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Volumn 168, Issue 1, 2006, Pages 184-194

A dynamic relationship between intracellular and extracellular pools of Aβ

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

EID: 30344448543     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2006.050593     Document Type: Article
Times cited : (219)

References (43)
  • 1
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ: Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81:741-766
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 2
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 4
    • 0030952217 scopus 로고    scopus 로고
    • Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42
    • Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C: Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. J Biol Chem 1997, 272:16085-16088
    • (1997) J Biol Chem , vol.272 , pp. 16085-16088
    • Wild-Bode, C.1    Yamazaki, T.2    Capell, A.3    Leimer, U.4    Steiner, H.5    Ihara, Y.6    Haass, C.7
  • 5
    • 0031781642 scopus 로고    scopus 로고
    • Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture
    • Skovronsky DM, Doms RW, Lee VM: Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture. J Cell Biol 1998, 141:1031-1039
    • (1998) J Cell Biol , vol.141 , pp. 1031-1039
    • Skovronsky, D.M.1    Doms, R.W.2    Lee, V.M.3
  • 7
    • 0030769092 scopus 로고    scopus 로고
    • Alzheimer's a beta(1-42) is generated, in the endoplasmic reticulum/intermediate compartment of NT2N cells
    • Cook DG, Forman MS, Sung JC, Leight S, Kolson DL, Iwatsubo T, Lee VM, Doms RW: Alzheimer's A beta(1-42) is generated, in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat Med 1997, 3:1021-1023
    • (1997) Nat Med , vol.3 , pp. 1021-1023
    • Cook, D.G.1    Forman, M.S.2    Sung, J.C.3    Leight, S.4    Kolson, D.L.5    Iwatsubo, T.6    Lee, V.M.7    Doms, R.W.8
  • 8
    • 0036727463 scopus 로고    scopus 로고
    • Presenilins are not required for a beta 42 production in the early secretory pathway
    • Wilson CA, Doms RW, Zheng H, Lee VM: Presenilins are not required for A beta 42 production in the early secretory pathway. Nat Neurosci 2002, 5:849-855
    • (2002) Nat Neurosci , vol.5 , pp. 849-855
    • Wilson, C.A.1    Doms, R.W.2    Zheng, H.3    Lee, V.M.4
  • 10
    • 11144356498 scopus 로고    scopus 로고
    • Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease
    • Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG: Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 2004, 24:3801-3809
    • (2004) J Neurosci , vol.24 , pp. 3801-3809
    • Kawarabayashi, T.1    Shoji, M.2    Younkin, L.H.3    Wen-Lang, L.4    Dickson, D.W.5    Murakami, T.6    Matsubara, E.7    Abe, K.8    Ashe, K.H.9    Younkin, S.G.10
  • 12
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings LM, Oddo S, Green KN, McGaugh JL, Laferla FM: Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 2005, 45:675-688
    • (2005) Neuron , vol.45 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    Laferla, F.M.5
  • 14
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM: Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging 2003, 24:1063-1070
    • (2003) Neurobiol Aging , vol.24 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3    Tseng, B.P.4    Laferla, F.M.5
  • 17
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM: Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 2004, 43:321-332
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    Laferla, F.M.5
  • 19
    • 24644460177 scopus 로고    scopus 로고
    • Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease
    • Smith IF, Hitt B, Green KN, Oddo S, LaFerla FM: Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease. J Neurochem 2005, 94:1711-1718.
    • (2005) J Neurochem , vol.94 , pp. 1711-1718
    • Smith, I.F.1    Hitt, B.2    Green, K.N.3    Oddo, S.4    Laferla, F.M.5
  • 20
    • 0346101885 scopus 로고    scopus 로고
    • Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
    • Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ: Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 2003, 40:1087-1093
    • (2003) Neuron , vol.40 , pp. 1087-1093
    • Leissring, M.A.1    Farris, W.2    Chang, A.Y.3    Walsh, D.M.4    Wu, X.5    Sun, X.6    Frosch, M.P.7    Selkoe, D.J.8
  • 21
    • 0035950225 scopus 로고    scopus 로고
    • Clearing the brain's amyloid cobwebs
    • Selkoe DJ: Clearing the brain's amyloid cobwebs. Neuron 2001, 32:177-180
    • (2001) Neuron , vol.32 , pp. 177-180
    • Selkoe, D.J.1
  • 23
    • 13644266898 scopus 로고    scopus 로고
    • Age- and region-dependent alterations in Abeta-degrading enzymes: Implications for Abeta-induced disorders
    • Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM: Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging 2005, 26:645-654
