Inhibition of I(Ks) channels by HMR 1556

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 6, 2000, Pages 480-488

  Gogelein, H ^a   Bruggemann, A ^a   Gerlach, U ^a   Brendel, J ^a   Busch, A E ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

HMR 1556; I(Ks) current; Langendorff perfused heart; Papillary muscle; Rate dependence; Ventricular myocytes; Xenopus oocytes

Indexed keywords

ION CHANNEL; ISOPRENALINE; N [3 HYDROXY 2,2 DIMETHYL 6 (4,4,4 TRIFLUOROBUTOXY)CHROMAN 4 YL] N METHYLMETHANESULFONAMIDE; N [3 HYDROXY 2,2 DIMETHYL 6 (4,4,4 TRIFLUOROBUTOXY)CHROMAN 4YL] N METHYLMETHANESULFONAMIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG; CHROMAN DERIVATIVE; MESSENGER RNA; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL PROTEIN I(SK); SULFONAMIDE; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; GUINEA PIG; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART PACING; HEART PAPILLARY MUSCLE; HEART RATE; ION CURRENT; ISOLATED HEART; NONHUMAN; OOCYTE; PATCH CLAMP; POTASSIUM CURRENT; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REPOLARIZATION; XENOPUS LAEVIS; ANIMAL; CYTOLOGY; DRUG EFFECT; GENETICS; HEART; HEART ATRIUM; HEART ATRIUM FUNCTION; HEART MUSCLE; HUMAN; IC 50; IN VITRO STUDY; METABOLISM; PERFUSION; PHYSIOLOGY; PURKINJE FIBER; RABBIT;

ANIMALS; ATRIAL FUNCTION; CHROMANS; GUINEA PIGS; HEART; HEART ATRIA; HUMANS; INHIBITORY CONCENTRATION 50; MYOCARDIUM; OOCYTES; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; PERFUSION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PURKINJE FIBERS; RABBITS; RNA, MESSENGER; SULFONAMIDES; XENOPUS LAEVIS;

EID: 0033625832     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000284     Document Type: Article

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