Aß internalization by neurons and glia

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Posse De Chaves, Elena ^a   Mohamed, Amany ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALPHA 2 MACROGLOBULIN; ALPHA SECRETASE; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; APOLIPOPROTEIN E4; CHOLERA TOXIN B SUBUNIT; CLATHRIN; CLUSTERIN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3B; FORMYLPEPTIDE RECEPTOR LIKE 1; INTEGRIN; LEUCINE RICH REPEAT KINASE 2; MEMANTINE; NICOTINIC RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEASOME; PROTEIN; TOLL LIKE RECEPTOR;

ALZHEIMER DISEASE; ASTROCYTE; CARBOXY TERMINAL SEQUENCE; ENDOCYTOSIS; EXTRACELLULAR SPACE; GLIA; GLIOBLASTOMA; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; INTERNALIZATION; MICROGLIA; MULTIVESICULAR BODY; NERVE CELL; NERVE CELL NECROSIS; NEUROBLASTOMA; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW;

EID: 79953280394     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/127984     Document Type: Review

References (216)

1. Minati L., Edginton T., Grazia Bruzzone M., Giaccone G., Reviews: current concepts in alzheimer's disease: a multidisciplinary review American Journal of Alzheimer's Disease and other Dementias 2009 24 2 95 121
2. Selkoe D. J., Alzheimer's disease: genes, proteins, and therapy Physiological Reviews 2001 81 2 741 766 (Pubitemid 32267077)
3. Hardy J., Allsop D., Amyloid deposition as the central event in the aetiology of Alzheimer's disease Trends in Pharmacological Sciences 1991 12 10 383 388
4. Hardy J. A., Higgins G. A., Alzheimer's disease: the amyloid cascade hypothesis Science 1992 256 5054 184 185
5. Selkoe D. J., The molecular pathology of Alzheimer's disease Neuron 1991 6 4 487 498
6. Wirths O., Multhaup G., Bayer T. A., A modified -amyloid hypothesis: intraneuronal accumulation of the -amyloid peptidethe first step of a fatal cascade Journal of Neurochemistry 2004 91 3 513 520 (Pubitemid 39431147)
7. Gouras G. K., Almeida C. G., Takahashi R. H., Intraneuronal A accumulation and origin of plaques in Alzheimer's disease Neurobiology of Aging 2005 26 9 1235 1244 (Pubitemid 41338539)
8. Cuello A. C., Intracellular and extracellular A, a tale of two neuropathologies Brain Pathology 2005 15 1 66 71 (Pubitemid 40224068)
9. LaFerla F. M., Green K. N., Oddo S., Intracellular amyloid- in Alzheimer's disease Nature Reviews Neuroscience 2007 8 7 499 509
10. Aho L., Pikkarainen M., Hiltunen M., Leinonen V., Alafuzoff I., Immunohistochemical visualization of amyloid- protein precursor and amyloid- in extra- and intracellular compartments in the human brain Journal of Alzheimer's Disease 2010 20 4 1015 1028
11. Gouras G. K., Tampellini D., Takahashi R. H., Capetillo-Zarate E., Intraneuronal -amyloid accumulation and synapse pathology in Alzheimer's disease Acta Neuropathologica 2010 119 5 523 541
12. Gouras G. K., Tsai J., Naslund J., Vincent B., Edgar M., Checler F., Greenfield J. P., Haroutunian V., Buxbaum J. D., Xu H., Greengard P., Relkin N. R., Intraneuronal A 42 accumulation in human brain American Journal of Pathology 2000 156 1 15 20
13. D'Andrea M. R., Nagele R. G., Wang H. Y., Peterson P. A., Lee D. H. S., Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease Histopathology 2001 38 2 120 134 (Pubitemid 32193626)
14. Wegiel J., Kuchna I., Nowicki K., Frackowiak J., Mazur-Kolecka B., Imaki H., Wegiel J., Mehta P. D., Silverman W. P., Reisberg B., deLeon M., Wisniewski T., Pirttilla T., Frey H., Lehtimki T., Kivimki T., Visser F. E., Kamphorst W., Potempska A., Bolton D., Currie J. R., Miller D. L., Intraneuronal A immunoreactivity is not a predictor of brain amyloidosis- or neurofibrillary degeneration Acta Neuropathologica 2007 113 4 389 402 (Pubitemid 46421628)
15. Bayer T. A., Wirths O., Intracellular accumulation of amyloid-Betaa predictor for synaptic dysfunction and neuron loss in Alzheimer's disease Frontiers in Aging Neuroscience 2010 2 8
16. Tampellini D., Gouras G. K., Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease Frontiers in Aging Neuroscience 2010 2
17. Cuello A. C., Canneva F., Impact of intracellular -amyloid in transgenic animals and cell models Neurodegenerative Diseases 2008 5 3-4 146 148 (Pubitemid 351347834)
18. Oddo S., Caccamo A., Shepherd J. D., Murphy M. P., Golde T. E., Kayed R., Metherate R., Mattson M. P., Akbari Y., LaFerla F. M., Triple-transgenic model of Alzheimer's Disease with plaques and tangles: intracellular A and synaptic dysfunction Neuron 2003 39 3 409 421 (Pubitemid 36937044)
19. Billings L. M., Oddo S., Green K. N., McGaugh J. L., LaFerla F. M., Intraneuronal A causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice Neuron 2005 45 5 675 688 (Pubitemid 40320703)
20. Oddo S., Billings L., Kesslak J. P., Cribbs D. H., LaFerla F. M., A immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome Neuron 2004 43 3 321 332 (Pubitemid 39061125)
21. Wirths O., Bayer T. A., Neuron loss in transgenic mouse models of Alzheimer's disease International Journal of Alzheimer's Disease 2010 2010
22. Skovronsky D. M., Doms R. W., Lee V. M. Y., Detection of a novel intraneuronal pool of insoluble amyloid protein that accumulates with time in culture Journal of Cell Biology 1998 141 4 1031 1039 (Pubitemid 28243969)
23. Greenfield J. P., Tsai J., Gouras G. K., Hai B., Thinakaran G., Checler F., Sisodia S. S., Greengard P., Xu H., Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer -amyloid peptides Proceedings of the National Academy of Sciences of the United States of America 1999 96 2 742 747 (Pubitemid 29061279)
24. Takahashi R. H., Almeida C. G., Kearney P. F., Yu F., Lin M. T., Milner T. A., Gouras G. K., Oligomerization of Alzheimer's -amyloid within processes and synapses of cultured neurons and brain Journal of Neuroscience 2004 24 14 3592 3599 (Pubitemid 38481116)
25. Busciglio J., Pelsman A., Wong C., Pigino G., Yuan M., Mori H., Yankner B. A., Altered metabolism of the amyloid precursor protein is associated with mitochondrial dysfunction in Down's syndrome Neuron 2002 33 5 677 688 (Pubitemid 34219240)
