Enhanced dispersion of repolarization explains increased arrhythmogenesis in severe versus therapeutic hypothermia

Circulation: Arrhythmia and Electrophysiology

Volumn 4, Issue 1, 2011, Pages 79-86

  Piktel, Joseph S ^a,b,c   Jeyaraj, Darwin ^a   Said, Tamer H ^a   Rosenbaum, David S ^a   Wilson, Lance D ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b AMERICAN HEART ASSOCIATION   (United States)

^c Society of Academic Emergency Meeting Annual Meeting   (United States)

Author keywords

Arrhythmias; Dispersion of repolarization; Hypothermia; Optical mapping; Ventricular fibrillation

Indexed keywords

ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; COOLING; DISEASE PREDISPOSITION; DISEASE SEVERITY; HEART ARRHYTHMIA; HEART BLOCK; HEART CONDUCTION; HEART LEFT VENTRICLE WALL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART REPOLARIZATION DISPERSION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HYPOTHERMIA; INDUCED HYPOTHERMIA; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; WARMING; ACTION POTENTIAL; ANIMAL; ANIMAL MODEL; COMPARATIVE STUDY; DOG; ELECTROCARDIOGRAPHY; HEART MUSCLE CONDUCTION SYSTEM; HOSPITALIZATION; INCIDENCE; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR; TEMPERATURE; TIME;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; DOGS; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HYPOTHERMIA; HYPOTHERMIA, INDUCED; INCIDENCE; MODELS, ANIMAL; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TACHYCARDIA, VENTRICULAR; TEMPERATURE; TIME FACTORS; VENTRICULAR FIBRILLATION;

EID: 79953797140     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.110.958355     Document Type: Article

References (31)

1. Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve outcome after cardiac arrest. N Engl J Med. 2002; 346:549-556.
2. Bernard SA, Gray TW, Buist M, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557-563. (Pubitemid 34438816)
3. Nolan JP, Morley PT, Vanden Hoek TL, Hickey RW. Therapeutic hypothermia after cardiac arrest: an advisory statement by the Advanced Life Support Task force of the International Liason Committee on Resuscitation. Circulation. 2003;108:118-121. (Pubitemid 36859031)
4. Murphy T, Zumwalt R, Fallico F, Sanchez C, Belson M, Rubin C, Azziz-Baumgartner E. Hypothermia-related deaths-United States, 1999-2002 and 2005. MMWR. 2006;55:282-284.
5. Hypothermia related deaths. MMWR. 2006;55:282-284.
6. Hauty MG, Esrig BC. Hill JG, Long WB. Prognostic factors in severe accidental hypothermia: experience from the Mt Hood tragedy J Trauma. 1987;27:1107-1112. (Pubitemid 18005105)
7. 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2005; 112(24 suppl):IV-84-IV-88.
8. Vassal T, Benoit-Gonin B, Carrat F, Guidet B, Maury E, Offenstadt G. Severe accidental hypothermia treated in an ICU, prognosis and outcome. Chest. 2001;120:1998-2003. (Pubitemid 34053466)
9. Yan GX, Antzelevitch CA. Cellular basis for the electrocardiographic J wave. Circulation. 1996;93:372-379.
10. Durakovic Z, Misigoj-Durakovic M, Corovic N, Curbillo-Turek M, Turek S. The corrected Q-T interval in the elderly with urban hypothermia. Coll Antropol. 1999;23:683-690.
11. Mortensen E, Berntsen R, Tveita T, Lathrop DA, Refsum H. Changes in ventricular fibrillation threshold during acute hypothermia: a model for future studies. J Basic Clin Physiol Pharmocol. 1993;4: 313-319. (Pubitemid 24370712)
12. Gambassi G, Cerbai E, Pahor M, Capogrossi MC, Carbonin P, Mugelli A. Temperature modulates calcium homeostasis and ventricular arrhythmias in myocardial preparations. Cardiovasc Res. 1994;28: 391-399. (Pubitemid 24131078)
13. Liu B, Arlock P, Wohlfart B, Johansson BW. Temperature effects on the Na and Ca currents in rat and hedgehog ventricular muscle. Cryobiology. 1991;28:96-104.
14. Suleiman MS, Chapman RA. Effect of temperature on the rise of intracellular sodium caused by calcium depletion in ferret ventricular muscle and the mechanism of the alleviation of the calcium paradox by hypothermia. Circ Res. 1990;67:1238-1246. (Pubitemid 20368021)
15. Marshall C, Elias C, Xue X, Dinh Le H, Omelchenko A, Hryshko LV, Tibbits GF. Determinants of cardiac Na+/Ca2+ exchanger temperature dependence: NH2-terminal transmembrane segments. Am J Physiol Cell Physiol. 2002;283:512-520.
16. Melinikov AL, Lathrop DA, Helgesen KG. Diazepam-induced Ca 2 + channel blockade reduces hypothermia-induced electromechanical changes in isolated guinea ventricular muscle. Eur J Anesth. 1998;15: 96-102. (Pubitemid 28349747)
17. Sprung J, Laszlo A, Turner LA, Kampine JP, Bosnjaak ZJ. Effects of hypothermia, potassium, and verapamil on the action potential characteristics of canine cardiac Purkinje fibers. Anesthesiology. 1995;2: 713-722.
18. Sprung J, Stowe DF, Kampine JP, Bosnjak ZJ. Hypothermia modifies anesthetic effect on contractile force and Ca2+ transients in cardiac Purkinje fibers. Am J Physiol. 1994;36:725-733.
19. Bjørnstad H, Jenssen D, Mortensen E. Diltiazem does not increase ventricular fibrillation threshold during hypothermia. Acta Anethesiol Scand. 1995;39:659-665.
20. Salama G, Kanai AJ, Huang D, Efimov RD, Girourd SD, Rosembaum DS. Hypoxia and hypothermia enhance spatial heterogeneities of repolarization in guinea pig hearts: analysis of spatial autocorrelation of optically recorded action potential durations. J Cardiovasc Electrophysiol. 1998;9: 164-183. (Pubitemid 28114615)
21. Kuo CS, Reddy CP, Munkata K, Surawicz B. Mechanism of ventricular arrhythmias caused by increased dispersion of repolarization. Eur Heart J. 1985;6(Suppl D):63-70. (Pubitemid 16172255)
22. Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation. 2002;105: 1247-1253. (Pubitemid 34225828)
23. Akar FG, Rosenbaum DS. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ Res. 2003;93: 638-645. (Pubitemid 37222160)
24. Morita H, Zipes D, Morita S, Wulks J. Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome. Heart Rhythm. 2007;4:2:188-189.
25. Girouard SD, Laurita KR, Rosenbaum DS. Unique properties of cardiac action potentials recorded with voltage-sensitive dyes. J Car-diovasc Electrophysiol. 1996;7:1024-1038. (Pubitemid 26389416)
26. Rosenbaum DS, Akar FG. The electrophysiologic substrate for reentry: unique insights fro high-resolution optical mapping with voltage-sensitive dyes: In: Cabo C, Rosenbaum DS, eds. Quantitative Cardiac Electro-physiology. New York, NY: Marcel Dekker Inc, 2002:555-582.
27. Akar FG, Laurita KR, Rosenbaum DS. Cellular basis for dispersion of repolarization underlying reentrant arrhythmias. J Electrocardiol. 2000; 33(Suppl):23-31. (Pubitemid 32167280)
28. Pajouh M, Wilson LD, Poelzing S, Johnson N, Rosenbaum DS. Iks blockade reduces dispersion of repolarization in heart failure. Heart Rhythm. 2006;2:7:731-738.
29. Fouts K, Fernandes B, Mal N, Liu J, Laurita K. Electrophysiological consequences of skeletal myoblast transplantation in normal infracted canine myocardium. Heart Rhythm. 2006;3:452-461.
30. Poelzing S, Roth BJ, Rosenbaum DS. Optical measurements reveal nature of intercellular coupling across ventricular wall. Am J Physiol Heart Circ Physiol. 2005;289:H1428-H1435. (Pubitemid 41368983)
31. Fedorov VV, Glukhov AV, Sudharshan S, Egorov Y, Rosenshtraukh LV, Efimov IR. Electrophysiological mechanisms of antiarrhythmic protection during hypothermia in winter hibernating versus nonhibernating mammals. Heart Rhythm 2008;5:11:1587-1596.