    • (2005) Neurobiol Aging , vol.26 , pp. 645-654
    • Caccamo, A.1    Oddo, S.2    Sugarman, M.C.3    Akbari, Y.4    Laferla, F.M.5
  • 26
    • 0037200036 scopus 로고    scopus 로고
    • Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines
    • Tian G, Sobotka-Briner CD, Zysk J, Liu X, Birr C, Sylvester MA, Edwards PD, Scott CD, Greenberg BD: Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines. J Biol Chem 2002, 277:31499-31505
    • (2002) J Biol Chem , vol.277 , pp. 31499-31505
    • Tian, G.1    Sobotka-Briner, C.D.2    Zysk, J.3    Liu, X.4    Birr, C.5    Sylvester, M.A.6    Edwards, P.D.7    Scott, C.D.8    Greenberg, B.D.9
  • 27
    • 0035824391 scopus 로고    scopus 로고
    • Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
    • Ni CY, Murphy MP, Golde TE, Carpenter G: Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 2001, 294:2179-2181
    • (2001) Science , vol.294 , pp. 2179-2181
    • Ni, C.Y.1    Murphy, M.P.2    Golde, T.E.3    Carpenter, G.4
  • 29
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM: Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 2002, 295:2264-2267
    • (2002) Science , vol.295 , pp. 2264-2267
    • Demattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 30
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma a beta clearance and decreases brain a beta burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM: Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2001, 98:8850-8855
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8850-8855
    • Demattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 31
    • 0035979145 scopus 로고    scopus 로고
    • Abeta immunization: Moving Abeta peptide from brain to blood
    • Lee VM: Abeta immunization: moving Abeta peptide from brain to blood. Proc Natl Acad Sci USA 2001, 98:8931-8932
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8931-8932
    • Lee, V.M.1
  • 34
    • 2542475986 scopus 로고    scopus 로고
    • Clearing amyloid through the blood-brain barrier
    • Zlokovic BV: Clearing amyloid through the blood-brain barrier. J Neurochem 2004, 89:807-811
    • (2004) J Neurochem , vol.89 , pp. 807-811
    • Zlokovic, B.V.1
  • 35
    • 0037111837 scopus 로고    scopus 로고
    • Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice
    • Lazarov O, Lee M, Peterson DA, Sisodia SS: Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci 2002, 22:9785-9793
    • (2002) J Neurosci , vol.22 , pp. 9785-9793
    • Lazarov, O.1    Lee, M.2    Peterson, D.A.3    Sisodia, S.S.4
  • 36
    • 0027195933 scopus 로고
    • Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
    • Jarrett JT, Lansbury Jr PT: Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 1993, 73:1055-1058
    • (1993) Cell , vol.73 , pp. 1055-1058
    • Jarrett, J.T.1    Lansbury Jr., P.T.2
  • 39
    • 0030793522 scopus 로고    scopus 로고
    • Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization
    • LaFerla FM, Troncoso JC, Strickland DK, Kawas CH, Jay G: Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. J Clin Invest 1997, 100:310-320
    • (1997) J Clin Invest , vol.100 , pp. 310-320
    • Laferla, F.M.1    Troncoso, J.C.2    Strickland, D.K.3    Kawas, C.H.4    Jay, G.5
  • 40
    • 0028981717 scopus 로고
    • The Alzheimer's a beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice
    • LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G: The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 1995, 9:21-30
    • (1995) Nat Genet , vol.9 , pp. 21-30
    • Laferla, F.M.1    Tinkle, B.T.2    Bieberich, C.J.3    Haudenschild, C.C.4    Jay, G.5
  • 41
    • 0037017399 scopus 로고    scopus 로고
    • Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons
    • Zhang Y, McLaughlin R, Goodyer C, LeBlanc A: Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 2002, 156:519-529
    • (2002) J Cell Biol , vol.156 , pp. 519-529
    • Zhang, Y.1    McLaughlin, R.2    Goodyer, C.3    Leblanc, A.4
  • 42
    • 0035120525 scopus 로고    scopus 로고
    • Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
    • D'Andrea MR, Nagele RG, Wang HY, Peterson PA, Lee DH: Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. Histopathology 2001, 38:120-134
    • (2001) Histopathology , vol.38 , pp. 120-134
    • D'Andrea, M.R.1    Nagele, R.G.2    Wang, H.Y.3    Peterson, P.A.4    Lee, D.H.5
  • 43
    • 1242274389 scopus 로고    scopus 로고
    • Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons
    • Magrane J, Smith RC, Walsh K, Querfurth HW: Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons. J Neurosci 2004, 24:1700-1706
    • (2004) J Neurosci , vol.24 , pp. 1700-1706
    • Magrane, J.1    Smith, R.C.2    Walsh, K.3    Querfurth, H.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.