-
1
-
-
0033591330
-
NOD1, an APAF-1-like activator of caspase-9 and nuclear factor-κB
-
Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G: NOD1, an APAF-1-like activator of caspase-9 and nuclear factor-κB. J Biol Chem (1999) 274(21):14560-14567.
-
(1999)
J Biol Chem
, vol.274
, Issue.21
, pp. 14560-14567
-
-
Inohara, N.1
Koseki, T.2
Del Peso, L.3
Hu, Y.4
Yee, C.5
Chen, S.6
Carrio, R.7
Merino, J.8
Liu, D.9
Ni, J.10
Nunez, G.11
-
2
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP et al: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 411(6837):603-606.
-
(2001)
Nature
, vol.411
, Issue.6837
, pp. 603-606
-
-
Ogura, Y.1
Bonen, D.K.2
Inohara, N.3
Nicolae, D.L.4
Chen, F.F.5
Ramos, R.6
Britton, H.7
Moran, T.8
Karaliuskas, R.9
Duerr, R.H.10
Achkar, J.P.11
-
3
-
-
40449140937
-
The NLR gene family: A standard nomenclature
-
Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM et al: The NLR gene family: A standard nomenclature. Immunity (2008) 28(3):285-287.
-
(2008)
Immunity
, vol.28
, Issue.3
, pp. 285-287
-
-
Ting, J.P.1
Lovering, R.C.2
Alnemri, E.S.3
Bertin, J.4
Boss, J.M.5
Davis, B.K.6
Flavell, R.A.7
Girardin, S.E.8
Godzik, A.9
Harton, J.A.10
Hoffman, H.M.11
-
4
-
-
77956220440
-
A role for the human nucleotide-binding domain, leucine-rich repeatcontaining family member NLRC5 in antiviral responses
-
Neerincx A, Lautz K, Menning M, Kremmer E, Zigrino P, Hösel M, Büning H, Schwarzenbacher R, Kufer TA: A role for the human nucleotide-binding domain, leucine-rich repeatcontaining family member NLRC5 in antiviral responses. J Biol Chem (2010) 285(34):26223-26232.
-
(2010)
J Biol Chem
, vol.285
, Issue.34
, pp. 26223-26232
-
-
Neerincx, A.1
Lautz, K.2
Menning, M.3
Kremmer, E.4
Zigrino, P.5
Hösel, M.6
Büning, H.7
Schwarzenbacher, R.8
Kufer, T.A.9
-
5
-
-
77949965210
-
Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
-
Dupaul-Chicoine J, Yeretssian G, Doiron K, Bergstrom KS, McIntire CR, LeBlanc PM, Meunier C, Turbide C, Gros P, Beauchemin N, Vallance BA et al: Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity (2010) 32(3):367-378.
-
(2010)
Immunity
, vol.32
, Issue.3
, pp. 367-378
-
-
Dupaul-Chicoine, J.1
Yeretssian, G.2
Doiron, K.3
Bergstrom, K.S.4
McIntire, C.R.5
Leblanc, P.M.6
Meunier, C.7
Turbide, C.8
Gros, P.9
Beauchemin, N.10
Vallance, B.A.11
-
6
-
-
39749084641
-
Active caspase-1 is a regulator of unconventional protein secretion
-
Keller M, Ruegg A, Werner S, Beer HD: Active caspase-1 is a regulator of unconventional protein secretion. Cell (2008) 132(5):818-831.
-
(2008)
Cell
, vol.132
, Issue.5
, pp. 818-831
-
-
Keller, M.1
Ruegg, A.2
Werner, S.3
Beer, H.D.4
-
7
-
-
41549157459
-
A molecular platform in neurons regulates inflammation after spinal cord injury
-
de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW: A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci (2008) 28(13):3404-3414.
-
(2008)
J Neurosci
, vol.28
, Issue.13
, pp. 3404-3414
-
-
De Rivero Vaccari, J.P.1
Lotocki, G.2
Marcillo, A.E.3
Dietrich, W.D.4
Keane, R.W.5
-
8
-
-
34247574122
-
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a sitespecific role in the inflammatory response
-
Kummer JA, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, van Bruggen R, Tschopp J: Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a sitespecific role in the inflammatory response. J Histochem Cytochem (2007) 55(5):443-452.
-
(2007)
J Histochem Cytochem
, vol.55
, Issue.5
, pp. 443-452
-
-
Kummer, J.A.1
Broekhuizen, R.2
Everett, H.3
Agostini, L.4
Kuijk, L.5
Martinon, F.6
Van Bruggen, R.7
Tschopp, J.8
-
9
-
-
67650492376
-
Inflammasomes are differentially expressed in cardiovascular and other tissues
-
Yin Y, Yan Y, Jiang X, Mai J, Chen NC, Wang H, Yang XF: Inflammasomes are differentially expressed in cardiovascular and other tissues. Int J Immunopathol Pharmacol (2009) 22(2): 311-322.
-
(2009)
Int J Immunopathol Pharmacol
, vol.22
, Issue.2
, pp. 311-322
-
-
Yin, Y.1
Yan, Y.2
Jiang, X.3
Mai, J.4
Chen, N.C.5
Wang, H.6
Yang, X.F.7
-
10
-
-
77956409550
-
NLRC5 limits the activation of inflammatory pathways
-
Benko S, Magalhaes JG, Philpott DJ, Girardin SE: NLRC5 limits the activation of inflammatory pathways. J Immunol (2010) 185(3):1681-1691.
-
(2010)
J Immunol
, vol.185
, Issue.3
, pp. 1681-1691
-
-
Benko, S.1
Magalhaes, J.G.2
Philpott, D.J.3
Girardin, S.E.4
-
11
-
-
4544234467
-
Mini-review: Specificity and expression of ciita, the master regulator of MHC class II genes
-
LeibundGut-Landmann S, Waldburger JM, Krawczyk M, Otten LA, Suter T, Fontana A, Acha-Orbea H, Reith W: Mini-review: Specificity and expression of ciita, the master regulator of MHC class II genes. Eur J Immunol (2004) 34(6):1513-1525.
-
(2004)
Eur J Immunol
, vol.34
, Issue.6
, pp. 1513-1525
-
-
Leibundgut-Landmann, S.1
Waldburger, J.M.2
Krawczyk, M.3
Otten, L.A.4
Suter, T.5
Fontana, A.6
Acha-Orbea, H.7
Reith, W.8
-
12
-
-
22244465576
-
Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-κB activation in muramyl dipeptide recognition
-
Barnich N, Aguirre JE, Reinecker HC, Xavier R, Podolsky DK: Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-κB activation in muramyl dipeptide recognition. J Cell Biol (2005) 170(1):21-26.
-
(2005)
J Cell Biol
, vol.170
, Issue.1
, pp. 21-26
-
-
Barnich, N.1
Aguirre, J.E.2
Reinecker, H.C.3
Xavier, R.4
Podolsky, D.K.5
-
13
-
-
38049177193
-
The pattern-recognition molecule NOD1 is localized at the plasma membrane at sites of bacterial interaction
-
Kufer TA, Kremmer E, Adam AC, Philpott DJ, Sansonetti PJ: The pattern-recognition molecule NOD1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol (2008) 10(2):477-486.
