Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: Implications for reverse rate dependency

British Journal of Pharmacology

Volumn 156, Issue 7, 2009, Pages 1076-1084

  Virág, László ^a   Acsai, Károly ^a,b   Hála, Ottó ^a   Zaza, Antonio ^c   Bitay, Miklós ^a   Bogáts, Gábor ^a   Papp, Julius Gy ^a,b   Varró, András ^a,b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Action potential duration; Antiarrhythmic drugs; Cardiac electrophysiology; I K1; I Kr; Reverse rate dependency

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; BARIUM CHLORIDE; CEVADINE; DELAYED RECTIFIER POTASSIUM CHANNEL; DOFETILIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; HUMAN CELL; MALE; MICROELECTRODE; NONHUMAN; PATCH CLAMP; POSITIVE FEEDBACK; POTASSIUM CURRENT; PRIORITY JOURNAL; ACTION POTENTIAL; ANIMAL; DOG; IN VITRO STUDY; PHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; DELAYED RECTIFIER POTASSIUM CHANNELS; DOGS; FEMALE; HUMANS; MALE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 67650684262     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00116.x     Document Type: Article

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