Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene

International Journal of Oncology

Volumn 28, Issue 2, 2006, Pages 447-456

  Mahlknecht, Ulrich ^a   Ho, Anthony D ^a   Voelter Mahlknecht, Susanne ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Chromatin; Chromosomes; Genes; Histone deacetylase; Histones; Sirtuins; Structural

Indexed keywords

SIRTUIN; SIRTUIN 6 PROTEIN, HUMAN;

ALU SEQUENCE; AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; CHROMOSOME 19; CHROMOSOME MAP; CPG ISLAND; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; HUMAN; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHYLOGENY; SEQUENCE ALIGNMENT;

ALU ELEMENTS; AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 19; CONSERVED SEQUENCE; CPG ISLANDS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PHYLOGENY; SEQUENCE ALIGNMENT; SIRTUINS;

EID: 39049184073     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.28.2.447     Document Type: Article

References (46)

1. Frye RA: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273: 793-798, 2000.
2. Frye RA: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun 260: 273-279, 1999.
3. Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L and Boeke JD: The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9: 2888-2902, 1995.
4. Voelter-Mahlknecht S, Ho AD and Mahlknecht U: FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2). Int J Oncol 27: 1187-1196, 2005.
5. Imai S, Armstrong CM, Kaeberlein M and Guarente L: Transcriptional silencing and longevity protein Sir2 is an NADdependent histone deacetylase. Nature 403: 795-800, 2000.
6. Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P and Reinberg D: Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 16: 93-105, 2004.
7. Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, et al: SIRT1 shows no substrate specificity in vitro. J Biol Chem 280: 9780-9785, 2005.
8. Blander G and Guarente L: The Sir2 family of protein deacetylases. Annu Rev Biochem 73: 417-435, 2004.
9. Straight AF, Shou W, Dowd GJ, Turck CW, Deshaies RJ, Johnson AD, et al: Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97: 245-256, 1999.
10. Fritze CE, Verschueren K, Strich R and Easton Esposito R: Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J 16: 6495-6509, 1997.
11. San-Segundo PA and Roeder GS: Pch2 links chromatin silencing to meiotic checkpoint control. Cell 97: 313-324, 1999.
12. Kaeberlein M, McVey M and Guarente L: The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580, 1999.
13. Shore D, Squire M and Nasmyth KA: Characterization of two genes required for the position-effect control of yeast mating-type genes. EMBO J 3: 2817-2823, 1984.
14. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, et al: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015, 2004.
15. Liszt G, Ford E, Kurtev M and Guarente L: Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem 280: 21313-21320, 2005.
16. Sauve AA and Schramm VL: SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates. Curr Med Chem 11: 807-826, 2004.
17. Tanny JC, Dowd GJ, Huang J, Hilz H and Moazed D: An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99: 735-745, 1999.
18. Tanny JC and Moazed D: Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: evidence for acetyl transfer from substrate to an NAD breakdown product. Proc Natl Acad Sci USA 98: 415-420, 2001.
19. Tanner KG, Landry J, Sternglanz R and Denu JM: Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci USA 97: 14178-14182, 2000.
20. Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, et al: Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418: 344-348, 2002.
21. Lin SJ, Defossez PA and Guarente L: Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128, 2000.
22. North BJ and Verdin E: Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol 5: 224.1-7, 2004.
23. Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, et al: Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563, 2004.
24. Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, et al: Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-148, 2001.
25. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, et al: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159, 2001.
26. Nemoto S, Fergusson MM and Finkel T: Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306: 2105-2108, 2004.
27. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, et al: Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392, 2004.
28. Starai VJ, Celic I, Cole RN, Boeke JD and Escalante-Semerena JC: Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science 298: 2390-2392, 2002.
29. +-dependent tubulin deacetylase. Mol Cell 11: 437-444, 2003.
30. Dryden SC, Nahhas FA, Nowak JE, Goustin AS and Tainsky MA: Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol 23: 3173-3185, 2003.
31. Birnboim HC and Doly J: A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 7: 1513-1523, 1979.
32. Mahlknecht U, Hoelzer D and Bucala R: Sequencing of genomic DNA. Biotechniques 27: 406-408, 1999.
33. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, et al: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402, 1997.
34. Wilbur WJ and Lipman DJ: Rapid similarity searches of nucleic acid and protein data banks. Proc Natl Acad Sci USA 80: 726-730, 1983.
35. Needleman SB and Wunsch CD: A general method applicable to the search for similarities in the amino acid sequence of two proteins. J Mol Biol 48: 443-453, 1970.
36. Thompson JD, Higgins DG and Gibson TJ: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680, 1994.
37. Feng DF and Doolittle RF: Progressive sequence alignment as a prerequisite to correct phylogenetic trees. J Mol Evol 25: 351-360, 1987.
38. Fitzgerald M and Shenk T: The sequence 5′-AAUAAA-3′forms parts of the recognition site for polyadenylation of late SV40 mRNAs. Cell 24: 251-260, 1981.
39. Yang YH, Chen YH, Zhang CY, Nimmakayalu MA, Ward DC and Weissman S: Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Genomics 69: 355-369, 2000.
40. Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T, et al: Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci USA 99: 4465-4470, 2002.
41. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, et al: A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA 101: 6062-6067, 2004.
42. Walker JR, Su AI, Self DW, Hogenesch JB, Lapp H, Maier R, Hoyer D and Bilbe G: Applications of a rat multiple tissue gene expression data set. Genome Res 14: 742-749, 2004.
43. Singer MF, Thayer RE, Grimaldi G, Lerman MI and Fanning TG: Homology between the KpnI primate and BamH1 (M1F-1) rodent families of long interspersed repeated sequences. Nucleic Acids Res 11: 5739-5745, 1983.
44. Lewin B: Regulation of transcription. Oxford University Press, New York, 1997.
45. Mitelman F, Mertens F and Johansson B: A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet: 417-474, 1997.
46. Mahlknecht U, Ottmann OG and Hoelzer D: When the band begins to play: Histone acetylation caught in the crossfire of gene control. Mol Carcinog 27: 268-271, 2000.