Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles

Journal of Neuropathology and Experimental Neurology

Volumn 58, Issue 3, 1999, Pages 275-287

  Callahan, Linda M ^a   Vaules, William A ^b   Coleman, Paul D ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

CA1; Cathepsin D; Message; NFT; NFT free; Quantitation; Synaptophysin

Indexed keywords

CATHEPSIN D; MESSENGER RNA; POLYADENYLIC ACID; SYNAPTOPHYSIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NEUROFIBRILLARY TANGLE; PERIKARYON; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

EID: 0033025080     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199903000-00007     Document Type: Article

References (58)

1. Alzheimer A. Uber eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiat 1907;64:146-48
2. Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR. An English translation of Alzheimer's 1907 paper, "Uber eine eigen-artige Erkankung der Hirnrinde". Clin Anat 1995;8:429-31
3. Ulrich J. The neuropathology of senile dementia. In: Meier-Ruge W., Karger S. eds. Teaching and training in geriatric medicine, 3. Dementing brain disease in old age. Switzerland, 1993:1-33
4. Koo E, Price DL. The neurobiology of dementia. In: Whitemore P. ed. Contemporary Neurology Series. Philadelphia: F.A. Davis Co., 1993;40:55-91
5. Kosik KS, Qiu WQ, Greenberg S. Cellular signaling pathways and cytoskeletal organization. Ann NY Acad Sci 1996;777:114-20
6. Bissette G, Seidler FJ, Nemeroff CB, Slotkin TA. High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy. Ann NY Acad Sci 1996;777:197-204
7. Braak H, Braak E. Evolution of the neuropathology of Alzheimer's disease. Acta Neurol Scand 1996;165:3-12
8. Cowburn RR, Fowler CJ, O'Neill C. Neurotransmitters, signal transduction and second-messengers in Alzheimer's disease. Acta Neurol Scand Supp 1996;165:25-32
9. Schmidt ML, Lee VM-Y, Forman M, Chiu T-S, Trojanowski JQ. Monoclonal antibodies to a 100-kd protein reveal abundant a beta-negative plaques throughout gray matter of Alzheimer's disease brains. Am J Pathol 1997;151:69-80
10. DeKosky S, Scheff S. Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity. Ann Neurol 1990;27:457-64
11. Davies C, Mann D, Sumpter P, Yates PA. A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. J Neurol Sci 1987;78:151-64
12. Gibson PH. Ultrastructural abnormalities in the cerebral neocortex and hippocampus associated with Alzheimer's disease and aging. Acta Neuropathol 1987;73:86-91
13. Scheff SW, Price DA. Synapse loss in the temporal lobe in Alzheimer's disease. Annals Neurol 1993;33:190-99
14. Scheff SW, DeKosky ST, Price DA. Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiol Aging 1990;11:29-37
15. Terry RD, Masliah E, Salmon DR et al. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Annals Neurol 1991;30:572-80
16. Gray EG, Paula-Barbosa M, Roher A. Alzheimer's disease: Paired helical filaments and cytomembranes. Neuropath Appl Neurobiol 1987;13:91-110
17. Ferreira A, Niclas J, Vale R, Banker G, Kosik KS. Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. J Cell Biol 1992;117:595-606
18. Christen B, Bienz M. A cis-element mediating ultrabithorax autoregulation in the central nervous system. Mech Dev 1992;39:73-80
19. Smith K, Sharp Z. A PIT-I binding site 3′ to the transcription start site inhibits transcription elongation in vitro. Biochem Biophys Res Comm 1991;177:790-96
20. Kim S, Lafyatis R, Kim K et al. Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. Cell Regul 1990;1:269-78
21. Ehrenreich H, Anderson R, Ogino Y et al. Selective autoregulation of endothelins in primary astrocyte cultures: Endothelin receptor-mediated potentiation of endothelin-1 secretion. New Biol 1991;3: 135-41
22. Callahan LM, Seiski DJ, Martzen MR, Cheetham JE, Coleman PD. Preliminary evidence: decreased GAP-43 message in tangle-bearing neurons relative to tangle-free neurons in Alzheimer's disease. Neurobiol Aging 1994;15:381-86
23. Callahan LM, Coleman PD. Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol Aging 1995;16:311-14
24. McKhann G, Drachmann D, Folstein K. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group. Neurology 1984;34:939-44
25. Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 1985;42(11):1097-1105
26. Simmons DM, Arriza JL, Swanson LW. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissue with radiolabeled single-stranded RNA probes. J Histotech 1989;12: 169-81
27. Rogers AW. Part I. The bases of autoradiography. New York: Elsevier/North-Holland Biomedical Press, 1979:61-132
28. Yen SH, Crowe A, Dickson DW. Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides. Amer J Path 1985;120:282-91
