-
1
-
-
26944467176
-
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses
-
Almeida, C. G., Tampellini, D., Takahashi, R. H., Greengard, P., Lin, M. T., Snyder, E. M., and Gouras, G. K. (2005). Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol. Dis. 20, 187-198.
-
(2005)
Neurobiol. Dis.
, vol.20
, pp. 187-198
-
-
Almeida, C.G.1
Tampellini, D.2
Takahashi, R.H.3
Greengard, P.4
Lin, M.T.5
Snyder, E.M.6
Gouras, G.K.7
-
2
-
-
49949083479
-
Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain
-
Aoki, M., Volkmann, I., Tjernberg, L. O., Winblad, B., and Bogdanovic, N. (2008). Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain. Neuroreport 19, 1085-1089.
-
(2008)
Neuroreport
, vol.19
, pp. 1085-1089
-
-
Aoki, M.1
Volkmann, I.2
Tjernberg, L.O.3
Winblad, B.4
Bogdanovic, N.5
-
3
-
-
0032551528
-
Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein
-
Bahr, B. A., Hoffman, K. B., Yang, A. J., Hess, U. S., Glabe, C. G., and Lynch, G. (1998). Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein. J. Comp. Neurol. 397, 139-147.
-
(1998)
J. Comp. Neurol.
, vol.397
, pp. 139-147
-
-
Bahr, B.A.1
Hoffman, K.B.2
Yang, A.J.3
Hess, U.S.4
Glabe, C.G.5
Lynch, G.6
-
4
-
-
84899561808
-
Globular amyloid beta-peptide oligomer-a homogenous and stable neuropathological protein in Alzheimer's disease
-
Barghorn, S., Nimmrich, V., Striebinger, A., Krantz, C., Keller, P., Janson, B., Bahr, M., Schmidt, M., Bitner, R. S., Harlan, J., Barlow, E., Ebert, U., and Hillen, H. (2005). Globular amyloid beta-peptide oligomer-a homogenous and stable neuropathological protein in Alzheimer's disease. J. Neurochem. 31, 31.
-
(2005)
J. Neurochem.
, vol.31
, pp. 31
-
-
Barghorn, S.1
Nimmrich, V.2
Striebinger, A.3
Krantz, C.4
Keller, P.5
Janson, B.6
Bahr, M.7
Schmidt, M.8
Bitner, R.S.9
Harlan, J.10
Barlow, E.11
Ebert, U.12
Hillen, H.13
-
5
-
-
37749003347
-
Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment
-
Bayer, T. A., and Wirths, O. (2008). Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment. Genes Brain Behav. 7(Suppl. 1), 6-11.
-
(2008)
Genes Brain Behav.
, vol.7
, Issue.SUPPL. 1
, pp. 6-11
-
-
Bayer, T.A.1
Wirths, O.2
-
6
-
-
0035203662
-
Key factors in Alzheimer's disease: β-amyloid precursor protein processing, metabolism and intraneuronal transport
-
Bayer, T. A., Wirths, O., Majtenyi, K., Hartmann, T., Multhaup, G., Beyreuther, K., and Czech, C. (2001). Key factors in Alzheimer's disease: β-amyloid precursor protein processing, metabolism and intraneuronal transport. Brain Pathol. 11, 1-11.
-
(2001)
Brain Pathol.
, vol.11
, pp. 1-11
-
-
Bayer, T.A.1
Wirths, O.2
Majtenyi, K.3
Hartmann, T.4
Multhaup, G.5
Beyreuther, K.6
Czech, C.7
-
7
-
-
42649141628
-
Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's disease
-
Bertoni-Freddari, C., Sensi, S. L., Giorgetti, B., Balietti, M., Di Stefano, G., Canzoniero, L. M., Casoli, T., and Fattoretti, P. (2008). Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's disease. Rejuvenation Res 11, 309-313.
-
(2008)
Rejuvenation Res
, vol.11
, pp. 309-313
-
-
Bertoni-Freddari, C.1
Sensi, S.L.2
Giorgetti, B.3
Balietti, M.4
Di Stefano, G.5
Canzoniero, L.M.6
Casoli, T.7
Fattoretti, P.8
-
8
-
-
0037135272
-
Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists
-
Bi, X., Gall, C. M., Zhou, J., and Lynch, G. (2002). Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists. Neuroscience 112, 827-840.
-
(2002)
Neuroscience
, vol.112
, pp. 827-840
-
-
Bi, X.1
Gall, C.M.2
Zhou, J.3
Lynch, G.4
-
9
-
-
14644442872
-
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
-
Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., and Laferla, F. M. (2005). Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45, 675-688.
-
(2005)
Neuron
, vol.45
, pp. 675-688
-
-
Billings, L.M.1
Oddo, S.2
Green, K.N.3
McGaugh, J.L.4
Laferla, F.M.5
-
10
-
-
0344826476
-
Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice
-
Blanchard, V., Moussaoui, S., Czech, C., Touchet, N., Bonici, B., Planche, M., Canton, T., Jedidi, I., Gohin, M., Wirths, O., Bayer, T. A., Langui, D., Duyckaerts, C., Tremp, G., and Pradier, L. (2003). Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice. Exp. Neurol. 184, 247-263.
-
(2003)
Exp. Neurol.
, vol.184
, pp. 247-263
-
-
Blanchard, V.1
Moussaoui, S.2
Czech, C.3
Touchet, N.4
Bonici, B.5
Planche, M.6
Canton, T.7
Jedidi, I.8
Gohin, M.9
Wirths, O.10
Bayer, T.A.11
Langui, D.12
Duyckaerts, C.13
Tremp, G.14
Pradier, L.15
-
11
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak, H., and Braak, E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.) 82, 239-259.
-
(1991)
Acta Neuropathol. (Berl.)
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
12
-
-
67349160489
-
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy
-
Breyhan, H., Wirths, O., Duan, K., Marcello, A., Rettig, J., and Bayer, T. A. (2009). APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy. Acta Neuropathol. 117, 677-685.
-
(2009)
Acta Neuropathol.
, vol.117
, pp. 677-685
-
-
Breyhan, H.1
Wirths, O.2
Duan, K.3
Marcello, A.4
Rettig, J.5
Bayer, T.A.6
-
13
-
-
0037186074
-
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome
-
Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., and Yankner, B. A. (2002). Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33, 677-688.
