Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: Underlying molecular, cellular and biophysical mechanisms

Journal of Physiology

Volumn 569, Issue 1, 2005, Pages 7-39

  Patel, Sangita P ^a   Campbell, Donald L ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; CALSENILIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; PHOSPHOTRANSFERASE; SPIDER VENOM; SUPEROXIDE DISMUTASE; VOLTAGE GATED POTASSIUM CHANNEL; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.4 ALPHA SUBUNIT; POTASSIUM CHANNEL KV4.2 ALPHA SUBUNIT; POTASSIUM CHANNEL KV4.3 ALPHA SUBUNIT; UNCLASSIFIED DRUG;

DENSITY GRADIENT; ENZYME PHOSPHORYLATION; HEART DEPOLARIZATION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE WALL; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; MOLECULAR MODEL; NONHUMAN; OXIDATION REDUCTION STATE; PHENOTYPE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE FIBER; REVIEW; SPECIES DIFFERENCE; BIOPHYSICS; CHANNEL GATING; MOLECULAR DYNAMICS; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOPHYSICS; CELL MEMBRANE; HEART VENTRICLES; HUMANS; ION CHANNEL GATING; MAMMALS; MODELS, BIOLOGICAL; MOLECULAR BIOLOGY; PHENOTYPE; POTASSIUM; SHAL POTASSIUM CHANNELS;

EID: 27744555896     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.086223     Document Type: Review

References (198)

1. Aldrich RW (1981). Inactivation of voltage-gated delayed potassium current in molluscan neurons. A kinetic model. Biophys J 36, 519-532.
2. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KT, Strassle RW, Trimmer JS & Rhodes KJ (2000). Modulation of A-type potassium channels by a family of calcium sensors. Nature 403, 553-556.
3. Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ & Sweatt JD (2000). Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem 275, 5337-5346.
4. Antzelevitch C, Zygmunt AC & Dumaine R (2003). Electrophysiology and pharmacology of ventricular repolarization. In Cardiac Repolarization, ed. Gussak I & Antzelevitch C, pp. 63-89. Human Press Inc., Totowa, NJ, USA.
5. Archer SL & Rusch NJ (2001). Potassium Channels in Cardiovascular Biology. Kluwer Academic/Plenum Publishers, New York.
6. Bähring R, Boland LM, Varghese A, Gebauer M & Pongs O (2001a). Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels. J Physiol 535, 65-81.
7. Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O & Isbrandt D (2001b). Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. J Biol Chem 276, 23888-23894.
8. + channel gating. Neuron 20, 1283-1294.
9. Barry DM, Xu H, Schuessler RB & Nerbonne JM (1998). Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 α subunit. Circ Res 83, 560-567.
10. 2+ reloading in mammalian ventricular myocytes. J Phyisol 559, 593-609.
11. Beck EJ, Bowlby M, An WF, Rhodes KJ & Covarrubias M (2002). Remodeling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein. J Physiol 538, 691-706.
12. Beck EJ & Corvarrubias M (2001). Kv4 channels exhibit modulation of closed-state inactivation in inside-out patches. Biophys J 81, 867-883.
13. Bernard C, Legros C, Ferrat G, Bischoff U, Marquardt A, Pongs O & Darbon H (2000). Solution structure of HPTX2, a toxin from Heteropoda venatoria spider that blocks Kv4.2 potassium channel. Protein Sci 9, 2059-2067.
14. Bers DM (2001). Excitation-Contraction Coupling and Cardiac Contractile Force, 2nd edn. Kluwer Academic Publishers, Dordrecht.
15. + channels: lipophilic interactions at the intracellular mouth of the pore. J Physiol 556, 109-120.
16. Bezanilla F (2000). The voltage sensor in voltage-dependent ion channels. Physiol Rev 80, 555-592.
17. Bezanilla F (2002). Voltage sensor movements. J General Physiol 120, 465-473.
18. Bezanilla F & Perozo E (2003). The voltage sensor and the gate in ion channels. Adv Protein Chem 63, 211-241.
19. Birnbaum SG, Varga AW, Yuan L-Y, Anderson AE, Sweatt JD & Schraeder LA (2004). Structure and function of Kv4-family transient potassium channels. Physiol Rev 84, 803-833.