-
(2008)
Cell Microbiol
, vol.10
, Issue.2
, pp. 477-486
-
-
Kufer, T.A.1
Kremmer, E.2
Adam, A.C.3
Philpott, D.J.4
Sansonetti, P.J.5
-
14
-
-
34447504037
-
The NOD2-Rick complex signals from the plasma membrane
-
Lecine P, Esmiol S, Metais JY, Nicoletti C, Nourry C, McDonald C, Nunez G, Hugot JP, Borg JP, Ollendorff V: The NOD2-Rick complex signals from the plasma membrane. J Biol Chem (2007) 282(20):15197-15207.
-
(2007)
J Biol Chem
, vol.282
, Issue.20
, pp. 15197-15207
-
-
Lecine, P.1
Esmiol, S.2
Metais, J.Y.3
Nicoletti, C.4
Nourry, C.5
McDonald, C.6
Nunez, G.7
Hugot, J.P.8
Borg, J.P.9
Ollendorff, V.10
-
15
-
-
38749097018
-
NLRX1 is a regulator of mitochondrial antiviral immunity
-
Moore CB, Bergstralh DT, Duncan JA, Lei Y, Morrison TE, Zimmermann AG, Accavitti-Loper MA, Madden VJ, Sun L, Ye Z, Lich JD et al: NLRX1 is a regulator of mitochondrial antiviral immunity. Nature (2008) 451(7178):573-577.
-
(2008)
Nature
, vol.451
, Issue.7178
, pp. 573-577
-
-
Moore, C.B.1
Bergstralh, D.T.2
Duncan, J.A.3
Lei, Y.4
Morrison, T.E.5
Zimmermann, A.G.6
Accavitti-Loper, M.A.7
Madden, V.J.8
Sun, L.9
Ye, Z.10
Lich, J.D.11
-
16
-
-
70350365362
-
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix
-
Arnoult D, Soares F, Tattoli I, Castanier C, Philpott DJ, Girardin SE: An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix. J Cell Sci (2009) 122(Pt 17):3161-3168.
-
(2009)
J Cell Sci
, vol.122
, Issue.PART 17
, pp. 3161-3168
-
-
Arnoult, D.1
Soares, F.2
Tattoli, I.3
Castanier, C.4
Philpott, D.J.5
Girardin, S.E.6
-
17
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
-
Martinon F, Burns K, Tschopp J: The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol Cell (2002) 10(2): 417-426.
-
(2002)
Mol Cell
, vol.10
, Issue.2
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
18
-
-
33646024628
-
The apoptosome activates caspase-9 by dimerization
-
Pop C, Timmer J, Sperandio S, Salvesen GS: The apoptosome activates caspase-9 by dimerization. Mol Cell (2006) 22(2): 269-275.
-
(2006)
Mol Cell
, vol.22
, Issue.2
, pp. 269-275
-
-
Pop, C.1
Timmer, J.2
Sperandio, S.3
Salvesen, G.S.4
-
19
-
-
37549002511
-
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
-
Shao W, Yeretssian G, Doiron K, Hussain SN, Saleh M: The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem (2007) 282(50):36321-36329.
-
(2007)
J Biol Chem
, vol.282
, Issue.50
, pp. 36321-36329
-
-
Shao, W.1
Yeretssian, G.2
Doiron, K.3
Hussain, S.N.4
Saleh, M.5
-
20
-
-
33847376042
-
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation
-
Faustin B, Lartigue L, Bruey JM, Luciano F, Sergienko E, Bailly-Maitre B, Volkmann N, Hanein D, Rouiller I, Reed JC: Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell (2007) 25(5): 713-724.
-
(2007)
Mol Cell
, vol.25
, Issue.5
, pp. 713-724
-
-
Faustin, B.1
Lartigue, L.2
Bruey, J.M.3
Luciano, F.4
Sergienko, E.5
Bailly-Maitre, B.6
Volkmann, N.7
Hanein, D.8
Rouiller, I.9
Reed, J.C.10
-
21
-
-
0035937775
-
Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins
-
Hlaing T, Guo RF, Dilley KA, Loussia JM, Morrish TA, Shi MM, Vincenz C, Ward PA: Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J Biol Chem (2001) 276(12):9230-9238.
-
(2001)
J Biol Chem
, vol.276
, Issue.12
, pp. 9230-9238
-
-
Hlaing, T.1
Guo, R.F.2
Dilley, K.A.3
Loussia, J.M.4
Morrish, T.A.5
Shi, M.M.6
Vincenz, C.7
Ward, P.A.8
-
22
-
-
31744441475
-
NALP1B controls mouse macrophage susceptibility to anthrax lethal toxin
-
Boyden ED, Dietrich WF: NALP1B controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet (2006) 38(2):240-244.
-
(2006)
Nat Genet
, vol.38
, Issue.2
, pp. 240-244
-
-
Boyden, E.D.1
Dietrich, W.F.2
-
23
-
-
33947497237
-
NALP1 in vitiligo-associated multiple autoimmune disease
-
Jin Y, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC, Fain PR, Spritz RA: NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med (2007) 356(12):1216-1225.
-
(2007)
N Engl J Med
, vol.356
, Issue.12
, pp. 1216-1225
-
-
Jin, Y.1
Mailloux, C.M.2
Gowan, K.3
Riccardi, S.L.4
Laberge, G.5
Bennett, D.C.6
Fain, P.R.7
Spritz, R.A.8
-
24
-
-
77957554717
-
Molecular mechanism of NLRP3 inflammasome activation
-
Jin C, Flavell RA: Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol (2010) 30(5):628-631.
-
(2010)
J Clin Immunol
, vol.30
, Issue.5
, pp. 628-631
-
-
Jin, C.1
Flavell, R.A.2
-
25
-
-
34247118826
-
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of toll-like receptor signaling
-
Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L, Vandenabeele P, Nunez G: Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of toll-like receptor signaling. Immunity (2007) 26(4):433-443.
-
(2007)
Immunity
, vol.26
, Issue.4
, pp. 433-443
-
-
Kanneganti, T.D.1
Lamkanfi, M.2
Kim, Y.G.3
Chen, G.4
Park, J.H.5
Franchi, L.6
Vandenabeele, P.7
Nunez, G.8
-
26
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E: Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol (2008) 9(8):847-856.
-
(2008)
Nat Immunol
, vol.9
, Issue.8
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
Rock, K.L.6
Fitzgerald, K.A.7
Latz, E.8
-
27
-
-
36849045915
-
The inflammasome: A danger sensing complex triggering innate immunity
-
Petrilli V, Dostert C, Muruve DA, Tschopp J: The inflammasome: A danger sensing complex triggering innate immunity. Curr Opin Immunol (2007) 19(6):615-622.
-
(2007)
Curr Opin Immunol
, vol.19
, Issue.6
, pp. 615-622
-
-
Petrilli, V.1
Dostert, C.2
Muruve, D.A.3
Tschopp, J.4
-
28
-
-
75649096002
-
Thioredoxininteracting protein links oxidative stress to inflammasome activation
-
Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J: Thioredoxininteracting protein links oxidative stress to inflammasome activation. Nat Immunol (2010) 11(2):136-140.
