Relation of Increased Short-Term Variability of QT Interval to Congenital Long-QT Syndrome

American Journal of Cardiology

Volumn 103, Issue 9, 2009, Pages 1244-1248

  Hinterseer, Martin ^a   Beckmann, Britt Maria ^a   Thomsen, Morten B ^c   Pfeufer, Arne ^b   Dalla Pozza, Robert ^a   Loeff, Markus ^a   Netz, Heinrich ^a   Steinbeck, Gerhard ^a   Vos, Marc A ^d   Kääb, Stefan ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTROMYOGRAPHY; FEMALE; GENE MUTATION; HEART BEAT; HEART RATE VARIABILITY; HIGH RISK POPULATION; HUMAN; LONG QT SYNDROME; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; QT INTERVAL; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; AGE FACTORS; ANTI-ARRHYTHMIA AGENTS; CASE-CONTROL STUDIES; CHILD; ELECTROCARDIOGRAPHY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEART CONDUCTION SYSTEM; HUMANS; LONG QT SYNDROME; MALE; MUTATION; PROGNOSIS; REFERENCE VALUES; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SEX FACTORS; YOUNG ADULT;

EID: 65249100849     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2009.01.011     Document Type: Article

References (23)

1. Moss A.J., and Kass R.S. Long QT syndrome: from channels to cardiac arrhythmias. J Clin Invest 115 (2005) 2018-2024
2. Schwartz P.J. The congenital long QT syndromes from genotype to phenotype: clinical implications. J Intern Med 259 (2006) 39-47
3. Keating M.T., and Sanguinetti M.C. Molecular and cellular mechanisms of cardiac arrhythmias. Cell 104 (2001) 569-580
4. Sanguinetti M.C., and Tristani-Firouzi M. HERG potassium channels and cardiac arrhythmia. Nature 440 (2006) 463-469
5. Marbán E. Cardiac channelopathies. Nature 415 (2002) 213-218
6. Roden D.M. Long QT syndrome: reduced repolarization reserve and the genetic link. J Intern Med 259 (2006) 59-69
7. Roden D.M. Taking the idio out of idiosyncratic-predicting torsades de pointes. Pacing Clin Electrophysiol 21 (1998) 1029-1034
8. Roden D.M. Clinical practice. Long-QT syndrome. N Engl J Med 358 (2008) 169-176
9. Vincent G.M., Timothy K.W., Leppert M., and Keating M. The spectrum of symptoms and QT intervals in carriers of gene for the long QT-syndrome. N Engl J Med 327 (1992) 846-852
10. Priori S.G., Schwartz P.J., Napolitano C., Bloise R., Ronchetti E., Grillo M., Vicentini A., Spazzolini C., Nastolli J., Bottelli G., Folli R., and Cappelletti D. Risk stratification in the long-QT syndrome. N Engl J Med 348 (2003) 1866-1874
11. Priori S.G., Napolitano C., and Schwartz P.J. Low penetrance in the long-QT syndrome: clinical impact. Circulation 99 (1999) 529-533
12. Shimizu W., Noda T., Takaki H., Kurita T., Nagaya N., Satomi K., Suyama K., Aihara N., Kamakura S., Sunagawa K., et al. Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome. J Am Coll Cardiol 41 (2003) 633-642
13. Hinterseer M., Thomsen M.B., Beckmann B.M., Pfeufer A., Schimpf R., Wichmann H.E., Steinbeck G., Vos M.A., and Kaab S. Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study. Eur Heart J 29 (2008) 185-190
14. Holle R., Happich M., Löwel H., Wichmann H.E., and MONICA/KORA Study Group. KORA-a research platform for population based health research. Gesundheitswesen 67 (2005) 19-25
15. Lepeschkin E., and Surawicz B. The measurement of the Q-T interval of the electrocardiogram. Circulation 6 (1952) 378-388
16. Bazett H.C. An analysis of the time-relations of electrocardiograms. Heart 7 (1920) 353-370
17. Merri M., Benhorin J., Alberti M., Locati E., and Moss A.J. Electrocardiographic quantitation of ventricular repolarization. Circulation 80 (1989) 1301-1308
18. Thomsen M.B., Verduyn S.C., Stengl M., Beekman J.D., de Pater G., van Opstal J., Volders P.G., and Vos M.A. Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs. Circulation 110 (2004) 2453-2459
19. Splawski I., Shen J., Timothy K.W., Lehmann M.H., Priori S., Robinson J.L., Moss A.J., Schwartz P.J., Towbin J.A., Vincent G.M., and Keating M.T. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 102 (2000) 1178-1185
20. Mönnig G., Eckardt L., Wedekind H., Haverkamp W., Gerss J., Milberg P., Wasmer K., Kirchhof P., Assmann G., Breithardt G., and Schulze-Bahr E. Electrocardiographic risk stratification in families with congenital long QT syndrome. Eur Heart J 27 (2006) 2074-2080
21. Hofman N., Wilde A.A., Kääb S., van Langen I.M., Tanck M.W., Mannens M.M., Hinterseer M., Beckmann B.M., and Tan H.L. Diagnostic criteria for congenital long QT syndrome in the era of molecular genetics: do we need a scoring system?. Eur Heart J 28 (2007) 575-580
22. Pfeufer A., Jalilzadeh S., Perz S., Mueller J.C., Hinterseer M., Illig T., Akyol M., Huth C., Schöpfer-Wendels A., Kuch B., et al. Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study. Circ Res 96 (2005) 693-701
23. Locati E.H., Zareba W., Moss A.J., Schwartz P.J., Vincent G.M., Lehmann M.H., Towbin J.A., Priori S.G., Napolitano C., Robinson J.L., et al. Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: findings from the International LQTS Registry. Circulation 97 (1998) 2237-2244