26. Chui D. H., Dobo E., Makifuchi T., Akiyama H., Kawakatsu S., Petit A., Checler F., Araki W., Takahashi K., Tabira T., Apoptotic neurons in Alzheimer's disease frequently show intracellular A 42 labeling Journal of Alzheimer's Disease 2001 3 2 231 239 (Pubitemid 32566522)
27. Zhang Y., McLaughlin R., Goodyer C., LeBlanc A., Selective cytotoxicity of intracellular amyloid peptide142 through p53 and Bax in cultured primary human neurons Journal of Cell Biology 2002 156 3 519 529 (Pubitemid 34839899)
28. LaFerla F. M., Tinkle B. T., Bieberich C. J., Haudenschild C. C., Jay G., The Alzheimer's A peptide induces neurodegeneration and apoptotic cell death in transgenic mice Nature Genetics 1995 9 1 21 29
29. Casas C., Sergeant N., Itier J. M., Blanchard V., Wirths O., Van Der Kolk N., Vingtdeux V., Van De Steeg E., Ret G., Canton T., Drobecq H., Clark A., Bonici B., Delacourte A., Benavides J., Schmitz C., Tremp G., Bayer T. A., Benoit P., Pradier L., Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated A accumulation in a novel Alzheimer transgenic model American Journal of Pathology 2004 165 4 1289 1300 (Pubitemid 39297734)
30. Takahashi R. H., Milner T. A., Li F., Nam E. E., Edgar M. A., Yamaguchi H., Beal M. F., Xu H., Greengard P., Gouras G. K., Intraneuronal Alzheimer A 42 accumulates in multivesicular bodies and is associated with synaptic pathology American Journal of Pathology 2002 161 5 1869 1879 (Pubitemid 35265544)
31. Meyer-Luehmann M., Spires-Jones T. L., Prada C., Garcia-Alloza M., De Calignon A., Rozkalne A., Koenigsknecht-Talboo J., Holtzman D. M., Bacskai B. J., Hyman B. T., Rapid appearance and local toxicity of amyloid- plaques in a mouse model of Alzheimer's disease Nature 2008 451 7179 720 724 (Pubitemid 351220570)
32. Almeida C. G., Tampellini D., Takahashi R. H., Greengard P., Lin M. T., Snyder E. M., Gouras G. K., Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses Neurobiology of Disease 2005 20 2 187 198 (Pubitemid 41476246)
33. Tampellini D., Magran J., Takahashi R. H., Li F., Lin M. T., Almeida C. G., Gouras G. K., Internalized antibodies to the A domain of APP reduce neuronal A and protect against synaptic alterations Journal of Biological Chemistry 2007 282 26 18895 18906 (Pubitemid 47100144)
34. Echeverria V., Cuello A. C., Intracellular A-beta amyloid, a sign for worse things to come? Molecular Neurobiology 2002 26 2-3 299 316 (Pubitemid 35239806)
35. Gyure K. A., Durham R., Stewart W. F., Smialek J. E., Troncoso J. C., Intraneuronal A -amyloid precedes development of amyloid plaques in Down syndrome Archives of Pathology and Laboratory Medicine 2001 125 4 489 492 (Pubitemid 32291552)
36. Nslund J., Haroutunian V., Mohs R., Davis K. L., Davies P., Greengard P., Buxbaum J. D., Correlation between elevated levels of amyloid -peptide in the brain and cognitive decline Journal of the American Medical Association 2000 283 12 1571 1577 (Pubitemid 30161512)
37. Ohyagi Y., Tsuruta Y., Motomura K., Miyoshi K., Kikuchi H., Iwaki T., Taniwaki T., Kira J. I., Intraneuronal amyloid 42 enhanced by heating but counteracted by formic acid Journal of Neuroscience Methods 2007 159 1 134 138 (Pubitemid 44792267)
38. Tabira T., Chui D. H., Kuroda S., Significance of intracellular Abeta42 accumulation in Alzheimer's disease Front Biosci 2002 7 a44 49
39. Aoki M., Volkmann I., Tjernberg L. O., Winblad B., Bogdanovic N., Amyloid -peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain NeuroReport 2008 19 11 1085 1089
40. Bahr B. A., Hoffman K. B., Yang A. J., Hess U. S., Glabe C. G., Lynch G., Amyloid protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein Journal of Comparative Neurology 1998 397 1 139 147 (Pubitemid 28304057)
41. Glabe C., Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease Journal of Molecular Neuroscience 2001 17 2 137 145 (Pubitemid 33063518)
42. Friedrich R. P., Tepper K., Rnicke R., Soom M., Westermann M., Reymann K., Kaether C., Fndrich M., Mechanism of amyloid plaque formation suggests an intracellular basis of A pathogenicity Proceedings of the National Academy of Sciences of the United States of America 2010 107 5 1942 1947
43. Murphy G. M., Forno L. S., Higgins L., Scardina J. M., Eng L. F., Cordell B., Development of a monoclonal antibody specific for the COOH-terminal of -amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders American Journal of Pathology 1994 144 5 1082 1088
44. Oddo S., Caccamo A., Smith I. F., Green K. N., LaFerla F. M., A dynamic relationship between intracellular and extracellular pools of A American Journal of Pathology 2006 168 1 184 194 (Pubitemid 43062572)
45. Martin B. L., Schrader-Fischer G., Busciglio J., Duke M., Paganetti P., Yankner B. A., Intracellular accumulation of -amyloid in cells expressing the Swedish mutant amyloid precursor protein Journal of Biological Chemistry 1995 270 45 26727 26730 (Pubitemid 3007225)
46. Tienari P. J., Ida N., Ikonen E., Simons M., Weidemann A., Multhaup G., Masters C. L., Dotti C. G., Beyreuther K., Intracellular and secreted Alzheimer -amyloid species are generated by distinct mechanisms in cultured hippocampal neurons Proceedings of the National Academy of Sciences of the United States of America 1997 94 8 4125 4130 (Pubitemid 27180510)
47. Turner R. S., Suzuki N., Chyung A. S. C., Younkin S. G., Lee V. M.-Y., Amyloids 40 and 42 are generated intracellularly in cultured human neurons and their secretion increases with maturation Journal of Biological Chemistry 1996 271 15 8966 8970
48. Xia W., Zhang J., Ostaszewski B. L., Kimberly W. T., Seubert P., Koo E. H., Shen J., Selkoe D. J., Presenilin 1 regulates the processing of -amyloid precursor protein C- terminal fragments and the generation of amyloid -protein in endoplasmic reticulum and Golgi Biochemistry 1998 37 47 16465 16471 (Pubitemid 28543904)
49. Pierrot N., Ghisdal P., Caumont A. S., Octave J. N., Intraneuronal amyloid- 1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death Journal of Neurochemistry 2004 88 5 1140 1150 (Pubitemid 38280681)
