Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: Role of repolarization reserve

British Journal of Pharmacology

Volumn 137, Issue 3, 2002, Pages 361-368

  Biliczki, Péter ^a   Virág, László ^a   Iost, Norbert ^b   Papp, Julius Gy ^a,b   Varró, András ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Action potential duration; Chromanol 293B; Dofetilide; Potassium channels; Proarrhythmia; Repolarization reserve

Indexed keywords

6 CYANO 4 (N ETHYLSULFONYL N METHYLAMINO) 3 HYDROXY 2,2 DIMETHYLCHROMANE; 6-CYANO-4-(N-ETHYLSULFONYL-N-METHYLAMINO)-3-HYDROXY-2,2-DIMETHYLCHROMANE; BARIUM CHLORIDE; BARIUM DERIVATIVE; CHLORIDE; CHROMAN DERIVATIVE; DOFETILIDE; PHENETHYLAMINE DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SULFONAMIDE; CHROMANOL 293B; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL; ARTICLE; COMPARATIVE STUDY; CYTOLOGY; DOG; DRUG EFFECT; ELECTRIC CONDUCTIVITY; FEMALE; HEART MUSCLE CELL; HEART VENTRICLE; IN VITRO STUDY; MALE; PATCH CLAMP; PHYSIOLOGY; AFTERDISCHARGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SPECIFICITY; ELECTRIC CURRENT; HEART PROARRHYTHMIA; HEART REPOLARIZATION; HEART VENTRICLE WALL; INHIBITION KINETICS; MICROELECTRODE; MUSCLE CELL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

ACTION POTENTIALS; ANIMALS; BARIUM COMPOUNDS; CHLORIDES; CHROMANS; DOGS; ELECTRIC CONDUCTIVITY; FEMALE; HEART VENTRICLES; MALE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SULFONAMIDES;

EID: 0036790560     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704881     Document Type: Article

References (26)

1. Antzelevitch, C., Sun, Z.Q., Zhang, Z.Q. & Yan, G.X. (1996). Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes. J. Am. Coll. Cardiol., 28, 1836-1848.
2. + current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc. Res., 38, 441-450.
3. Brendorp, B., Elming, H., Jun, L., Kober, L., Malik, M., Jensen, G.B. & Torp-Pedersen, C. (2001). The Diamond Study Group. QTc interval as a guide to select those patients with congestive heart failure and reduced left ventricular systolic function who will benefit from antiarrhythmic treatment with dofetilide. Circulation, 103, 1422-1427.
4. Ks in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations. J. Cardiovasc. Electrophysiol., 13, 172-177.
5. sK channels by the chromanol 293B. Pflügers Archiv-Eur. J. Physiol., 432, 1094-1096.
6. + channels and drug-acquired long QT syndrome. Therapie, 55, 185-193.
7. + channels. J. Cardiovasc. Pharmacol., 30, 42-54.
8. Gintant, G.A., Limberis, J.T., McDermott, J.S., Wegner, C.D. & Cox, B.F. (2001). The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis. J. Cardiovasc. Pharmacol., 37, 607-618.
9. Kääb, S., Nuss, H.B., Chiamvimonvart, N., O'Rourke, B., Kass, D.A., Marban, E. & Tomaselli, G.F. (1996). Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ. Res., 78, 262-273.
10. + channels from guineapig cardiomyocytes. J. Physiol., 532, 115-126.
11. Näbauer, M. & Kääb, S. (1998). Potassium channel down-regulation in heart failure. Cardiovasc. Res., 37, 324-334.
12. Pinney, S.P., Koller, B.S., Franz, M.R. & Woosley, R.L. (1995). Terfenadine increases the QT interval in isolated guinea pig heart. J. Cardiovasc. Pharmacol., 25, 30-40.
13. Priori, S.G., Bloise, R. & Crotti, L. (2001). The long QT syndrome. Europace, 3, 16-27.
14. Priori, S.G., Napolitano, C., Bloise, R. & Schwartz, P.J. (1998). Low penetrance in the long QT syndrome: the importance of molecular diagnosis. Eur. Heart J., 19 (Abstract suppl.), 424.
15. + channel Kvl.5 by the antibiotic erythromycin. Naunyn-Schmiedebergs Arch. Pharmacol., 355, 743-750.
16. Roden, D.M. (1998). Taking the "idio" out of "idiosyncratic": Predicting torsades de pointes. PACE, 21, 1029-1034.
17. Roden, D.M., Lazzara, R., Rosen, M., Schwartz, P.J., Towbin, J. & Vincent, G.M., for the SADS Foundation Task Force on LQTS. (1996). Multiple mechanisms in the long-QT syndrome current knowledge, gaps, and future directions. Circulation, 94, 1996-2012.
18. Singh, B.N. & Vaughan Williams, E.M. (1970). A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474. Br. J. Pharmacol., 39, 675-687.
19. Sun, Z.Q., Thomas, G.P. & Antzelevitch, C. (2001). Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J. Cardiovasc. Electrophysiol., 12, 472-478.
20. Swan, H., Saarinen, K., Kontula, K., Toivonen, L. & Viitasalo, M. (1998). Evaluation of QT interval duration and dispersion and proposed clinical criteria in diagnosis of long QT syndrome in patients with a genetically uniform type of LQT1. J. Am. Coll. Cardiol., 32, 486-491.
21. Tomaselli, G.F. & Marban, E. (1999). Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc. Res., 42, 270-283.
22. Ks in dog ventricular muscle and Purkinje fibre repolarization. J. Physiol., 523, 67-81.
23. Verduyn, S.C., Vos, M.A., van der Zande, J., van der Hulst, F.F. & Wellens, H.J. (1997). Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: reversal by magnesium. Cardiovasc. Res., 34, 453-463.
24. + currents in dog with chronic complete atrioventricular block and acquired torsades de pointes. Circulation, 100, 2455-2461.
25. Vos, M.A., Verduyn, S.C., Gorgels, A.P.M., Lipcsei, G.C. & Wellens, H.J.J. (1995). Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation, 91, 846-872.
26. Weerapura, M., Nattel, S., Courtemanche, M., Doern, D., Ethier, N. & Hébert, T.E. (2000). State-dependent barium block of wild-type and inactivation-deficient HERG channels in Xenopus oocytes. J. Physiol., 526, 265-278.