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Volumn 118, Issue 12, 2008, Pages 4002-4013

apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; ISOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

EID: 57449084208     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI36663     Document Type: Article
Times cited : (631)

References (67)
  • 1
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola, C. 2004. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat. Rev. Neurosci. 5:347-360.
    • (2004) Nat. Rev. Neurosci , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 2
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic, B.V. 2008. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 57:178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 3
    • 29444442794 scopus 로고    scopus 로고
    • Rovelet-Lecrux, A., et al. 2006. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet. 38:24-26.
    • Rovelet-Lecrux, A., et al. 2006. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet. 38:24-26.
  • 4
    • 33749177143 scopus 로고    scopus 로고
    • A hundred years of Alzheimer's disease research
    • Hardy, J. 2006. A hundred years of Alzheimer's disease research. Neuron. 52:3-13.
    • (2006) Neuron , vol.52 , pp. 3-13
    • Hardy, J.1
  • 5
    • 48949117577 scopus 로고    scopus 로고
    • The role of the cell surface LRP and soluble LRP in blood-brain barrier Aβ clearance in Alzheimer's disease
    • Deane, R., Sagare, A., and Zlokovic, B.V. 2008. The role of the cell surface LRP and soluble LRP in blood-brain barrier Aβ clearance in Alzheimer's disease. Curr. Pharm. Des. 14:1601-1605.
    • (2008) Curr. Pharm. Des , vol.14 , pp. 1601-1605
    • Deane, R.1    Sagare, A.2    Zlokovic, B.V.3
  • 6
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal tau
    • Lee, V.M.Y., Balin, B.J., Otvos, L., Jr., and Trojanowski, J.Q. 1991. A68: A major subunit of paired helical filaments and derivatized forms of normal tau. Science. 251:675-678.
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.Y.1    Balin, B.J.2    Otvos Jr., L.3    Trojanowski, J.Q.4
  • 7
    • 22344438508 scopus 로고    scopus 로고
    • Tau suppression in a neurodegenerative mouse model improves memory function
    • SantaCruz, K., et al. 2005. Tau suppression in a neurodegenerative mouse model improves memory function. Science. 309:476-481.
    • (2005) Science , vol.309 , pp. 476-481
    • SantaCruz, K.1
  • 8
    • 23044468691 scopus 로고    scopus 로고
    • The synaptic Abeta hypothesis of Alzheimer disease
    • Tanzi, R.E. 2005. The synaptic Abeta hypothesis of Alzheimer disease. Nat. Neurosci. 8:977-979.
    • (2005) Nat. Neurosci , vol.8 , pp. 977-979
    • Tanzi, R.E.1
  • 9
    • 23044445669 scopus 로고    scopus 로고
    • Regulation of NMDA receptor trafficking by amyloid-β
    • Snyder, E.M., et al. 2005. Regulation of NMDA receptor trafficking by amyloid-β. Nat. Neurosci. 8:1051-1058.
    • (2005) Nat. Neurosci , vol.8 , pp. 1051-1058
    • Snyder, E.M.1
  • 10
    • 0035950225 scopus 로고    scopus 로고
    • Clearing the brain's amyloid cobwebs
    • Selkoe, D.J. 2001. Clearing the brain's amyloid cobwebs. Neuron. 32:177-180.
    • (2001) Neuron , vol.32 , pp. 177-180
    • Selkoe, D.J.1
  • 11
    • 38149132450 scopus 로고    scopus 로고
    • Role of Aβ transport and clearance in the pathogenesis and treatment of Alzheimer's disease
    • S. Sisodia, and R.E. Tanzi, editors. Springer. New York, New York, USA
    • Holtzman, D.M., and Zlokovic, B.V. 2007. Role of Aβ transport and clearance in the pathogenesis and treatment of Alzheimer's disease. In Alzheimer's disease: advances in genetics, molecular and cellular biology. S. Sisodia, and R.E. Tanzi, editors. Springer. New York, New York, USA. 179-198.
    • (2007) Alzheimer's disease: Advances in genetics, molecular and cellular biology , pp. 179-198
    • Holtzman, D.M.1    Zlokovic, B.V.2
  • 12
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
    • Haass, C., and Selkoe, D.J. 2007. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide. Nat. Rev. Mol. Cell Biol. 8:101-112.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 13
    • 0033943469 scopus 로고    scopus 로고
    • Clearance of amyloid β-peptide from brain: Transport or metabolism?