50. Nathalie P., Jean-Nol O., Processing of amyloid precursor protein and amyloid peptide neurotoxicity Current Alzheimer Research 2008 5 2 92 99 (Pubitemid 351536335)
51. Soriano S., Chyung A. S. C., Chen X., Stokin G. B., Lee V. M. Y., Koo E. H., Expression of -amyloid precursor protein-CD3 chimeras to demonstrate the selective generation of amyloid/ and amyloid peptides within secretory and endocytic compartments Journal of Biological Chemistry 1999 274 45 32295 32300
52. Kimura N., Yanagisawa K., Terao K., Ono F., Sakakibara I., Ishii Y., Kyuwa S., Yoshikawa Y., Age-related changes of intracellular A in cynomolgus monkey brains Neuropathology and Applied Neurobiology 2005 31 2 170 180 (Pubitemid 40444918)
53. Wild-Bode C., Yamazaki T., Capell A., Leimer U., Steiner H., Ihara Y., Haass C., Intracellular generation and accumulation of amyloid -peptide terminating at amino acid 42 Journal of Biological Chemistry 1997 272 26 16085 16088 (Pubitemid 27276419)
54. LaFerla F. M., Troncoso J. C., Strickland D. K., Kawas C. H., Jay G., Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular A stabilization Journal of Clinical Investigation 1997 100 2 310 320 (Pubitemid 27349077)
55. Nagele R. G., D'Andrea M. R., Anderson W. J., Wang H. Y., Intracellular accumulation of -amyloid in neurons is facilitated by the 7 nicotinic acetylcholine receptor in Alzheimer's disease Neuroscience 2002 110 2 199 211 (Pubitemid 34214939)
56. Bi X., Gall C. M., Zhou J., Lynch G., Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists Neuroscience 2002 112 4 827 840 (Pubitemid 34667047)
57. Clifford P. M., Zarrabi S., Siu G., Kinsler K. J., Kosciuk M. C., Venkataraman V., D'Andrea M. R., Dinsmore S., Nagele R. G., A peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons Brain Research 2007 1142 1 223 236 (Pubitemid 46413194)
58. Yang A. J., Knauer M., Burdick D. A., Glabe C., Intracellular A 142 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells Journal of Biological Chemistry 1995 270 24 14786 14792
59. Yang A. J., Chandswangbhuvana D., Shu T., Henschen A., Glabe C. G., Intracellular accumulation of insoluble, newly synthesized A n-42 in amyloid precursor protein-transfected cells that have been treated with A 142 Journal of Biological Chemistry 1999 274 29 20650 20656
60. Tampellini D., Rahman N., Gallo E. F., Huang Z., Dumont M., Capetillo-Zarate E., Ma T., Zheng R., Lu B., Nanus D. M., Lin M. T., Gouras G. K., Synaptic activity reduces intraneuronal A , promotes APP transport to synapses, and protects against A -related synaptic alterations Journal of Neuroscience 2009 29 31 9704 9713
61. Snyder E. M., Nong Y., Almeida C. G., Paul S., Moran T., Choi E. Y., Nairn A. C., Salter M. W., Lombroso P. J., Gouras G. K., Greengard P., Regulation of NMDA receptor trafficking by amyloid- Nature Neuroscience 2005 8 8 1051 1058 (Pubitemid 41061516)
62. Lorenzo A., Yuan M., Zhang Z., Paganetti P. A., Sturchler-Pierrat C., Staufenbiel M., Mautino J., Sol Vigo F., Sommer B., Yankner B. A., Amyloid interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease Nature Neuroscience 2000 3 5 460 464 (Pubitemid 30495627)
63. Shaked G. M., Kummer M. P., Lu D. C., Galvan V., Bredesen D. E., Koo E. H., Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597624) FASEB Journal 2006 20 8 1254 1256
64. Burdick D., Kosmoski J., Knauer M. F., Glabe C. G., Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A 142, in differentiated PC12 cells Brain Research 1997 746 1-2 275 284 (Pubitemid 27060356)
65. Yu C., Nwabuisi-Heath E., Laxton K., Ladu M. J., Endocytic pathways mediating oligomeric A 42 neurotoxicity Molecular Neurodegeneration 2010 5 1, article 19
66. Saavedra L., Mohamed A., Ma V., Kar S., De Chaves E. P., Internalization of -amyloid peptide by primary neurons in the absence of apolipoprotein E Journal of Biological Chemistry 2007 282 49 35722 35732 (Pubitemid 350277136)
67. Qiu Z., Strickland D. K., Hyman B. T., Rebeck G. W., -macroglobulin enhances the clearance of endogenous soluble -amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons Journal of Neurochemistry 1999 73 4 1393 1398 (Pubitemid 29440138)
68. Narita M., Holtzman D. M., Schwartz A. L., Bu G., -macroglobulin complexes with and mediates the endocytosis of -amyloid peptide via cell surface low-density lipoprotein receptor-related protein Journal of Neurochemistry 1997 69 5 1904 1911 (Pubitemid 27452736)
69. Wilhelmus M. M. M., Otte-Hller I., van Triel J. J. J., Veerhuis R., Maat-Schieman M. L. C., Bu G., De Waal R. M. W., Verbeek M. M., Lipoprotein receptor-related protein-1 mediates amyloid- -mediated cell death of cerebrovascular cells American Journal of Pathology 2007 171 6 1989 1999
70. Ida N., Masters C. L., Beyreuther K., Rapid cellular uptake of Alzheimer amyloid A4 peptide by cultured human neuroblastoma cells FEBS Letters 1996 394 2 174 178 (Pubitemid 26341500)
71. Hu X., Crick S. L., Bu G., Frieden C., Pappu R. V., Lee J. M., Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide Proceedings of the National Academy of Sciences of the United States of America 2010 106 48 20324 20329
72. Kang D. E., Pietrzik C. U., Baum L., Chevallier N., Merriam D. E., Kounnas M. Z., Wagner S. L., Troncoso J. C., Kawas C. H., Katzman R., Koo E. H., Modulation of amyloid -protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway Journal of Clinical Investigation 2000 106 9 1159 1166
73. Mayor S., Pagano R. E., Pathways of clathrin-independent endocytosis Nature Reviews Molecular Cell Biology 2007 8 8 603 612 (Pubitemid 47106613)
74. Doherty G. J., McMahon H. T., Mechanisms of endocytosis Annual Review of Biochemistry 2009 78 857 902
75. Kumari S., Mg S., Mayor S., Endocytosis unplugged: multiple ways to enter the cell Cell Research 2010 20 3 256 275
76. de Chaves E. P., Narayanaswami V., Apolipoprotein E and cholesterol in aging and disease in the brain Future Lipidology 2008 3 5 505 530
77. Kim J., Basak J. M., Holtzman D. M., The role of apolipoprotein E in Alzheimer's disease Neuron 2009 63 3 287 303
78. Bu G., Apolipoprotein e and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy Nature Reviews Neuroscience 2009 10 5 333 344
