Two Components of Delayed Rectifier Current in Canine Atrium and Ventricle: Does IKs Play a Role in the Reverse Rate Dependence of Class III Agents?

Circulation Research

Volumn 78, Issue 1, 1996, Pages 26-37

  Gintant, Gary A ^a,b  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atrial myocytes; Delayed rectifier K+ currents; E 4031; Reverse rate dependence; Ventricular myocytes

Indexed keywords

ANTIARRHYTHMIC AGENT;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; DOG; DRUG EFFECT; HEART ATRIUM MUSCLE; HEART DEPOLARIZATION; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE WALL; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SLOW INWARD CURRENT;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATRIAL FUNCTION; CELLS, CULTURED; DOGS; ELECTROPHYSIOLOGY; HEART VENTRICLES; ION TRANSPORT; PIPERIDINES; POTASSIUM; PYRIDINES;

EID: 0030056967     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.78.1.26     Document Type: Article

References (44)

1. Gintant GA, Cohen IS, Datyner NB, Kline RP. Time-dependent outward currents in the heart. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE, eds. The Heart and Cardiovascular System. 2nd ed. New York, NY: Raven Press Publishers; 1992: 1121-1169.
2. + current: differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol. 1990;96:195-215.
3. + current is composed of two currents in guinea pig atrial cells. Am J Physiol. 1991;260:H393-H399.
4. Chinn K. Two delayed rectifiers in guinea-pig ventricular myocytes distinguished by tail current kinetics. J Pharmacol Exp Ther. 1993; 264:553-560.
5. + current in cardiac myocytes by dofetilide. J Pharmacol Exp Ther. 1992;262:809-817.
6. Follmer CH, Colatsky TJ. Block of delayed rectifier potassium current, iK, by flecainide and E-4031 in cat ventricular myocytes. Circulation. 1990;82:289-293.
7. + currents in isolated adult rat ventricular myocytes. J Gen Physiol. 1991;97:973-1011.
8. + channel. Circ Res. 1993;72:707-714.
9. Tande PM, Bjornstad H, Yang T, Refsum H. Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel iK blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium. J Cardiovasc Pharmacol. 1990; 16:401-410.
10. Ks in electrical heterogeneity. Am J Physiol. 1995;268: H605-H613.
11. Ks contributes to the longer action potential of the M cell. Circ Res. 1995;76:351-365.
12. Hondeghem LM, Snyders DJ. Class III antiarrhythmic agents have a lot of potential but a long way to go: reduced effectiveness and dangers of reverse use-dependence. Circulation. 1990;81:686-690.
13. + current by dofetilide. Circ Res. 1993;72:75-83.
14. Gwilt M, Arrowsmith JE, Blackburn KJ, Burges RA, Cross PE, Dalrymple HW, Higgins AJ. UK-68,798; a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J Pharmacol Exp Ther. 1991;256:318-324.
15. Spinelli W, Moubarak IS, Parsons RW, Colatsky TJ. Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of iK block and lack of reverse use dependence in cat ventricular myocytes. Cardiovasc Res. 1993;27:1580-1591.
16. Antzelevitch C, Sicouri S, Litovsky S, Lukas A, Krishnan SC, Di Diego JM, Gintant GA, Liu D-W. Heterogeneity within the ventricular wall: electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res. 1991;69:1427-1449.
17. Furukawa T, Kimura S, Furukawa N, Bassett AL, Myerburg RJ. Potassium rectifier currents differ in myocytes of endocardial and epicardial origin. Circ Res. 1992;70:91-103.
18. Colatsky TJ, Follmer CH, Starmer CF. Channel specificity in antiarrhythmic drug action: mechanism of potassium channel block and its role in suppression and aggravating cardiac arrhythmias. Circulation. 1990;82:2235-2242.
19. Gintant GA, Liu D-W. β-Adrenergic modulation of fast inward sodium current in canine myocardium: syncytial preparations versus isolated myocytes. Circ Res. 1992;70:844-850.