-
(2010)
Nat Immunol
, vol.11
, Issue.2
, pp. 136-140
-
-
Zhou, R.1
Tardivel, A.2
Thorens, B.3
Choi, I.4
Tschopp, J.5
-
29
-
-
33744493091
-
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via IPAF
-
Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, Aderem A: Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via IPAF. Nat Immunol (2006) 7(6):569-575.
-
(2006)
Nat Immunol
, vol.7
, Issue.6
, pp. 569-575
-
-
Miao, E.A.1
Alpuche-Aranda, C.M.2
Dors, M.3
Clark, A.E.4
Bader, M.W.5
Miller, S.I.6
Aderem, A.7
-
30
-
-
77649241461
-
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
-
Miao EA, Mao DP, Yudkovsky N, Bonneau R, Lorang CG, Warren SE, Leaf IA, Aderem A: Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci USA (2010) 107(7):3076-3080.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.7
, pp. 3076-3080
-
-
Miao, E.A.1
Mao, D.P.2
Yudkovsky, N.3
Bonneau, R.4
Lorang, C.G.5
Warren, S.E.6
Leaf, I.A.7
Aderem, A.8
-
31
-
-
52549099416
-
Critical function for NAIP5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
-
Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM et al: Critical function for NAIP5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol (2008) 9(10):1171-1178.
-
(2008)
Nat Immunol
, vol.9
, Issue.10
, pp. 1171-1178
-
-
Lightfield, K.L.1
Persson, J.2
Brubaker, S.W.3
Witte, C.E.4
Von Moltke, J.5
Dunipace, E.A.6
Henry, T.7
Sun, Y.H.8
Cado, D.9
Dietrich, W.F.10
Monack, D.M.11
-
32
-
-
0037228017
-
Birc1e is the gene within the LGN1 locus associated with resistance to legionella pneumophila
-
Diez E, Lee SH, Gauthier S, Yaraghi Z, Tremblay M, Vidal S, Gros P: Birc1e is the gene within the LGN1 locus associated with resistance to legionella pneumophila. Nat Genet (2003) 33(1):55-60.
-
(2003)
Nat Genet
, vol.33
, Issue.1
, pp. 55-60
-
-
Diez, E.1
Lee, S.H.2
Gauthier, S.3
Yaraghi, Z.4
Tremblay, M.5
Vidal, S.6
Gros, P.7
-
33
-
-
70350454786
-
Restriction of legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators IRF1 and irf8 and NOD-like receptors naip5 and NLRC4
-
Fortier A, Doiron K, Saleh M, Grinstein S, Gros P: Restriction of legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators IRF1 and irf8 and NOD-like receptors naip5 and NLRC4. Infect Immun (2009) 77(11):4794-4805.
-
(2009)
Infect Immun
, vol.77
, Issue.11
, pp. 4794-4805
-
-
Fortier, A.1
Doiron, K.2
Saleh, M.3
Grinstein, S.4
Gros, P.5
-
34
-
-
78149487761
-
Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting nf-κB signaling
-
doi:10.4049/jimmunol.1002517
-
Labbe K, Miu J, Yeretssian G, Serghides L, Tam M, Finney CA, Erdman LK, Goulet ML, Kain KC, Stevenson MM, Saleh M: Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting nf-κB signaling. J Immunol (2010):doi:10.4049/jimmunol.1002517.
-
(2010)
J Immunol
-
-
Labbe, K.1
Miu, J.2
Yeretssian, G.3
Serghides, L.4
Tam, M.5
Finney, C.A.6
Erdman, L.K.7
Goulet, M.L.8
Kain, K.C.9
Stevenson, M.M.10
Saleh, M.11
-
35
-
-
77749260601
-
Experimental cerebral malaria progresses independently of the NLRP3 inflammasome
-
Reimer T, Shaw MH, Franchi L, Coban C, Ishii KJ, Akira S, Horii T, Rodriguez A, Nunez G: Experimental cerebral malaria progresses independently of the NLRP3 inflammasome. Eur J Immunol (2010) 40(3):764-769.
-
(2010)
Eur J Immunol
, vol.40
, Issue.3
, pp. 764-769
-
-
Reimer, T.1
Shaw, M.H.2
Franchi, L.3
Coban, C.4
Ishii, K.J.5
Akira, S.6
Horii, T.7
Rodriguez, A.8
Nunez, G.9
-
36
-
-
20444442787
-
Pypaf3, a pyrin-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1β secretion
-
Kinoshita T, Wang Y, Hasegawa M, Imamura R, Suda T: Pypaf3, a pyrin-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1β secretion. J Biol Chem (2005) 280(23):21720-21725.
-
(2005)
J Biol Chem
, vol.280
, Issue.23
, pp. 21720-21725
-
-
Kinoshita, T.1
Wang, Y.2
Hasegawa, M.3
Imamura, R.4
Suda, T.5
-
37
-
-
28844494900
-
The caterpiller protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor α-, and mycobacterium tuberculosis-induced pro-inflammatory signals
-
Williams KL, Lich JD, Duncan JA, Reed W, Rallabhandi P, Moore C, Kurtz S, Coffield VM, Accavitti-Loper MA, Su L, Vogel SN et al: The caterpiller protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor α-, and mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 280(48):39914-39924.
-
(2005)
J Biol Chem
, vol.280
, Issue.48
, pp. 39914-39924
-
-
Williams, K.L.1
Lich, J.D.2
Duncan, J.A.3
Reed, W.4
Rallabhandi, P.5
Moore, C.6
Kurtz, S.7
Coffield, V.M.8
Accavitti-Loper, M.A.9
Su, L.10
Vogel, S.N.11
-
38
-
-
40249111682
-
NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production
-
Tattoli I, Carneiro LA, Jehanno M, Magalhaes JG, Shu Y, Philpott DJ, Arnoult D, Girardin SE: NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production. EMBO Rep (2008) 9(3):293-300.
-
(2008)
EMBO Rep
, vol.9
, Issue.3
, pp. 293-300
-
-
Tattoli, I.1
Carneiro, L.A.2
Jehanno, M.3
Magalhaes, J.G.4
Shu, Y.5
Philpott, D.J.6
Arnoult, D.7
Girardin, S.E.8
-
39
-
-
0012722659
-
NOD2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
-
Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ: NOD2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 278(11):8869-8872.
-
(2003)
J Biol Chem
, vol.278
, Issue.11
, pp. 8869-8872
-
-
Girardin, S.E.1
Boneca, I.G.2
Viala, J.3
Chamaillard, M.4
Labigne, A.5
Thomas, G.6
Philpott, D.J.7
Sansonetti, P.J.8
-
40
-
-
0033591330
-
NOD1, an APAF-1-like activator of caspase-9 and nuclear factor-κB
-
Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G: NOD1, an APAF-1-like activator of caspase-9 and nuclear factor-κB. J Biol Chem (1999) 274(21):14560-14567.
