Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes

Circulation Research

Volumn 103, Issue 7, 2008, Pages 733-742

  Xiao, Ling ^a,b   Coutu, Pierre ^a   Villeneuve, Louis R ^a   Tadevosyan, Artavazd ^a   Maguy, Ange ^a   Le Bouter, Sabrina ^a   Allen, Bruce G ^a,b   Nattel, Stanley ^a,b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Arrhythmias; Calcium; Calmodulin; Potassium channels; Remodeling

Indexed keywords

A 7; CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CALMODULIN; CALMODULIN INHIBITOR; CYCLOSPORIN A; INCA 6; KV CHANNEL INTERACTING PROTEIN; KV CHANNEL INTERACTING PROTEIN 2; MESSENGER RNA; N (4 AMINOBUTYL) 5 CHLORO 2 NAPSYLAMIDE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NIMODIPINE; PHOSPHOLAMBAN; POTASSIUM CHANNEL KV1.4; POTASSIUM CHANNEL KV4.3; QUINONE DERIVATIVE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THREONINE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT3; UNCLASSIFIED DRUG; VALSARTAN; VOLTAGE GATED POTASSIUM CHANNEL; CALCIUM; CALCIUM BINDING PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE INHIBITOR; SHAL POTASSIUM CHANNEL; SODIUM CALCIUM EXCHANGE PROTEIN; TRANSCRIPTION FACTOR NF AT C3; TRANSCRIPTION FACTOR NF-AT C3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DOWN REGULATION; ENZYME ACTIVITY; HEART LEFT VENTRICLE MUSCLE; HEART MUSCLE CELL; MALE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SODIUM CALCIUM EXCHANGE; ACTIVE TRANSPORT; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; CELL NUCLEUS; DRUG ANTAGONISM; DRUG EFFECT; HEART VENTRICLE; ION TRANSPORT; METABOLISM; PHOSPHORYLATION; SARCOPLASMIC RETICULUM; TACHYCARDIA;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CALCINEURIN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL NUCLEUS; CELLS, CULTURED; DOGS; HEART VENTRICLES; ION TRANSPORT; KV CHANNEL-INTERACTING PROTEINS; MYOCYTES, CARDIAC; NFATC TRANSCRIPTION FACTORS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SARCOPLASMIC RETICULUM; SHAL POTASSIUM CHANNELS; SODIUM-CALCIUM EXCHANGER; TACHYCARDIA;

EID: 54449101791     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.171157     Document Type: Article

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