Leucine-rich glioma inactivated 3 is involved in amyloid β peptide uptake by astrocytes and endocytosis itself

NeuroReport

Volumn 19, Issue 12, 2008, Pages 1175-1179

  Okabayashi, Sachi ^a,b   Kimura, Nobuyuki ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b The Corporation for Production and Research of Laboratory Primates   (Japan)

Author keywords

Alzheimer's disease; Amyloid beta protein; Endocytosis; Leucine rich glioma inactivated 3

Indexed keywords

AMYLOID BETA PROTEIN; LEUCINE RICH GLIOMA INACTIVATED 3 PROTEIN; MEMBRANE PROTEIN; TRANSFERRIN; UNCLASSIFIED DRUG; LGI3 PROTEIN, MOUSE; NERVE PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENDOCYTOSIS; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; RNA INTERFERENCE; ANIMAL; CYTOLOGY; FEMALE; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PREGNANCY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; WESTERN BLOTTING;

AMYLOID BETA-PROTEIN; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; ENDOCYTOSIS; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE TISSUE PROTEINS; NEURONS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; TRANSFERRIN;

EID: 51649124533     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32830a4cc4     Document Type: Article

References (13)

1. Glenner GG. Alzheimer's disease: its proteins and genes. Cell 1988; 2: 307-308.
2. Glenner GG. The proteins and genes of Alzheimer's disease. Biomed Pharmacother 1988; 42:579-854.
3. Younkin SG. The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition. Tohoku J Exp Med 1994; 174:217-223.
4. Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 2004; 30:631-639.
5. Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokohujita J, et al. Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. Am J Pathol 1998; 152:983-992.
6. Matsunaga W, Shirokawa T, Isobe K. Specific uptake of Aβ 1-40 in rat brain occurs in astrocyte, but not in microglia. Neurosci Lett 2003; 342: 129-131.
7. Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, et al. Adult mouse astrocytes degrade amyloid-β in vitro and in situ. Nat Med 2003; 9:453-457.
8. Kimura N, Ishii Y, Suzaki S, Negishi T, Kyuwa S, Yoshikawa Y. Aβ upregulates and colocalizes with LGI3 in rat cultured astrocytes. Cell Mol Neurobiol 2007; 27:335-350.
9. Okabayashi S, Kimura N. Immunohistochemical and biochemical analyses of LGI3 in monkey brain: LGI3 accumulates in aged monkey brains. Cell Mol Neurobiol 2007; 27:819-830.
10. Negishi T, Ishii Y, Kyuwa S, Kuroda Y, Yoshikawa Y. Primary culture of cortical neurons, type-1 astrocytes, and microglial cells from cynomolgus monkey (Macaca fascicularis) fetuses. J Neurosci Method 2003; 131:33-140.
11. Ida N, Hartmann T, Pantel J, Schröder J, Zerfass R, Fö rstl H, et al. Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive western blot assay. J Biol Chem 1996; 271:22908-22914.
12. Saavedra L, Mohamed A, Ma V, Kar S, De Chaves EP. Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E. J Biol Chem 2007; 282:35722-35732.
13. Small SA, Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron 2006; 52:15-31.