-
(1999)
J Biol Chem
, vol.274
, Issue.21
, pp. 14560-14567
-
-
Inohara, N.1
Koseki, T.2
Del Peso, L.3
Hu, Y.4
Yee, C.5
Chen, S.6
Carrio, R.7
Merino, J.8
Liu, D.9
Ni, J.10
Núñez, G.11
-
41
-
-
66949138341
-
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2
-
Bertrand MJ, Doiron K, Labbé K, Korneluk RG, Barker PA, Saleh M: Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity (2009) 30(6):789-801.
-
(2009)
Immunity
, vol.30
, Issue.6
, pp. 789-801
-
-
Bertrand, M.J.1
Doiron, K.2
Labbé, K.3
Korneluk, R.G.4
Barker, P.A.5
Saleh, M.6
-
42
-
-
33845768987
-
Integrating cell-signalling pathways with nf-κb and ikk function
-
Perkins ND: Integrating cell-signalling pathways with nf-κb and ikk function. Nat Rev Mol Cell Biol (2007) 8(1):49-62.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.1
, pp. 49-62
-
-
Perkins, N.D.1
-
43
-
-
45549093755
-
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to bacillus anthracis infection and muramyl dipeptide
-
Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M: A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci USA (2008) 105(22):7803-7808.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.22
, pp. 7803-7808
-
-
Hsu, L.C.1
Ali, S.R.2
McGillivray, S.3
Tseng, P.H.4
Mariathasan, S.5
Humke, E.W.6
Eckmann, L.7
Powell, J.J.8
Nizet, V.9
Dixit, V.M.10
Karin, M.11
-
44
-
-
40149084641
-
Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity
-
LeBlanc PM, Yeretssian G, Rutherford N, Doiron K, Nadiri A, Zhu L, Green DR, Gruenheid S, Saleh M: Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity Cell Host Microbe (2008) 3(3):146-157.
-
(2008)
Cell Host Microbe
, vol.3
, Issue.3
, pp. 146-157
-
-
Leblanc, P.M.1
Yeretssian, G.2
Rutherford, N.3
Doiron, K.4
Nadiri, A.5
Zhu, L.6
Green, D.R.7
Gruenheid, S.8
Saleh, M.9
-
45
-
-
34247265509
-
A crucial function of sgt1 and hsp90 in inflammasome activity links mammalian and plant innate immune responses
-
Mayor A, Martinon F, De Smedt T, Petrilli V, Tschopp J: A crucial function of sgt1 and hsp90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol (2007) 8(5):497-503.
-
(2007)
Nat Immunol
, vol.8
, Issue.5
, pp. 497-503
-
-
Mayor, A.1
Martinon, F.2
De Smedt, T.3
Petrilli, V.4
Tschopp, J.5
-
46
-
-
33644772156
-
A short isoform of NOD2/CARD15, NOD2-s, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways
-
Rosenstiel P, Huse K, Till A, Hampe J, Hellmig S, Sina C, Billmann S, von Kampen O, Waetzig GH, Platzer M, Seegert D et al: A short isoform of NOD2/CARD15, NOD2-s, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways. Proc Natl Acad Sci USA (2006) 103(9):3280-3285.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.9
, pp. 3280-3285
-
-
Rosenstiel, P.1
Huse, K.2
Till, A.3
Hampe, J.4
Hellmig, S.5
Sina, C.6
Billmann, S.7
Von Kampen, O.8
Waetzig, G.H.9
Platzer, M.10
Seegert, D.11
-
47
-
-
77951902675
-
NLRC5 negatively regulates the NF-κB and type i interferon signaling pathways
-
Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ, Wang RF: NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways. Cell (2010) 141(3):483-496.
-
(2010)
Cell(
, vol.141
, Issue.3
, pp. 483-496
-
-
Cui, J.1
Zhu, L.2
Xia, X.3
Wang, H.Y.4
Legras, X.5
Hong, J.6
Ji, J.7
Shen, P.8
Zheng, S.9
Chen, Z.J.10
Wang, R.F.11
-
48
-
-
0035941220
-
Cardinal, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-κB activation pathways
-
Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ: Cardinal, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-κB activation pathways. J Biol Chem (2001) 276(47): 44069-44077.
-
(2001)
J Biol Chem
, vol.276
, Issue.47
, pp. 44069-44077
-
-
Bouchier-Hayes, L.1
Conroy, H.2
Egan, H.3
Adrain, C.4
Creagh, E.M.5
MacFarlane, M.6
Martin, S.J.7
-
49
-
-
34548225362
-
NF-κB is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of ikkβ
-
Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Goktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N et al: NF-κB is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of ikkβ. Cell (2007) 130(5):918-931.
-
(2007)
Cell
, vol.130
, Issue.5
, pp. 918-931
-
-
Greten, F.R.1
Arkan, M.C.2
Bollrath, J.3
Hsu, L.C.4
Goode, J.5
Miething, C.6
Goktuna, S.I.7
Neuenhahn, M.8
Fierer, J.9
Paxian, S.10
Van Rooijen, N.11
-
50
-
-
67650421494
-
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
-
Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J: T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature (2009) 460(7252):269-273.
-
(2009)
Nature
, vol.460
, Issue.7252
, pp. 269-273
-
-
Guarda, G.1
Dostert, C.2
Staehli, F.3
Cabalzar, K.4
Castillo, R.5
Tardivel, A.6
Schneider, P.7
Tschopp, J.8
-
51
-
-
62649092113
-
Mechanism of Bcl-2 andBcl-xL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization
-
Faustin B, Chen Y, Zhai D, Le Negrate G, Lartigue L, Satterthwait A, Reed JC: Mechanism of Bcl-2 andBcl-xL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization. Proc Natl Acad Sci USA (2009) 106(10):3935-3940.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.10
, pp. 3935-3940
-
-
Faustin, B.1
Chen, Y.2
Zhai, D.3
Le Negrate, G.4
Lartigue, L.5
Satterthwait, A.6
Reed, J.C.7
-
52
-
-
0034730325
-
Iceberg: A novel inhibitor of interleukin-1β generation
-
Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit VM: Iceberg: A novel inhibitor of interleukin-1β generation. Cell (2000) 103(1):99-111.
-
(2000)
Cell
, vol.103
, Issue.1
, pp. 99-111
-
-
Humke, E.W.1
Shriver, S.K.2
Starovasnik, M.A.3
Fairbrother, W.J.4
Dixit, V.M.5
-
53
-
-
0034743434
-
Regulation of IL-1β generation by pseudo-ICE and iceberg, two dominant negative caspase recruitment domain proteins
-
Druilhe A, Srinivasula SM, Razmara M, Ahmad M, Alnemri ES: Regulation of IL-1β generation by pseudo-ICE and iceberg, two dominant negative caspase recruitment domain proteins. Cell Death Differ (2001) 8(6):649-657.
-
(2001)
Cell Death Differ
, vol.8
, Issue.6
, pp. 649-657
-
-
Druilhe, A.1
Srinivasula, S.M.2
Razmara, M.3
Ahmad, M.4
Alnemri, E.S.5
-
54
-
-
33646175602
-
Enhanced bacterial clearance and sepsis resistance in caspase-12- deficient mice
-
Saleh M, Mathison JC, Wolinski MK, Bensinger SJ, Fitzgerald P, Droin N, Ulevitch RJ, Green DR, Nicholson DW: Enhanced bacterial clearance and sepsis resistance in caspase-12- deficient mice. Nature (2006) 440(7087):1064-1068.
