Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: Implications for the influence of dietary compounds on cardiac repolarisation

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 371, Issue 6, 2005, Pages 516-525

  Scholz, Eberhard P ^a   Zitron, Edgar ^a   Kiesecker, Claudia ^a   Lück, Sonja ^a   Thomas, Dierk ^a   Kathöfer, Sven ^a   Kreye, Volker A W ^a   Katus, Hugo A ^a   Kiehn, Johann ^a   Schoels, Wolfgang ^a   Karle, Christoph A ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Arrhythmia; Flavonoids; Grapefruit; HERG channel; Molecular electrophysiology; Naringenin; Pharmacology; Potassium channels

Indexed keywords

FLAVONOID; NARINGENIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GRAPEFRUIT; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; MICROELECTRODE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; POTASSIUM CURRENT; VOLTAGE CLAMP; XENOPUS;

ANIMALS; CITRUS PARADISI; DIET; ETHER-A-GO-GO POTASSIUM CHANNELS; FLAVANONES; HEART; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; XENOPUS;

EID: 24044536663     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-005-1069-z     Document Type: Article

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