메뉴 건너뛰기




Volumn 5, Issue 7, 2010, Pages

Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; ESTROGEN RELATED RECEPTOR ALPHA; GLUTATHIONE PEROXIDASE 1; MANGANESE SUPEROXIDE DISMUTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; SIRTUIN 3; HEAT SHOCK PROTEIN; MITOCHONDRIAL DNA; PPARGC1A PROTEIN, HUMAN; PPARGC1A PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

EID: 77955347446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011707     Document Type: Article
Times cited : (604)

References (56)
  • 1
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J, Handschin C, Spiegelman BM (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1: 361-370.
    • (2005) Cell Metab , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 2
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • Finck BN, Kelly DP (2006) PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 116: 615-622.
    • (2006) J Clin Invest , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 3
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisomeproliferator- activated receptor delta activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S, Yu RT, Ham J, et al. (2003) Peroxisomeproliferator- activated receptor delta activates fat metabolism to prevent obesity. Cell 113: 159-170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5
  • 4
    • 0036633114 scopus 로고    scopus 로고
    • To ERR in the estrogen pathway
    • Giguere V (2002) To ERR in the estrogen pathway. Trends Endocrinol Metab 13: 220-225.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 220-225
    • Giguere, V.1
  • 5
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98: 115-124.
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3    Zhang, C.4    Adelmant, G.5
  • 6
    • 0038036024 scopus 로고    scopus 로고
    • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells
    • St-Pierre J, Lin J, Krauss S, Tarr PT, Yang R, et al. (2003) Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem 278: 26597-26603.
    • (2003) J Biol Chem , vol.278 , pp. 26597-26603
    • St-Pierre, J.1    Lin, J.2    Krauss, S.3    Tarr, P.T.4    Yang, R.5
  • 7
    • 0035855905 scopus 로고    scopus 로고
    • CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    • Herzig S, Long F, Jhala US, Hedrick S, Quinn R, et al. (2001) CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413: 179-183.
    • (2001) Nature , vol.413 , pp. 179-183
    • Herzig, S.1    Long, F.2    Jhala, U.S.3    Hedrick, S.4    Quinn, R.5
  • 8
    • 0035855858 scopus 로고    scopus 로고
    • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    • Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, et al. (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413: 131-138.
    • (2001) Nature , vol.413 , pp. 131-138
    • Yoon, J.C.1    Puigserver, P.2    Chen, G.3    Donovan, J.4    Wu, Z.5
  • 9
    • 5344252327 scopus 로고    scopus 로고
    • Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    • Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, et al. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119: 121-135.
    • (2004) Cell , vol.119 , pp. 121-135
    • Lin, J.1    Wu, P.H.2    Tarr, P.T.3    Lindenberg, K.S.4    St-Pierre, J.5
  • 10
    • 21144446106 scopus 로고    scopus 로고
    • PGC- 1alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis
    • Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, et al. (2005) PGC- 1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 3: e101.
    • (2005) PLoS Biol , vol.e101 , pp. 3
    • Leone, T.C.1    Lehman, J.J.2    Finck, B.N.3    Schaeffer, P.J.4    Wende, A.R.5
  • 11
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120: 483-495.
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 12
    • 0033667705 scopus 로고    scopus 로고
    • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
    • Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, et al. (2000) Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26: 435-439.
    • (2000) Nat Genet , vol.26 , pp. 435-439
    • Arsenijevic, D.1    Onuma, H.2    Pecqueur, C.3    Raimbault, S.4    Manning, B.S.5
  • 14
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neuro degeneration by the PGC-1 transcriptional co activators
    • St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, et al. (2006) Suppression of reactive oxygen species and neuro degeneration by the PGC-1 transcriptional co activators. Cell 127: 397-408.
    • (2006) Cell , vol.127 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3    Silvaggi, J.M.4    Rhee, J.5
  • 15
    • 0347989301 scopus 로고    scopus 로고
    • Estrogen receptor-related receptors: Orphan receptors desperately seeking a ligand
    • Horard B, Vanacker JM (2003) Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand. J Mol Endocrinol 31: 349-357.
    • (2003) J Mol Endocrinol , vol.31 , pp. 349-357
    • Horard, B.1    Vanacker, J.M.2
  • 16
    • 0023857147 scopus 로고
    • Identification of a new class of steroid hormone receptors
    • Giguere V, Yang N, Segui P, Evans RM (1988) Identification of a new class of steroid hormone receptors. Nature 331: 91-94.
    • (1988) Nature , vol.331 , pp. 91-94
    • Giguere, V.1    Yang, N.2    Segui, P.3    Evans, R.M.4
  • 17
    • 0242580188 scopus 로고    scopus 로고
    • Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha
    • Luo J, Sladek R, Carrier J, Bader JA, Richard D, et al. (2003) Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol 23: 7947-7956.