20. Blaustein RO & Miller C (2004). Shake, rattle or roll? Nature 427, 499-500.
21. Bondarenko VE, Szigeti GP, Bett GC, Kim SJ & Rasmusson RL (2004). Computer model of action potential of mouse ventricular myocytes. Am J Physiol 287, H1378-H1403.
22. Bourne Y, Dannenberg J, Pollmann V, Marchot P & Pongs O (2001). Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1). J Biol Chem 276, 11949-11955.
23. to, in the sinoatrial node. Cardiovascular Res 52, 519-520.
24. Brahmajothi MV & Campbell DL (1999). Heterogeneous basal expression of nitric oxide synthase and superoxide dismutase isoforms in mammalian heart. Implications for mechanisms governing indirect and direct nitric-oxide-related effects. Circ Res 85, 575-587.
25. to) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J General Physiol 113, 581-600.
26. + channel mRNA in isolated ferret cardiac myocytes. Circ Res 78, 1083-1089.
27. + currents in adult mouse ventricles. J Physiol 559, 103-120.
28. (K,slow). Am J Physiol 281, H1201-H1209.
29. to. Biophys J 82, 1186.
30. Campbell DL, Qu Y, Rasmusson RL & Strauss HC (1993a). The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed-state reverse use-dependent block by 4-aminopyridine. J General Physiol 101, 603-626.
31. Campbell DL, Rasmusson RL, Comer MB & Strauss HC (1995). The cardiac calcium-independent transient outward potassium current: kinetics, molecular properties, and role in ventricular repolarization. In Cardiac Electrophysiology: from Cell to Bedside, ed. Zipes DP & Jalife J, pp. 83-96. Saunders, Philadelphia.
32. Campbell DL, Rasmusson RL, Qu Y & Strauss HC (1993b). The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis. J General Physiol 101, 571-601.
33. Campbell DL, Rasmusson RL & Strauss HC (1992). Ionic current mechanisms generating vertebrate primary cardiac pacemaker activity at the single cell level: An integrative view. Ann Rev Physiol 54, 279-302.
34. Campbell DL, Stamler JS & Strauss HC (1996). Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. J General Physiol 108, 277-293.
35. Campomanes CR, Carroll KL, Manganas LN, Hershberger ME, Gong B, Antonucci DE, Rhodes KJ & Trimmer JS (2002). Kv β subunit oxidoreductase activity and Kv1 potassium channel trafficking. J Biol Chem 277, 8298-8305.
36. Carmeliet E & Vereecke J (2002). Ionic currents and action potentials in cardiac cells. In Cellular Cardiac Electrophysiology, pp. 95-117. Kluwer Academic Publishers, Boston.
37. + current densities in rat ventricle. Life Sci 63, 391-400.
38. Castellino RC, Morales MJ, Strauss HC & Rasmusson RL (1995). Time- and voltage-dependent modulation of a Kv1.4 channel by a β-subunit (Kvβ3) cloned from ferret ventricle. Am J Physiol 269, H385-H391.
39. Cha A, Snyder GE, Selvin PR & Bezanilla F (1999). Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy. Nature 402, 809-813.
40. Chagot B, Escoubas P, Villegas E, Bernard C, Ferrat G, Corzo G, Lazdunski M & Darbon H (2004). Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the therapsid spider Phrixotrichus auratus. Protein Sci 13, 1197-1208.
41. Chang L-S, Chen C-Y & Wu TT (2003). Functional implication with the metal-binding properties of KChIP1. Biochem Biophys Res Commun 311, 258-263.
42. Chien KR (1999). Molecular Basis of Cardiovascular Disease. W. B. Saunders Company, Philadelphia.
43. + channels. Proc Natl Acad Sci U S A 88, 5092-5095.
44. Clark RB, Bouchard RA, Salinas-Stefanon E, Sanchez-Chapula J & Giles WR (1993). Heterogeneity of action potential waveforms and potassium currents in rat ventricle. Cardiovasc Res 27, 1795-1799.
45. Clark RB, Giles WR & Imaizumi Y (1988). Properties of the transient outward current in rabbit atrial cells. J Physiol 405, 147-168.
