Cell
, vol.27
, pp. 149-162
-
-
Yuan, Z.1
Zhang, X.2
Sengupta, N.3
Lane, W.S.4
Seto, E.5
-
93
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottaviani E., and De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N.Y. Acad. Sci. 908 (2000) 244-254
-
(2000)
Ann. N.Y. Acad. Sci.
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
Bonafe, M.2
Valensin, S.3
Olivieri, F.4
De Luca, M.5
Ottaviani, E.6
De Benedictis, G.7
-
94
-
-
0033793152
-
The network and the remodeling theories of aging: historical background and new perspectives
-
Franceschi C., Valensin S., Bonafe M., Paolisso G., Yashin A.I., Monti D., and De Benedictis G. The network and the remodeling theories of aging: historical background and new perspectives. Exp. Gerontol. 35 (2000) 879-896
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 879-896
-
-
Franceschi, C.1
Valensin, S.2
Bonafe, M.3
Paolisso, G.4
Yashin, A.I.5
Monti, D.6
De Benedictis, G.7
-
95
-
-
0038718728
-
Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries
-
Csiszar A., Ungvari Z., Koller A., Edwards J.G., and Kaley G. Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries. FASEB J. 17 (2003) 1183-1185
-
(2003)
FASEB J.
, vol.17
, pp. 1183-1185
-
-
Csiszar, A.1
Ungvari, Z.2
Koller, A.3
Edwards, J.G.4
Kaley, G.5
-
96
-
-
23744439082
-
Gene expression responses to DNA damage are altered in human aging and in Werner syndrome
-
Kyng K.J., May A., Stevnsner T., Becker K.G., Kolvra S., and Bohr V.A. Gene expression responses to DNA damage are altered in human aging and in Werner syndrome. Oncogene 24 (2005) 5026-5042
-
(2005)
Oncogene
, vol.24
, pp. 5026-5042
-
-
Kyng, K.J.1
May, A.2
Stevnsner, T.3
Becker, K.G.4
Kolvra, S.5
Bohr, V.A.6
-
97
-
-
0000847978
-
Gene-expression profile of the ageing brain in mice
-
Lee C.K., Weindruch R., and Prolla T.A. Gene-expression profile of the ageing brain in mice. Nat. Genet. 25 (2000) 294-297
-
(2000)
Nat. Genet.
, vol.25
, pp. 294-297
-
-
Lee, C.K.1
Weindruch, R.2
Prolla, T.A.3
-
98
-
-
0035098360
-
Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice
-
Weindruch R., Kayo T., Lee C.K., and Prolla T.A. Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. J. Nutr. 131 (2001) 918S-923S
-
(2001)
J. Nutr.
, vol.131
-
-
Weindruch, R.1
Kayo, T.2
Lee, C.K.3
Prolla, T.A.4
-
99
-
-
39149086075
-
Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues
-
Swindell W.R. Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues. Mech. Ageing Dev. 129 (2008) 138-153
-
(2008)
Mech. Ageing Dev.
, vol.129
, pp. 138-153
-
-
Swindell, W.R.1
-
100
-
-
58149090925
-
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
-
Kawahara T.L., Michishita E., Adler A.S., Damian M., Berber E., Lin M., McCord R.A., Ongaigui K.C., Boxer L.D., Chang H.Y., and Chua K.F. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 136 (2009) 62-74
-
(2009)
Cell
, vol.136
, pp. 62-74
-
-
Kawahara, T.L.1
Michishita, E.2
Adler, A.S.3
Damian, M.4
Berber, E.5
Lin, M.6
McCord, R.A.7
Ongaigui, K.C.8
Boxer, L.D.9
Chang, H.Y.10
Chua, K.F.11
-
101
-
-
3242719545
-
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., and Mayo M.W. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23 (2004) 2369-2380
-
(2004)
EMBO J.
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
Frye, R.A.6
Mayo, M.W.7
-
102
-
-
0035669040
-
Resveratrol inhibits TNF alpha-induced endothelial cell activation
-
Bertelli A.A., Baccalini R., Battaglia E., Falchi M., and Ferrero M.E. Resveratrol inhibits TNF alpha-induced endothelial cell activation. Therapie 56 (2001) 613-616
-
(2001)
Therapie
, vol.56
, pp. 613-616
-
-
Bertelli, A.A.1
Baccalini, R.2
Battaglia, E.3
Falchi, M.4
Ferrero, M.E.5
-
103
-
-
20344407841
-
Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications
-
de la Lastra C.A., and Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol. Nutr. Food Res. 49 (2005) 405-430
-
(2005)
Mol. Nutr. Food Res.
, vol.49
, pp. 405-430
-
-
de la Lastra, C.A.1
Villegas, I.2
-
104
-
-
33646572516
-
The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model
-
Martin A.R., Villegas I., Sanchez-Hidalgo M., and de la Lastra C.A. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. Br. J. Pharmacol. 147 (2006) 873-885
-
(2006)
Br. J. Pharmacol.
, vol.147
, pp. 873-885
-
-
Martin, A.R.1
Villegas, I.2
Sanchez-Hidalgo, M.3
de la Lastra, C.A.4
-
105
-
-
51649112590
-
sirt1-null mice develop an autoimmune-like condition
-
Sequeira J., Boily G., Bazinet S., Saliba S., He X., Jardine K., Kennedy C., Staines W., Rousseaux C., Mueller R., and McBurney M.W. sirt1-null mice develop an autoimmune-like condition. Exp. Cell Res. 314 (2008) 3069-3074
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 3069-3074
-
-
Sequeira, J.1
Boily, G.2
Bazinet, S.3
Saliba, S.4
He, X.5
Jardine, K.6
Kennedy, C.7
Staines, W.8
Rousseaux, C.9
Mueller, R.10
McBurney, M.W.11
-
106
-
-
48349144852
-
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
-
Pearson K.J., Baur J.A., Lewis K.N., Peshkin L., Price N.L., Labinskyy N., Swindell W.R., Kamara D., Minor R.K., Perez E., Jamieson H.A., Zhang Y., Dunn S.R., Sharma K., Pleshko N., Woollett L.A., Csiszar A., Ikeno Y., Le Couteur D., Elliott P.J., Becker K.G., Navas P., Ingram D.K., Wolf N.S., Ungvari Z., Sinclair D.A., and de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell. Metab. 8 (2008) 157-168
-
(2008)
Cell. Metab.
, vol.8
, pp. 157-168
-
-
Pearson, K.J.1
Baur, J.A.2
Lewis, K.N.3
Peshkin, L.4
Price, N.L.5
Labinskyy, N.6
Swindell, W.R.7
Kamara, D.8
Minor, R.K.9
Perez, E.10
Jamieson, H.A.11
Zhang, Y.12
Dunn, S.R.13
Sharma, K.14
Pleshko, N.15
Woollett, L.A.16
Csiszar, A.17
Ikeno, Y.18
Le Couteur, D.19
Elliott, P.J.20
Becker, K.G.21
Navas, P.22
Ingram, D.K.23
Wolf, N.S.24
Ungvari, Z.25
Sinclair, D.A.26
de Cabo, R.27
more..
|