    • (2003) Mol Cell Biol , vol.23 , pp. 7947-7956
    • Luo, J.1    Sladek, R.2    Carrier, J.3    Bader, J.A.4    Richard, D.5
  • 18
    • 34247554887 scopus 로고    scopus 로고
    • Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma
    • Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, et al. (2007) Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab 5: 345-356.
    • (2007) Cell Metab , vol.5 , pp. 345-356
    • Dufour, C.R.1    Wilson, B.J.2    Huss, J.M.3    Kelly, D.P.4    Alaynick, W.A.5
  • 19
    • 0037174798 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha
    • Huss JM, Kopp RP, Kelly DP (2002) Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J Biol Chem 277: 40265-40274.
    • (2002) J Biol Chem , vol.277 , pp. 40265-40274
    • Huss, J.M.1    Kopp, R.P.2    Kelly, D.P.3
  • 20
    • 0142091356 scopus 로고    scopus 로고
    • PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whoseexpression induces a high-energy expenditure and antagonizes obesity
    • Kamei Y, Ohizumi H, Fujitani Y, Nemoto T, Tanaka T, et al. (2003) PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whoseexpression induces a high-energy expenditure and antagonizes obesity. Proc Natl Acad Sci USA 100: 12378-12383.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12378-12383
    • Kamei, Y.1    Ohizumi, H.2    Fujitani, Y.3    Nemoto, T.4    Tanaka, T.5
  • 21
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: Insights into their biological function
    • Michan S, Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404: 1-13.
    • (2007) Biochem J , vol.404 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 22
    • 34547875773 scopus 로고    scopus 로고
    • Sirtuins: Critical regulators at the crossroads between cancer and aging
    • Saunders LR, Verdin E (2007) Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 26: 5489-5504.
    • (2007) Oncogene , vol.26 , pp. 5489-5504
    • Saunders, L.R.1    Verdin, E.2
  • 23
    • 33745931074 scopus 로고    scopus 로고
    • Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
    • Hallows WC, Lee S, Denu JM (2006) Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci USA 103: 10230-10235.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10230-10235
    • Hallows, W.C.1    Lee, S.2    Denu, J.M.3
  • 24
    • 33745889628 scopus 로고    scopus 로고
    • Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
    • Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E (2006) Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci USA 103: 10224-10229.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10224-10229
    • Schwer, B.1    Bunkenborg, J.2    Verdin, R.O.3    Andersen, J.S.4    Verdin, E.5
  • 25
    • 37549002891 scopus 로고    scopus 로고
    • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    • Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, et al. (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol 27: 8807-8814.
    • (2007) Mol Cell Biol , vol.27 , pp. 8807-8814
    • Lombard, D.B.1    Alt, F.W.2    Cheng, H.L.3    Bunkenborg, J.4    Streeper, R.S.5
  • 26
    • 55749084738 scopus 로고    scopus 로고
    • A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    • Ahn BH, Kim HS, Song S, Lee IH, Liu J, et al. (2008) A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci USA 105: 14447-14452.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14447-14452
    • Ahn, B.H.1    Kim, H.S.2    Song, S.3    Lee, I.H.4    Liu, J.5
  • 27
    • 70349208608 scopus 로고    scopus 로고
    • Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
    • Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, et al. (2009) Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest 119: 2758-2771.
    • (2009) J Clin Invest , vol.119 , pp. 2758-2771
    • Sundaresan, N.R.1    Gupta, M.2    Kim, G.3    Rajamohan, S.B.4    Isbatan, A.5
  • 28
    • 53549105529 scopus 로고    scopus 로고
    • SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
    • Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP (2008) SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol 28: 6384-6401.
    • (2008) Mol Cell Biol , vol.28 , pp. 6384-6401
    • Sundaresan, N.R.1    Samant, S.A.2    Pillai, V.B.3    Rajamohan, S.B.4    Gupta, M.P.5
  • 29
    • 51449083112 scopus 로고    scopus 로고
    • SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression
    • Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, et al. (2008) SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci 4: 291-299.
    • (2008) Int J Biol Sci , vol.4 , pp. 291-299
    • Jacobs, K.M.1    Pennington, J.D.2    Bisht, K.S.3    Aykin-Burns, N.4    Kim, H.S.5
  • 30
    • 10744232772 scopus 로고    scopus 로고
    • Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
    • Rose G, Dato S, Altomare K, Bellizzi D, Garasto S, et al. (2003) Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol 38: 1065-1070.