46. to-like potassium channel from ferret ventricle. Am J Physiol 267, H1383-H139.
47. Craig TA, Benson LM, Venyaminov SY, Klimtchuk ES, Bajzer Z, Prendergast FG, Naylor S & Kumar R (2002). The metal binding properties of DREAM. Evidence for calcium-mediated changes in DREAM structure. J Biol Chem 277, 10955-10966.
48. + channel in a lipid bilayer. Science 306, 491-495.
49. Deal KK, England SK & Tamkum MM (1996). Molecular physiology of cardiac potassium channels. Physiol Rev 76, 49-67.
50. de Bakker JMT & Opthof T (2002). Is the apico-basal gradient larger than the transmural gradient? J Cardiovas Pharm 39, 328-331.
51. Decher N, Barth AS, Gonzalez T, Steinmyer K & Sanguinetti MC (2004). Novel KChIP2isoforms increase functional diversity of transient outward potassium current. J Physiol 557, 761-772.
52. Decher N, Uyguner O, Scherer CR, Karaman B, Yüskelapak M, Busch AE, Steinmeyer K & Wollnik B (2001). hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant. Cardiovas Res 52, 255-264.
53. Deck KA & Trautwein W (1964). Ionic currents in cardiac excitation. Pflugers Arch 280, 63-80.
54. + channel behaves like an open-channel blocker. Neuron 7, 743-753.
55. to? Circulation 106, 423-429.
56. Deschênes I & Tomaselli GF (2002). Modulation of Kv4.3 current by accessory subunits. FEBS Lett 528, 183-188.
57. to1 in cardiac electrogenesis. Br J Pharmacol 126, 251-263.
58. Dixon JE & McKinnon D (1994). Quantitative analysis of mRNA expression in atrial and ventricular muscle of rats. Circ Res 79, 659-668.
59. Dixon JE, Shi W, Wang H-S, MacDonald CYuH, Wymore R, Cohen IS & McKinnon D (1996). Role of the Kv4.3 potassium channel in ventricular muscle: a molecular correlate for the transient outward current. Circ Res 79, 659-668.
60. + conduction and selectivity. Science 280, 69-77.
61. + channels. J Memb Biol 188, 73-86.
62. Favre J-F, Calmels TPG, Rouanet S, Javré J-L, Cheval B & Bril A (1999). Characterization of Kv4.3 in HEK 293 cells: comparison with the rate ventricular transient outward potassium current. Cardiovasc Res 41, 188-199.
63. Fedida D, Braun AP & Giles WR (1993). Alpha-1 adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiol Rev 73, 469-487.
64. Fedida D & Giles WR (1991). Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle. J Physiol 442, 191-209.
65. Franqueza L, Valenzuela C, Eck J, Tamkun MM, Tamargo J & Snyders DJ (1999). Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line. Cardiovasc Res 41, 212-219.
66. Gandhi CS & Isacoff EY (2002). Molecular models of voltage sensing. J General Physiol 120, 455-463.
67. Gebauer M, Isbrandt D, Sauter K, Callsen B, Nolting A, Pongs O & Bähring R (2004). N-type inactivation features of Kv4.2 channel gating. Biophys J 56, 210-223.
68. Giles W & Imaizumi Y (1988). Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol 405, 123-145.
69. Glauner KS, Mannuzzu LM, Gandhi CS & Isacoff EY (1999). Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel. Nature 402, 813-817.
70. to1 in shaping action potential morphology and duration. Circ Res 87, 1026-1033.
71. + channel beta subunit. Cell 97, 943-952.
72. + current diversity in mouse ventricular myocytes. J Physiol 521, 587-599.
73. to,s: early afterdepolarizations, atrioventricular block, and ventricular arrhythmia in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit. Circ Res 87, 73-79.
74. + current. Circ Res 90, 586-593.
75. + currents in the mammalian myocardium by neuronal calcium sensor-1. J Biol Chem 277, 26436-26443.
76. Gussack I & Antzelevitch C (2003). Cardiac Repolarization. Humana Press, Totowa, NJ, USA.
77. Han W, Bao W, Wang Z & Nattel S (2002a). Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle. Circ Res 91, 790-797.