-
(2002)
Neuron
, vol.33
, pp. 677-688
-
-
Busciglio, J.1
Pelsman, A.2
Wong, C.3
Pigino, G.4
Yuan, M.5
Mori, H.6
Yankner, B.A.7
-
14
-
-
14444272986
-
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
-
Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., and Black, R. A. (1998). Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273, 27765-27767.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27765-27767
-
-
Buxbaum, J.D.1
Liu, K.N.2
Luo, Y.3
Slack, J.L.4
Stocking, K.L.5
Peschon, J.J.6
Johnson, R.S.7
Castner, B.J.8
Cerretti, D.P.9
Black, R.A.10
-
15
-
-
0032558784
-
Neuron loss in APP transgenic mice
-
Calhoun, M. E., Wiederhold, K. H., Abramowski, D., Phinney, A. L., Probst, A., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., and Jucker, M. (1998). Neuron loss in APP transgenic mice. Nature 395, 755-756.
-
(1998)
Nature
, vol.395
, pp. 755-756
-
-
Calhoun, M.E.1
Wiederhold, K.H.2
Abramowski, D.3
Phinney, A.L.4
Probst, A.5
Sturchler-Pierrat, C.6
Staufenbiel, M.7
Sommer, B.8
Jucker, M.9
-
16
-
-
4644276796
-
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
-
Casas, C., Sergeant, N., Itier, J. M., Blanchard, V., Wirths, O., van der Kolk, N., Vingtdeux, V., van de Steeg, E., Ret, G., Canton, T., Drobecq, H., Clark, A., Bonici, B., Delacourte, A., Benavides, J., Schmitz, C., Tremp, G., Bayer, T. A., Benoit, P., and Pradier, L. (2004). Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am. J. Pathol. 165, 1289-1300.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 1289-1300
-
-
Casas, C.1
Sergeant, N.2
Itier, J.M.3
Blanchard, V.4
Wirths, O.5
van der Kolk, N.6
Vingtdeux, V.7
van de Steeg, E.8
Ret, G.9
Canton, T.10
Drobecq, H.11
Clark, A.12
Bonici, B.13
Delacourte, A.14
Benavides, J.15
Schmitz, C.16
Tremp, G.17
Bayer, T.A.18
Benoit, P.19
Pradier, L.20
more..
-
17
-
-
28744449206
-
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
-
Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., and Yan, S. D. (2005). Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J. 19, 2040-2041.
-
(2005)
FASEB J.
, vol.19
, pp. 2040-2041
-
-
Caspersen, C.1
Wang, N.2
Yao, J.3
Sosunov, A.4
Chen, X.5
Lustbader, J.W.6
Xu, H.W.7
Stern, D.8
McKhann, G.9
Yan, S.D.10
-
18
-
-
77952882727
-
Intracellular Abeta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease
-
doi: 1016/j.neurobiolaging.2008.07.022
-
Christensen, D. Z., Bayer, T. A., and Wirths, O. (2008a). Intracellular Abeta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease. Neurobiol. Aging. doi: 1016/j.neurobiolaging.2008.07.022.
-
(2008)
Neurobiol. Aging.
-
-
Christensen, D.Z.1
Bayer, T.A.2
Wirths, O.3
-
19
-
-
56749152364
-
Transient intraneuronal Abeta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice
-
Christensen, D. Z., Kraus, S. L., Flohr, A., Cotel, M. C., Wirths, O., and Bayer, T. A. (2008b). Transient intraneuronal Abeta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice. Acta Neuropathol. 116, 647-655.
-
(2008)
Acta Neuropathol.
, vol.116
, pp. 647-655
-
-
Christensen, D.Z.1
Kraus, S.L.2
Flohr, A.3
Cotel, M.C.4
Wirths, O.5
Bayer, T.A.6
-
20
-
-
0032895651
-
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
-
Chui, D. H., Tanahashi, H., Ozawa, K., Ikeda, S., Checler, F., Ueda, O., Suzuki, H., Araki, W., Inoue, H., Shirotani, K., Takahashi, K., Gallyas, F., and Tabira, T. (1999). Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat. Med. 5, 560-564.
-
(1999)
Nat. Med.
, vol.5
, pp. 560-564
-
-
Chui, D.H.1
Tanahashi, H.2
Ozawa, K.3
Ikeda, S.4
Checler, F.5
Ueda, O.6
Suzuki, H.7
Araki, W.8
Inoue, H.9
Shirotani, K.10
Takahashi, K.11
Gallyas, F.12
Tabira, T.13
-
21
-
-
0037133908
-
Lipofuscin and Abeta42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains
-
D'Andrea, M. R., Nagele, R. G., Gumula, N. A., Reiser, P. A., Polkovitch, D. A., Hertzog, B. M., and Andrade-Gordon, P. (2002). Lipofuscin and Abeta42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains. Neurosci. Lett. 323, 45-49.
-
(2002)
Neurosci. Lett.
, vol.323
, pp. 45-49
-
-
D'Andrea, M.R.1
Nagele, R.G.2
Gumula, N.A.3
Reiser, P.A.4
Polkovitch, D.A.5
Hertzog, B.M.6
Andrade-Gordon, P.7
-
22
-
-
0035120525
-
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
-
D'Andrea, M. R., Nagele, R. G., Wang, H. Y., Peterson, P. A., and Lee, D. H. (2001). Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. Histopathology 38, 120-134.
-
(2001)
Histopathology
, vol.38
, pp. 120-134
-
-
D'Andrea, M.R.1
Nagele, R.G.2
Wang, H.Y.3
Peterson, P.A.4
Lee, D.H.5
-
23
-
-
0037448062
-
The use of formic acid to embellish amyloid plaque detection in Alzheimer's disease tissues misguides key observations
-
D'Andrea, M. R., Reiser, P. A., Polkovitch, D. A., Gumula, N. A., Branchide, B., Hertzog, B. M., Schmidheiser, D., Belkowski, S., Gastard, M. C., and Andrade-Gordon, P. (2003). The use of formic acid to embellish amyloid plaque detection in Alzheimer's disease tissues misguides key observations. Neurosci. Lett. 342, 114-118.
-
(2003)
Neurosci. Lett.
