Cardiac strong inward rectifier potassium channels

Journal of Molecular and Cellular Cardiology

Volumn 48, Issue 1, 2010, Pages 45-54

  Anumonwo, Justus M B ^a   Lopatin, Anatoli N ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cardiac excitability; IK1; IKACh; Kir channels

Indexed keywords

ADRENERGIC RECEPTOR; CALCIUM ION; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR3; MAGNESIUM ION; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POLYAMINE; PROTON; SPERMINE; UNCLASSIFIED DRUG;

ADRENERGIC STIMULATION; CARDIAC CHANNELOPATHY; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; HEART ATRIUM FIBRILLATION; HEART MUSCLE; HEART MUSCLE EXCITABILITY; HUMAN; LONG QT SYNDROME; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN QUATERNARY STRUCTURE; REGULATORY MECHANISM; REVIEW; SHORT QT SYNDROME;

ACTION POTENTIALS; ANIMALS; HEART; HUMANS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; MYOCARDIUM; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 73049109262     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.08.013     Document Type: Review

References (181)

1. Katz B. Les constantes electriques de la membrane du muscle. Arch. Sci. Physiol. 2 (1949) 285-299
2. Mascher D., and Peper K. Two components of inward current in myocardial muscle fibers. Pflugers Arch. 307 3 (1969) 190-203
3. Beeler Jr. G.W., and Reuter H. Voltage clamp experiments on ventricular myocardial fibres. J. Physiol. (Lond) 207 1 (1970) 165-190
4. Rougier O., Vassort G., and Stampfli R. Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique. Pflugers Arch. Gesamte Physiol. Menschen Tiere 301 2 (1968) 91-108
5. Weidmann S. Rectifier properties of Purkinje fibers. Am. J. Physiol. 183 (1955) 671
6. Hutter O.F., and Noble D. Rectifying properties of cardiac muscle. Nature 188 (1960) 495
7. Kubo Y., Reuveny E., Slesinger P.A., Jan Y.N., and Jan L.Y. Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature 364 6440 (1993) 802-806
8. Kubo Y., Baldwin T.J., Jan Y.N., and Jan L.Y. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 362 6416 (1993) 127-133
9. Lopatin A.N., Makhina E.N., and Nichols C.G. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372 6504 (1994) 366-369
10. + channels. Science 266 5187 (1994) 1068-1072
11. + channels is caused by intracellular spermine. Cell 80 1 (1995) 149-154
12. + channels to intracellular spermine. FEBS Lett. 356 2-3 (1994) 199-203
13. Kubo Y., Adelman J.P., Clapham D.E., Jan L.Y., Karschin A., Kurachi Y., et al. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol. Rev. 57 4 (2005 Dec) 509-526
14. + channel, Kir2.5, is upregulated under chronic cold stress in fish cardiac myocytes. J. Exp. Biol. 211 Pt 13 (2008) 2162-2171
15. KACh currents in oocytes. Neuron 16 2 (1996 Feb) 423-429
16. + channels from guinea-pig cardiomyocytes. J. Physiol. 532 Pt 1 (2001) 115-126
17. Wickman K., Nemec J., Gendler S.J., and Clapham D.E. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron 20 1 (1998 Jan) 103-114
18. +-channel proteins. Nature 374 6518 (1995) 135-141
19. Cohen S.S. A Guide to the Polyamines (1998), Oxford University Press
20. Vandenberg C.A. Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions. Proc. Natl. Acad. Sci. U. S. A. 84 8 (1987) 2560-2564
21. 2+. Nature 325 7000 (1987) 156-159
22. + channels exhibit no intrinsic rectification. J. Gen. Physiol. 120 4 (2002) 539-551
23. Watanabe S., Kusama-Eguchi K., Kobayashi H., and Igarashi K. Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver. J. Biol. Chem. 266 31 (1991 Nov 5) 20803-20809
24. + currents in atria and ventricles of the guinea-pig heart. J. Physiol. 563 Pt 3 (2005 Mar 15) 713-724
25. Ishihara K. Time-dependent outward currents through the inward rectifier potassium channel IRK1. The role of weak blocking molecules. J. Gen. Physiol. 109 2 (1997) 229-243