    • Zlokovic, B.V., Yamada, Y., Holtzman, D.M., Ghiso, J., and Frangione, B. 2000. Clearance of amyloid β-peptide from brain: transport or metabolism? Nat. Med. 6:718-719.
    • (2000) Nat. Med , vol.6 , pp. 718-719
    • Zlokovic, B.V.1    Yamada, Y.2    Holtzman, D.M.3    Ghiso, J.4    Frangione, B.5
  • 14
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's Aβ peptide: The many roads to perdition
    • Tanzi, R.E., Moir, R.D., and Wagner, S.L. 2004. Clearance of Alzheimer's Aβ peptide: the many roads to perdition. Neuron. 43:605-608.
    • (2004) Neuron , vol.43 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagner, S.L.3
  • 15
    • 46749099351 scopus 로고    scopus 로고
    • New therapeutic targets in the neurovascular pathway in Alzheimer's disease
    • Zlokovic, B.V. 2008. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics. 5:409-414.
    • (2008) Neurotherapeutics , vol.5 , pp. 409-414
    • Zlokovic, B.V.1
  • 16
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer's amyloid β(1-40)-peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
    • Shibata, M., et al. 2000. Clearance of Alzheimer's amyloid β(1-40)-peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106:1489-1499.
    • (2000) J. Clin. Invest , vol.106 , pp. 1489-1499
    • Shibata, M.1
  • 17
    • 4043061467 scopus 로고    scopus 로고
    • LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
    • Deane, R., et al. 2004. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 43:333-344.
    • (2004) Neuron , vol.43 , pp. 333-344
    • Deane, R.1
  • 18
    • 27644489474 scopus 로고    scopus 로고
    • P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    • Cirrito, J.R., et al. 2005. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J. Clin. Invest. 115:3285-3290.
    • (2005) J. Clin. Invest , vol.115 , pp. 3285-3290
    • Cirrito, J.R.1
  • 19
    • 34247506244 scopus 로고    scopus 로고
    • Bell, R.D., et al. 2007. Transport pathways for clearance of human Alzheimer's amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab. 27:909-918.
    • Bell, R.D., et al. 2007. Transport pathways for clearance of human Alzheimer's amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab. 27:909-918.
  • 20
    • 40849102300 scopus 로고    scopus 로고
    • LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model
    • Nazer, B., Hong, S., and Selkoe, D.J. 2008. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiol. Dis. 30:94-102.
    • (2008) Neurobiol. Dis , vol.30 , pp. 94-102
    • Nazer, B.1    Hong, S.2    Selkoe, D.J.3
  • 21
    • 4143138471 scopus 로고    scopus 로고
    • In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology
    • Holtzman, D.M. 2004. In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology. J. Mol. Neurosci. 23:247-254.
    • (2004) J. Mol. Neurosci , vol.23 , pp. 247-254
    • Holtzman, D.M.1
  • 22
    • 4243215848 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
    • Holtzman, D.M., et al. 2000. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 97:2892-2897.
    • (2000) Proc. Natl. Acad. Sci. U. S. A , vol.97 , pp. 2892-2897
    • Holtzman, D.M.1
  • 23
    • 9144224765 scopus 로고    scopus 로고
    • ApoE and clusterin cooperatively suppress Aβ levels and deposition: Evidence that apoE regulates extracellular Aβ metabolism in vivo
    • DeMattos, R.B., et al. 2004. ApoE and clusterin cooperatively suppress Aβ levels and deposition: Evidence that apoE regulates extracellular Aβ metabolism in vivo. Neuron. 41:193-202.
    • (2004) Neuron , vol.41 , pp. 193-202
    • DeMattos, R.B.1
  • 24
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • Zlokovic, B.V. 2005. Neurovascular mechanisms of Alzheimer's neurodegeneration Trends Neurosci. 28:202-208.
    • (2005) Trends Neurosci , vol.28 , pp. 202-208
    • Zlokovic, B.V.1
  • 25
    • 44649197748 scopus 로고    scopus 로고
    • ApoE promotes the proteolytic degradation of Aβ
    • Jiang, Q., et al. 2008. ApoE promotes the proteolytic degradation of Aβ. Neuron. 58:681-693.
    • (2008) Neuron , vol.58 , pp. 681-693
    • Jiang, Q.1
  • 26
    • 0031278270 scopus 로고    scopus 로고
    • Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
    • Bales, K.R., et al. 1997. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nat. Genet. 17:263-264.
    • (1997) Nat. Genet , vol.17 , pp. 263-264
    • Bales, K.R.1
  • 27
    • 0033559412 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease
    • Holtzman, D.M., et al. 1999. Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease. J. Clin. Invest. 103:R15-R21.