, vol.342
, pp. 114-118
-
-
D'Andrea, M.R.1
Reiser, P.A.2
Polkovitch, D.A.3
Gumula, N.A.4
Branchide, B.5
Hertzog, B.M.6
Schmidheiser, D.7
Belkowski, S.8
Gastard, M.C.9
Andrade-Gordon, P.10
-
24
-
-
34249672242
-
Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
-
De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., and Klein, W. L. (2007). Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J. Biol. Chem. 282, 11590-11601.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 11590-11601
-
-
De Felice, F.G.1
Velasco, P.T.2
Lambert, M.P.3
Viola, K.4
Fernandez, S.J.5
Ferreira, S.T.6
Klein, W.L.7
-
25
-
-
0035110055
-
Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease
-
Ditaranto, K., Tekirian, T. L., and Yang, A. J. (2001). Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease. Neurobiol. Dis. 8, 19-31.
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 19-31
-
-
Ditaranto, K.1
Tekirian, T.L.2
Yang, A.J.3
-
26
-
-
33845565678
-
Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice
-
Dong, H., Martin, M. V., Chambers, S., and Csernansky, J. G. (2007). Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice. J. Comp. Neurol. 500, 311-321.
-
(2007)
J. Comp. Neurol.
, vol.500
, pp. 311-321
-
-
Dong, H.1
Martin, M.V.2
Chambers, S.3
Csernansky, J.G.4
-
27
-
-
36949016215
-
Alzheimer disease models and human neuropathology: similarities and differences
-
Duyckaerts, C., Potier, M. C., and Delatour, B. (2008). Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol. 115, 5-38.
-
(2008)
Acta Neuropathol.
, vol.115
, pp. 5-38
-
-
Duyckaerts, C.1
Potier, M.C.2
Delatour, B.3
-
28
-
-
67650484613
-
Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease
-
Dziewczapolski, G., Glogowski, C. M., Masliah, E., and Heinemann, S. F. (2009). Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J. Neurosci. 29, 8805-8815.
-
(2009)
J. Neurosci.
, vol.29
, pp. 8805-8815
-
-
Dziewczapolski, G.1
Glogowski, C.M.2
Masliah, E.3
Heinemann, S.F.4
-
29
-
-
40449090190
-
Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice
-
Eckert, A., Hauptmann, S., Scherping, I., Rhein, V., Muller-Spahn, F., Gotz, J., and Muller, W. E. (2008). Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegener. Dis. 5, 157-159.
-
(2008)
Neurodegener. Dis.
, vol.5
, pp. 157-159
-
-
Eckert, A.1
Hauptmann, S.2
Scherping, I.3
Rhein, V.4
Muller-Spahn, F.5
Gotz, J.6
Muller, W.E.7
-
30
-
-
1542284022
-
Intra-and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease
-
Fernandez-Vizarra, P., Fernandez, A. P., Castro-Blanco, S., Serrano, J., Bentura, M. L., Martinez-Murillo, R., Martinez, A., Rodrigo, J., Encinas, J. M., Munoz, P., Alonso, D., Gomez, M. B., Sanchez, J., Rios-Tejada, F., Salas, E., Lisazoain, I., Leza, J. C., Lopez, J. C., Manuel Encinas, J., Lorenzo, P., Pedrosa, J. A., Peinado, M. A., Richart, A., Santacana, M., Cuttitta, F., Uttenthal, L. O., Bosca, L., Rodriguez, I., and Ruiz-Cabello, J. (2004). Intra-and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease. Histol. Histopathol. 19, 823-844.
-
(2004)
Histol. Histopathol.
, vol.19
, pp. 823-844
-
-
Fernandez-Vizarra, P.1
Fernandez, A.P.2
Castro-Blanco, S.3
Serrano, J.4
Bentura, M.L.5
Martinez-Murillo, R.6
Martinez, A.7
Rodrigo, J.8
Encinas, J.M.9
Munoz, P.10
Alonso, D.11
Gomez, M.B.12
Sanchez, J.13
Rios-Tejada, F.14
Salas, E.15
Lisazoain, I.16
Leza, J.C.17
Lopez, J.C.18
Manuel Encinas, J.19
Lorenzo, P.20
Pedrosa, J.A.21
Peinado, M.A.22
Richart, A.23
Santacana, M.24
Cuttitta, F.25
Uttenthal, L.O.26
Bosca, L.27
Rodriguez, I.28
Ruiz-Cabello, J.29
more..
-
31
-
-
84880187096
-
Mice as models: transgenic approaches and Alzheimer's disease
-
Games, D., Buttini, M., Kobayashi, D., Schenk, D., and Seubert, P. (2006). Mice as models: transgenic approaches and Alzheimer's disease. J. Alzheimers Dis. 9(Suppl.), 133-149.
-
(2006)
J. Alzheimers Dis.
, vol.9
, Issue.SUPPL.
, pp. 133-149
-
-
Games, D.1
Buttini, M.2
Kobayashi, D.3
Schenk, D.4
Seubert, P.5
-
32
-
-
0042838303
-
Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., and Klein, W. L. (2003). Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc. Natl. Acad. Sci. U.S.A. 100, 10417-10422.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 10417-10422
-
-
Gong, Y.1
Chang, L.2
Viola, K.L.3
Lacor, P.N.4
Lambert, M.P.5
Finch, C.E.6
Krafft, G.A.7
Klein, W.L.8
-
33
-
-
0033622324
-
Intraneuronal Abeta42 accumulation in human brain
-
Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., Greengard, P., and Relkin, N. R. (2000). Intraneuronal Abeta42 accumulation in human brain. Am. J. Pathol. 156, 15-20.
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 15-20
-
-
Gouras, G.K.1
Tsai, J.2
Naslund, J.3
Vincent, B.4
Edgar, M.5
Checler, F.6
Greenfield, J.P.7
Haroutunian, V.8
Buxbaum, J.D.9
Xu, H.10
Greengard, P.11
Relkin, N.R.12
-
34
-
-
0024563160
-
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease
-
Grundke-Iqbal, I., Iqbal, K., George, L., Tung, Y. C., Kim, K. S., and Wisniewski, H. M. (1989). Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 86, 2853-2857.
-
(1989)
Proc. Natl. Acad. Sci. U.S.A.
, vol.86
, pp. 2853-2857
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
George, L.3
Tung, Y.C.4
Kim, K.S.5
Wisniewski, H.M.6
-
35
-
-
0034745017
-
Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome
-
Gyure, K. A., Durham, R., Stewart, W. F., Smialek, J. E., and Troncoso, J. C. (2001). Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Arch. Pathol. Lab. Med. 125, 489-492.