79. Christensen D. Z., Schneider-Axmann T., Lucassen P. J., Bayer T. A., Wirths O., Accumulation of intraneuronal A correlates with ApoE4 genotype Acta Neuropathologica 2010 119 5 555 566
80. Han S. H., Hulette C., Saunders A. M., Einstein G., Pericak-Vance M., Strittmatter W. J., Roses A. D., Schmechel D. E., Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls Experimental Neurology 1994 128 1 13 26 (Pubitemid 24278361)
81. Han S. H., Einstein G., Weisgraber K. H., Strittmatter W. J., Saunders A. M., Pericak-Vance M., Roses A. D., Schmechel D. E., Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study Journal of Neuropathology and Experimental Neurology 1994 53 5 535 544 (Pubitemid 24276812)
82. Zerbinatti C. V., Wahrle S. E., Kim H., Cam J. A., Bales K., Paul S. M., Holtzman D. M., Bu G., Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal A 42 accumulation in amyloid model mice Journal of Biological Chemistry 2006 281 47 36180 36186 (Pubitemid 46041352)
83. Van Uden E., Mallory M., Veinbergs I., Alford M., Rockenstein E., Masliah E., Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein Journal of Neuroscience 2002 22 21 9298 9304 (Pubitemid 35356173)
84. Gylys K. H., Fein J. A., Tan A. M., Cole G. M., Apolipoprotein E enhances uptake of soluble but not aggregated amyloid- protein into synaptic terminals Journal of Neurochemistry 2003 84 6 1442 1451 (Pubitemid 36343610)
85. Yamada K., Hashimoto T., Yabuki C., Nagae Y., Tachikawa M., Strickland D. K., Liu Q., Bu G., Basak J. M., Holtzman D. M., Ohtsuki S., Terasaki T., Iwatsubo T., The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid peptides in an in vitro model of the blood-brain barrier cells Journal of Biological Chemistry 2008 283 50 34554 34562
86. Yamauchi K., Tozuka M., Hidaka H., Nakabayashi T., Sugano M., Katsuyama T., Isoform-specific effect of apolipoprotein E on endocytosis of -amyloid in cultures of neuroblastoma cells Annals of Clinical and Laboratory Science 2002 32 1 65 74 (Pubitemid 34137435)
87. Deane R., Sagare A., Hamm K., Parisi M., Lane S., Finn M. B., Holtzman D. M., Zlokovic B. V., apoE isoform-specific disruption of amyloid peptide clearance from mouse brain Journal of Clinical Investigation 2008 118 12 4002 4013
88. Beffert U., Aumont N., Dea D., Lussier-Cacan S., Davignon J., Poirier J., -amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons Journal of Neurochemistry 1998 70 4 1458 1466 (Pubitemid 28136958)
89. Yang D. S., Small D. H., Seydel U., Smith J. D., Hallmayer J., Gandy S. E., Martins R. N., Apolipoprotein E promotes the binding and uptake of -amyloid into Chinese hamster ovary cells in an isoform-specific manner Neuroscience 1999 90 4 1217 1226 (Pubitemid 29170140)
90. Beffert U., Aumont N., Dea D., Lussier-Cacan S., Davignon J., Poirier J., Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures Molecular Brain Research 1999 68 1-2 181 185 (Pubitemid 29244006)
91. Zlokovic B. V., Deane R., Sagare A. P., Bell R. D., Winkler E. A., Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid -peptide elimination from the brain Journal of Neurochemistry 2010 115 5 1077 1089
92. Dafnis I., Stratikos E., Tzinia A., Tsilibary E. C., Zannis V. I., Chroni A., An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42 Journal of Neurochemistry 2010 115 4 873 884
93. Head B. P., Insel P. A., Do caveolins regulate cells by actions outside of caveolae? Trends in Cell Biology 2007 17 2 51 57 (Pubitemid 46199179)
94. Kirkham M., Parton R. G., Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers Biochimica et Biophysica Acta 2005 1745 3 273 286 (Pubitemid 41330782)
95. Burns M. P., Rebeck G. W., Intracellular cholesterol homeostasis and amyloid precursor protein processing Biochimica et Biophysica Acta 2010 1801 8 853 859
96. Fantini J., Yahi N., Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases Expert Reviews in Molecular Medicine 2010 12, article e27
97. Matsuzaki K., Kato K., Yanagisawa K., A polymerization through interaction with membrane gangliosides Biochimica et Biophysica Acta 2010 1801 8 868 877
98. Arispe N., Doh M., Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease A P (140) and (142) peptides FASEB Journal 2002 16 12 1526 1536 (Pubitemid 35154635)
99. Wakabayashi M., Matsuzaki K., Formation of amyloids by A -(142) on NGF-differentiated PC12 cells: roles of gangliosides and cholesterol Journal of Molecular Biology 2007 371 4 924 933 (Pubitemid 47101820)
100. Yip C. M., Elton E. A., Darabie A. A., Morrison M. R., Mclaurin J., Cholesterol, a modulator of membrane-associated A -fibrillogenesis and neurotoxicity Journal of Molecular Biology 2001 311 4 723 734 (Pubitemid 32803731)
101. Posse de Chaves E. I., Bussire M., Vance D. E., Campenot R. B., Vance J. E., Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons Journal of Biological Chemistry 1997 272 5 3028 3035 (Pubitemid 27053357)
102. Oddo S., LaFerla F. M., The role of nicotinic acetylcholine receptors in Alzheimer's disease Journal of Physiology Paris 2006 99 2-3 172 179
103. Buckingham S. D., Jones A. K., Brown L. A., Sattelle D. B., Nicotinic acetylcholine receptor signalling: roles in alzheimer's disease and amyloid neuroprotection Pharmacological Reviews 2009 61 1 39 61
104. John P. A. S., Cellular trafficking of nicotinic acetylcholine receptors Acta Pharmacologica Sinica 2009 30 6 656 662
105. Wang H.-Y., Lee D. H. S., D'Andrea M. R., Peterson P. A., Shank R. P., Reitz A. B., -Amyloid142 binds to 7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology Journal of Biological Chemistry 2000 275 8 5626 5632 (Pubitemid 30115201)
106. Wang H.-Y., Lee D. H. S., Davis C. B., Shank R. P., Amyloid peptide A 1-42 binds selectively and with picomolar affinity to 7 nicotinic acetylcholine receptors Journal of Neurochemistry 2000 75 3 1155 1161 (Pubitemid 30660505)
107. Wang H. Y., Bakshi K., Shen C., Frankfurt M., Trocm-Thibierge C., Morain P., S 24795 limits -amyloid- 7 nicotinic receptor interaction and reduces Alzheimer's disease-like pathologies Biological Psychiatry 2010 67 6 522 530
