Pharmacologically induced long qt type 2 can be rescued by activation of iks with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes

Journal of Cardiovascular Pharmacology

Volumn 54, Issue 2, 2009, Pages 169-177

  Nissen, Jakob Dahl ^a   Diness, Jonas Goldin ^a,b   Diness, Thomas Goldin ^a   Hansen, Rie Schultz ^b   Grunnet, Morten ^a,b   Jespersen, Thomas ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

Author keywords

Isolated guinea pig cardiomyocytes; Kv11.1; Kv7.1; Long QT syndrome 2; Mink; Ventricular arrhythmia

Indexed keywords

1,3 DIHYDRO 5 (2 FLUOROPHENYL) 3 (1H INDOL 3 YLMETHYL) 1 METHYL 2H 1,4 BENZODIAZEPIN 2 1; 1,3 DIHYDRO 5 (2 FLUOROPHENYL) 3 (1H INDOL 3 YLMETHYL) 1 METHYL 2H 1,4 BENZODIAZEPIN 2 ONE; BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; GUINEA PIG; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART PACING; HEART REPOLARIZATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT PROLONGATION; RISK REDUCTION;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZODIAZEPINES; DELAYED RECTIFIER POTASSIUM CHANNELS; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; FEMALE; GUINEA PIGS; HEART VENTRICLES; LONG QT SYNDROME; MYOCYTES, CARDIAC;

EID: 74249116161     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181af6db3     Document Type: Article

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