    • (1999) J. Clin. Invest , vol.103
    • Holtzman, D.M.1
  • 28
    • 0036233168 scopus 로고    scopus 로고
    • Human and murine apoE markedly alters Aβ metabolism before and after plaque formation in a mouse model of Alzheimer's disease
    • Fagan, A.M., et al. 2002. Human and murine apoE markedly alters Aβ metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol. Dis. 9:305-318.
    • (2002) Neurobiol. Dis , vol.9 , pp. 305-318
    • Fagan, A.M.1
  • 29
    • 0042821761 scopus 로고    scopus 로고
    • Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice
    • Fryer, J.D., et al. 2003. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. J. Neurosci. 23:7889-7896.
    • (2003) J. Neurosci , vol.23 , pp. 7889-7896
    • Fryer, J.D.1
  • 30
    • 15244340676 scopus 로고    scopus 로고
    • Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
    • Fryer, J.D., et al. 2005. Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J. Neurosci. 25:2803-2810.
    • (2005) J. Neurosci , vol.25 , pp. 2803-2810
    • Fryer, J.D.1
  • 31
    • 45549095658 scopus 로고    scopus 로고
    • Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice
    • Xu, F., et al. 2008. Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. J. Neurosci. 28:5312-5320.
    • (2008) J. Neurosci , vol.28 , pp. 5312-5320
    • Xu, F.1
  • 32
    • 0035947646 scopus 로고    scopus 로고
    • Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates
    • Li, Y., Lu, W., Marzolo, M.P., and Bu, G. 2001. Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates. J. Biol. Chem. 276:18000-18006.
    • (2001) J. Biol. Chem , vol.276 , pp. 18000-18006
    • Li, Y.1    Lu, W.2    Marzolo, M.P.3    Bu, G.4
  • 33
    • 20244388997 scopus 로고    scopus 로고
    • Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β
    • Morikawa, M., et al. 2005. Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β. Neurobiol. Dis. 19:66-76.
    • (2005) Neurobiol. Dis , vol.19 , pp. 66-76
    • Morikawa, M.1
  • 34
    • 30844472909 scopus 로고    scopus 로고
    • IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
    • Deane, R., et al. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J. Neurosci. 25:11495-11503.
    • (2005) J. Neurosci , vol.25 , pp. 11495-11503
    • Deane, R.1
  • 35
    • 27144457812 scopus 로고    scopus 로고
    • Molecular mechanisms of lipoprotein receptor signalling
    • May, P., Herz, J., and Bock, H.H. 2005. Molecular mechanisms of lipoprotein receptor signalling. Cell. Mol. Life Sci. 62:2325-2338.
    • (2005) Cell. Mol. Life Sci , vol.62 , pp. 2325-2338
    • May, P.1    Herz, J.2    Bock, H.H.3
  • 37
    • 0030779128 scopus 로고    scopus 로고
    • Isoform-specific effects of apolipoproteins E2, E3 and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta
    • Martel, C.L., et al. 1997. Isoform-specific effects of apolipoproteins E2, E3 and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. J. Neurochem. 69:1995-2004.
    • (1997) J. Neurochem , vol.69 , pp. 1995-2004
    • Martel, C.L.1
  • 38
    • 0030005627 scopus 로고    scopus 로고
    • Apolipoprotein E alleles as risk factors in Alzheimer's disease
    • Roses, A.D. 1996. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu. Rev. Med. 47:387-400.
    • (1996) Annu. Rev. Med , vol.47 , pp. 387-400
    • Roses, A.D.1
  • 39
    • 20444504698 scopus 로고    scopus 로고
    • The genetic epidemiology of neurodegenerative disease
    • Bertram, L., and Tanzi, R.E. 2005. The genetic epidemiology of neurodegenerative disease. J. Clin. Invest. 115:1449-1457.
    • (2005) J. Clin. Invest , vol.115 , pp. 1449-1457
    • Bertram, L.1    Tanzi, R.E.2
  • 40
    • 1842557570 scopus 로고    scopus 로고
    • Lipoprotein receptors in the vascular wall
    • Herz, J., and Hui, D.Y. 2004. Lipoprotein receptors in the vascular wall. Curr. Opin. Lipidol. 15:175-181.
