메뉴 건너뛰기




Volumn 24, Issue 44, 2004, Pages 9838-9846

Microglial phagocytosis of fibrillar β-amyloid through a β1 integrin-dependent mechanism

Author keywords

6 1 integrin; amyloid; Alzheimer's disease; CD36; Microglia; Phagocytosis

Indexed keywords

AMYLOID BETA PROTEIN; BETA1 INTEGRIN; CD36 ANTIGEN; CD47 ANTIGEN; CELL SURFACE RECEPTOR; COMPLEMENT RECEPTOR; IMMUNOGLOBULIN RECEPTOR; SCAVENGER RECEPTOR;

EID: 7744235869     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2557-04.2004     Document Type: Article
Times cited : (368)

References (49)
  • 1
    • 0033046220 scopus 로고    scopus 로고
    • Mechanisms of phagocytosis in macrophages
    • Aderem A, Underhill DM (1999) Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 17:593-623.
    • (1999) Annu Rev Immunol , vol.17 , pp. 593-623
    • Aderem, A.1    Underhill, D.M.2
  • 2
    • 0029829896 scopus 로고    scopus 로고
    • Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
    • Allen LA, Aderem A (1996) Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages. J Exp Med 184:627-637.
    • (1996) J Exp Med , vol.184 , pp. 627-637
    • Allen, L.A.1    Aderem, A.2
  • 3
    • 0030038809 scopus 로고    scopus 로고
    • Scavenging of Alzheimer's amyloid beta-protein by microglia in culture
    • Ard MD, Cole GM, Wei J, Mehrle AP, Fratkin JD (1996) Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. J Neurosci Res 43:190-202.
    • (1996) J Neurosci Res , vol.43 , pp. 190-202
    • Ard, M.D.1    Cole, G.M.2    Wei, J.3    Mehrle, A.P.4    Fratkin, J.D.5
  • 4
    • 0037387147 scopus 로고    scopus 로고
    • A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation
    • Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE (2003) A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci 23:2665-2674.
    • (2003) J Neurosci , vol.23 , pp. 2665-2674
    • Bamberger, M.E.1    Harris, M.E.2    McDonald, D.R.3    Husemann, J.4    Landreth, G.E.5
  • 7
    • 0034595821 scopus 로고    scopus 로고
    • Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia
    • Brazil MI, Chung H, Maxfield FR (2000) Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia. J Biol Chem 275:16941-16947.
    • (2000) J Biol Chem , vol.275 , pp. 16941-16947
    • Brazil, M.I.1    Chung, H.2    Maxfield, F.R.3
  • 8
    • 0032573378 scopus 로고    scopus 로고
    • Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
    • CaronE, Hall A (1998) Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science 282:1717-1721.
    • (1998) Science , vol.282 , pp. 1717-1721
    • Caron, E.1    Hall, A.2
  • 9
    • 0035826957 scopus 로고    scopus 로고
    • Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice
    • Chung H, Brazil MI, Irizarry MC, Hyman BT, Maxfield FR (2001) Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice. NeuroReport 12:1151-1154.
    • (2001) NeuroReport , vol.12 , pp. 1151-1154
    • Chung, H.1    Brazil, M.I.2    Irizarry, M.C.3    Hyman, B.T.4    Maxfield, F.R.5
  • 10
    • 0030965756 scopus 로고    scopus 로고
    • Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3
    • Chung J, Gao AG, Frazier WA (1997) Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. J Biol Chem 272:14740-14746.
    • (1997) J Biol Chem , vol.272 , pp. 14740-14746
    • Chung, J.1    Gao, A.G.2    Frazier, W.A.3
  • 11
    • 0033080919 scopus 로고    scopus 로고
    • Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion proteins
    • Combs CK, Johnson DE, Cannady SB, Lehman TM, Landreth GE (1999) Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion proteins. J Neurosci 19:928-939.
    • (1999) J Neurosci , vol.19 , pp. 928-939
    • Combs, C.K.1    Johnson, D.E.2    Cannady, S.B.3    Lehman, T.M.4    Landreth, G.E.5
  • 13
    • 0034059454 scopus 로고    scopus 로고
