Novel γ-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1

FASEB Journal

Volumn 24, Issue 7, 2010, Pages 2464-2474

  Wu, Fang ^a   Schweizer, Claude ^a   Rudinskiy, Nikita ^a   Taylor, David M ^a   Kazantsev, Aleksey ^b   Luthi Carter, Ruth ^a   Fraering, Patrick C ^a  

^a EPFL   (Switzerland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Amyloi peptides; Off target effect; Presenilin 1; Substrate binding sites

Indexed keywords

1 [(4 METHOXY 2 NITROPHENYLIMINO)METHYL]NAPHTHOL; 1 NAPHTHALDEHYDE; 2 HYDROXY 1 NAPHTHALDEHYDE; 2 NAPHTHALDEHYDE; 2 NAPHTHOL; AFN 941; AGK 2; AK 1; AK 7; BENZALDEHYDE; C2 8; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; JANUS KINASE 3; LDDN 9918; M 15; N',N''' DI[(2 HYDROXY 1 NAPHTHYL)METHYLIDENE]CARBONIC DIHYDRAZIDE; NICOTINAMIDE; PRESENILIN 1; PYRIDOXAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SALICYLALDEHYDE; SIRTINOL; SIRTUIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; JAK3 DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; BINDING SITES; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; JANUS KINASE 3; NAPHTHALENES; NUCLEOTIDES; PRESENILIN-1; SIRTUIN 2; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 77954450977     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-148031     Document Type: Article

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