20. Liu D-W, Gintant GA, Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res. 1993;72:671-687.
21. Hamill OP, Marty E, Neher B, Sakmann B, Sigworth FJ. Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 1981;391: 85-100.
22. Horn R, Marty A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J Gen Physiol. 1988;92: 145-159.
23. Balser JR, Bennett PB, Roden DM. Time-dependent outward current in guinea pig ventricular myocytes: gating kinetics of the delayed rectifier. J Gen Physiol. 1990;96:835-863.
24. + channels. J Pharmacol Exp Ther. 1985;234:134-140.
25. Bennett PB, McKinney LC, Kass RS, Begenisich T. Delayed rectification in the calf cardiac Purkinje fiber: evidence for multiple state kinetics. Biophys J. 1985;48:553-567.
26. + current in guinea pig or ferret ventricular cells. J Mol Cell Cardiol. 1989;21(suppl II):S.21.
27. Campbell DL, Rasmusson RL, Qu Y, Strauss HC. The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes, II: closed state reverse use-dependent block by 4-aminopyridine. J Gen Physiol. 1993;101:603-626.
28. Gintant GA, Datnyer NB, Cohen IS. Gating of delayed rectification in acutely isolated canine cardiac Purkinje myocytes. Biophys J. 1985;48:1059-1064.
29. Shibasaki T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J Physiol (Lond). 1987;387:227-250.
30. + current (iKs) in rabbit ventricular myocytes. Biophys J. 1995; 68(suppl 2, pt 2):A147. Abstract.
31. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res. 1993;73:379-385.
32. Isomoto S, Shimizu A, Konoe A, Kaibara M, Centurion OA, Fukatani M, Yano K. Electrophysiologic effects of E-4031, a new class III antiarrhythmic agent, in patients with supraventricular tachyarrhythmias. Am J Cardiol. 1993;712:1464-1467.
33. Tham TCK, MacLennan, BA, Burke MT, Harron DWG. Pharmacodynamics and pharmacokinetics of the class III antiarrhythmic agent dofetilide (UK-68,798) in humans. J Cardiovasc Pharmacol. 1993;21:507-512.
34. Swanson R, Folander K, Antanavage J, Smith J. The IsK gene is expressed in human heart. Biophys J. 1991;59:452a. Abstract.
35. Murai T, Kakizuka A, Takumi T, Ohkubo H, Nakanishi S. Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity. Biophys Res Commun. 1989;161: 176-181.
36. Wang Z, Fermini B, Nattel S. Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc Res. 1994;28:1540-1546.
37. + current in ventricular myocytes of the guinea pig type: theoretical formulation and their role in repolarization. Circ Res. 1995;77:140-152.
38. + channel mRNA in cultured atrial cardiac myocytes (AT-1 cells). Circ Res. 1994;75:870-878.
39. Gintant GA. Pharmacologic dissection of delayed rectifier current (iK) in canine ventricular myocytes by E-4031 and terfenadine; iKr and iKs 'swap.' Biophys J. 1994:66(suppl 2, pt 2):A-210. Abstract.
40. Woosley RL, Chen Y, Freiman JP, Gillis RA. Mechanism of the cardiotoxic actions of terfenadine. JAMA. 1993;269:1532-1536.
41. Hiraoka M, Sawada K, Nitta J, Adaniya H. E-4031. In: Bingh BN, Wellens HJJ, Hiraoka M, eds. Electropharmacological Control of Cardiac Arrhythmias. Mt Kisco, NY: Futura Publishing Co Inc; 1994:535-550.
42. Martin CL, Chinn K. Contribution of delayed rectifier and inward rectifier to repolarization of the action potential: pharmacologic separation. J Cardiovasc Pharmacol. 1992;19:830-837.
43. Gintant GA. Pharmacologic identification of iKs in canine ventricular myocytes: effects of NE-10064 (azimilide). Circulation. 1994; 90(suppl I, pt 2):I-146. Abstract.
44. Shimizu A, Kaibara M, Centurion O, Kapukuu G, Hirata T, Fukatani M, Yano K, Hashiba K. Electrophysiologic effects of a new class III antiarrhythmic agent, E-4031, on atrial flutter, atrial refractoriness, and conduction delay in a canine sterile pericarditis model. J Cardiovasc Pharmacol. 1993;21:656-662.