108. Small D. H., Maksel D., Kerr M. L., Ng J., Hou X., Chu C., Mehrani H., Unabia S., Azari M. F., Loiacono R., Aguilar M.-I., Chebib M., The -amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the 7 nicotinic acetylcholine receptor Journal of Neurochemistry 2007 101 6 1527 1538 (Pubitemid 46848846)
109. Hernandez C. M., Kayed R., Zheng H., Sweatt J. D., Dineley K. T., Loss of 7 nicotinic receptors enhances -amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease Journal of Neuroscience 2010 30 7 2442 2453
110. Dziewczapolski G., Glogowski C. M., Masliah E., Heinemann S. F., Deletion of the 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease Journal of Neuroscience 2009 29 27 8805 8815
111. Miguel-Hidalgo J. J., Alvarez X. A., Cacabelos R., Quack G., Neuroprotection by memantine against neurodegeneration induced by -amyloid(1-40) Brain Research 2002 958 1 210 221 (Pubitemid 35441230)
112. Harkany T., brahm I., Timmerman W., Laskay G., Tth B., Sasvri M., Knya C., Sebens J. B., Korf J., Nyakas C., Zarndi M., Sos K., Penke B., Luiten P. G.M., -Amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis European Journal of Neuroscience 2000 12 8 2735 2745
113. Decker H., Lo K. Y., Unger S. M., Ferreira S. T., Silverman M. A., Amyloid- peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3 in primary cultured hippocampal neurons Journal of Neuroscience 2010 30 27 9166 9171
114. Mattson M. P., Cheng B., Davis D., Bryant K., Lieberburg I., Rydel R. E., -amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity Journal of Neuroscience 1992 12 2 376 389
115. Tremblay R., Chakravarthy B., Hewitt K., Tauskela J., Morley P., Atkinson T., Durkin J. P., Transient NMDA receptor inactivation provides long-term protection cultured cortical neurons from a variety of death signals Journal of Neuroscience 2000 20 19 7183 7192
116. Song M. S., Rauw G., Baker G. B., Kar S., Memantine protects rat cortical cultured neurons against -amyloid-induced toxicity by attenuating tau phosphorylation European Journal of Neuroscience 2008 28 10 1989 2002
117. Kurup P., Zhang Y., Xu J., Venkitaramani D. V., Haroutunian V., Greengard P., Nairn A. C., Lombroso P. J., A -mediated NMDA receptor endocytosis in alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61 Journal of Neuroscience 2010 30 17 5948 5957
118. Dearie R., Sagare A., Zlokovic B. V., The role of the cell surface LRP and soluble LRP in blood-brain barrier A clearance in Alzheimer's disease Current Pharmaceutical Design 2008 14 16 1601 1605 (Pubitemid 352002987)
119. Yan S. D., Chen XI., Fu J., Chen M., Zhu H., Roher A., Slattery T., Zhao L., Nagashima M., Morser J., Migheli A., Nawroth P., Stern D., Schmidt A. M., RAGE and amyloid- peptide neurotoxicity in Alzheimer's disease Nature 1996 382 6593 685 691 (Pubitemid 26282167)
120. Chen X., Walker D. G., Schmidt A. M., Arancio O., Lue L. F., Yan S. D., RAGE: a potential target for A -mediated cellular perturbation in Alzheimer's disease Current Molecular Medicine 2007 7 8 735 742
121. Lue L. F., Walker D. G., Brachova L., Beach T. G., Rogers J., Schmidt A. M., Stern D. M., Yan S. D., Involvement of microglial receptor for advanced glycation endproducts (RAGE)in Alzheimer's disease: identification of a cellular activation mechanism Experimental Neurology 2001 171 1 29 45 (Pubitemid 32848443)
122. Takuma K., Fang F., Zhang W., Yan S., Fukuzaki E., Du H., Sosunov A., McKhann G., Funatsu Y., Nakamichi N., Nagai T., Mizoguchi H., Ibi D., Hori O., Ogawa S., Stern D. M., Yamada K., Yan S. S., RAGE-mediated signaling contributes to intraneuronal transport of amyloid- and neuronal dysfunction Proceedings of the National Academy of Sciences of the United States of America 2010 106 47 20021 20026
123. Ditaranto K., Tekirian T. L., Yang A. J., Lysosomal membrane damage in soluble A -mediated cell death in Alzheimer's disease Neurobiology of Disease 2001 8 1 19 31 (Pubitemid 32171815)
124. Almeida C. G., Takahashi R. H., Gouras G. K., -amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system Journal of Neuroscience 2006 26 16 4277 4288 (Pubitemid 44315387)
125. Langui D., Girardot N., El Hachimi K. H., Allinquant B., Blanchard V., Pradier L., Duyckaerts C., Subcellular topography of neuronal A peptide in APPxPS1 transgenic mice American Journal of Pathology 2004 165 5 1465 1477 (Pubitemid 39435147)
126. Schmitz C., Rutten B. P. F., Pielen A., Schfer S., Wirths O., Tremp G., Czech C., Blanchard V., Multhaup G., Rezaie P., Korr H., Steinbusch H. W. M., Pradier L., Bayer T. A., Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease American Journal of Pathology 2004 164 4 1495 1502 (Pubitemid 38387814)
127. Knauer M. F., Soreghan B., Burdick D., Kosmoski J., Glabe C. G., Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/ protein Proceedings of the National Academy of Sciences of the United States of America 1992 89 16 7437 7441
128. Nixon R. A., Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases Neurobiology of Aging 2005 26 3 373 382 (Pubitemid 40082721)
129. Guicciardi M. E., Leist M., Gores G. J., Lysosomes in cell death Oncogene 2004 23 16 2881 2890 (Pubitemid 38638850)
130. Liu R. Q., Zhou Q. H., Ji S. R., Zhou Q., Feng DU., Wu YI., Sui S. F., Membrane localization of -amyloid 142 in lysosomes: a possible mechanism for lysosome labilization Journal of Biological Chemistry 2010 285 26 19986 19996
131. Kane M. D., Schwarz R. D., Pierre L. S., Watson M. D., Emmerling M. R., Boxer P. A., Walker G. K., Inhibitors of V-type ATPases, bafilomycin A1 and concanamycin A, protect against -amyloid-mediated effects on 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) reduction Journal of Neurochemistry 1999 72 5 1939 1947 (Pubitemid 29185997)
132. Ji Z. S., Mllendorff K., Cheng I. H., Miranda R. D., Huang Y., Mahley R. W., Reactivity of apolipoprotein E4 and amyloid peptide: lysosomal stability and neurodegeneration Journal of Biological Chemistry 2006 281 5 2683 2692 (Pubitemid 43845731)
133. Hoffman K. B., Bi X., Pham J. T., Lynch G., -amyloid increases cathepsin D levels in hippocampus Neuroscience Letters 1998 250 2 75 78 (Pubitemid 28348296)