78. Han W, Wang C & Nattel S (2000). A comparison of transient outward currents in canine cardiac Purkinje cells and ventricular myocytes. Am J Physiol 279, H466-H474.
79. Han W, Zhang L, Schram G & Nattel S (2002b). Properties of potassium currents in Purkinje cells of failing human hearts. Am J Physiol 283, H2495-H2503.
80. + current in the Kv4 channel subfamily. J Biol Chem 279, 5450-5459.
81. + channel signature sequence. Biophys J 66, 1061-1067.
82. Hille B (2001a). Gating mechanisms: kinetic thinking. Ion Channels of Excitable Membranes, 3rd edn, pp. 575-602. Sinauer Associates, Inc., Sunderland, MA, USA.
83. Hille B (2001b). Classic mechanisms of block. Ion Channels of Excitable Membranes, 3rd edn, pp. 503-537. Sinauer Associates, Inc., Sunderland, MA, USA.
84. Hodgkin AL & Huxley AF (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117, 500-544.
85. Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS & An WF (2002). Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. Proc Natl Acad Sci U S A 99, 1035-1040.
86. Holmqvist MH, Cao J, Knoppers MH, Jurman ME, Distefano PS, Rhodes KJ, Xie Y & An WF (2001). Kinetic modulation of Kv4-mediated A-current by arachidonic acid is dependent on potassium channel interacting proteins. J Neurosci 21, 4154-4161.
87. Hoshi T, Zagotta WN & Aldrich RW (1990). Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250, 533-538.
88. + channels: effects of alterations in the carboxy-terminal region. Neuron 7, 547-556.
89. Huelsing DJ, Spitzer KW & Pollard AE (2003). Spontaneous activity induced in rabbit Purkinje myocytes during coupling to a depolarized model cell. Cardiovasc Res 59, 620-627.
90. Ikura M (1996). Calcium binding and conformational response in EF-hand proteins. Trends Biochem Sci 21, 14-17.
91. Iyer V, Mazhari R & Winslow RL (2004). A computational model of the human left-ventricular epicardial myocyte. Biophys J 87, 1507-1525.
92. + channel inactivation mediated by the concerted action of the cytoplasmic N- and C-terminal domains. Biophys J 72, 163-174.
93. Jerng H, Qian Y & Pfaffinger PJ (2004). Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys J 87, 2380-2396.
94. Jerng HH, Shahidulla M & Corvarrubias M (1999). Inactivation gating of Kv4 potassium channels. Molecular interactions involving the inner vestibule of the pore. J General Physiol 113, 641-660.
95. + channels expressed in Xenopus oocytes. J Physiol 549, 683-695.
96. + channel. Nature 423, 33-41.
97. + channel. Nature 423, 42-48.
98. + channels in an open conformation. Nature 430, 806-810.
99. Kääb S, Dixon J, Duc J, Ashen D, Näbaeur M, Beuckelmann DJ, Steinbeck G, McKinnon D & Tomaselli GF (1998). Molecular basis of transient outward potassium current down regulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98, 1383-1393.
100. to channels: Kv4.2-KChIP2 complexes carry four subunits of each type. J Biol Chem 279, 5549-5554.
101. to: Kv4.2-KChIP2 ion channels by electron microscopy at 21 Å resolution. Neuron 41, 513-519.
102. to and confers susceptibility to ventricular tachycardia. Cell 107, 801-813.
103. + channels. Am J Physiol 278, C931-C941.
104. Laine M, Lin MA, Bannister JP, Silverman WR, Mock AF, Roux B & Papazian DM (2003). Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron 39, 467-481.
105. Laine M, Papazian DM & Roux B (2004). Critical assessment of a proposed model of Shaker. FEBS Lett 564, 257-263.
106. + channel S4. Neuron 16, 387-397.
107. Lee S-Y & MacKinnon R (2004). A membrane access mechanism for ion channel inhibition by voltage sensor toxins from spider venom. Nature 430, 232-235.
108. +: evidence for transmembrane communication. Am J Physiol 284, H71-H80.
109. to in ventricle. Am J Physiol 286, H1901-H1909.