    • (2004) Curr. Opin. Lipidol , vol.15 , pp. 175-181
    • Herz, J.1    Hui, D.Y.2
  • 41
    • 0029920929 scopus 로고    scopus 로고
    • Zlokovic, B.V., et al. 1996. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's disease amyloid beta at the bloodbrain and blood-cerebrospinal fluid barriers. Proc. Natl. Acad. Sci. U. S. A. 93:4229-4234.
    • Zlokovic, B.V., et al. 1996. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's disease amyloid beta at the bloodbrain and blood-cerebrospinal fluid barriers. Proc. Natl. Acad. Sci. U. S. A. 93:4229-4234.
  • 42
    • 0030755944 scopus 로고    scopus 로고
    • A new function for the LDL receptor: Transcytosis of LDL across the blood-brain barrier
    • Dehouck, B., et al. 1997. A new function for the LDL receptor: Transcytosis of LDL across the blood-brain barrier. J. Cell Biol. 138:877-889.
    • (1997) J. Cell Biol , vol.138 , pp. 877-889
    • Dehouck, B.1
  • 43
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • Kreuter, J. 2001. Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 47:65-81.
    • (2001) Adv. Drug Deliv. Rev , vol.47 , pp. 65-81
    • Kreuter, J.1
  • 44
    • 0025878638 scopus 로고
    • Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation
    • Linton, M.F., et al. 1991. Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation. J. Clin. Invest. 88:270-281.
    • (1991) J. Clin. Invest , vol.88 , pp. 270-281
    • Linton, M.F.1
  • 45
    • 0042691314 scopus 로고    scopus 로고
    • Differential metabolism of ApoE isoforms in plasma and CSF
    • Wahrle, S.E., and Holtzman, D.M. 2003. Differential metabolism of ApoE isoforms in plasma and CSF. Exp. Neurol. 183:4-6.
    • (2003) Exp. Neurol , vol.183 , pp. 4-6
    • Wahrle, S.E.1    Holtzman, D.M.2
  • 46
    • 23244454385 scopus 로고    scopus 로고
    • The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and LDL receptor
    • Ruiz, J., et al. 2005. The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and LDL receptor. J. Lipid Res. 46:1721-1731.
    • (2005) J. Lipid Res , vol.46 , pp. 1721-1731
    • Ruiz, J.1
  • 47
    • 0032839621 scopus 로고    scopus 로고
    • Apolipoprotein E: From atherosclerosis to Alzheimer's disease and beyond
    • Mahley, R.W., and Huang, Y. 1999. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr. Opin. Lipidol. 10:207-217.
    • (1999) Curr. Opin. Lipidol , vol.10 , pp. 207-217
    • Mahley, R.W.1    Huang, Y.2
  • 48
    • 21844432675 scopus 로고    scopus 로고
    • The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice
    • Fryer, J.D., et al. 2005. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. J. Biol. Chem. 280:25754-25759.
    • (2005) J. Biol. Chem , vol.280 , pp. 25754-25759
    • Fryer, J.D.1
  • 49
    • 0025302165 scopus 로고
    • Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein
    • Kowal, R.C., et al. 1990. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J. Biol. Chem. 265:10771-10779.
    • (1990) J. Biol. Chem , vol.265 , pp. 10771-10779
    • Kowal, R.C.1
  • 50
    • 0141742030 scopus 로고    scopus 로고
    • Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein
    • Narita, M., et al. 2002. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. J. Biochem. 132:743-749.
    • (2002) J. Biochem , vol.132 , pp. 743-749
    • Narita, M.1
  • 51
    • 34948888151 scopus 로고    scopus 로고
    • Clearance of amyloid-β by circulating lipoprotein receptors
    • Sagare, A., et al. 2007. Clearance of amyloid-β by circulating lipoprotein receptors. Nat. Med. 13:1029-1031.
    • (2007) Nat. Med , vol.13 , pp. 1029-1031
    • Sagare, A.1
  • 52
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease
    • Strittmatter, W.J., et al. 1993. Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 90:1977-1981.
    • (1993) Proc. Natl. Acad. Sci. U. S. A , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1
  • 53
    • 0028906808 scopus 로고
    • Purif ication of apolipoprotein E attenuates isoform-specific binding to beta-amyloid
    • LaDu, M.J., et al. 1995. Purif ication of apolipoprotein E attenuates isoform-specific binding to beta-amyloid. J. Biol. Chem. 270:9039-9042.
    • (1995) J. Biol. Chem , vol.270 , pp. 9039-9042
    • LaDu, M.J.1
  • 54
    • 0034214329 scopus 로고    scopus 로고
    • Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides
    • Tokuda, T., et al. 2000. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem. J. 348:359-365.