-
(2001)
Arch. Pathol. Lab. Med.
, vol.125
, pp. 489-492
-
-
Gyure, K.A.1
Durham, R.2
Stewart, W.F.3
Smialek, J.E.4
Troncoso, J.C.5
-
36
-
-
51349110166
-
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
-
Hansson Petersen, C. A., Alikhani, N., Behbahani, H., Wiehager, B., Pavlov, P. F., Alafuzoff, I., Leinonen, V., Ito, A., Winblad, B., Glaser, E., and Ankarcrona, M. (2008). The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc. Natl. Acad. Sci. U.S.A. 105, 13145-13150.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 13145-13150
-
-
Hansson Petersen, C.A.1
Alikhani, N.2
Behbahani, H.3
Wiehager, B.4
Pavlov, P.F.5
Alafuzoff, I.6
Leinonen, V.7
Ito, A.8
Winblad, B.9
Glaser, E.10
Ankarcrona, M.11
-
37
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy, J., and Allsop, D. (1991). Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12, 383-388.
-
(1991)
Trends Pharmacol. Sci.
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
38
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy, J., and Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
39
-
-
0032756213
-
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits
-
Holcomb, L. A., Gordon, M. N., Jantzen, P., Hsiao, K., Duff, K., and Morgan, D. (1999). Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav. Genet. 29, 177-185.
-
(1999)
Behav. Genet.
, vol.29
, pp. 177-185
-
-
Holcomb, L.A.1
Gordon, M.N.2
Jantzen, P.3
Hsiao, K.4
Duff, K.5
Morgan, D.6
-
40
-
-
13044287361
-
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
-
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G. Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., and Mucke, L. (1999). Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc. Natl. Acad. Sci. U.S.A. 96, 3228-3233.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 3228-3233
-
-
Hsia, A.Y.1
Masliah, E.2
McConlogue, L.3
Yu, G.Q.4
Tatsuno, G.5
Hu, K.6
Kholodenko, D.7
Malenka, R.C.8
Nicoll, R.A.9
Mucke, L.10
-
41
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., Smith, T. S., Simmons, D. L., Walsh, F. S., Dingwall, C., and Christie, G. (1999). Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell. Neurosci. 14, 419-427.
-
(1999)
Mol. Cell. Neurosci.
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
Smith, T.S.11
Simmons, D.L.12
Walsh, F.S.13
Dingwall, C.14
Christie, G.15
-
42
-
-
0030612033
-
APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1
-
Irizarry, M. C., McNamara, M., Fedorchak, K., Hsiao, K., and Hyman, B. T. (1997a). APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neurol. 56, 965-973.
-
(1997)
J. Neuropathol. Exp. Neurol.
, vol.56
, pp. 965-973
-
-
Irizarry, M.C.1
McNamara, M.2
Fedorchak, K.3
Hsiao, K.4
Hyman, B.T.5
-
43
-
-
0030611097
-
Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
-
Irizarry, M. C., Soriano, F., McNamara, M., Page, K. J., Schenk, D., Games, D., and Hyman, B. T. (1997b). Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 17, 7053-7059.
-
(1997)
J. Neurosci.
, vol.17
, pp. 7053-7059
-
-
Irizarry, M.C.1
Soriano, F.2
McNamara, M.3
Page, K.J.4
Schenk, D.5
Games, D.6
Hyman, B.T.7
-
44
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., and Malinow, R. (2003). APP processing and synaptic function. Neuron 37, 925-937.
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
-
45
-
-
0035993237
-
Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets
-
Klein, W. L. (2002). Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochem. Int. 41, 345-352.
-
(2002)
Neurochem. Int.
, vol.41
, pp. 345-352
-
-
Klein, W.L.1
-
46
-
-
0035297712
-
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
-
Klein, W. L., Krafft, G. A., and Finch, C. E. (2001). Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci. 24, 219-224.
-
(2001)
Trends Neurosci.
, vol.24
, pp. 219-224
-
-
Klein, W.L.1
Krafft, G.A.2
Finch, C.E.3
-
47
-
-
0026778656
-
Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein
-
Knauer, M. F., Soreghan, B., Burdick, D., Kosmoski, J., and Glabe, C. G. (1992). Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein. Proc. Natl. Acad. Sci. U.S.A. 89, 7437-7441.
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 7437-7441
-
-
Knauer, M.F.1
Soreghan, B.2
Burdick, D.3
Kosmoski, J.4
Glabe, C.G.5
-
48
-
-
34447649563
-
Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms
-
Knobloch, M., Farinelli, M., Konietzko, U., Nitsch, R. M., and Mansuy, I. M. (2007a). Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms. J. Neurosci. 27, 7648-7653.
-
(2007)
J. Neurosci.
, vol.27
, pp. 7648-7653
-
-
Knobloch, M.1
Farinelli, M.2
Konietzko, U.3
Nitsch, R.M.4
Mansuy, I.M.5
-
49
-
-
34447564164
-
Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice
-
Knobloch, M., Konietzko, U., Krebs, D. C., and Nitsch, R. M. (2007b). Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol. Aging 28, 1297-1306.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1297-1306
-
-
Knobloch, M.1
Konietzko, U.2
Krebs, D.C.3
Nitsch, R.M.4
-
50
-
-
0034327364
-
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease
-
Kumar-Singh, S., De Jonghe, C., Cruts, M., Kleinert, R., Wang, R., Mercken, M., De Strooper, B., Vanderstichele, H., Lofgren, A., Vanderhoeven, I., Backhovens, H., Vanmechelen, E., Kroisel, P. M., and Van Broeckhoven, C. (2000). Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. Hum. Mol. Genet. 9, 2589-2598.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2589-2598
-
-
Kumar-Singh, S.1
De Jonghe, C.2
Cruts, M.3
Kleinert, R.4
Wang, R.5
Mercken, M.6
De Strooper, B.7
Vanderstichele, H.8
Lofgren, A.9
Vanderhoeven, I.10
Backhovens, H.11
Vanmechelen, E.12
Kroisel, P.M.13
Van Broeckhoven, C.14
-
51
-
-
20844458090
-
Synaptic targeting by Alzheimer's-related amyloid beta oligomers
-
Lacor, P. N., Buniel, M. C., Chang, L., Fernandez, S. J., Gong, Y., Viola, K. L., Lambert, M. P., Velasco, P. T., Bigio, E. H., Finch, C. E., Krafft, G. A., and Klein, W. L. (2004). Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J. Neurosci. 24, 10191-10200.
