QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids

Circulation

Volumn 111, Issue 7, 2005, Pages 835-838

  Zitron, Edgar ^a   Scholz, Eberhard ^a   Owen, Robert W ^b   Lück, Sonja ^a   Kiesecker, Claudia ^a   Thomas, Dierk ^a   Kathöfer, Sven ^a   Niroomand, Feraydoon ^a   Kiehn, Johann ^a   Kreye, Volker A W ^a   Katus, Hugo A ^a   Schoels, Wolfgang ^a   Karle, Christoph A ^a,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Antiarrhythmia agents; Arrhythmia; Ion channels; Nutrition; Pharmacology

Indexed keywords

7 ETHOXYCOUMARIN; APIGENIN; AURANTIIN; BERGAPTEN; CHRYSIN; COUMARIN; COUMARIN DERIVATIVE; FISETIN; FLAVANONE DERIVATIVE; FLAVONE; FLAVONE DERIVATIVE; FLAVONOID; FUROCOUMARIN DERIVATIVE; GALANGIN; GLYCOSIDE; HESPERETIN; HESPERIDIN; KAEMPFEROL; METHOXSALEN; MORIN; MYRICETIN; NARINGENIN; NEOHESPERIDIN; POTASSIUM CHANNEL HERG; PSORALEN; QUERCETIN; RUTOSIDE; SCOPOLETIN; UMBELLIFERONE; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DIET; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; EMBRYO; FEMALE; GRAPEFRUIT JUICE; HEART ELECTROPHYSIOLOGY; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IC 50; INGESTION; MALE; NONHUMAN; NORMAL HUMAN; OBSERVATION; OOCYTE; PRIORITY JOURNAL; QT PROLONGATION; XENOPUS;

ADULT; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BEVERAGES; CATION TRANSPORT PROTEINS; CITRUS PARADISI; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; FLAVANONES; FLAVONOIDS; HUMANS; INHIBITORY CONCENTRATION 50; MALE; OOCYTES; POTASSIUM CHANNELS, VOLTAGE-GATED; TRANSDUCTION, GENETIC; XENOPUS;

EID: 20044393294     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000155617.54749.09     Document Type: Article

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