26. Lopatin A.N., Makhina E.N., and Nichols C.G. The mechanism of inward rectification of potassium channels: "long-pore plugging" by cytoplasmic polyamines. J. Gen. Physiol. 106 5 (1995) 923-955
27. + conduction and selectivity. Science 280 5360 (1998) 69-77
28. Kuo A., Gulbis J.M., Antcliff J.F., Rahman T., Lowe E.D., Zimmer J., et al. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 300 5627 (2003 Jun 20) 1922-1926
29. Nishida M., and MacKinnon R. Structural basis of inward rectification. Cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 Å resolution. Cell 111 7 (2002) 957-965
30. Pegan S., Arrabit C., Zhou W., Kwiatkowski W., Collins A., Slesinger P.A., et al. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat. Neurosci. 8 3 (2005 Mar) 279-287
31. 2+ of the inward rectifier, IRK1. J. Physiol. 478 Pt 1 (1994) 1-6
32. + channel. Neuron 14 5 (1995) 1047-1054
33. + channel. J. Physiol. 531 Pt 3 (2001) 645-660
34. Kurata H.T., Phillips L.R., Rose T., Loussouarn G., Herlitze S., Fritzenschaft H., et al. Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis. J. Gen. Physiol. 124 5 (2004 Nov) 541-554
35. + channels in rabbit atrial myocytes. Intracellular substance-mediated mechanism of inward rectification. J. Biol. Chem. 270 16 (1995 Apr 21) 9289-9294
36. + channel. J. Biol. Chem. 278 49 (2003) 49537-49548
37. Makary S.M., Claydon T.W., Dibb K.M., and Boyett M.R. Base of pore loop is important for rectification, activation, permeation, and block of Kir3.1/Kir3.4. Biophys. J. 90 11 (2006) 4018-4034
38. + channel block by the polyamine spermine. J. Gen. Physiol. 125 (2005 Mar 14) 413-426
39. + channels. J. Gen. Physiol. 127 5 (2006 May) 467-480
40. + channel reconstituted in lipid bilayers. Biophys. J. 70 6 (1996) 2680-2687
41. Lee J.K., John S.A., and Weiss J.N. Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1. J. Gen. Physiol. 113 4 (1999) 555-564
42. Morishige K., Takahashi N., Findlay I., Koyama H., Zanelli J.S., Peterson C., et al. Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain. FEBS Lett. 336 3 (1993) 375-380
43. Raab-Graham K.F., Radeke C.M., and Vandenberg C.A. Molecular cloning and expression of a human heart inward rectifier potassium channel. NeuroReport 5 18 (1994) 2501-2505
44. Choe H., Sackin H., and Palmer L.G. Permeation properties of inward-rectifier potassium channels and their molecular determinants. J. Gen. Physiol. 115 4 (2000) 391-404
45. Takahashi N., Morishige K., Jahangir A., Yamada M., Findlay I., Koyama H., et al. Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. J. Biol. Chem. 269 37 (1994) 2329-23274
46. + channel from human atrium. Circ. Res. 76 3 (1995) 343-350
47. Makhina E.N., Kelly A.J., Lopatin A.N., Mercer R.W., and Nichols C.G. Cloning and expression of a novel human brain inward rectifier potassium channel. J. Biol. Chem. 269 32 (1994) 20468-20474
48. Perier F., Radeke C.M., and Vandenberg C.A. Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus. Proc. Natl. Acad. Sci. U. S. A. 91 13 (1994) 6240-6244
49. Morishige K., Takahashi N., Jahangir A., Yamada M., Koyama H., Zanelli J.S., et al. Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 346 2-3 (1994) 251-256
50. + inward rectifier channel associated with motoneurons of cranial nerve nuclei. J. Neurosci. 18 11 (1998 Jun 1) 4096-4105
51. Schram G., Pourrier M., Wang Z., White M., and Nattel S. Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents. Cardiovasc. Res. 59 2 (2003 Aug 1) 328-338
52. Preisig-Muller R., Schlichthorl G., Goerge T., Heinen S., Bruggemann A., Rajan S., et al. Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. Proc. Natl. Acad. Sci. U. S. A. 99 11 (2002) 7774-7779
53. + channels. J. Biol. Chem. 270 48 (1995 Dec 1) 28660-28667
54. + channels Kir2.1 expressed in Xenopus oocytes. Biophys. J. 75 5 (1998) 2313-2322
55. + channels to metabolic inhibitors. J. Biol. Chem. 277 39 (2002 Sep 27) 35815-35818