-
(2004)
J. Neurosci.
, vol.24
, pp. 10191-10200
-
-
Lacor, P.N.1
Buniel, M.C.2
Chang, L.3
Fernandez, S.J.4
Gong, Y.5
Viola, K.L.6
Lambert, M.P.7
Velasco, P.T.8
Bigio, E.H.9
Finch, C.E.10
Krafft, G.A.11
Klein, W.L.12
-
52
-
-
33846633336
-
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
Lacor, P. N., Buniel, M. C., Furlow, P. W., Clemente, A. S., Velasco, P. T., Wood, M., Viola, K. L., and Klein, W. L. (2007). Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J. Neurosci. 27, 796-807.
-
(2007)
J. Neurosci.
, vol.27
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
Clemente, A.S.4
Velasco, P.T.5
Wood, M.6
Viola, K.L.7
Klein, W.L.8
-
53
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., Wals, P., Zhang, C., Finch, C. E., Krafft, G. A., and Klein, W. L. (1998). Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. U.S.A. 95, 6448-6453.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
54
-
-
0033616716
-
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
-
Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., and Fahrenholz, F. (1999). Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. U.S.A. 96, 3922-3927.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 3922-3927
-
-
Lammich, S.1
Kojro, E.2
Postina, R.3
Gilbert, S.4
Pfeiffer, R.5
Jasionowski, M.6
Haass, C.7
Fahrenholz, F.8
-
55
-
-
7244234180
-
Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice
-
Langui, D., Girardot, N., El Hachimi, K. H., Allinquant, B., Blanchard, V., Pradier, L., and Duyckaerts, C. (2004). Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice. Am. J. Pathol. 165, 1465-1477.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 1465-1477
-
-
Langui, D.1
Girardot, N.2
El Hachimi, K.H.3
Allinquant, B.4
Blanchard, V.5
Pradier, L.6
Duyckaerts, C.7
-
56
-
-
34748872706
-
The role of intracellular amyloid beta in Alzheimer's disease
-
Li, M., Chen, L., Lee, D. H., Yu, L. C., and Zhang, Y. (2007). The role of intracellular amyloid beta in Alzheimer's disease. Prog. Neurobiol. 83, 131-139.
-
(2007)
Prog. Neurobiol.
, vol.83
, pp. 131-139
-
-
Li, M.1
Chen, L.2
Lee, D.H.3
Yu, L.C.4
Zhang, Y.5
-
57
-
-
27744512118
-
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
-
Lord, A., Kalimo, H., Eckman, C., Zhang, X. Q., Lannfelt, L., and Nilsson, L. N. (2006). The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice. Neurobiol. Aging 27, 67-77.
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 67-77
-
-
Lord, A.1
Kalimo, H.2
Eckman, C.3
Zhang, X.Q.4
Lannfelt, L.5
Nilsson, L.N.6
-
58
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue, L. F., Kuo, Y. M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., and Rogers, J. (1999). Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155, 853-862.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
Beach, T.7
Kurth, J.H.8
Rydel, R.E.9
Rogers, J.10
-
59
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., Trinchese, F., Liu, S., Gunn-Moore, F., Lue, L. F., Walker, D. G., Kuppusamy, P., Zewier, Z. L., Arancio, O., Stern, D., Yan, S. S., and Wu, H. (2004). ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304, 448-452.
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
Caspersen, C.7
Chen, X.8
Pollak, S.9
Chaney, M.10
Trinchese, F.11
Liu, S.12
Gunn-Moore, F.13
Lue, L.F.14
Walker, D.G.15
Kuppusamy, P.16
Zewier, Z.L.17
Arancio, O.18
Stern, D.19
Yan, S.S.20
Wu, H.21
more..
-
60
-
-
33646152108
-
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression
-
Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., and Reddy, P. H. (2006). Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum. Mol. Genet. 15, 1437-1449.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1437-1449
-
-
Manczak, M.1
Anekonda, T.S.2
Henson, E.3
Park, B.S.4
Quinn, J.5
Reddy, P.H.6
-
61
-
-
0035830408
-
Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
-
Masliah, E., Mallory, M., Alford, M., DeTeresa, R., Hansen, L. A., McKeel, D. W. Jr., and Morris, J. C. (2001). Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology 56, 127-129.
-
(2001)
Neurology
, vol.56
, pp. 127-129
-
-
Masliah, E.1
Mallory, M.2
Alford, M.3
DeTeresa, R.4
Hansen, L.A.5
McKeel Jr., D.W.6
Morris, J.C.7
-
62
-
-
0028235419
-
Synaptic and neuritic alterations during the progression of Alzheimer's disease
-
Masliah, E., Mallory, M., Hansen, L., DeTeresa, R., Alford, M., and Terry, R. (1994). Synaptic and neuritic alterations during the progression of Alzheimer's disease. Neurosci. Lett. 174, 67-72.
-
(1994)
Neurosci. Lett.
, vol.174
, pp. 67-72
-
-
Masliah, E.1
Mallory, M.2
Hansen, L.3
DeTeresa, R.4
Alford, M.5
Terry, R.6
-
63
-
-
0022156464
-
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
-
Masters, C. L., Multhaup, G., Simms, G., Pottgiesser, J., Martins, R. N., and Beyreuther, K. (1985). Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J. 4, 2757-2763.
-
(1985)
EMBO J.
, vol.4
, pp. 2757-2763
-
-
Masters, C.L.1
Multhaup, G.2
Simms, G.3
Pottgiesser, J.4
Martins, R.N.5
Beyreuther, K.6
-
64
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean, C. A., Cherny, R. A., Fraser, F. W., Fuller, S. J., Smith, M. J., Beyreuther, K., Bush, A. I., and Masters, C. L. (1999). Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann. Neurol. 46, 860-866.
-
(1999)
Ann. Neurol.
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
Beyreuther, K.6
Bush, A.I.7
Masters, C.L.8
-
65
-
-
0033621540
-
Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease [letter]
-
Mochizuki, A., Tamaoka, A., Shimohata, A., Komatsuzaki, Y., and Shoji, S. (2000). Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease [letter]. Lancet 355, 42-43.