110. Linse S & Forsén (1995). Determinants that govern high-affinity calcium binding. In Calcium Regulation of Cellular Function, ed. Means AR, pp. 89-151. Raven Press, Ltd, New York.
111. Liu DW, Gintant GA & Antzelevitch C (1993). Ionic bases for electrophysiological distinctions among epicardial, midmyocardial and endocardial myocytes from the free wall of the canine left ventricle. Circ Res 72, 671-687.
112. London B (2001). Cardiac arrhythmias: from (transgenic) mice to men. J Cardiovasc Electrophysiol 12, 1089-1092.
113. London B, Wang DW, Hill JA & Bennet PB (1998b). The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physiol 509, 171-182.
114. + channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily. Cell 79, 1133-1135.
115. to: Kv1.4 redux. Circ Res 84, 620-622.
116. MacKinnon R (2003). Potassium channels. FEBS Lett 555, 62-65.
117. Mannuzzu LM, Moronne MM & Isacoff EY (1996). Direct physical measure of conformational rearrangement underlying potassium channel gating. Science 271, 213-216.
118. Morales MJ, Castellino RC, Crews AL, Rasmusson RL & Strauss HC (1995). A novel β subunit increases rate of inactivation of specific voltage-gated channel α subunits. J Biol Chem 270, 6272-6277.
119. Näbauer M, Beuckelmann DJ, Überfuhr P & Steinbeck G (1996). Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93, 168-177.
120. + channel-modifying factor. J Physiol 537, 801-809.
121. + channels. Neuron 37, 449-461.
122. +-currents. Proc Natl Acad Sci U S A 98, 12808-12813.
123. Nef P (1996). Neuron specific calcium sensors (the NCS subfamily). In Guidebook to the Calcium-Binding Proteins, ed.Celio, MR, Pauls T & Schwaller B, pp. 94-98. Oxford University Press, Oxford.
124. + channel diversity in the mammalian myocardium. J Physiol 525, 285-298.
125. + channel diversity and functioning in the mammalian heart. In Handbook of Physiology, section 2, The Cardiovascular System, vol. I, The Heart, ed. Page E, Fozzard HA & Solaro RJ, pp. 568-594. Oxford University Press, New York.
126. Nerbonne JM (2004). Studying cardiac arrhythmias in the mouse - a reasonable model for probing mechanisms? Trends Cardiovas Med 14, 83-93.
127. Nerbonne JM & Kass RS (2003). Physiology and molecular biology of ion channels contributing to ventricular repolarization. In Cardiac Repolarization, ed. Gussack I & Antzelevitch C, pp. 25-62. Humana Press, Totowa, New Jersey.
128. Norton RS & Pallaghy PK (1998). The cysteine knot structure of ion channel toxins and related polypeptides. Toxicon 36, 1573-1583.
129. + channel interacting protein 2. Biochem Biophys Res Com 282, 96-102.
130. to) in normal and diseased myocardium. J Mol Cell Cardiol 33, 851-872.
131. + channels. In Potassium Channels in Cardiovascular Biology, ed. Archer SL & Rusch NJ, pp. 387-426. Kluwer Academic/Plenum Pubishers, New York.
132. Patel SP, Campbell DL & Strauss HC (2002b). Elucidating KChIP effects on Kv4.3 inactivation and recovery kinetics with a minimal KChIP2 isoform. J Physiol 545 1, 5-11.
133. Patel SP, Campbell DL, Morales MJ & Strauss HC (2002a). Heterogeneous expression of KChIP2 isoforms in the ferret heart. J Physiol 539, 649-656.
134. Patel SP, Parai R, Parai R & Campbell DL (2004). Regulation of Kv4.3 voltage-dependent gating kinetics by KChIP2 isoforms. J Physiol 557, 19-41.
135. + channels. Physiol Rev 71, 1047-1080.
136. 2 sensitivity to Kv4.2 but not Shaker channels. J General Physiol 113, 897-907.
137. + currents in mammalian cell lines and cardiac myocytes. Pflugers Arch 437, 381-392.
138. Po S, Snyders DJ, Baker R, Tamkun MM & Bennet PB (1992). Functional expression of an inactivating potassium channel cloned from human heart. Circ Res 71, 732-736.