56. + channels by proton-mediated interactions of N- and C-terminal domains. J. Biol. Chem. 275 41 (2000 Oct 13) 31573-31580
57. + channel. Am. J. Physiol., Cell Physiol. 279 3 (2000) C771-C784
58. Munoz V., Vaidyanathan R., Tolkacheva E.G., Dhamoon A.S., Taffet S.M., and Anumonwo J.M. Kir2.3 isoform confers pH sensitivity to heteromeric Kir2.1/Kir2.3 channels in HEK293 cells. Heart Rhythm 4 4 (2007 Apr) 487-496
59. + current. Circ. Res. 94 10 (2004 Apr 15) 1332-1339
60. Panama B.K., and Lopatin A.N. Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels. J. Physiol. 571 2 (2006 Mar 1) 287-302
61. + channels. J. Physiol. 568 Pt 3 (2005 Nov 1) 749-766
62. K(ACh)). Evidence for functional homomeric GIRK4 channels. J. Biol. Chem. 276 31 (2001 Aug 3) 28873-28880
63. + channel. J. Gen. Physiol. 106 1 (1995 Jul) 1-23
64. + channel. J. Physiol. 526 Pt 2 (2000 Jul 15) 341-347
65. + channel. Proc. Natl. Acad. Sci. U. S. A. 99 7 (2002 Apr 2) 4325-4330
66. K1) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes. J. Physiol. 533 Pt 3 (2001) 697-710
67. +-mediated vasodilation. Circ. Res. 87 2 (2000) 160-166
68. K1 in the mouse heart leads to altered cardiac excitability. J. Mol. Cell. Cardiol. 35 4 (2003 Apr) 367-378
69. Miake J., Marban E., and Nuss H.B. Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression. J. Clin. Invest. 111 10 (2003 May) 1529-1536
70. Miake J., Marban E., and Nuss H.B. Biological pacemaker created by gene transfer. Nature 419 6903 (2002) 132-133
71. K1 in the mouse heart leads to multiple abnormalities of cardiac excitability. Am. J. Physiol., Heart Circ. Physiol. 287 6 (2004 Jul 22) H2790-H2802
72. K1 in the mouse heart is proarrhythmic. Basic Res. Cardiol. 102 5 (2007 Jun 5) 416-428
73. K1) in the mouse heart accelerates and stabilizes rotors. J. Physiol. 578 Pt 1 (2007 Jan 1) 315-326
74. KACh in atrial fibrillation using a mouse knockout model. J. Am. Coll. Cardiol. 37 8 (2001 Jun 15) 2136-2143
75. Samie F.H., Berenfeld O., Anumonwo J., Mironov S.F., Udassi S., Beaumont J., et al. Rectification of the background potassium current: a determinant of rotor dynamics in ventricular fibrillation. Circ. Res. 89 12 (2001) 1216-1223
76. Warren M., Guha P.K., Berenfeld O., Zaitsev A., Anumonwo J.M., Dhamoon A.S., et al. Blockade of the inward rectifying potassium current terminates ventricular fibrillation in the guinea pig heart. J. Cardiovasc. Electrophysiol. 14 6 (2003 Jun) 621-631
77. K1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers. Circ. Res. 104 3 (2009 Feb 13) 355-364
78. K,ACh gradients determine unequal left/right atrial frequencies and rotor dynamics. Cardiovasc. Res. 59 4 (2003 Oct 1) 863-873
79. + electrode experiments. Biophys. J. 16 4 (1976) 367-372
80. + fluctuations in canine Purkinje fibres. Nature 286 5768 (1980) 68-71
81. + accumulation. J. Physiol. 537 Pt 3 (2001) 979-992
82. Nygren A., and Giles W.R. Mathematical simulation of slowing of cardiac conduction velocity by elevated extracellular. Ann. Biomed. Eng. 28 8 (2000) 951-957
83. K1 modulates the U-wave: insights in a 100-year-old enigma. Heart Rhythm 6 3 (2009 Mar) 393-400
84. + current in isolated canine cardiac Purkinje myocytes. Biophys. J. 52 4 (1987 Oct) 519-525
85. Giles W.R., and Imaizumi Y. Comparison of potassium currents in rabbit atrial and ventricular cells. J. Physiol. (Lond) 405 (1988) 123-145
86. Varro A., Nanasi P.P., and Lathrop D.A. Potassium currents in isolated human atrial and ventricular cardiocytes. Acta Physiol. Scand. 149 2 (1993) 133-142
87. Melnyk P., Zhang L., Shrier A., and Nattel S. Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle. Am. J. Physiol., Heart Circ. Physiol. 283 3 (2002) H1H33-H1123
88. + currents in myocytes from left and right atria of adult mice. Am. J. Physiol., Heart Circ. Physiol. 285 5 (2003 Nov) H1837-H1848