-
(2000)
Lancet
, vol.355
, pp. 42-43
-
-
Mochizuki, A.1
Tamaoka, A.2
Shimohata, A.3
Komatsuzaki, Y.4
Shoji, S.5
-
66
-
-
0033525520
-
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
-
Moechars, D., Dewachter, I., Lorent, K., Reverse, D., Baekelandt, V., Naidu, A., Tesseur, I., Spittaels, K., Haute, C. V., Checler, F., Godaux, E., Cordell, B., and Van Leuven, F. (1999). Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J. Biol. Chem. 274, 6483-6492.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6483-6492
-
-
Moechars, D.1
Dewachter, I.2
Lorent, K.3
Reverse, D.4
Baekelandt, V.5
Naidu, A.6
Tesseur, I.7
Spittaels, K.8
Haute, C.V.9
Checler, F.10
Godaux, E.11
Cordell, B.12
Van Leuven, F.13
-
67
-
-
0035997524
-
Intraneuronal Abeta42 accumulation in Down syndrome brain
-
Mori, C., Spooner, E. T., Wisniewsk, K. E., Wisniewski, T. M., Yamaguch, H., Saido, T. C., Tolan, D. R., Selkoe, D. J., and Lemere, C. A. (2002). Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid 9, 88-102.
-
(2002)
Amyloid
, vol.9
, pp. 88-102
-
-
Mori, C.1
Spooner, E.T.2
Wisniewsk, K.E.3
Wisniewski, T.M.4
Yamaguch, H.5
Saido, T.C.6
Tolan, D.R.7
Selkoe, D.J.8
Lemere, C.A.9
-
68
-
-
0030698871
-
Life and death of neurons in the aging brain
-
Morrison, J. H., and Hof, P. R. (1997). Life and death of neurons in the aging brain. Science 278, 412-419.
-
(1997)
Science
, vol.278
, pp. 412-419
-
-
Morrison, J.H.1
Hof, P.R.2
-
69
-
-
0037066072
-
Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease
-
Nagele, R. G., D'Andrea, M. R., Anderson, W. J., and Wang, H. Y. (2002). Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 110, 199-211.
-
(2002)
Neuroscience
, vol.110
, pp. 199-211
-
-
Nagele, R.G.1
D'Andrea, M.R.2
Anderson, W.J.3
Wang, H.Y.4
-
70
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Naslund, J., Haroutunian, V., Mohs, R., Davis, K. L., Davies, P., Greengard, P., and Buxbaum, J. D. (2000). Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283, 1571-1577.
-
(2000)
JAMA
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Mohs, R.3
Davis, K.L.4
Davies, P.5
Greengard, P.6
Buxbaum, J.D.7
-
71
-
-
17944368176
-
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
-
Nilsberth, C., Westlind-Danielsson, A., Eckman, C. B., Condron, M. M., Axelman, K., Forsell, C., Stenh, C., Luthman, J., Teplow, D. B., Younkin, S. G., Naslund, J., and Lannfelt, L. (2001). The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat. Neurosci. 4, 887-893.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Eckman, C.B.3
Condron, M.M.4
Axelman, K.5
Forsell, C.6
Stenh, C.7
Luthman, J.8
Teplow, D.B.9
Younkin, S.G.10
Naslund, J.11
Lannfelt, L.12
-
72
-
-
38549141544
-
Amyloid {beta} oligomers (A{beta}1-42 globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents
-
Nimmrich, V., Grimm, C., Draguhn, A., Barghorn, S., Lehmann, A., Schoemaker, H., Hillen, H., Gross, G., Ebert, U., and Bruehl, C. (2008). Amyloid {beta} oligomers (A{beta}1-42 globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. J. Neurosci. 28, 788-797.
-
(2008)
J. Neurosci.
, vol.28
, pp. 788-797
-
-
Nimmrich, V.1
Grimm, C.2
Draguhn, A.3
Barghorn, S.4
Lehmann, A.5
Schoemaker, H.6
Hillen, H.7
Gross, G.8
Ebert, U.9
Bruehl, C.10
-
73
-
-
33749521100
-
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
-
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., Berry, R., and Vassar, R. (2006). Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 26, 10129-10140.
-
(2006)
J. Neurosci.
, vol.26
, pp. 10129-10140
-
-
Oakley, H.1
Cole, S.L.2
Logan, S.3
Maus, E.4
Shao, P.5
Craft, J.6
Guillozet-Bongaarts, A.7
Ohno, M.8
Disterhoft, J.9
Van Eldik, L.10
Berry, R.11
Vassar, R.12
-
74
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
-
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., and LaFerla, F. M. (2003). Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
75
-
-
33947247360
-
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
-
Ohno, M., Cole, S. L., Yasvoina, M., Zhao, J., Citron, M., Berry, R., Disterhoft, J. F., and Vassar, R. (2007). BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiol. Dis. 26, 134-145.
-
(2007)
Neurobiol. Dis.
, vol.26
, pp. 134-145
-
-
Ohno, M.1
Cole, S.L.2
Yasvoina, M.3
Zhao, J.4
Citron, M.5
Berry, R.6
Disterhoft, J.F.7
Vassar, R.8
-
76
-
-
33751248758
-
Intraneuronal amyloid beta42 enhanced by heating but counteracted by formic acid
-
Ohyagi, Y., Tsuruta, Y., Motomura, K., Miyoshi, K., Kikuchi, H., Iwaki, T., Taniwaki, T., and Kira, J. (2007). Intraneuronal amyloid beta42 enhanced by heating but counteracted by formic acid. J. Neurosci. Methods 159, 134-138.
-
(2007)
J. Neurosci. Methods
, vol.159
, pp. 134-138
-
-
Ohyagi, Y.1
Tsuruta, Y.2
Motomura, K.3
Miyoshi, K.4
Kikuchi, H.5
Iwaki, T.6
Taniwaki, T.7
Kira, J.8
-
77
-
-
39149122810
-
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
-
Reddy, P. H., and Beal, M. F. (2008). Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends. Mol. Med. 14, 45-53.
-
(2008)
Trends. Mol. Med.