    • (2000) Biochem. J , vol.348 , pp. 359-365
    • Tokuda, T.1
  • 55
    • 0037394788 scopus 로고    scopus 로고
    • Adult mouse astrocyte degrade amyloid-β in vitro and in situ
    • Wyss-Coray, T., et al. 2003. Adult mouse astrocyte degrade amyloid-β in vitro and in situ. Nat. Med. 9:453-457.
    • (2003) Nat. Med , vol.9 , pp. 453-457
    • Wyss-Coray, T.1
  • 56
    • 3142781310 scopus 로고    scopus 로고
    • Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
    • Koistinaho, M., et al. 2004. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides. Nat. Med. 10:719-726.
    • (2004) Nat. Med , vol.10 , pp. 719-726
    • Koistinaho, M.1
  • 57
    • 0034663037 scopus 로고    scopus 로고
    • Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta protein
    • Cole, G.M., and Ard, M.D. 2000. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta protein. Microsc. Res. Tech. 50:316-324.
    • (2000) Microsc. Res. Tech , vol.50 , pp. 316-324
    • Cole, G.M.1    Ard, M.D.2
  • 58
    • 0141529993 scopus 로고    scopus 로고
    • In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-β metabolism and half-life
    • Cirrito, J.R., et al. 2003. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-β metabolism and half-life. J. Neurosci. 23:8844-8853.
    • (2003) J. Neurosci , vol.23 , pp. 8844-8853
    • Cirrito, J.R.1
  • 59
    • 17044433857 scopus 로고    scopus 로고
    • Apolipoprotein E genotype regulates amyloid-β cytotoxicity
    • Wilhelmus, M.M.M., et al. 2005. Apolipoprotein E genotype regulates amyloid-β cytotoxicity. J. Neurosci. 25:3621-3627.
    • (2005) J. Neurosci , vol.25 , pp. 3621-3627
    • Wilhelmus, M.M.M.1
  • 60
    • 33746932145 scopus 로고    scopus 로고
    • Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils
    • Hatters, D.M., Zhong, N., Rutenber, E., and Weisgraber, K.H. 2006. Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils. J. Mol. Biol. 361:932-944.
    • (2006) J. Mol. Biol , vol.361 , pp. 932-944
    • Hatters, D.M.1    Zhong, N.2    Rutenber, E.3    Weisgraber, K.H.4
  • 61
    • 29444460533 scopus 로고    scopus 로고
    • Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
    • Ye, S., et al. 2005. Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proc. Natl. Acad. Sci. U. S. A. 102:18700- 18705.
    • (2005) Proc. Natl. Acad. Sci. U. S. A , vol.102 , pp. 18700-18705
    • Ye, S.1
  • 62
    • 33845484383 scopus 로고    scopus 로고
    • Blocking the apolipoprotein E/amyloid-β interaction as potential therapeutic approach for Alzheimer's disease
    • Sadowski, M.J., et al. 2006. Blocking the apolipoprotein E/amyloid-β interaction as potential therapeutic approach for Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 103:18787-18792.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 18787-18792
    • Sadowski, M.J.1
  • 63
    • 33645808672 scopus 로고    scopus 로고
    • Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
    • Mahley, R.W., Weisgraber, K.H., and Huang, Y. 2006. Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 103:5644-5651.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 5644-5651
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 64
    • 38349146483 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease: Molecular mechanisms and therapeutic opportunities
    • Cedazo-Mínguez, A. 2007. Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities. J. Cell. Mol. Med. 11:1227-1238.
    • (2007) J. Cell. Mol. Med , vol.11 , pp. 1227-1238
    • Cedazo-Mínguez, A.1
  • 66
    • 7744223882 scopus 로고    scopus 로고
    • Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: Application to amyloid-β peptide in wild type and Alzheimer's Tg2576 mice
    • LaRue, B., et al. 2004. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-β peptide in wild type and Alzheimer's Tg2576 mice. J. Neurosci. Methods. 138:233-242.
    • (2004) J. Neurosci. Methods , vol.138 , pp. 233-242
    • LaRue, B.1
  • 67
    • 0142138142 scopus 로고    scopus 로고
    • A simple method for isolation and characterization of mouse brain microvascular endothelial cells
    • Wu, Z., Hofman, F.M., and Zlokovic, B.V. 2003. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J. Neurosci. Methods. 130:53-63.
    • (2003) J. Neurosci. Methods , vol.130 , pp. 53-63
    • Wu, Z.1    Hofman, F.M.2    Zlokovic, B.V.3


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