89. K1 rectification in the mouse heart. Biophysical Journal (49th Annual Meeting, 2005) 1402-Pos. 2005.
90. + current in pacemaker cells dissociated from rat sinoatrial node. J. Physiol. 523 Pt 3 (2000 Mar 15) 593-605
91. Cho H.S., Takano M., and Noma A. The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node. J. Physiol. 550 Pt 1 (2003 Jul 1) 169-180
92. Kokubun S., Nishimura M., Noma A., and Irisawa H. Membrane currents in the rabbit atrioventricular node cell. Pflugers Arch. 393 1 (1982 Mar) 15-22
93. Munk A.A., Adjemian R.A., Zhao J., Ogbaghebriel A., and Shrier A. Electrophysiological properties of morphologically distinct cells isolated from the rabbit atrioventricular node. J. Physiol. 493 Pt 3 (1996 Jun 15) 801-818
94. Yuill K.H., and Hancox J.C. Characteristics of single cells isolated from the atrioventricular node of the adult guinea-pig heart. Pflugers Arch. 445 3 (2002 Dec) 311-320
95. + currents in adult mouse ventricles. J. Physiol. 559 Pt 1 (2004 Jun 11) 103-120
96. K1 in the mouse heart. Am. J. Physiol., Heart Circ. Physiol. 293 6 (2007 Dec) H3558-H3567
97. Furukawa T., Kimura S., Furukawa N., Bassett A.L., and Myerburg R.J. Potassium rectifier currents differ in myocytes of endocardial and epicardial origin. Circ. Res. 70 1 (1992 Jan) 91-103
98. + channels in mammalian ventricular myocytes. Am. J. Physiol. 266 5 Pt 2 (1994 May) H1812-H1821
99. K1). Cell. Physiol. Biochem. 21 4 (2008) 259-268
100. Noma A., and Trautwein W. Relaxation of the ACh-induced potassium current in the rabbit sinoatrial node cell. Pflugers Arch. 377 3 (1978 Nov 30) 193-200
101. + channels in isolated pacemaker cells of the mammalian heart. Nature 303 5914 (1983 May 19-25) 250-253
102. + current in adult mouse atria. Br. J. Pharmacol. 140 3 (2003 Oct) 576-584
103. Mitcheson J.S., Hancox J.C., and Levi A.J. Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture. Pflugers Arch. 431 6 (1996) 814-827
104. 1 response to barium. J. Mol. Cell. Cardiol. 31 12 (1999) 2207-2213
105. Almers W. Potassium conductance changes in skeletal muscle and the potassium concentration in the transverse tubules. J. Physiol. (Lond) 225 1 (1972) 33-56
106. Almers W. The decline of potassium permeability during extreme hyperpolarization in frog skeletal muscle. J. Physiol. (Lond) 225 1 (1972) 57-83
107. Leonoudakis D., Mailliard W., Wingerd K., Clegg D., and Vandenberg C. Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. J. Cell. Sci. 114 Pt 5 (2001) 987-998
108. Gaborit N., Le Bouter S., Szuts V., Varro A., Escande D., Nattel S., et al. Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J. Physiol. 582 Pt 2 (2007 Jul 15) 675-693
109. Wang Z., Yue L., White M., Pelletier G., and Nattel S. Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. Circulation 98 22 (1998) 2422-2428
110. +-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4. J. Physiol. 585 Pt 1 (2007 Nov 15) 3-13
111. K,ACh is constitutively active in patients with chronic atrial fibrillation. Circulation 112 24 (2005 Dec 13) 3697-3706
112. + current in rabbit ventricular myocytes. J. Physiol. 441 (1991 Sep) 673-684
113. 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes. Pflugers Arch. 421 5 (1992 Aug) 431-439
114. + channel function and phosphorylation in guinea-pig ventricle. J. Physiol. (Lond) 486 Pt 3 (1995) 661-678