, vol.14
, pp. 45-53
-
-
Reddy, P.H.1
Beal, M.F.2
-
78
-
-
63849197629
-
Amyloid beta-protein assembly and Alzheimer disease
-
Roychaudhuri, R., Yang, M., Hoshi, M. M., and Teplow, D. B. (2009). Amyloid beta-protein assembly and Alzheimer disease. J. Biol. Chem. 284, 4749-4753.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 4749-4753
-
-
Roychaudhuri, R.1
Yang, M.2
Hoshi, M.M.3
Teplow, D.B.4
-
79
-
-
33749854516
-
Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons
-
Rui, Y., Tiwari, P., Xie, Z., and Zheng, J. Q. (2006). Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons. J. Neurosci. 26, 10480-10487.
-
(2006)
J. Neurosci.
, vol.26
, pp. 10480-10487
-
-
Rui, Y.1
Tiwari, P.2
Xie, Z.3
Zheng, J.Q.4
-
80
-
-
21244480573
-
Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice
-
Rutten, B. P., Van der Kolk, N. M., Schafer, S., van Zandvoort, M. A., Bayer, T. A., Steinbusch, H. W., and Schmitz, C. (2005). Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice. Am. J. Pathol. 167, 161-173.
-
(2005)
Am. J. Pathol.
, vol.167
, pp. 161-173
-
-
Rutten, B.P.1
Van der Kolk, N.M.2
Schafer, S.3
van Zandvoort, M.A.4
Bayer, T.A.5
Steinbusch, H.W.6
Schmitz, C.7
-
81
-
-
34247611481
-
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
-
Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., and Mufson, E. J. (2007). Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology 68, 1501-1508.
-
(2007)
Neurology
, vol.68
, pp. 1501-1508
-
-
Scheff, S.W.1
Price, D.A.2
Schmitt, F.A.3
DeKosky, S.T.4
Mufson, E.J.5
-
82
-
-
12144288683
-
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
-
Schmitz, C., Rutten, B. P., Pielen, A., Schafer, S., Wirths, O., Tremp, G., Czech, C., Blanchard, V., Multhaup, G., Rezaie, P., Korr, H., Steinbusch, H. W., Pradier, L., and Bayer, T. A. (2004). Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am. J. Pathol. 164, 1495-1502.
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1495-1502
-
-
Schmitz, C.1
Rutten, B.P.2
Pielen, A.3
Schafer, S.4
Wirths, O.5
Tremp, G.6
Czech, C.7
Blanchard, V.8
Multhaup, G.9
Rezaie, P.10
Korr, H.11
Steinbusch, H.W.12
Pradier, L.13
Bayer, T.A.14
-
83
-
-
35348860241
-
Presenilin: running with scissors in the membrane
-
Selkoe, D. J., and Wolfe, M. S. (2007). Presenilin: running with scissors in the membrane. Cell 131, 215-221.
-
(2007)
Cell
, vol.131
, pp. 215-221
-
-
Selkoe, D.J.1
Wolfe, M.S.2
-
84
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberburg, I., Power, M., Tan, H., Tatsuno, G., Tung, J., Schenk, D., Seubert, P., Suomensaari, S. M., Wang, S., Walker, D., John, V. (1999). Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomensaari, S.M.22
Wang, S.23
Walker, D.24
John, V.25
more..
-
85
-
-
1842732209
-
Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain
-
Takahashi, R. H., Almeida, C. G., Kearney, P. F., Yu, F., Lin, M. T., Milner, T. A., and Gouras, G. K. (2004). Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. J. Neurosci. 24, 3592-3599.
-
(2004)
J. Neurosci.
, vol.24
, pp. 3592-3599
-
-
Takahashi, R.H.1
Almeida, C.G.2
Kearney, P.F.3
Yu, F.4
Lin, M.T.5
Milner, T.A.6
Gouras, G.K.7
-
86
-
-
0036827031
-
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology
-
Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., and Gouras, G. K. (2002). Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am. J. Pathol. 161, 1869-1879.
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1869-1879
-
-
Takahashi, R.H.1
Milner, T.A.2
Li, F.3
Nam, E.E.4
Edgar, M.A.5
Yamaguchi, H.6
Beal, M.F.7
Xu, H.8
Greengard, P.9
Gouras, G.K.10
-
87
-
-
73949088883
-
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction
-
Takuma, K., Fang, F., Zhang, W., Yan, S., Fukuzaki, E., Du, H., Sosunov, A., McKhann, G., Funatsu, Y., Nakamichi, N., Nagai, T., Mizoguchi, H., Ibi, D., Hori, O., Ogawa, S., Stern, D. M., Yamada, K., and Yan, S. S. (2009). RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc. Natl. Acad. Sci. U.S.A. 106, 20021-20026.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 20021-20026
-
-
Takuma, K.1
Fang, F.2
Zhang, W.3
Yan, S.4
Fukuzaki, E.5
Du, H.6
Sosunov, A.7
McKhann, G.8
Funatsu, Y.9
Nakamichi, N.10
Nagai, T.11
Mizoguchi, H.12
Ibi, D.13
Hori, O.14
Ogawa, S.15
Stern, D.M.16
Yamada, K.17
Yan, S.S.18
-
88
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
-
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., and Katzman, R. (1991). Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30, 572-580.
-
(1991)
Ann. Neurol.
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
89
-
-
37549016329
-
Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease
-
Van Broeck, B., Vanhoutte, G., Pirici, D., Van Dam, D., Wils, H., Cuijt, I., Vennekens, K., Zabielski, M., Michalik, A., Theuns, J., De Deyn, P. P., Van der Linden, A., Van Broeckhoven, C., and Kumar-Singh, S. (2008). Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease. Neurobiol. Aging 29, 241-252.
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 241-252
-
-
Van Broeck, B.1
Vanhoutte, G.2
Pirici, D.3
Van Dam, D.4
Wils, H.5
Cuijt, I.6
Vennekens, K.7
Zabielski, M.8
Michalik, A.9
Theuns, J.10
De Deyn, P.P.11
Van der Linden, A.12
Van Broeckhoven, C.13
Kumar-Singh, S.14
-
90
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999). Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
91
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., and Selkoe, D. J. (2002). Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
92
-
-
0034609516
-
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain
-
Walsh, D. M., Tseng, B. P., Rydel, R. E., Podlisny, M. B., and Selkoe, D. J. (2000). The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry 39, 10831-10839.