    • An immunoglobulin superfamily-like domain unique to the Yersinia pseudotuberculosis invasin protein is required for stimulation of bacterial uptake via integrin receptors
    • Dersch P, Isberg RR (2000) An immunoglobulin superfamily-like domain unique to the Yersinia pseudotuberculosis invasin protein is required for stimulation of bacterial uptake via integrin receptors. Infect Immun 68:2930-2938.
    • (2000) Infect Immun , vol.68 , pp. 2930-2938
    • Dersch, P.1    Isberg, R.R.2
  • 14
    • 18144453796 scopus 로고    scopus 로고
    • Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease
    • DeWitt DA, Perry G, Cohen M, Doller C, Silver J (1998) Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp Neurol 149:329-340.
    • (1998) Exp Neurol , vol.149 , pp. 329-340
    • DeWitt, D.A.1    Perry, G.2    Cohen, M.3    Doller, C.4    Silver, J.5
  • 16
    • 0027082156 scopus 로고
    • A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion
    • Ghiso J, Rostagno A, Gardella JE, Liem L, Gorevic PD, Frangione B (1992) A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion. Biochem J 288:1053-1059.
    • (1992) Biochem J , vol.288 , pp. 1053-1059
    • Ghiso, J.1    Rostagno, A.2    Gardella, J.E.3    Liem, L.4    Gorevic, P.D.5    Frangione, B.6
  • 17
    • 0028925751 scopus 로고
    • Signal transduction of phagocytosis
    • Greenberg S (1995) Signal transduction of phagocytosis. Trends Cell Biol 5:93-99.
    • (1995) Trends Cell Biol , vol.5 , pp. 93-99
    • Greenberg, S.1
  • 18
    • 0032753490 scopus 로고    scopus 로고
    • Modular components of phagocytosis
    • Greenberg S (1999) Modular components of phagocytosis. J Leukoc Biol 66:712-717.
    • (1999) J Leukoc Biol , vol.66 , pp. 712-717
    • Greenberg, S.1
  • 19
    • 0027513572 scopus 로고
    • Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages
    • Greenberg S, Chang P, Silverstein SC (1993) Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages. J Exp Med 177:529-534.
    • (1993) J Exp Med , vol.177 , pp. 529-534
    • Greenberg, S.1    Chang, P.2    Silverstein, S.C.3
  • 20
    • 0032732224 scopus 로고    scopus 로고
    • Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors
    • Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L (1999) Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol 155:1741-1747.
    • (1999) Am J Pathol , vol.155 , pp. 1741-1747
    • Huang, F.1    Buttini, M.2    Wyss-Coray, T.3    McConlogue, L.4    Kodama, T.5    Pitas, R.E.6    Mucke, L.7
  • 21
    • 0036847848 scopus 로고    scopus 로고
    • Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system
    • Husemann J, Loike JD, Anankov R, Febbraio M, Silverstein SC (2002) Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia 40:195-205.
    • (2002) Glia , vol.40 , pp. 195-205
    • Husemann, J.1    Loike, J.D.2    Anankov, R.3    Febbraio, M.4    Silverstein, S.C.5
  • 22
    • 0033920740 scopus 로고    scopus 로고
    • Signaling and invasin-promoted uptake via integrin receptors
    • Isberg RR, Hamburger Z, Dersch P (2000) Signaling and invasin-promoted uptake via integrin receptors. Microbes Infect 2:793-801.
    • (2000) Microbes Infect , vol.2 , pp. 793-801
    • Isberg, R.R.1    Hamburger, Z.2    Dersch, P.3
  • 23
    • 0017755887 scopus 로고
    • Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages
    • Kaplan G (1977) Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages. Scand J Immunol 6:797-807.
    • (1977) Scand J Immunol , vol.6 , pp. 797-807
    • Kaplan, G.1
  • 24
    • 0038645158 scopus 로고    scopus 로고
    • Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia
    • Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Miki H, Takenawa T, Shimohama S (2003) Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia. J Pharmacol Sci 92:115-123.