115. Gorostiza P., Guarner V., Cardenas M., and Valenzuela F. Effects of alpha adrenergic stimulation on time independent potassium current of isolated ventricular myocytes. Life Sci. 56 17 (1995 Mar 17) 1407-1414
116. 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2. Naunyn-Schmiedeberg's Arch. Pharmacol. 375 5 (2007 Jul) 311-322
117. 1A receptors. J. Mol. Cell. Cardiol. 44 1 (2008 Jan) 84-94
118. + channels in RBL-1 cells. J. Biol. Chem. 271 11 (1996) 6114-6121
119. Shyng S.L., Sha Q., Ferrigni T., Lopatin A.N., and Nichols C.G. Depletion of intracellular polyamines relieves inward rectification of potassium channels. Proc. Natl. Acad. Sci. U. S. A. 93 21 (1996) 12014-12019
120. Lopatin A.N., Shantz L.M., Mackintosh C.A., Nichols C.G., and Pegg A.E. Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. J. Mol. Cell. Cardiol. 32 11 (2000) 2007-2024
121. + channels in guinea-pig ventricular cells. J. Physiol. 470 (1993 Oct) 295-311
122. + current during the ventricular action potential. Circ. Res. 82 9 (1998) 947-956
123. + channel in guinea-pig cardiac myocytes. J. Physiol. (Lond) 510 Pt 3 (1998) 755-771
124. + channel of guinea-pig ventricular cell membrane. Pflugers Arch. 422 3 (1992 Dec) 280-286
125. Komukai K., Brette F., Pascarel C., and Orchard C.H. Electrophysiological response of rat ventricular myocytes to acidosis. Am. J. Physiol., Heart Circ. Physiol. 283 1 (2002 Jul) H412-H422
126. Komukai K., Brette F., and Orchard C.H. Electrophysiological response of rat atrial myocytes to acidosis. Am. J. Physiol., Heart Circ. Physiol. 283 2 (2002 Aug) H715-H724
127. Hilgemann D.W. Cytoplasmic ATP-dependent regulation of ion transporters and channels: mechanisms and messengers. Annu. Rev. Physiol. 59 (1997) 193-220
128. Hilgemann D.W., Feng S., and Nasuhoglu C. The complex and intriguing lives of PIP2 with ion channels and transporters. Sci, STKE 2001 111 (2001 Dec 4) RE19
129. 2. Science 273 5277 (1996 Aug 16) 956-959
130. + channels. Pflugers Arch. 455 1 (2007 Oct) 83-95
131. + channels. Channels (Austin) 1 2 (2007 Mar-Apr) 124-134
132. Rohacs T., Lopes C.M., Jin T., Ramdya P.P., Molnar Z., and Logothetis D.E. Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proc. Natl. Acad. Sci. U. S. A. 100 2 (2003 Jan 21) 745-750
133. + channels for phosphoinositides. J. Biol. Chem. 274 51 (1999 Dec 17) 36065-36072
134. + ions depends on the presence of phosphatidylinositol phosphates. Proc. Natl. Acad. Sci. U. S. A. 95 3 (1998 Feb 3) 1307-1312
135. 2) regulation of strong inward rectifier Kir2.1 channels: multilevel positive cooperativity. J. Physiol. 586 7 (2008 Apr 1) 1833-1848
136. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ. Res. 80 6 (1997 Jun) 772-781
137. Dobrev D., Wettwer E., Kortner A., Knaut M., Schuler S., and Ravens U. Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation. Cardiovasc. Res. 54 2 (2002 May) 397-404
138. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ. Res. 73 2 (1993 Aug) 379-385
139. Pogwizd S.M., Schlotthauer K., Li L., Yuan W., and Bers D.M. Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual β-adrenergic responsiveness. Circ. Res. 88 11 (2001 Jun 8) 1159-1167
140. K1 in rat ventricular cells: a novel paradigm for arrhythmia in heart failure?. Cardiovasc. Res. 68 2 (2005 Nov 1) 204-212