139. Pourrier M, Herrera D, Caballero R, Schram G, Wang Z & Nattel S (2004). The Kv4.2 N-terminal restores fast inactivation and confers KChIP2 modulatory effects on N-terminal-deleted Kv1.4 channels. Pflugers Arch 449, 235-247.
140. Puglisi JL & Bers DM (2001). LabHEART: an interactive computer model of rabbit ventricular myocyte ion channel and Ca transport. Am J Physiol 281, C2049-C2060.
141. Puglisi JL, Wang F & Bers DM (2004). Modeling the isolated cardiac myocyte. Prog Biophys Mol Biol 85, 28-38.
142. + channel (Kv1.4) expressed in Xenopus oocytes. J Physiol 489, 709-721.
143. + channels. Circ Res 20, 739-750.
144. + channel (Kv1.4) cloned from ferret ventricle and expressed in Xenopus oocytes. J Physiol 485, 59-71.
145. Ren X, Shand SH & Takimoto K (2003). Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide. J Biol Chem 278, 43564-45570.
146. + channels. In Potassium Channels in Cardiovascular Biology, ed. Archer SL & Rusch SJ, pp. 195-217. Kluwer Academic/Plenum Publishers, New York.
147. 2+/calmodulin-dependent protein kinase. J Neurosci 17, 3379-3391.
148. Rosati B, Grau F, Rodriguez S, Li H, Nerbonne JM & McKinnon D (2003). Concordant expression of KChIP2 mRNA, protein, and transient outward current throughout the canine ventricle. J Physiol 548, 815-822.
149. Rosati B, Pan Z, Lypen S, Wang H-S, Cohen I, Dixon JE & McKinnon D (2001). Regulation of KChIP2 potassium channel β subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533, 119-125.
150. Rudy Y (2002). The cardiac ventricular action potential. In Handbook of Physiology, section 2, the Cardiovascular System, vol. I, The Heart, ed. Page E, Fozzard H A & Solaro RJ, pp. 531-547. Oxford University Press, New York.
151. A channels reopen during recovery from inactivation. Nature 353, 657-660.
152. A channels by cysteine oxidation. Nature 352, 711-714.
153. Ruta V & MacKinnon R (2004). Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry 43, 10071-100079.
154. to). J Physiol 546, 5-18.
155. Sanguinetti MC & Bennett PB (2003). Antiarrhythmic drug target choices and screening. Circ Res 93, 491-499.
156. Sanguinetti MC, Johnson JH, Hammerland LG, Kelbaugh PR, Volkmann RA, Saccomano NA & Mueller AL (1997). Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol 51, 491-498.
157. + channels regulate binding to and modulation by KChIP1. Neuron 41, 587-598.
158. + channel. Neuron 35, 935-949.
159. Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ & Sweatt JD (2002). PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. J Neurosci 22, 10123-10133.
160. + channels operating at subthreshold potentials with unique expression in heart and brain. J Neurophysiol 75, 2174-2179.
161. Shahidullah M & Covarrubias M (2003). The link between ion permeation and inactivation gating of Kv4 potassium channels. Biophys J 84, 928-941.
162. Shiau Y-S, Haung P-T, Liou H-H, Liaw Y-C, Shiau Y-Y & Lou K-L (2003). Structural basis of binding and inhibition of novel tarantula toxins in mammalian voltage-dependent potassium channels. Chem Res Toxicol 16, 1217-1225.
163. Shimoni Y, Severson D & Giles W (1995). Thyroid status and diabetes modulate regional differences in potassium currents in rat ventricle. J Physiol 488, 673-688.
164. Sokolova O (2004). Structure of cation channels, revealed by single particle electron microscopy. FEBS Lett 564, 251-256.
165. Sokolova O, Kolmakova-Partensky L & Gigorieff N (2001). Three dimensional structure of a voltage-gated potassium channel at 2.5 nm resolution. Structure 9, 215-220.
166. + channel. J General Physiol 117, 469-490.
167. Starace DM & Bezanilla F (2004). A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature 427, 548-553.
168. + channel. Neuron 19, 1319-1327.
169. Strauss HC, Morales MJ, Wang S, Brahmajothi MV & Campbell DL
170. Strauss HC & Rasmusson RL (2002). Restitution, ventricular fibrillation, and drugs: where are we now? J Cardiovas Electrophysiol 13, 915-917.