134. Cataldo A. M., Barnett J. L., Berman S. A., Li J., Quarless S., Bursztajn S., Lippa C., Nixon R. A., Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system Neuron 1995 14 3 671 680
135. Callahan L. M., Vaules W. A., Coleman P. D., Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles Journal of Neuropathology and Experimental Neurology 1999 58 3 275 287 (Pubitemid 29140968)
136. Ginsberg S. D., Hemby S. E., Lee V. M. Y., Eberwine J. H., Trojanowski J. Q., Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons Annals of Neurology 2000 48 1 77 87 (Pubitemid 30432434)
137. Cataldo A. M., Barnett J. L., Pieroni C., Nixon R. A., Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased -amyloidogenesis Journal of Neuroscience 1997 17 16 6142 6151 (Pubitemid 27329890)
138. Jin L. W., Maezawa I., Vincent I., Bird T., Intracellular accumulation of amyloidogenic fragments of amyloid- precursor protein in neurons with niemann-pick type C defects is associated with endosomal abnormalities American Journal of Pathology 2004 164 3 975 985 (Pubitemid 38235479)
139. Weible M. W., Hendry I. A., What is the importance of multivesicular bodies in retrograde axonal transport in vivo? Journal of Neurobiology 2004 58 2 230 243 (Pubitemid 38173721)
140. Wood W. G., Eckert G. P., Igbavboa U., Mller W. E., Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease Biochimica et Biophysica Acta 2003 1610 2 281 290 (Pubitemid 36324471)
141. Delcroix J. D., Valletta J., Wu C., Howe C. L., Lai C. F., Cooper J. D., Belichenko P. V., Salehi A., Mobley W. C., Trafficking the NGF signal: implications for normal and degenerating neurons Progress in Brain Research 2004 146 3 23 (Pubitemid 37541372)
142. Deinhardt K., Salinas S., Verastegui C., Watson R., Worth D., Hanrahan S., Bucci C., Schiavo G., Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway Neuron 2006 52 2 293 305 (Pubitemid 44548343)
143. Posse de Chaves E. I., Rusinol A. E., Vance D. E., Campenot R. B., Vance J. E., Role of lipoproteins in the delivery of lipids to axons during axonal regeneration Journal of Biological Chemistry 1997 272 49 30766 30773 (Pubitemid 27527513)
144. Salehi A., Delcroix J. D., Mobley W. C., Traffic at the intersection of neurotrophic factor signaling and neurodegeneration Trends in Neurosciences 2003 26 2 73 80 (Pubitemid 36110541)
145. Salehi A., Delcroix J. D., Swaab D. F., Alzheimer's disease and NGF signaling Journal of Neural Transmission 2004 111 3 323 345 (Pubitemid 38316609)
146. Poon W. W., Blurton-Jones M., Tu C. H., Feinberg L. M., Chabrier M. A., Harris J. W., Jeon N. L., Cotman C. W., -Amyloid impairs axonal BDNF retrograde trafficking. Neurobiology of Aging. In press
147. Katzmann D. J., Odorizzi G., Emr S. D., Receptor downregulation and multivesicular-body sorting Nature Reviews Molecular Cell Biology 2002 3 12 893 905 (Pubitemid 35477368)
148. Gregori L., Fuchs C., Figueiredo-Pereira M. E., van Nostrand W. E., Goldgaber D., Amyloid -protein inhibits ubiquitin-dependent protein degradation in vitro Journal of Biological Chemistry 1995 270 34 19702 19708
149. Oh S., Hong H. S., Hwang E., Sim H. J., Lee W., Shin SU. J., Mook-Jung I., Amyloid peptide attenuates the proteasome activity in neuronal cells Mechanisms of Ageing and Development 2005 126 12 1292 1299 (Pubitemid 41572246)
150. Tseng B. P., Green K. N., Chan J. L., Blurton-Jones M., LaFerla F. M., A inhibits the proteasome and enhances amyloid and tau accumulation Neurobiology of Aging 2008 29 11 1607 1618
151. Pigino G., Morfini G., Atagi Y., Deshpande A., Yu C., Jungbauer L., LaDu M., Busciglio J., Brady S., Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta Proceedings of the National Academy of Sciences of the United States of America 2009 106 14 5907 5912
152. Harris-White M. E., Chu T., Baiverde Z., Sigel J. J., Flanders K. C., Frautschy S. A., Effects of transforming growth factor- (isoforms 13) on amyloid- deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures Journal of Neuroscience 1998 18 24 10366 10374 (Pubitemid 29016556)
153. Wirths O., Multhaup G., Czech C., Feldmann N., Blanchard V., Tremp G., Beyreuther K., Pradier L., Bayer T. A., Intraneuronal APP/A trafficking and plaque formation in -amyloid precursor protein and presenilin-1 transgenic mice Brain Pathology 2002 12 3 275 286 (Pubitemid 34743210)
154. Song M. S., Saavedra L., de Chaves E. I. P., Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to A in distal axons Neurobiology of Aging 2006 27 9 1224 1238 (Pubitemid 44088575)
155. Picone P., Carrotta R., Montana G., Nobile M. R., San Biagio P. L., Di Carlo M., A oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures Biophysical Journal 2009 96 10 4200 4211
156. Chafekar S. M., Baas F., Scheper W., Oligomer-specific A toxicity in cell models is mediated by selective uptake Biochimica et Biophysica Acta 2008 1782 9 523 531
157. Itagaki S., McGeer P. L., Akiyama H., Zhu S., Selkoe D., Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease Journal of Neuroimmunology 1989 24 3 173 182 (Pubitemid 19271472)
158. Haga S., Akai K., Ishii T., Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody Acta Neuropathologica 1989 77 6 569 575 (Pubitemid 19125369)
159. Kato S., Gondo T., Hoshii Y., Takahashi M., Yamada M., Ishihara T., Confocal observation of senile plaques in Alzheimer's disease: senile plaque morphology and relationship between senile plaques and astrocytes Pathology International 1998 48 5 332 340 (Pubitemid 28355156)
160. Wegiel J., Wang K.-C., Tarnawski M., Lach B., Microglial cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plaque degradation Acta Neuropathologica 2000 100 4 356 364 (Pubitemid 30497003)
161. Pihlaja R., Koistinaho J., Malm T., Sikkil H., Vainio S., Koistinaho M., Transplanted astrocytes internalize deposited -amyloid peptides in a transgenic mouse model of Alzheimer's disease GLIA 2008 56 2 154 163 (Pubitemid 350292308)