141. Tsuji Y., Opthof T., Kamiya K., Yasui K., Liu W., Lu Z., et al. Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle. Cardiovasc. Res. 48 2 (2000 Nov) 300-309
142. Rozanski G.J., Xu Z., Whitney R.T., Murakami H., and Zucker I.H. Electrophysiology of rabbit ventricular myocytes following sustained rapid ventricular pacing. J. Mol. Cell. Cardiol. 29 2 (1997 Feb) 721-732
143. + channel response to acetylcholine and to G protein-mediated activation in atrial myocytes isolated from failing human hearts. Circulation 90 5 (1994 Nov) 2213-2224
144. Li D., Melnyk P., Feng J., Wang Z., Petrecca K., Shrier A., et al. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation 101 22 (2000 Jun 6) 2631-2638
145. + current density in arrhythmogenic subendocardial Purkinje myocytes from the infarcted heart. J. Cardiovasc. Electrophysiol. 9 3 (1998 Mar) 299-311
146. Kleiman R.B., and Houser S.R. Outward currents in normal and hypertrophied feline ventricular myocytes. Am. J. Physiol. 256 5 Pt 2 (1989 May) H1450-H1461
147. Furukawa T., Bassett A.L., Furukawa N., Kimura S., and Myerburg R.J. The ionic mechanism of reperfusion-induced early afterdepolarizations in feline left ventricular hypertrophy. J. Clin. Invest. 91 4 (1993 Apr) 1521-1531
148. + channel family in rat ventricular myocytes. Am. J. Physiol. 272 4 Pt 2 (1997 Apr) H1741-H1750
149. + channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes. Circ. Res. 95 3 (2004 Aug 6) 325-332
150. K1 in the myocardial response to hypoxia. Cardiovasc. Res. 25 1 (1991 Jan) 17-26
151. + conductance during metabolic inhibition by cyanide in guinea pig ventricular myocytes. Nippon Ika Daigaku Zasshi 57 4 (1990 Aug) 308-321
152. K1 underlies early action potential shortening during hypoxia in the mouse heart. J. Mol. Cell. Cardiol. 43 1 (2007 July) 27-38
153. Curran M.E., Splawski I., Timothy K.W., Vincent G.M., Green E.D., and Keating M.T. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80 5 (1995 Mar 10) 795-803
154. Wang Q., Shen J., Splawski I., Atkinson D., Li Z., Robinson J.L., et al. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80 5 (1995 Mar 10) 805-811
155. Priori S.G., Barhanin J., Hauer R.N., Haverkamp W., Jongsma H.J., Kleber A.G., et al. Genetic and molecular basis of cardiac arrhythmias; impact on clinical management. Study group on molecular basis of arrhythmias of the Working Group on Arrhythmias of the European Society of Cardiology. Eur. Heart J. 20 3 (1999 Feb) 174-195
156. Ackerman M.J. Cardiac channelopathies: it's in the genes. Nat. Med. 10 5 (2004 May) 463-464
157. Ackerman M.J., and Clapham D.E. Ion channels-basic science and clinical disease. N. Engl. J. Med. 336 22 (1997 May 29) 1575-1586
158. Priori S.G., and Cerrone M. Genetic arrhythmias. Ital. Heart J. 6 3 (2005 Mar) 241-248
159. 2+ exchanger. Heart Rhythm 5 10 (2008 Oct) 1453-1454
160. Chen L., Marquardt M.L., Tester D.J., Sampson K.J., Ackerman M.J., and Kass R.S. Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc. Natl. Acad. Sci. U. S. A. 104 52 (2007 Dec 26) 20990-20995
161. Plaster N.M., Tawil R., Tristani-Firouzi M., Canun S., Bendahhou S., Tsunoda A., et al. Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell 105 4 (2001 May 18) 511-519
162. Terzic A., Vivaudou M., Moreau C., Olson T.M., Jahangir A., Zingman L.V., et al. Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. 1 ed (2008), Springer
