Gender disparity in cardiac electrophysiology: Implications for cardiac safety pharmacology

Pharmacology and Therapeutics

Volumn 127, Issue 1, 2010, Pages 9-18

  Jonsson, M K B ^a   Vos, M A ^a   Duker, G ^b   Demolombe, S ^c   van Veen, T A B ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ASTRAZENECA R AND D   (Sweden)

^c INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Arrhythmias; Cardiac electrophysiology; Gender difference; Long QT; Sex hormones

Indexed keywords

ANDROGEN; ESTROGEN; PROGESTERONE; SEX HORMONE; TESTOSTERONE;

DRUG SAFETY; ELECTROCARDIOGRAM; EMBRYONIC STEM CELL; GENE EXPRESSION REGULATION; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; INHERITANCE; ION TRANSPORT; LONG QT SYNDROME; MENSTRUAL CYCLE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; SIGNAL TRANSDUCTION; TESTOSTERONE BLOOD LEVEL; TORSADE DES POINTES; ADVERSE DRUG REACTION; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; FEMALE; GENE EXPRESSION; GENETICS; HEART; MALE; PHYSIOLOGY; RISK FACTOR; SEXUAL DEVELOPMENT;

ANIMALS; ARRHYTHMIAS, CARDIAC; DRUG TOXICITY; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; GENE EXPRESSION; GONADAL STEROID HORMONES; HEART; HUMANS; MALE; PHARMACEUTICAL PREPARATIONS; RISK FACTORS; SEX CHARACTERISTICS; TORSADES DE POINTES; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS;

EID: 77953543840     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2010.04.002     Document Type: Review

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