-
(2006)
Nature
, vol.440
, Issue.7087
, pp. 1064-1068
-
-
Saleh, M.1
Mathison, J.C.2
Wolinski, M.K.3
Bensinger, S.J.4
Fitzgerald, P.5
Droin, N.6
Ulevitch, R.J.7
Green, D.R.8
Nicholson, D.W.9
-
55
-
-
2342457148
-
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
-
Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG et al: Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 429(6987):75-79.
-
(2004)
Nature
, vol.429
, Issue.6987
, pp. 75-79
-
-
Saleh, M.1
Vaillancourt, J.P.2
Graham, R.K.3
Huyck, M.4
Srinivasula, S.M.5
Alnemri, E.S.6
Steinberg, M.H.7
Nolan, V.8
Baldwin, C.T.9
Hotchkiss, R.S.10
Buchman, T.G.11
-
56
-
-
67049158196
-
Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection
-
Yeretssian G, Doiron K, Shao W, Leavitt BR, Hayden MR, Nicholson DW, Saleh M: Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection. Proc Natl Acad Sci USA (2009) 106(22):9016-9020.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.22
, pp. 9016-9020
-
-
Yeretssian, G.1
Doiron, K.2
Shao, W.3
Leavitt, B.R.4
Hayden, M.R.5
Nicholson, D.W.6
Saleh, M.7
-
57
-
-
0038682430
-
The paad/pyrin-only protein pop1/asc2 is a modulator of asc-mediated nuclear-factor-κ B and pro-caspase-1 regulation
-
Stehlik C, Krajewska M, Welsh K, Krajewski S, Godzik A, Reed JC: The paad/pyrin-only protein pop1/asc2 is a modulator of asc-mediated nuclear-factor-κ B and pro-caspase-1 regulation. Biochem J (2003) 373(Pt 1):101-113.
-
(2003)
Biochem J
, vol.373
, Issue.PART 1
, pp. 101-113
-
-
Stehlik, C.1
Krajewska, M.2
Welsh, K.3
Krajewski, S.4
Godzik, A.5
Reed, J.C.6
-
58
-
-
33847730763
-
Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation
-
Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. Infect Immun (2007) 75(3): 1484-1492.
-
(2007)
Infect Immun
, vol.75
, Issue.3
, pp. 1484-1492
-
-
Dorfleutner, A.1
Bryan, N.B.2
Talbott, S.J.3
Funya, K.N.4
Rellick, S.L.5
Reed, J.C.6
Shi, X.7
Rojanasakul, Y.8
Flynn, D.C.9
Stehlik, C.10
-
59
-
-
69949088960
-
Nlr-mediated control of inflammasome assembly in the host response against bacterial pathogens
-
Brodsky IE, Monack D: Nlr-mediated control of inflammasome assembly in the host response against bacterial pathogens. Semin Immunol (2009) 21(4):199-207.
-
(2009)
Semin Immunol
, vol.21
, Issue.4
, pp. 199-207
-
-
Brodsky, I.E.1
Monack, D.2
-
60
-
-
47249095738
-
Multiple NOD-like receptors activate caspase 1 during Listeria monocytogenes infection
-
Warren SE, Mao DP, Rodriguez AE, Miao EA, Aderem A: Multiple NOD-like receptors activate caspase 1 during Listeria monocytogenes infection. J Immunol (2008) 180(11):7558-7564.
-
(2008)
J Immunol
, vol.180
, Issue.11
, pp. 7558-7564
-
-
Warren, S.E.1
Mao, D.P.2
Rodriguez, A.E.3
Miao, E.A.4
Aderem, A.5
-
61
-
-
77955390094
-
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
-
Broz P, Newton K, Lamkanfi M, Mariathasan S, Dixit VM, Monack DM: Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med (2010) 207(8):1745-1755.
-
(2010)
J Exp Med
, vol.207
, Issue.8
, pp. 1745-1755
-
-
Broz, P.1
Newton, K.2
Lamkanfi, M.3
Mariathasan, S.4
Dixit, V.M.5
Monack, D.M.6
-
62
-
-
74049126045
-
Recognition of RNA virus by Rig-I results in activation of CARD9 and inflammasome signaling for interleukin 1 β production
-
Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschlager N, Schlee M, Rothenfusser S, Barchet W, Kato H et al: Recognition of RNA virus by Rig-I results in activation of CARD9 and inflammasome signaling for interleukin 1 β production. Nat Immunol (2010) 11(1):63-69.
-
(2010)
Nat Immunol
, vol.11
, Issue.1
, pp. 63-69
-
-
Poeck, H.1
Bscheider, M.2
Gross, O.3
Finger, K.4
Roth, S.5
Rebsamen, M.6
Hannesschlager, N.7
Schlee, M.8
Rothenfusser, S.9
Barchet, W.10
Kato, H.11
-
63
-
-
64049111768
-
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
-
Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, Ting JP: The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity (2009) 30(4):556-565.
-
(2009)
Immunity
, vol.30
, Issue.4
, pp. 556-565
-
-
Allen, I.C.1
Scull, M.A.2
Moore, C.B.3
Holl, E.K.4
McElvania-Tekippe, E.5
Taxman, D.J.6
Guthrie, E.H.7
Pickles, R.J.8
Ting, J.P.9
-
64
-
-
64049096334
-
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza a virus via the regulation of caspase-1
-
Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC et al: The intracellular sensor NLRP3 mediates key innate and healing responses to influenza a virus via the regulation of caspase-1. Immunity (2009) 30(4):566-575.
-
(2009)
Immunity
, vol.30
, Issue.4
, pp. 566-575
-
-
Thomas, P.G.1
Dash, P.2
Aldridge Jr., J.R.3
Ellebedy, A.H.4
Reynolds, C.5
Funk, A.J.6
Martin, W.J.7
Lamkanfi, M.8
Webby, R.J.9
Boyd, K.L.10
Doherty, P.C.11
-
65
-
-
60549112774
-
Inflammasome recognition of influenza virus is essential for adaptive immune responses
-
Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A: Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med (2009) 206(1): 79-87.
-
(2009)
J Exp Med
, vol.206
, Issue.1
, pp. 79-87
-
-
Ichinohe, T.1
Lee, H.K.2
Ogura, Y.3
Flavell, R.4
Iwasaki, A.5
-
66
-
-
70349317039
-
Cutting edge: Candida albicans hyphae formation triggers activation of the NLRP3 inflammasome
-
Joly S, Ma N, Sadler JJ, Soll DR, Cassel SL, Sutterwala FS: Cutting edge: Candida albicans hyphae formation triggers activation of the NLRP3 inflammasome. J Immunol (2009) 183(6):3578-3581.
-
(2009)
J Immunol
, vol.183
, Issue.6
, pp. 3578-3581
-
-
Joly, S.1
Ma, N.2
Sadler, J.J.3
Soll, D.R.4
Cassel, S.L.5
Sutterwala, F.S.6
-
67
-
-
76249120134
-
Recognition of peptidoglycan from the microbiota by NOD1 enhances systemic innate immunity
-
Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y, Weiser JN: Recognition of peptidoglycan from the microbiota by NOD1 enhances systemic innate immunity. Nature Med (2010) 16(2):228-231.