    • (2003) J Pharmacol Sci , vol.92 , pp. 115-123
    • Kitamura, Y.1    Shibagaki, K.2    Takata, K.3    Tsuchiya, D.4    Taniguchi, T.5    Gebicke-Haerter, P.J.6    Miki, H.7    Takenawa, T.8    Shimohama, S.9
  • 25
    • 0031753157 scopus 로고    scopus 로고
    • Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia
    • Kopec KK, Carroll RT (1998) Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia. J Neurochem 71:2123-2131.
    • (1998) J Neurochem , vol.71 , pp. 2123-2131
    • Kopec, K.K.1    Carroll, R.T.2
  • 26
    • 0035715822 scopus 로고    scopus 로고
    • Effects of microenvironment on morphology and function of the microglial cell line BV-2
    • Laurenzi MA, Arcuri C, Rossi R, Marconi P, Bocchini V (2001) Effects of microenvironment on morphology and function of the microglial cell line BV-2. Neurochem Res 26:1209-1216.
    • (2001) Neurochem Res , vol.26 , pp. 1209-1216
    • Laurenzi, M.A.1    Arcuri, C.2    Rossi, R.3    Marconi, P.4    Bocchini, V.5
  • 28
    • 0030961544 scopus 로고    scopus 로고
    • Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
    • McDonald DR, Brunden KR, Landreth GE (1997) Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci 17:2284-2294.
    • (1997) J Neurosci , vol.17 , pp. 2284-2294
    • McDonald, D.R.1    Brunden, K.R.2    Landreth, G.E.3
  • 29
    • 0037413824 scopus 로고    scopus 로고
    • Microtubule-dependent regulation of Rho GTPases during internalisation of Yersinia pseudotuberculosis
    • McGee K, Holmfeldt P, Fallman M (2003) Microtubule-dependent regulation of Rho GTPases during internalisation of Yersinia pseudotuberculosis. FEBS Lett 533:35-41.
    • (2003) FEBS Lett , vol.533 , pp. 35-41
    • McGee, K.1    Holmfeldt, P.2    Fallman, M.3
  • 30
    • 0032587404 scopus 로고    scopus 로고
    • The engagement of beta1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and beta1 integrin
    • Miller LA, Hong JJ, Kinch MS, Harrison ML, Geahlen RL (1999) The engagement of beta1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and beta1 integrin. Eur J Immunol 29:1426-1434.
    • (1999) Eur J Immunol , vol.29 , pp. 1426-1434
    • Miller, L.A.1    Hong, J.J.2    Kinch, M.S.3    Harrison, M.L.4    Geahlen, R.L.5
  • 32
    • 0025963617 scopus 로고
    • Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis
    • Newman SL, Mikus LK, Tucci MA (1991) Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis. J Immunol 146:967-974.
    • (1991) J Immunol , vol.146 , pp. 967-974
    • Newman, S.L.1    Mikus, L.K.2    Tucci, M.A.3
  • 33
    • 0037143448 scopus 로고    scopus 로고
    • Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis
    • Olazabal IM, Caron E, May RC, Schilling K, Knecht DA, Machesky LM (2002) Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis. Curr Biol 12:1413-1418.
    • (2002) Curr Biol , vol.12 , pp. 1413-1418
    • Olazabal, I.M.1    Caron, E.2    May, R.C.3    Schilling, K.4    Knecht, D.A.5    Machesky, L.M.6
  • 34
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
    • Paresce DM, Ghosh RN, Maxfield FR (1996) Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 17:553-565.
    • (1996) Neuron , vol.17 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 35
    • 0028854921 scopus 로고
    • Recombinant GST/CD36 fusion proteins define a thrombospondin binding domain. Evidence for a single calcium-dependent binding site on CD36
    • Pearce S, Wu J, Silverstein RL (1995) Recombinant GST/CD36 fusion proteins define a thrombospondin binding domain. Evidence for a single calcium-dependent binding site on CD36. J Biol Chem 270:2981-2986.
    • (1995) J Biol Chem , vol.270 , pp. 2981-2986
    • Pearce, S.1    Wu, J.2    Silverstein, R.L.3
  • 36
    • 0142149188 scopus 로고    scopus 로고
    • Rac2 specificity in macrophage integrin signaling: Potential role for Syk kinase