163. Zhang L., Benson D.W., Tristani-Firouzi M., Ptacek L.J., Tawil R., Schwartz P.J., et al. Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: characteristic T-U-wave patterns predict the KCNJ2 genotype. Circulation 111 21 (2005 May 31) 2720-2726
164. Plaster N.M., Tawil R., Tristani-Firouzi M., Canun S., Bendahhou S., Tsunoda A., et al. Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell 105 4 (2001) 511-519
165. Andelfinger G., Tapper A.R., Welch R.C., Vanoye C.G., George Jr. A.L., and Benson D.W. KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes. Am. J. Hum. Genet. 71 3 (2002 Sep) 663-668
166. Schulze-Bahr E. Short QT syndrome or Andersen syndrome: yin and yang of Kir2.1 channel dysfunction. Circ. Res. 96 7 (2005 Apr 15) 703-704
167. 2 interactions underlie channelopathies. Neuron 34 6 (2002 Jun 13) 933-944
168. Bjerregaard P., and Gussak I. Short QT syndrome: mechanisms, diagnosis and treatment. Nat. Clin. Pract. Cardiovasc. Med. 2 2 (2005 Feb) 84-87
169. Gussak I., Brugada P., Brugada J., Wright R.S., Kopecky S.L., Chaitman B.R., et al. Idiopathic short QT interval: a new clinical syndrome?. Cardiology 94 2 (2000) 99-102
170. Brugada R., Hong K., Dumaine R., Cordeiro J., Gaita F., Borggrefe M., et al. Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation 109 1 (2004 Jan 6) 30-35
171. Bellocq C., van Ginneken A.C., Bezzina C.R., Alders M., Escande D., Mannens M.M., et al. Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation 109 20 (2004 May 25) 2394-2397
172. Priori S.G., Pandit S.V., Rivolta I., Berenfeld O., Ronchetti E., Dhamoon A., et al. A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circ. Res. 96 7 (2005 April 15) 800-807
173. Chen Y.H., Xu S.J., Bendahhou S., Wang X.L., Wang Y., Xu W.Y., et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299 5604 (2003 Jan 10) 251-254
174. Yang Y., Xia M., Jin Q., Bendahhou S., Shi J., Chen Y., et al. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am. J. Hum. Genet. 75 5 (2004 Nov) 899-905
175. Olson T.M., Alekseev A.E., Liu X.K., Park S., Zingman L.V., Bienengraeber M., et al. Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum. Mol. Genet. 15 14 (2006 Jul 15) 2185-2191
176. Xia M., Jin Q., Bendahhou S., He Y., Larroque M.M., Chen Y., et al. A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem. Biophys. Res. Commun. 332 4 (2005 Jul 15) 1012-1019
177. Leenhardt A., Lucet V., Denjoy I., Grau F., Ngoc D.D., and Coumel P. Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patients. Circulation 91 5 (1995 Mar 1) 1512-1519
178. Tester D.J., Arya P., Will M., Haglund C.M., Farley A.L., Makielski J.C., et al. Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing. Heart Rhythm 3 7 (2006 Jul) 800-805
179. Priori S.G., Napolitano C., Memmi M., Colombi B., Drago F., Gasparini M., et al. Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation 106 1 (2002 Jul 2) 69-74
180. Postma A.V., Denjoy I., Hoorntje T.M., Lupoglazoff J.M., Da Costa A., Sebillon P., et al. Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia. Circ. Res. 91 8 (2002 Oct 18) e21-e26
181. Eckhardt L.L., Farley A.L., Rodriguez E., Ruwaldt K., Hammill D., Tester D.J., et al. KCNJ2 mutations in arrhythmia patients referred for LQT testing: a mutation T305A with novel effect on rectification properties. Heart Rhythm 4 3 (2007 Mar) 323-329