Cardiac ventricular repolarization reserve: A principle for understanding drug-related proarrhythmic risk

British Journal of Pharmacology

Volumn 164, Issue 1, 2011, Pages 14-36

  Varró, András ^a,b   Baczkó, István ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

adverse drug reactions; cardiovascular pharmacology; K channels; repolarization, repolarization reserve; safety pharmacology; sudden cardiac death; Torsades de Pointes

Indexed keywords

ANTIARRHYTHMIC AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; DELAYED RECTIFIER POTASSIUM CHANNEL; ELIPRODIL; FLAVONOID; INWARDLY RECTIFYING POTASSIUM CHANNEL; NICORANDIL; NS 1643; NS 3623; PINACIDIL; SOTALOL; UNCLASSIFIED DRUG;

BODY TEMPERATURE DISORDER; CALCIUM CURRENT; CALCIUM SIGNALING; CARDIOMYOPATHY; CARDIOVASCULAR RISK; DIABETES MELLITUS; DIETARY INTAKE; DISEASE ASSOCIATION; DISEASE COURSE; DRUG MECHANISM; FOOD COMPOSITION; GENDER; GENETIC DISORDER; GENETIC SUSCEPTIBILITY; HEART ARRHYTHMIA; HEART DEATH; HEART DEPOLARIZATION; HEART FAILURE; HEART INNERVATION; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE CONDUCTION SYSTEM; HEART PROARRHYTHMIA; HEART VENTRICLE REPOLARIZATION RESERVE; HUMAN; HYPOKALEMIA; HYPOTHYROIDISM; KIDNEY FAILURE; NONHUMAN; PATHOPHYSIOLOGY; POTASSIUM CURRENT; PRIORITY JOURNAL; QT PROLONGATION; REVIEW; RISK ASSESSMENT; SODIUM CURRENT; SYMPATHETIC INNERVATION; SYMPATHETIC TONE; TACHYCARDIA; TORSADE DES POINTES;

ANIMALS; ARRHYTHMIAS, CARDIAC; HEART; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; PHARMACEUTICAL PREPARATIONS; RISK FACTORS; TORSADES DE POINTES;

EID: 79961230591     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01367.x     Document Type: Review

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