-
(2000)
Biochemistry
, vol.39
, pp. 10831-10839
-
-
Walsh, D.M.1
Tseng, B.P.2
Rydel, R.E.3
Podlisny, M.B.4
Selkoe, D.J.5
-
93
-
-
0034006944
-
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
-
Wang, H. Y., Lee, D. H., D'Andrea, M. R., Peterson, P. A., Shank, R. P., and Reitz, A. B. (2000). beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J. Biol. Chem. 275, 5626-5632.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5626-5632
-
-
Wang, H.Y.1
Lee, D.H.2
D'Andrea, M.R.3
Peterson, P.A.4
Shank, R.P.5
Reitz, A.B.6
-
94
-
-
33947261641
-
Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration
-
Wegiel, J., Kuchna, I., Nowicki, K., Frackowiak, J., Mazur-Kolecka, B., Imaki, H., Wegiel, J., Mehta, P. D., Silverman, W. P., Reisberg, B., Deleon, M., Wisniewski, T., Pirttilla, T., Frey, H., Lehtimaki, T., Kivimaki, T., Visser, F. E., Kamphorst, W., Potempska, A., Bolton, D., Currie, J. R., and Miller, D. L. (2007). Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration. Acta Neuropathol. (Berl.) 113, 389-402.
-
(2007)
Acta Neuropathol. (Berl.)
, vol.113
, pp. 389-402
-
-
Wegiel, J.1
Kuchna, I.2
Nowicki, K.3
Frackowiak, J.4
Mazur-Kolecka, B.5
Imaki, H.6
Wegiel, J.7
Mehta, P.D.8
Silverman, W.P.9
Reisberg, B.10
Deleon, M.11
Wisniewski, T.12
Pirttilla, T.13
Frey, H.14
Lehtimaki, T.15
Kivimaki, T.16
Visser, F.E.17
Kamphorst, W.18
Potempska, A.19
Bolton, D.20
Currie, J.R.21
Miller, D.L.22
more..
-
95
-
-
69949135716
-
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
-
Wirths, O., Breyhan, H., Cynis, H., Schilling, S., Demuth, H. U., and Bayer, T. A. (2009). Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathol. 487-496.
-
(2009)
Acta Neuropathol
, pp. 487-496
-
-
Wirths, O.1
Breyhan, H.2
Cynis, H.3
Schilling, S.4
Demuth, H.U.5
Bayer, T.A.6
-
96
-
-
42649134163
-
Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease
-
Wirths, O., Breyhan, H., Schafer, S., Roth, C., and Bayer, T. A. (2008). Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease. Neurobiol. Aging 29, 891-901.
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 891-901
-
-
Wirths, O.1
Breyhan, H.2
Schafer, S.3
Roth, C.4
Bayer, T.A.5
-
97
-
-
7244236841
-
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade
-
Wirths, O., Multhaup, G., and Bayer, T. A. (2004). A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade. J. Neurochem. 91, 513-520.
-
(2004)
J. Neurochem.
, vol.91
, pp. 513-520
-
-
Wirths, O.1
Multhaup, G.2
Bayer, T.A.3
-
98
-
-
0035933279
-
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice
-
Wirths, O., Multhaup, G., Czech, C., Blanchard, V., Moussaoui, S., Tremp, G., Pradier, L., Beyreuther, K., and Bayer, T. A. (2001). Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci. Lett. 306, 116-120.
-
(2001)
Neurosci. Lett.
, vol.306
, pp. 116-120
-
-
Wirths, O.1
Multhaup, G.2
Czech, C.3
Blanchard, V.4
Moussaoui, S.5
Tremp, G.6
Pradier, L.7
Beyreuther, K.8
Bayer, T.A.9
-
99
-
-
0036019155
-
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice
-
Wirths, O., Multhaup, G., Czech, C., Feldmann, N., Blanchard, V., Tremp, G., Beyreuther, K., Pradier, L., and Bayer, T. A. (2002). Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice. Brain Pathol. 12, 275-286.
-
(2002)
Brain Pathol.
, vol.12
, pp. 275-286
-
-
Wirths, O.1
Multhaup, G.2
Czech, C.3
Feldmann, N.4
Blanchard, V.5
Tremp, G.6
Beyreuther, K.7
Pradier, L.8
Bayer, T.A.9
-
100
-
-
34548553576
-
Age-dependent axonal degeneration in an Alzheimer mouse model
-
Wirths, O., Weis, J., Kayed, R., Saido, T. C., and Bayer, T. A. (2007). Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol. Aging 28, 1689-1699.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1689-1699
-
-
Wirths, O.1
Weis, J.2
Kayed, R.3
Saido, T.C.4
Bayer, T.A.5
-
101
-
-
33947242870
-
When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease
-
Wolfe, M. S. (2007). When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease. EMBO Rep. 8, 136-140.
-
(2007)
EMBO Rep.
, vol.8
, pp. 136-140
-
-
Wolfe, M.S.1
-
102
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashier, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., Carter, D. B., Tomasselli, A. G., Parodi, L. A., Heinrikson, R. L., and Gurney, M. E. (1999). Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402, 533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
Brashier, J.R.7
Stratman, N.C.8
Mathews, W.R.9
Buhl, A.E.10
Carter, D.B.11
Tomasselli, A.G.12
Parodi, L.A.13
Heinrikson, R.L.14
Gurney, M.E.15
-
103
-
-
0032526652
-
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis
-
Yang, A. J., Chandswangbhuvana, D., Margol, L., and Glabe, C. G. (1998). Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis. J. Neurosci. Res. 2, 691-698.
-
(1998)
J. Neurosci. Res.
, vol.2
, pp. 691-698
-
-
Yang, A.J.1
Chandswangbhuvana, D.2
Margol, L.3
Glabe, C.G.4
-
104
-
-
75349092711
-
Expression of {beta}-amyloid induced age-dependent presynaptic and axonal changes in Drosophila
-
Zhao, X. L., Wang, W. A., Tan, J. X., Huang, J. K., Zhang, X., Zhang, B. Z., Wang, Y. H., Yangcheng, H. Y., Zhu, H. L., Sun, X. J., and Huang, F. D. (2010). Expression of {beta}-amyloid induced age-dependent presynaptic and axonal changes in Drosophila. J. Neurosci. 30, 1512-1522.
-
(2010)
J. Neurosci.
, vol.30
, pp. 1512-1522
-
-
Zhao, X.L.1
Wang, W.A.2
Tan, J.X.3
Huang, J.K.4
Zhang, X.5
Zhang, B.Z.6
Wang, Y.H.7
Yangcheng, H.Y.8
Zhu, H.L.9
Sun, X.J.10
Huang, F.D.11
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