-
(2010)
Nature Med
, vol.16
, Issue.2
, pp. 228-231
-
-
Clarke, T.B.1
Davis, K.M.2
Lysenko, E.S.3
Zhou, A.Y.4
Yu, Y.5
Weiser, J.N.6
-
68
-
-
34247254780
-
NOD1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity
-
Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ: NOD1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity (2007) 26(4):445-459.
-
(2007)
Immunity
, vol.26
, Issue.4
, pp. 445-459
-
-
Fritz, J.H.1
Le Bourhis, L.2
Sellge, G.3
Magalhaes, J.G.4
Fsihi, H.5
Kufer, T.A.6
Collins, C.7
Viala, J.8
Ferrero, R.L.9
Girardin, S.E.10
Philpott, D.J.11
-
69
-
-
70350569295
-
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β-dependent adaptive immunity against tumors
-
Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL et al: Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β-dependent adaptive immunity against tumors. Nature Med (2009) 15(10):1170-1178.
-
(2009)
Nature Med
, vol.15
, Issue.10
, pp. 1170-1178
-
-
Ghiringhelli, F.1
Apetoh, L.2
Tesniere, A.3
Aymeric, L.4
Ma, Y.5
Ortiz, C.6
Vermaelen, K.7
Panaretakis, T.8
Mignot, G.9
Ullrich, E.10
Perfettini, J.L.11
-
70
-
-
50849112477
-
The nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity
-
Franchi L, Nunez G: The nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity. Eur J Immunol (2008) 38(8):2085-2089.
-
(2008)
Eur J Immunol
, vol.38
, Issue.8
, pp. 2085-2089
-
-
Franchi, L.1
Nunez, G.2
-
71
-
-
70449713915
-
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
-
McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P: Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 183(7): 4403-4414.
-
(2009)
J Immunol
, vol.183
, Issue.7
, pp. 4403-4414
-
-
McKee, A.S.1
Munks, M.W.2
MacLeod, M.K.3
Fleenor, C.J.4
Van Rooijen, N.5
Kappler, J.W.6
Marrack, P.7
-
72
-
-
45749111446
-
Crucial role for the NALP3 inflammasome in the immunostimulatory properties of aluminium adjuvants
-
Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA: Crucial role for the NALP3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature (2008) 453(7198):1122-1126.
-
(2008)
Nature
, vol.453
, Issue.7198
, pp. 1122-1126
-
-
Eisenbarth, S.C.1
Colegio, O.R.2
O'Connor, W.3
Sutterwala, F.S.4
Flavell, R.A.5
-
73
-
-
56149119563
-
Cutting edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
-
Kool M, Petrilli V, De Smedt T, Rolaz A, Hammad H, van Nimwegen M, Bergen IM, Castillo R, Lambrecht BN, Tschopp J: Cutting edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol (2008) 181(6):3755-3759.
-
(2008)
J Immunol
, vol.181
, Issue.6
, pp. 3755-3759
-
-
Kool, M.1
Petrilli, V.2
De Smedt, T.3
Rolaz, A.4
Hammad, H.5
Van Nimwegen, M.6
Bergen, I.M.7
Castillo, R.8
Lambrecht, B.N.9
Tschopp, J.10
-
74
-
-
47849087075
-
Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
-
Li H, Willingham SB, Ting JP, Re F: Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol (2008) 181(1):17-21.
-
(2008)
J Immunol
, vol.181
, Issue.1
, pp. 17-21
-
-
Li, H.1
Willingham, S.B.2
Ting, J.P.3
Re, F.4
-
75
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V et al: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 411(6837):599-603.
-
(2001)
Nature
, vol.411
, Issue.6837
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
Lesage, S.4
Cezard, J.P.5
Belaiche, J.6
Almer, S.7
Tysk, C.8
O'Morain, C.A.9
Gassull, M.10
Binder, V.11
-
76
-
-
58149159542
-
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
-
Villani AC, Lemire M, Fortin G, Louis E, Silverberg MS, Collette C, Baba N, Libioulle C, Belaiche J, Bitton A, Gaudet D et al: Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet (2009) 41(1):71-76.
-
(2009)
Nat Genet
, vol.41
, Issue.1
, pp. 71-76
-
-
Villani, A.C.1
Lemire, M.2
Fortin, G.3
Louis, E.4
Silverberg, M.S.5
Collette, C.6
Baba, N.7
Libioulle, C.8
Belaiche, J.9
Bitton, A.10
Gaudet, D.11
-
77
-
-
77950002937
-
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
-
Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD: The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 32(3):379-391
-
(2010)
Immunity
, vol.32
, Issue.3
, pp. 379-391
-
-
Zaki, M.H.1
Boyd, K.L.2
Vogel, P.3
Kastan, M.B.4
Lamkanfi, M.5
Kanneganti, T.D.6
-
78
-
-
77952303410
-
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
-
Allen IC, TeKippe EM, Woodford RM, Uronis JM, Holl EK, Rogers AB, Herfarth HH, Jobin C, Ting JP: The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 207(5):1045-1056.
-
(2010)
J Exp Med
, vol.207
, Issue.5
, pp. 1045-1056
-
-
Allen, I.C.1
Tekippe, E.M.2
Woodford, R.M.3
Uronis, J.M.4
Holl, E.K.5
Rogers, A.B.6
Herfarth, H.H.7
Jobin, C.8
Ting, J.P.9
-
79
-
-
77955350419
-
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18
-
Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai R-M, Wang E, Ma W, Haines D, O'hUigin C, Marincola FM et al: MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18. J Exp Med (2010) 207(8):1625-1636.
-
(2010)
J Exp Med
, vol.207
, Issue.8
, pp. 1625-1636
-
-
Salcedo, R.1
Worschech, A.2
Cardone, M.3
Jones, Y.4
Gyulai, Z.5
Dai, R.-M.6
Wang, E.7
Ma, W.8
Haines, D.9
O'Huigin, C.10
Marincola, F.M.11
-
80
-
-
77956128040
-
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
-
Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M, Tschopp J, Endres S, Latz E, Schnurr M: Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut (2010) 59(9):1192-1199.
-
(2010)
Gut
, vol.59
, Issue.9
, pp. 1192-1199
-
-
Bauer, C.1
Duewell, P.2
Mayer, C.3
Lehr, H.A.4
Fitzgerald, K.A.5
Dauer, M.6
Tschopp, J.7
Endres, S.8
Latz, E.9
Schnurr, M.10
-
81
-
-
34250835251
-
The inflammasome mediates UVB-induced activation and secretion of interleukin-1β by keratinocytes
-
Feldmeyer L, Keller M, Niklaus G, Hohl D, Werner S, Beer HD: The inflammasome mediates UVB-induced activation and secretion of interleukin-1β by keratinocytes. Curr Biol (2007) 17(13):1140-1145.