29. Yen SH, Dickson DW, Crowe A, Butler M, Shelanski ML. Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP 2. Amer J Path 1987;126:81-91
30. Faust PL, Kornfeld S, Chirgwin JM. Cloning and sequence analysis of cDNA for human cathepsin D. Proc Natl Acad Sci 1985;82: 4910-14
31. Angerer LM, Angerer RC. Detection of poly A + RNA in sea urchin eggs and embryos by quantitative in situ hybridization. Nuc Acids Res 1981;9:2819-40
32. Griffin WST, Ling C, White CL, Morrison-Bogorad M. Polyadenylated messenger RNA in paired helical filament-immunoreactive neurons in Alzheimer disease. Alz Dis Assoc Dis 1990;4:69-78
33. Angerer RC, Angerer LM. Localization of mRNAs by in situ hybridization. Methods in Cell Biology 1991;35:37-71
34. Cox KH, DeLeon DV, Angerer LM, Angerer RC. Detection of mRNAs in sea urchin embryos by in situ hybridization using assymmetric RNA probes. Dev Biol 1984;101:485-502
35. Griffin WST. Methods for hybridization and quantitation of mRNA in individual brain cells. In: Valentino KL, Eberwine JH, Barchas JD. eds. In situ hybridization. Applications to neurobiology. New York: Oxford University Press, 1987; Chapter 5
36. Johnson S, Morgan D, Finch CE. Extensive post-mortem stability of RNA from rat and human brain. J Neuroscience Res 1986;16: 267-80
37. Lukiw WJ, Wong L, McLachlan DR. Cytoskeletal messenger RNA stability in human neocortex: Studies in normal aging and in Alzheimer's disease. Internat J Neurosci 1990;55:81-88
38. Eastwood SL, Burnet PWJ, McDonald B, Clinton J, Harrison PJ. Synaptophysin gene expression in human brain: A quantitative in situ hybridization and immunocytochemical study. Neurosci 1994;59:881-92
39. West MJ. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 1993;14:287-93
40. Braak E, Braak H, Mandelkow E. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropath 1994;87:554-67
41. Amaral DG, Insausti R. Hippocampal Formation PY - 1990. In: The human nervous system. New York: Academic Press, 1990: 711-55
42. Braak H. The Hippocampal Formation. In: Barlow, HB, Bizzi, E, Florey, E, Grusser, O-J, van der Loos, H. eds. Architectonics of the human telencephalic cortex. New York: Springer-Verlag. 1980;Chapter 5:26-48
43. Sproull N. The Scheffe test for posthoc multiple comparisons after an ANOVA. In: Sproull N. ed. Handbook of research methods. Mecutchen, NJ: The Scarecrow Press, Inc., 1988:277-87
44. Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exptl Neurol 1997;56:933-44
45. Cataldo AM, Barnett JL, Berman SA, et al. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system. Neuron 1995;14(3):671-80
46. Nixon RA, Cataldo AM. The endosomal-lysosomal system of neurons: New roles. Trends in Neurosciences 1995;18:489-96
47. Hyman BT, Elvhage TE, Reiter J. Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease. Am J Path 1994;144:565-72
48. Morrison MR, Griffin WS. The isolation and in vitro translation of undegraded messenger RNAs from human postmortem brain. Analyt Biochem 1981;113:318-24
49. Hatanpaa K, Brady DR, Stoll J, Rapoport SI, Chandrasekaran K. Neuronal activity and early neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1996;40:411-20
50. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Consensus recommendations for the postmortem diagnosis of Alzheimer's Disease. Neurobiol Aging 1997;18:S1-S2
51. Kosik KS, Crandall JE, Mufson EJ, Neve RL. Tau in situ hybridization in normal and Alzheimer brain: Localization in the somatodendritic compartment. Ann Neurol 1989;26:352-61
52. Brion JP, Flament-Durand J. Distribution and expression of the alpha-tubulin mRNA in the hippocampus and the temporal cortex in Alzheimer's disease. Path Res Pract 1995;191:490-98
53. Schmidt ML, Murray JM, Trojanowski JQ. Continuity of neuropil threads with tangle-bearing and tangle-free neurons in Alzheimer disease cortex. A confocal laser scanning microscopy study. Mol Chem Neuropath 1993;18:299-312
54. Trojanowski JQ, Lee VMY. Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: Focusing on phosphatases. FASEB Journal 1995;9:1570-76
55. Wischik CM, Edwards PC, Lai RY, et al. Quantitative analysis of tau protein in paired helical filament preparations: Implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease. Neurobiol Aging 1995;16:409-17
56. Mandelkow EM, Biernat J, Drewes G, Gustke N, Trinczek B, Mandelkow E. Tau domains, phosphorylation, and interactions with microtubules. Neurobiol Aging 1995;16:355-62
57. Gomez-Isla T, Price JL, McKeel DWJ, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 1996;16:4491-4500
58. Heffernan JM, Eastwood SL, Nagy Z, Sanders MW, McDonald B, Harrison PJ. Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and is negatively correlated with the severity of dementia. Exptl Neurol 1998;150:235-39