    • Pradip D, Peng X, Durden DL (2003) Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase. J Biol Chem 278:41661-41669.
    • (2003) J Biol Chem , vol.278 , pp. 41661-41669
    • Pradip, D.1    Peng, X.2    Durden, D.L.3
  • 37
    • 0034814056 scopus 로고    scopus 로고
    • Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease
    • Rogers J, Lue LF (2001) Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem Int 39:333-340.
    • (2001) Neurochem Int , vol.39 , pp. 333-340
    • Rogers, J.1    Lue, L.F.2
  • 39
    • 0034992123 scopus 로고    scopus 로고
    • 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: No evidence of intracellular amyloid
    • Stalder M, Deller T, Staufenbiel M, Jucker M (2001) 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid. Neurobiol Aging 22:427-434.
    • (2001) Neurobiol Aging , vol.22 , pp. 427-434
    • Stalder, M.1    Deller, T.2    Staufenbiel, M.3    Jucker, M.4
  • 41
    • 7744224673 scopus 로고    scopus 로고
    • Microglia and neuroinflammation: A pathological perspective
    • Streit WJ, Mrak RE, Griffin WS (2004) Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 1:14.
    • (2004) J Neuroinflammation , vol.1 , pp. 14
    • Streit, W.J.1    Mrak, R.E.2    Griffin, W.S.3
  • 42
    • 0028179865 scopus 로고
    • Alzheimer beta-amyloid peptide 25-35: Electrostatic interactions with phospholipid membranes
    • Terzi E, Holzemann G, Seelig J (1994) Alzheimer beta-amyloid peptide 25-35: electrostatic interactions with phospholipid membranes. Biochemistry 33:7434-7441.
    • (1994) Biochemistry , vol.33 , pp. 7434-7441
    • Terzi, E.1    Holzemann, G.2    Seelig, J.3
  • 44
    • 0035877075 scopus 로고    scopus 로고
    • Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q
    • Webster SD, Galvan MD, Ferran E, Garzon-Rodriguez W, Glabe CG, Tenner AJ (2001) Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. J Immunol 166:7496-7503.
    • (2001) J Immunol , vol.166 , pp. 7496-7503
    • Webster, S.D.1    Galvan, M.D.2    Ferran, E.3    Garzon-Rodriguez, W.4    Glabe, C.G.5    Tenner, A.J.6
  • 45
    • 0034651748 scopus 로고    scopus 로고
    • Visualization of beta-amyloid peptide (Abeta) phagocytosis by human mononuclear phagocytes: Dependency on Abeta aggregate size
    • Weltzien RB, Pachter JS (2000) Visualization of beta-amyloid peptide (Abeta) phagocytosis by human mononuclear phagocytes: dependency on Abeta aggregate size. J Neurosci Res 59:522-527.
    • (2000) J Neurosci Res , vol.59 , pp. 522-527
    • Weltzien, R.B.1    Pachter, J.S.2
  • 46
    • 0034775391 scopus 로고    scopus 로고
    • Yersinia enterocolitica invasin triggers phagocytosis via beta1 integrins, CDC42Hs and WASp in macrophages
    • Wiedemann A, Linder S, Grassl G, Albert M, Autenrieth I, Aepfelbacher M (2001) Yersinia enterocolitica invasin triggers phagocytosis via beta1 integrins, CDC42Hs and WASp in macrophages. Cell Microbiol 3:693-702.
    • (2001) Cell Microbiol , vol.3 , pp. 693-702
    • Wiedemann, A.1    Linder, S.2    Grassl, G.3    Albert, M.4    Autenrieth, I.5    Aepfelbacher, M.6
  • 48
    • 0037531198 scopus 로고    scopus 로고
    • Intracranially administered anti-Aβ antibodies reduce β-amyloid deposition by mechanisms both independent of and associated with microglial activation
    • Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D (2003) Intracranially administered anti-Aβ antibodies reduce β-amyloid deposition by mechanisms both independent of and associated with microglial activation. J Neurosci 23:3745-3751.
    • (2003) J Neurosci , vol.23 , pp. 3745-3751
    • Wilcock, D.M.1    DiCarlo, G.2    Henderson, D.3    Jackson, J.4    Clarke, K.5    Ugen, K.E.6    Gordon, M.N.7    Morgan, D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.