-
(2007)
Curr Biol
, vol.17
, Issue.13
, pp. 1140-1145
-
-
Feldmeyer, L.1
Keller, M.2
Niklaus, G.3
Hohl, D.4
Werner, S.5
Beer, H.D.6
-
82
-
-
77956394358
-
Inflammasome and IL-1β-mediated disorders
-
Hoffman HM, Wanderer AA: Inflammasome and IL-1β-mediated disorders. Curr Allergy Asthma Rep (2010) 10(4):229-235.
-
(2010)
Curr Allergy Asthma Rep
, vol.10
, Issue.4
, pp. 229-235
-
-
Hoffman, H.M.1
Wanderer, A.A.2
-
83
-
-
66949115474
-
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
-
Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P et al: Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity (2009) 30(6):875-887.
-
(2009)
Immunity
, vol.30
, Issue.6
, pp. 875-887
-
-
Brydges, S.D.1
Mueller, J.L.2
McGeough, M.D.3
Pena, C.A.4
Misaghi, A.5
Gandhi, C.6
Putnam, C.D.7
Boyle, D.L.8
Firestein, G.S.9
Horner, A.A.10
Soroosh, P.11
-
84
-
-
66949175347
-
A mutation in the NLRP3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
-
Meng G, Zhang F, Fuss I, Kitani A, Strober W: A mutation in the NLRP3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity (2009) 30(6):860-874.
-
(2009)
Immunity
, vol.30
, Issue.6
, pp. 860-874
-
-
Meng, G.1
Zhang, F.2
Fuss, I.3
Kitani, A.4
Strober, W.5
-
85
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J: Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 440(7081):237-241.
-
(2006)
Nature
, vol.440
, Issue.7081
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
86
-
-
43249125839
-
Innate immune activation through NALP3 inflammasome sensing of asbestos and silica
-
Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J: Innate immune activation through NALP3 inflammasome sensing of asbestos and silica. Science (2008) 320(5876):674-677.
-
(2008)
Science
, vol.320
, Issue.5876
, pp. 674-677
-
-
Dostert, C.1
Petrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
Tschopp, J.6
-
87
-
-
61749099391
-
Acetaminopheninduced hepatotoxicity in mice is dependent on TLR9 and the NALP3 inflammasome
-
Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ: Acetaminopheninduced hepatotoxicity in mice is dependent on TLR9 and the NALP3 inflammasome. J Clin Invest (2009) 119(2):305-314.
-
(2009)
J Clin Invest
, vol.119
, Issue.2
, pp. 305-314
-
-
Imaeda, A.B.1
Watanabe, A.2
Sohail, M.A.3
Mahmood, S.4
Mohamadnejad, M.5
Sutterwala, F.S.6
Flavell, R.A.7
Mehal, W.Z.8
-
88
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T et al: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature (2010) 464(7293):1357-1361.
-
(2010)
Nature
, vol.464
, Issue.7293
, pp. 1357-1361
-
-
Duewell, P.1
Kono, H.2
Rayner, K.J.3
Sirois, C.M.4
Vladimer, G.5
Bauernfeind, F.G.6
Abela, G.S.7
Franchi, L.8
Nunez, G.9
Schnurr, M.10
Espevik, T.11
-
89
-
-
0033587128
-
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
-
Ona VO, Li M, Vonsattel JP, Andrews LJ, Khan SQ, Chung WM, Frey AS, Menon AS, Li XJ, Stieg PE, Yuan J et al: Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature (1999) 399(6733):263-267.
-
(1999)
Nature
, vol.399
, Issue.6733
, pp. 263-267
-
-
Ona, V.O.1
Li, M.2
Vonsattel, J.P.3
Andrews, L.J.4
Khan, S.Q.5
Chung, W.M.6
Frey, A.S.7
Menon, A.S.8
Li, X.J.9
Stieg, P.E.10
Yuan, J.11
-
90
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
-
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT: The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat Immunol (2008) 9(8): 857-865.
-
(2008)
Nat Immunol
, vol.9
, Issue.8
, pp. 857-865
-
-
Halle, A.1
Hornung, V.2
Petzold, G.C.3
Stewart, C.R.4
Monks, B.G.5
Reinheckel, T.6
Fitzgerald, K.A.7
Latz, E.8
Moore, K.J.9
Golenbock, D.T.10
-
91
-
-
34250792190
-
Activation of the IL-1β-processing inflammasome is involved in contact hypersensitivity
-
Watanabe H, Gaide O, Petrilli V, Martinon F, Contassot E, Roques S, Kummer JA, Tschopp J, French LE: Activation of the IL-1β-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol (2007) 127(8):1956-1963.
-
(2007)
J Invest Dermatol
, vol.127
, Issue.8
, pp. 1956-1963
-
-
Watanabe, H.1
Gaide, O.2
Petrilli, V.3
Martinon, F.4
Contassot, E.5
Roques, S.6
Kummer, J.A.7
Tschopp, J.8
French, L.E.9
-
92
-
-
33644985564
-
Critical role for NALP3/cias1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1
-
Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galan JE, Askenase PW, Flavell RA: Critical role for NALP3/cias1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 24(3):317-327.
-
(2006)
Immunity
, vol.24
, Issue.3
, pp. 317-327
-
-
Sutterwala, F.S.1
Ogura, Y.2
Szczepanik, M.3
Lara-Tejero, M.4
Lichtenberger, G.S.5
Grant, E.P.6
Bertin, J.7
Coyle, A.J.8
Galan, J.E.9
Askenase, P.W.10
Flavell, R.A.11
-
93
-
-
0034618862
-
The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1
-
Dinarello CA: The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1. N Eng J Med (2000) 343(10):732-734.
-
(2000)
N Eng J Med
, vol.343
, Issue.10
, pp. 732-734
-
-
Dinarello, C.A.1
-
94
-
-
0037231664
-
Cytokine traps: Multi-component, high-affinity blockers of cytokine action
-
Economides AN, Carpenter LR, Rudge JS, Wong V, Koehler-Stec EM, Hartnett C, Pyles EA, Xu X, Daly TJ, Young MR, Fandl JP et al: Cytokine traps: Multi-component, high-affinity blockers of cytokine action. Nat Med (2003) 9(1):47-52.
-
(2003)
Nat Med
, vol.9
, Issue.1
, pp. 47-52
-
-
Economides, A.N.1
Carpenter, L.R.2
Rudge, J.S.3
Wong, V.4
Koehler-Stec, E.M.5
Hartnett, C.6
Pyles, E.A.7
Xu, X.8
Daly, T.J.9
Young, M.R.10
Fandl, J.P.11
-
95
-
-
49449094892
-
A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 trap) in patients with familial cold autoinflammatory syndrome
-
Goldbach-Mansky R, Shroff SD, Wilson M, Snyder C, Plehn S, Barham B, Pham TH, Pucino F, Wesley RA, Papadopoulos JH, Weinstein SP et al: A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 trap) in patients with familial cold autoinflammatory syndrome. Arthritis Rheum (2008) 58(8): 2432-2442.
-
(2008)
Arthritis Rheum
, vol.58
, Issue.8
, pp. 2432-2442
-
-
Goldbach-Mansky, R.1
Shroff, S.D.2
Wilson, M.3
Snyder, C.4
Plehn, S.5
Barham, B.6
Pham, T.H.7
Pucino, F.8
Wesley, R.A.9
Papadopoulos, J.H.10
Weinstein, S.P.11
-
96
-
-
77958474050
-
Critical appraisal of canakinumab in the treatment of adults and children with cryopyrinassociated periodic syndrome (caps)
-
Toker O, Hashkes PJ: Critical appraisal of canakinumab in the treatment of adults and children with cryopyrinassociated periodic syndrome (caps). Biologics (2010) 4: 131-138.