162. Hu J., Akama K. T., Krafft G. A., Chromy B. A., van Eldik L. J., Amyloid- peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release Brain Research 1998 785 2 195 206 (Pubitemid 28179382)
163. Nagele R. G., D'Andrea M. R., Lee H., Venkataraman V., Wang H. Y., Astrocytes accumulate A 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains Brain Research 2003 971 2 197 209 (Pubitemid 36423321)
164. Allaman I., Gavillet M., Blanger M., Laroche T., Viertl D., Lashuel H. A., Magistretti P. J., Amyloid- aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability Journal of Neuroscience 2010 30 9 3326 3338
165. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G. M., Cooper N. R., Eikelenboom P., Emmerling M., Fiebich B. L., Finch C. E., Frautschy S., Griffin W. S. T., Hampel H., Hull M., Landreth G., Lue L. F., Mrak R., MacKenzie I. R., McGeer P. L., O'Banion M. K., Pachter J., Pasinetti G., Plata-Salaman C., Rogers J., Rydel R., Shen Y., Streit W., Strohmeyer R., Tooyoma I., Van Muiswinkel F. L., Veerhuis R., Walker D., Webster S., Wegrzyniak B., Wenk G., Wyss-Coray T., Inflammation and Alzheimer's disease Neurobiology of Aging 2000 21 3 383 421 (Pubitemid 30349107)
166. Farfara D., Lifshitz V., Frenkel D., Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease: Alzheimer's Review Series Journal of Cellular and Molecular Medicine 2008 12 3 762 780 (Pubitemid 351718063)
167. Kong Y., Ruan L., Qian L., Liu X., Le Y., Norepinephrine promotes microglia to uptake and degrade amyloid peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme Journal of Neuroscience 2010 30 35 11848 11857
168. Mandrekar S., Jiang Q., Lee C. Y. D., Koenigsknecht-Talboo J., Holtzman D. M., Landreth G. E., Microglia mediate the clearance of soluble a through fluid phase macropinocytosis Journal of Neuroscience 2009 29 13 4252 4262
169. Wyss-Coray T., Lin C., Yan F., Yu G. Q., Rohde M., Mcconlogue L., Masliah E., Mucke L., TGF- 1 promotes microglial amyloid- clearance and reduces plaque burden in transgenic mice Nature Medicine 2001 7 5 612 618 (Pubitemid 32448330)
170. Chung H., Brazil M. I., Soe T. T., Maxfield F. R., Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid -peptide by microglial cells Journal of Biological Chemistry 1999 274 45 32301 32308
171. Nishimura T., Ikeda K., Akiyama H., Arai T., Kondo H., Okochi M., Furiya Y., Mori H., Oda T., Kato M., Iseki E., Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene Neuroscience Letters 1997 224 3 169 172 (Pubitemid 27140408)
172. Funato H., Yoshimura M., Yamazaki T., Saido T. C., Ito Y., Yokofujita J., Okeda R., Ihara Y., Astrocytes containing amyloid -protein (A )-positive granules are associated with a 40-positive diffuse plaques in the aged human brain American Journal of Pathology 1998 152 4 983 992 (Pubitemid 28173360)
173. Kurt M. A., Davies D. C., Kidd M., -Amyloid immunoreactivity in astrocytes in Alzheimer's disease brain biopsies: an electron microscope study Experimental Neurology 1999 158 1 221 228 (Pubitemid 29344335)
174. Matsunaga W., Shirokawa T., Isobe K., Specific uptake of A 1-40 in rat brain occurs in astrocyte, but not in microglia Neuroscience Letters 2003 342 1-2 129 131 (Pubitemid 36513924)
175. Wegiel J., Wang K. C., Imaki H., Rubenstein R., Wronska A., Osuchowski M., Lipinski W. J., Walker L. C., LeVine H., The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP mice Neurobiology of Aging 2001 22 1 49 61 (Pubitemid 32332998)
176. Frackowiak J., Wisniewski H. M., Wegiel J., Merz G. S., Iqbal K., Wang K. C., Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce -amyloid fibrils Acta Neuropathologica 1992 84 3 225 233
177. Paresce D. M., Ghosh R. N., Maxfield F. R., Microglial cells internalize aggregates of the Alzheimer's disease amyloid -protein via a scavenger receptor Neuron 1996 17 3 553 565 (Pubitemid 26322226)
178. Stalder M., Deller T., Staufenbiel M., Jucker M., 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid Neurobiology of Aging 2001 22 3 427 434 (Pubitemid 32510915)
179. Bolmont T., Haiss F., Eicke D., Radde R., Mathis C. A., Klunk W. E., Kohsaka S., Jucker M., Calhoun M. E., Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance Journal of Neuroscience 2008 28 16 4283 4292
180. Zhao J., Paganini L., Mucke L., Gordon M., Refolo L., Carman M., Sinha S., Oltersdorf T., Lieberburg I., McConlogue L., -Secretase processing of the -amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes Journal of Biological Chemistry 1996 271 49 31407 31411 (Pubitemid 26408593)
181. Bigl M., Apelt J., Luschekina E. A., Lange-Dohna C., Roner S., Schliebs R., Expression of -secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology Neuroscience Letters 2000 292 2 107 110
182. Scott S. A., Johnson S. A., Zarow C., Perlmutter L. S., Inability to detect -amyloid protein precursor mRNA in Alzheimer plaque- associated microglia Experimental Neurology 1993 121 1 113 118 (Pubitemid 23192197)
183. Lesn S., Docagne F., Gabriel C., Liot G., Lahiri D. K., Bue L., Plawinski L., Delacourte A., MacKenzie E. T., Buisson A., Vivien D., Transforming growth factor- 1 potentiates amyloid- generation in astrocytes and in transgenic mice Journal of Biological Chemistry 2003 278 20 18408 18418 (Pubitemid 36799463)
184. Hong H. S., Hwang E. M., Sim H. J., Cho H.-J., Boo J. H., Oh S. S., Kim S. U., Mook-Jung I., Interferon stimulates -secretase expression and sAPP production in astrocytes Biochemical and Biophysical Research Communications 2003 307 4 922 927 (Pubitemid 36871661)
185. Nadler Y., Alexandrovich A., Grigoriadis N., Hartmann T., Jagannatha Rao K. S., Shohami E., Stein R., Increased expression of the -secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury GLIA 2008 56 5 552 567
186. Koistinaho M., Lin S., Wu X., Esterman M., Koger D., Hanson J., Higgs R., Liu F., Malkani S., Bales K. R., Paul S. M., Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid- peptides Nature Medicine 2004 10 7 719 726 (Pubitemid 38937637)
187. Yin K. J., Cirrito J. R., Yan P., Hu X., Xiao Q., Pan X., Bateman R., Song H., Hsu F. F., Turk J., Xu J., Hsu C. Y., Mills J. C., Holtzman D. M., Lee J. M., Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid- peptide catabolism Journal of Neuroscience 2006 26 43 10939 10948 (Pubitemid 44772184)
