Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects

Translational Research

Volumn 151, Issue 5, 2008, Pages 267-272

  Piccirillo, Gianfranco ^a   Magrì, Damiano ^a   Matera, Sabrina ^a   Magnanti, Marzia ^a   Pasquazzi, Eleonora ^a   Schifano, Erika ^a   Velitti, Stefania ^a   Mitra, Marilena ^a   Marigliano, Vincenzo ^a   Paroli, Marino ^a   Ghiselli, Andrea ^a  

^a Dipartimento di Scienze Cardiovascolari Respiratorie e Morfologiche   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; NARINGENIN; PLACEBO; SOTALOL;

ADULT; ARTICLE; CARDIOMYOPATHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONGESTIVE CARDIOMYOPATHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GRAPEFRUIT JUICE; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HUMAN; HYPERTENSIVE HEART DISEASE; MALE; MYOCARDIAL DISEASE; PRIORITY JOURNAL; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; RISK; SUDDEN DEATH;

EID: 42249100309     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2008.03.002     Document Type: Article

References (31)

1. Zitron E., Scholz E., Owen R.W., et al. QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids. Circulation 111 (2005) 835-838
2. Lazzara R. Amiodarone and torsades de pointes. Ann Int Med 111 (1989) 549-551
3. Roden D.M. Long QT Syndrome: reduced repolarization reserve and genetic link. J Int Med 259 (2006) 59-69
4. Anderson M.E. QT interval prolongation and arrhythmia: an unbreakable connection?. J Int Med 259 (2006) 81-90
5. Knekt P., Kumpulainen J., Jarvinen R., et al. Flavonoid intake and risk of chronic disease. Am J Clin Nutr 76 (2002) 560-568
6. Hertog M.G., Feskens E.J., Hollman P.C., Katan M.B., and Kromhout D. Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Lancet 312 (1993) 478-481
7. Lin J., Rexrode K.M., Hu F., et al. Dietary Intakes of Flavonols and Flavones and Coronary Heart Disease in US Women. Am J Epidemiol (2007) Mar 22; [Epub ahead of print].
8. Rimm E.B., Katan M.B., Ascherio A., Stampfer M.J., and Willett W.C. Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Ann Intern Med 125 5 (1996) 384-389
9. Yochum L., Kushi L.H., Meyer K., and Folsom A.R. Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. 15. Am J Epidemiol 149 10 (1999) 943-949
10. Geleijnse J.M., Launer L.J., Van der Kuip D.A., Hofman A., and Witteman J.C. Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am J Clin Nutr 75 (2002) 880-886
11. Atiga W.L., Calkins H., Lawrence J.H., Tomaselli G.F., Smith J.M., and Berger R.D. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J Cardiovasc Electrophysiol 9 9 (1998) 899-908
12. Haigney M.C., Zareba W., Gentlesk P.J., et al. QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II. J Am Coll Cardiol 44 (2004) 1481-1487
13. Piccirillo G., Magrì D., Matera S., et al. QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular systolic dysfunction: a prospective study. Eur Heart J 28 11 (2007) 1344-1350
14. Piccirillo G., Germanò G., Quaglione R., et al. QT interval and autonomic control in hypertensive subjects with left ventricular hypertrophy. Clin Sci 102 (2002) 363-371
15. Berger R.D., Kasper E.K., Baughman K.L., Marban E., Calkins H., and Tomaselli G.F. Beat-to-beat QT interval variability. Novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation 96 (1997) 1557-1565
16. Erlund I., Meririnne E., Alfthan G., and Aro A. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J Nutr 131 2 (2001) 235-241
17. Mattila P., Astola J., and Kumpulainen J. Determination of flavonoids in plant material by HPLC with diode-array and electro-array detections. J Agric Food Chem 48 12 (2000) 5834-5841
18. Piccirillo G., Cacciafesta M., Lionetti M., et al. The influence of age, the autonomic nervous system and anxiety on QT interval variability. Clin Sci 101 (2001) 429-438
19. Lehmann M.H., Hardy S., Archibald D., Quart B., and MacNeil D.J. Sex difference in risk of torsade de pointes with d,l-sotalol. Circulation 94 10 (1996) 2535-2541
20. Waldo A.L., Camm A.J., deRuyter H., et al. Survival with oral d-sotalol in patients with left ventricular dysfunction after myocardial infarction: rationale, design, and methods (the SWORD trial). Am J Cardiol 75 (1995) 1023-1027
21. Yan G.X., and Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 98 (1998) 1928-1936
22. Antzelevitch C., and Oliva A. Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polymorphic VT, long QT, short QT and Brugada syndromes. J Int Med 259 (2006) 48-58
23. Rosen M.R., and Cohen I.S. Molecular/genetic determinants of repolarization and their modification by environmental stress. J Int Med 259 (2006) 7-23
24. Lankipalli R.S., Zhu T., Guo D., and Yan G.X. Mechanisms underlying arrhythmogenesis in long-QT syndrome. J Electrocardiol 38 (2005) 69-73
25. Tomaselli G.F., and Zipes D.P. What causes sudden death in heart failure?. Circ Res 95 (2004) 754-763
26. Thomas D., Karle C.A., and Kiehn J. The cardiac hERG/Ikr potassium channel as pharmacological target: structure, function, regulation and clinical applications. Curr Pharm Design 12 (2006) 2271-2283
27. Kamiya K., Nishiyama A., Yasui K., Hojo M., Sanguinetti M.C., and Kodama I. Short and long term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current. Circulation 103 (2001) 1317-1324
28. Singh B.N., Venkatesh N., Nademanee K., Josephson M.A., and Kannan R. The historical development, cellular electrophysiology and pharmacology of amiodarone. Prog Cardiovasc Dis 31 (1989) 249-280
29. Splawski I., Timothy K.W., Tateyama M., et al. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 297 (2002) 1333-1336
30. Ackerman M.J., Splawski I., Makielski J.C., et al. Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian and Hispanic individuals: implications for arrhythmogenic susceptibility and Brugada/long-QT syndrome genetic testing. Heart Rhythm 1 (2004) 600-607
31. Yang T., and Roden D.M. Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence. Circulation 93 (1996) 407-411