    • (2003) Exp Gerontol , vol.38 , pp. 1065-1070
    • Rose, G.1    Dato, S.2    Altomare, K.3    Bellizzi, D.4    Garasto, S.5
  • 31
    • 19944433088 scopus 로고    scopus 로고
    • A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
    • Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, et al. (2005) A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85: 258-263.
    • (2005) Genomics , vol.85 , pp. 258-263
    • Bellizzi, D.1    Rose, G.2    Cavalcante, P.3    Covello, G.4    Dato, S.5
  • 32
    • 0037108799 scopus 로고    scopus 로고
    • SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
    • Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP (2002) SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci USA 99: 13653-13658.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13653-13658
    • Onyango, P.1    Celic, I.2    McCaffery, J.M.3    Boeke, J.D.4    Feinberg, A.P.5
  • 33
    • 0037135972 scopus 로고    scopus 로고
    • The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
    • Schwer B, North BJ, Frye RA, Ott M, Verdin E (2002) The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 158: 647-657.
    • (2002) J Cell Biol , vol.158 , pp. 647-657
    • Schwer, B.1    North, B.J.2    Frye, R.A.3    Ott, M.4    Verdin, E.5
  • 34
    • 0034331238 scopus 로고    scopus 로고
    • Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene
    • Yang YH, Chen YH, Zhang CY, Nimmakayalu MA, Ward DC, et al. (2000) Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Genomics 69: 355-369.
    • (2000) Genomics , vol.69 , pp. 355-369
    • Yang, Y.H.1    Chen, Y.H.2    Zhang, C.Y.3    Nimmakayalu, M.A.4    Ward, D.C.5
  • 35
    • 17144424946 scopus 로고    scopus 로고
    • SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
    • Shi T, Wang F, Stieren E, Tong Q (2005) SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem 280: 13560-13567.
    • (2005) J Biol Chem , vol.280 , pp. 13560-13567
    • Shi, T.1    Wang, F.2    Stieren, E.3    Tong, Q.4
  • 36
    • 63749099484 scopus 로고    scopus 로고
    • A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein
    • Cooper HM, Huang JY, Verdin E, Spelbrink JN (2009) A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PLoS ONE 4: e4986.
    • (2009) PLoS ONE , vol.4
    • Cooper, H.M.1    Huang, J.Y.2    Verdin, E.3    Spelbrink, J.N.4
  • 37
    • 61449209922 scopus 로고    scopus 로고
    • Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3
    • Jin L, Galonek H, Israelian K, Choy W, Morrison M, et al. (2009) Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci 18: 514-525.
    • (2009) Protein Sci , vol.18 , pp. 514-525
    • Jin, L.1    Galonek, H.2    Israelian, K.3    Choy, W.4    Morrison, M.5
  • 39
    • 33644868031 scopus 로고    scopus 로고
    • Estrogenrelated receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription
    • Herzog B, Cardenas J, Hall RK, Villena JA, Budge PJ, et al. (2006) Estrogenrelated receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem 281: 99-106.
    • (2006) J Biol Chem , vol.281 , pp. 99-106
    • Herzog, B.1    Cardenas, J.2    Hall, R.K.3    Villena, J.A.4    Budge, P.J.5
  • 40
    • 2442701392 scopus 로고    scopus 로고
    • PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
    • Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, et al. (2004) PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med 10: 530-534.
    • (2004) Nat Med , vol.10 , pp. 530-534
    • Koo, S.H.1    Satoh, H.2    Herzig, S.3    Lee, C.H.4    Hedrick, S.5
  • 41
    • 0141991324 scopus 로고    scopus 로고
    • Specific gene inhibition by adenovirus-mediated expression of small interfering RNA
    • Zhao LJ, Jian H, Zhu H (2003) Specific gene inhibition by adenovirus-mediated expression of small interfering RNA. Gene 316: 137-141.
    • (2003) Gene , vol.316 , pp. 137-141
    • Zhao, L.J.1    Jian, H.2    Zhu, H.3
  • 42
    • 34247259630 scopus 로고    scopus 로고
    • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
    • Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, et al. (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. Embo J 26: 1913-1923.
    • (2007) Embo J , vol.26 , pp. 1913-1923
    • Gerhart-Hines, Z.1    Rodgers, J.T.2    Bare, O.3    Lerin, C.4    Kim, S.H.5
  • 43
    • 1542790433 scopus 로고    scopus 로고
    • Primary hepatocyte culture in collagen gel mixture and collagen sandwich
    • Wang YJ, Liu HL, Guo HT, Wen HW, Liu J (2004) Primary hepatocyte culture in collagen gel mixture and collagen sandwich. World J Gastroenterol 10: 699-702.