188. Ladu M. J., Shah J. A., Reardon C. A., Getz G. S., Bu G., Hu J., Guo L., Van Eldik L. J., Apolipoprotein E receptors mediate the effects of -amyloid on astrocyte cultures Journal of Biological Chemistry 2000 275 43 33974 33980
189. Nuutinen T., Huuskonen J., Suuronen T., Ojala J., Miettinen R., Salminen A., Amyloid- 142 induced endocytosis and clusterin/apoJ protein accumulation in cultured human astrocytes Neurochemistry International 2007 50 3 540 547 (Pubitemid 46186605)
190. Matsubara E., Soto C., Governale S., Frangione B., Ghiso J., Apolipoprotein J and Alzheimer's amyloid solubility Biochemical Journal 1996 316 2 671 679
191. Bartl M. M., Luckenbach T., Bergner O., Ullrich O., Koch-Brandt C., Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes Experimental Cell Research 2001 271 1 130 141 (Pubitemid 33071000)
192. Nielsen H. M., Mulder S. D., Belin J. A. M., Musters R. J. P., Eikelenboom P., Veerhuis R., Astrocytic A 142 uptake is determined by A -aggregation state and the presence of amyloid-associated proteins GLIA 2010 58 10 1235 1246
193. Husemann J., Loike J. D., Anankov R., Febbraio M., Silverstein S. C., Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system GLIA 2002 40 2 195 205 (Pubitemid 35337377)
194. Alarcn R., Fuenzalida C., Santibez M., von Bernhardi R., Expression of scavenger receptors in glial cells: comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound -amyloid Journal of Biological Chemistry 2005 280 34 30406 30415 (Pubitemid 41216224)
195. Wyss-Coray T., Loike J. D., Brionne T. C., Lu E., Anankov R., Yan F., Silverstein S. C., Husemann J., Adult mouse astrocytes degrade amyloid- in vitro and in situ Nature Medicine 2003 9 4 453 457 (Pubitemid 36460080)
196. Migeotte I., Communi D., Parmentier M., Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses Cytokine and Growth Factor Reviews 2006 17 6 501 519 (Pubitemid 44793122)
197. Brandenburg L. O., Konrad M., Wruck C., Koch T., Pufe T., Lucius R., Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells Neuroscience 2008 156 2 266 276
198. Kimura N., Ishii Y., Suzaki S., Negishi T., Kyuwa S., Yoshikawa Y., A upregulates and colocalizes with LGI3 in cultured rat astrocytes Cellular and Molecular Neurobiology 2007 27 3 335 350 (Pubitemid 46763881)
199. Okabayashi S., Kimura N., Leucine-rich glioma inactivated 3 is involved in amyloid peptide uptake by astrocytes and endocytosis itself NeuroReport 2008 19 12 1175 1179
200. Satoh K., Hata M., Yokota H., A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by -amyloid Biochemical and Biophysical Research Communications 2002 290 2 756 762 (Pubitemid 34687505)
201. Buchanan S. G. S. C., Gay N. J., Structural and functional diversity in the leucine-rich repeat family of proteins Progress in Biophysics and Molecular Biology 1996 65 1-2 1 44 (Pubitemid 27161007)
202. Okabayashi S., Kimura N., LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation NeuroReport 2010 21 9 606 610
203. Nielsen H. M., Veerhuis R., Holmqvist BO., Janciauskiene S., Binding and uptake of A 142 by primary human astrocytes in vitro GLIA 2009 57 9 978 988
204. Lee C. Y. D., Landreth G. E., The role of microglia in amyloid clearance from the AD brain Journal of Neural Transmission 2010 117 949 960
205. Jiang Q., Lee C. Y. D., Mandrekar S., Wilkinson B., Cramer P., Zelcer N., Mann K., Lamb B., Willson T. M., Collins J. L., Richardson J. C., Smith J. D., Comery T. A., Riddell D., Holtzman D. M., Tontonoz P., Landreth G. E., ApoE promotes the proteolytic degradation of A Neuron 2008 58 5 681 693 (Pubitemid 351778466)
206. Koenigsknecht J., Landreth G., Microglial phagocytosis of fibrillar -amyloid through a 1 integrin-dependent mechanism Journal of Neuroscience 2004 24 44 9838 9846 (Pubitemid 39463564)
207. Liu Y., Walter S., Stagi M., Cherny D., Letiembre M., Schulz-Schaeffer W., Heine H., Penke B., Neumann H., Fassbender K., LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide Brain 2005 128 8 1778 1789 (Pubitemid 41373649)
208. Chen K., Iribarren P., Hu J., Chen J., Gong W., Cho E. H., Lockett S., Dunlop N. M., Ji M. W., Activation of toll-like receptor 2 on microglia promotes cell uptake of alzheimer disease-associated amyloid peptide Journal of Biological Chemistry 2006 281 6 3651 3659 (Pubitemid 43845983)
209. Tahara K., Kim H. D., Jin J. J., Maxwell J. A., Li L., Fukuchi K. I., Role of toll-like receptor signalling in A uptake and clearance Brain 2006 129 11 3006 3019 (Pubitemid 44684521)
210. Bamberger M. E., Harris M. E., McDonald D. R., Husemann J., Landreth G. E., A cell surface receptor complex for fibrillar -amyloid mediates microglial activation Journal of Neuroscience 2003 23 7 2665 2674 (Pubitemid 36418601)
211. Reed-Geaghan E. G., Savage J. C., Hise A. G., Landreth G. E., CD14 and toll-like receptors 2 and 4 are required for fibrillar A -stimulated microglial activation Journal of Neuroscience 2009 29 38 11982 11992
212. Cui Y. H., Le Y., Gong W., Proost P., Van Damme J., Murphy W. J., Ji Ming Wang., Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells Journal of Immunology 2002 168 1 434 442 (Pubitemid 34014146)
213. Koenigsknecht-Talboo J., Landreth G. E., Microglial phagocytosis induced by fibrillar -amyloid and IgGs are differentially regulated by proinflammatory cytokines Journal of Neuroscience 2005 25 36 8240 8249 (Pubitemid 41292118)
214. Rogers J., Strohmeyer R., Kovelowski C. J., Li R., Microglia and inflammatory mechanisms in the clearance of amyloid peptide GLIA 2002 40 2 260 269 (Pubitemid 35337383)
215. Brazil M. I., Chung H., Maxfield F. R., Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia Journal of Biological Chemistry 2000 275 22 16941 16947 (Pubitemid 30398933)
216. Webster S. D., Galvan M. D., Ferran E., Garzon-Rodriguez W., Glabe C. G., Tenner A. J., Antibody-mediated phagocytosis of the amyloid -peptide in microglia is differentially modulated by C1q Journal of Immunology 2001 166 12 7496 7503 (Pubitemid 32525628)