-
(2010)
Biologics
, vol.4
, pp. 131-138
-
-
Toker, O.1
Hashkes, P.J.2
-
97
-
-
77952287367
-
Targeting IL-1β in disease; The expanding role of NLRP3 inflammasome
-
Ioannis M, Panagiotis S, Konstantinos R: Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome. Eur J Intern Med (2010) 21(3):157-163.
-
(2010)
Eur J Intern Med
, vol.21
, Issue.3
, pp. 157-163
-
-
Ioannis, M.1
Panagiotis, S.2
Konstantinos, R.3
-
98
-
-
77958125448
-
Inflammasomedependent release of the alarmin hmgb1 in endotoxemia
-
Lamkanfi M, Sarkar A, Vande Walle L, Vitari AC, Amer AO, Wewers MD, Tracey KJ, Kanneganti TD, Dixit VM: Inflammasomedependent release of the alarmin hmgb1 in endotoxemia. J Immunol (2010) 185(7):4385-4392.
-
(2010)
J Immunol
, vol.185
, Issue.7
, pp. 4385-4392
-
-
Lamkanfi, M.1
Sarkar, A.2
Vande Walle, L.3
Vitari, A.C.4
Amer, A.O.5
Wewers, M.D.6
Tracey, K.J.7
Kanneganti, T.D.8
Dixit, V.M.9
-
99
-
-
70149123249
-
Damps and inflammatory processes: The role of redox in the different outcomes
-
Carta S, Castellani P, Delfino L, Tassi S, Vene R, Rubartelli A: Damps and inflammatory processes: The role of redox in the different outcomes. J Leukoc Biol (2009) 86(3):549-555.
-
(2009)
J Leukoc Biol
, vol.86
, Issue.3
, pp. 549-555
-
-
Carta, S.1
Castellani, P.2
Delfino, L.3
Tassi, S.4
Vene, R.5
Rubartelli, A.6
-
100
-
-
77649260429
-
Reactive oxygen species-independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease
-
van de Veerdonk FL, Smeekens SP, Joosten LA, Kullberg BJ, Dinarello CA, van der Meer JW, Netea MG: Reactive oxygen species-independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease. Proc Natl Acad Sci USA (2010) 107(7):3030-3033.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.7
, pp. 3030-3033
-
-
Van De Veerdonk, F.L.1
Smeekens, S.P.2
Joosten, L.A.3
Kullberg, B.J.4
Dinarello, C.A.5
Van Der Meer, J.W.6
Netea, M.G.7
-
101
-
-
68349157477
-
Malarial hemozoin is a NALP3 inflammasome activating danger signal
-
Dostert C, Guarda G, Romero JF, Menu P, Gross O, Tardivel A, Suva ML, Stehle JC, Kopf M, Stamenkovic I, Corradin G et al: Malarial hemozoin is a NALP3 inflammasome activating danger signal. PLoS One (2009) 4(8):e6510.
-
(2009)
PLoS One
, vol.4
, Issue.8
-
-
Dostert, C.1
Guarda, G.2
Romero, J.F.3
Menu, P.4
Gross, O.5
Tardivel, A.6
Suva, M.L.7
Stehle, J.C.8
Kopf, M.9
Stamenkovic, I.10
Corradin, G.11
-
102
-
-
74049105256
-
Pure hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid
-
Griffith JW, Sun T, McIntosh MT, Bucala R: Pure hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J Immunol (2009) 183(8):5208-5220.
-
(2009)
J Immunol
, vol.183
, Issue.8
, pp. 5208-5220
-
-
Griffith, J.W.1
Sun, T.2
McIntosh, M.T.3
Bucala, R.4
-
103
-
-
70049101754
-
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases
-
Shio MT, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA, Olivier M: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog (2009) 5(8):e1000559.
-
(2009)
PLoS Pathog
, vol.5
, Issue.8
-
-
Shio, M.T.1
Eisenbarth, S.C.2
Savaria, M.3
Vinet, A.F.4
Bellemare, M.J.5
Harder, K.W.6
Sutterwala, F.S.7
Bohle, D.S.8
Descoteaux, A.9
Flavell, R.A.10
Olivier, M.11
-
104
-
-
67349271142
-
Syk kinase signalling couples to the NLRP3 inflammasome for anti-fungal host defence
-
Gross O, Poeck H, Bscheider M, Dostert C, Hannesschlager N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A et al: Syk kinase signalling couples to the NLRP3 inflammasome for anti-fungal host defence. Nature (2009) 459(7245):433-436.
-
(2009)
Nature
, vol.459
, Issue.7245
, pp. 433-436
-
-
Gross, O.1
Poeck, H.2
Bscheider, M.3
Dostert, C.4
Hannesschlager, N.5
Endres, S.6
Hartmann, G.7
Tardivel, A.8
Schweighoffer, E.9
Tybulewicz, V.10
Mocsai, A.11
-
105
-
-
65549154784
-
An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans
-
Hise AG, Tomalka J, Ganesan S, Patel K, Hall BA, Brown GD, Fitzgerald KA: An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe (2009) 5(5): 487-497.
-
(2009)
Cell Host Microbe
, vol.5
, Issue.5
, pp. 487-497
-
-
Hise, A.G.1
Tomalka, J.2
Ganesan, S.3
Patel, K.4
Hall, B.A.5
Brown, G.D.6
Fitzgerald, K.A.7
-
106
-
-
33644615366
-
Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans
-
Murdoch S, Djuric U, Mazhar B, Seoud M, Khan R, Kuick R, Bagga R, Kircheisen R, Ao A, Ratti B, Hanash S et al: Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat Genet (2006) 38(3): 300-302.
-
(2006)
Nat Genet
, vol.38
, Issue.3
, pp. 300-302
-
-
Murdoch, S.1
Djuric, U.2
Mazhar, B.3
Seoud, M.4
Khan, R.5
Kuick, R.6
Bagga, R.7
Kircheisen, R.8
Ao, A.9
Ratti, B.10
Hanash, S.11
-
107
-
-
40349113175
-
Mutations in NALP12 cause hereditary periodic fever syndromes
-
Jeru I, Duquesnoy P, Fernandes-Alnemri T, Cochet E, Yu JW, Lackmy-Port-Lis M, Grimprel E, Landman-Parker J, Hentgen V, Marlin S, McElreavey K et al: Mutations in NALP12 cause hereditary periodic fever syndromes. Proc Natl Acad Sci USA (2008) 105(5):1614-1619.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.5
, pp. 1614-1619
-
-
Jeru, I.1
Duquesnoy, P.2
Fernandes-Alnemri, T.3
Cochet, E.4
Yu, J.W.5
Lackmy-Port-Lis, M.6
Grimprel, E.7
Landman-Parker, J.8
Hentgen, V.9
Marlin, S.10
McElreavey, K.11
|