171. + channels. Neuron 18, 675-682.
172. Taggart P, Sutton P, Opthof T, Coronel R & Kallis K (2003). Electrotonic cancellation of transmural electrical gradients in the left ventricle in man. Prog Biophys Mol Bio 82, 243-254.
173. + channel cDNAs from human ventricle. FASEB J 5, 331-337.
174. Tombola F, Pathak MM & Isacoff EY (2005). Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron 45, 379-388.
175. Tseng GN, Jiang M & Yao JA (1996). Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. J Pharmacol Exp Ther 279, 865-876.
176. Tseng-Crank JCL, Tseng G-N, Schwartz A & Tanouye MA (1990). Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library. FEBS Lett 268, 63-68.
177. Van Wagoner DR & Nerbonne JM (2001). Molecular mechanisms of atrial fibrillation. In Heart Physiology and Pathophysiology, 4th edn, ed. Sperelakis N, Kurachi Y, Terzic A & Cohen MV, pp. 1107-1124. Academic Press, San Diego.
178. Varro A, Lathrop DA, Hester SB, Nanasi PP & Papp JG (1993). Ionic currents and action potentials in rabbit, rat and guinea pig ventricular myocytes. Basic Res Cardiol 88, 93-102.
179. + channel. Proc Biol Sci 248, 9-18.
180. + current in cells exhibiting the hyperpolarization-activated current. Cardiovascular Res 52, 517-518.
181. Wada K, Yokotani N, Hunter C, Doi K, Wenthold J & Shimaski S (1992). Differential expression of two distinct forms of mRNA encoding members of a depeptidyl aminopeptidase family. Proc Natl Acad Sci U S A 89, 197-201.
182. o dependence. J Physiol 557, 105-717.
183. Wang S, Patel SP, Qu Y, Hua P, Strauss HC & Morales MJ (2002). Kinetic properties of Kv4.3 and their modulation by KChIP2b. Biochem Biophys Res Comm 293, 223-229.
184. + channel regulatory protein, KChAP. J Biol Chem 273, 11745-11751.
185. + channel subunit in the mouse heart. Circ Res 85, 1067-1076.
186. Winslow RL, Contassa S & Greenstein JL (2005). Using models of the myocyte for functional interpretation of cardiac proteomic data. J Physiol 563, 73-81.
187. Winslow RL, Scollan DF, Holmes A, Yung CK, Zhaang J & Jafri MS (2000). Electrophysiological modeling of cardiac ventricular function: from cell to organ. Ann Rev Biomed Eng 2, 119-155.
188. Wissmann R, Bildl W, Oliver D, Beyermann M, Kalbitzer H-R, Bentrop D & Fakler B (2003). Solution structure and function of the 'tandem inactivation domain' of neuronal A-type potassium channel Kv1.4. J Biol Chem 278, 16142-16150.
189. + currents in adult mouse ventricular myocytes. J General Physiol 113, 661-677.
190. Yang E-K, Alvira MR, Levitan ES & Takimoto K (2001). Kvβ subunits increase expression of Kv4.3 channels by interacting with their C termini. J Biol Chem 276, 4839-4844.
191. Yellen G (1998). The moving parts of voltage-gated ion channels. Quart Rev Biophys 31, 239-295.
192. Yellen G (2002). The voltage-gated potassium channels and their relatives. Nature 419, 35-42.
193. Yeola SW & Snyders DJ (1997). Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current. Cardiovas Res 33, 540-547.
194. Zagotta WN, Hoshi T & Aldrich RW (1990). Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived ftom ShB. Science 250, 568-571.
195. Zhang M, Jiang M & Tseng GN (2001). MinK-related peptide associates with Kv4.2 and modulates its function: potential role as beta subunit of cardiac transient outward channel? Circ Res 88, 1012-1019.
196. + channels. Neuron 41, 573-586.
197. + currents in the heart. Am J Physiol 285, H1641-H1649.
198. Zicha S, Xiao L, Stafford S, Cha TJ, Han W, Varro A & Nattel S (2004). Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. J Physiol 561, 735-748.