    • (2004) World J Gastroenterol , vol.10 , pp. 699-702
    • Wang, Y.J.1    Liu, H.L.2    Guo, H.T.3    Wen, H.W.4    Liu, J.5
  • 44
    • 70349333218 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma coactivator-1alpha enhances antiproliferative activity of 59-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase
    • Kong X, Fan H, Liu X, Wang R, Liang J, et al. (2009) peroxisome proliferatoractivated receptor gamma coactivator-1alpha enhances antiproliferative activity of 59-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Mol Pharmacol 76: 854-860.
    • (2009) Mol Pharmacol , vol.76 , pp. 854-860
    • Kong, X.1    Fan, H.2    Liu, X.3    Wang, R.4    Liang, J.5
  • 45
    • 33747893489 scopus 로고    scopus 로고
    • Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability
    • Slane BG, Aykin-Burns N, Smith BJ, Kalen AL, Goswami PC, et al. (2006) Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Res 66: 7615-7620.
    • (2006) Cancer Res , vol.66 , pp. 7615-7620
    • Slane, B.G.1    Aykin-Burns, N.2    Smith, B.J.3    Kalen, A.L.4    Goswami, P.C.5
  • 47
    • 2342592545 scopus 로고    scopus 로고
    • The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis
    • Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, et al. (2004) The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci USA 101: 6472-6477.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6472-6477
    • Schreiber, S.N.1    Emter, R.2    Hock, M.B.3    Knutti, D.4    Cardenas, J.5
  • 48
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5
  • 49
    • 2342477730 scopus 로고    scopus 로고
    • Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
    • Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, et al. (2004) Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci USA 101: 6570-6575.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6570-6575
    • Mootha, V.K.1    Handschin, C.2    Arlow, D.3    Xie, X.4    St Pierre, J.5
  • 50
    • 28544438180 scopus 로고    scopus 로고
    • PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: A mechanism for transcriptional control of muscle glucose metabolism
    • Wende AR, Huss JM, Schaeffer PJ, Giguere V, Kelly DP (2005) PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol 25: 10684-10694.
    • (2005) Mol Cell Biol , vol.25 , pp. 10684-10694
    • Wende, A.R.1    Huss, J.M.2    Schaeffer, P.J.3    Giguere, V.4    Kelly, D.P.5
  • 51
    • 10344261154 scopus 로고    scopus 로고
    • Mitochondrial superoxide and aging: Uncoupling-protein activity and superoxide production
    • Brand MD, Buckingham JA, Esteves TC, Green K, Lambert AJ, et al. (2004) Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production. Biochem Soc Symp. pp 203-213.
    • (2004) Biochem Soc Symp , pp. 203-213
    • Brand, M.D.1    Buckingham, J.A.2    Esteves, T.C.3    Green, K.4    Lambert, A.J.5
  • 52
    • 33845327501 scopus 로고    scopus 로고
    • SIRT1: Linking adaptive cellular responses to aging-associated changes in organismal physiology
    • Anastasiou D, Krek W (2006) SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiology. Physiology (Bethesda) 21: 404-410.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 404-410
    • Anastasiou, D.1    Krek, W.2
  • 53
    • 33644749330 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
    • Kukidome D, Nishikawa T, Sonoda K, Imoto K, Fujisawa K, et al. (2006) Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 55: 120-127.
    • (2006) Diabetes , vol.55 , pp. 120-127
    • Kukidome, D.1    Nishikawa, T.2    Sonoda, K.3    Imoto, K.4    Fujisawa, K.5
  • 54
    • 19444365211 scopus 로고    scopus 로고
    • PGC- 1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells
    • Valle I, Alvarez-Barrientos A, Arza E, Lamas S, Monsalve M (2005) PGC- 1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc Res 66: 562-573.
    • (2005) Cardiovasc Res , vol.66 , pp. 562-573
    • Valle, I.1    Alvarez-Barrientos, A.2    Arza, E.3    Lamas, S.4    Monsalve, M.5
  • 55
    • 34548627517 scopus 로고    scopus 로고
    • Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
    • Yang H, Yang T, Baur JA, Perez E, Matsui T, et al. (2007) Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130: 1095-1107.
    • (2007) Cell , vol.130 , pp. 1095-1107
    • Yang, H.1    Yang, T.2    Baur, J.A.3    Perez, E.4    Matsui, T.5
  • 56
    • 34247271282 scopus 로고    scopus 로고
    • SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
    • Scher MB, Vaquero A, Reinberg D (2007) SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev 21: 920-928.
    • (2007) Genes Dev , vol.21 , pp. 920-928
    • Scher, M.B.1    Vaquero, A.2    Reinberg, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.