NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

EMBO Reports

Volumn 9, Issue 3, 2008, Pages 293-300

  Tattoli, Ivan ^a   Carneiro, Leticia A ^a   Jéhanno, Muguette ^b   Magalhaes, Joao G ^a   Shu, Youmin ^c   Philpott, Dana J ^a   Arnoult, Damien ^d   Girardin, Stephen E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b INSTITUT PASTEUR   (France)

^c Origene Technologies   (United States)

^d HÔPITAL PAUL BROUSSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE; NOD LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; PROTEIN NLRX1; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; CELL LINE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; INFECTION RESISTANCE; INNATE IMMUNITY; MICROBIAL IMMUNITY; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

SHIGELLA;

EID: 40249111682     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7401161     Document Type: Article

References (11)

1. Akira S, Takeda K (2004) Toll‐like receptor signalling. Nat Rev Immunol 4: 499–511
2. Desagher S, Osen‐Sand A, Nichols A, Eskes R, Montessuit S, Lauper S, Maundrell K, Antonsson B, Martinou JC (1999) Bid‐induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol 144: 891–901
3. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE (2006) Nod‐like proteins in immunity, inflammation and disease. Nat Immunol 7: 1250–1257
4. Girardin SE, Yaniv M (2001) A direct interaction between JNK1 and CrkII is critical for Rac1‐induced JNK activation. EMBO J 20: 3437–3446
5. Girardin SE et al (2001) CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri. EMBO Rep 2: 736–742
6. Girardin SE et al (2003) Nod1 detects a unique muropeptide from Gram‐negative bacterial peptidoglycan. Science 300: 1584–1587
7. Gloire G, Legrand‐Poels S, Piette J (2006) NF‐κB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72: 1493–1505
8. Golstein P, Kroemer G (2007) Cell death by necrosis: towards a molecular definition. Trends Biochem Sci 32: 37–43
9. Meylan E, Tschopp J, Karin M (2006) Intracellular pattern recognition receptors in the host response. Nature 442: 39–44
10. Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW (2004) ASC is a Bax adaptor and regulates the p53‐Bax mitochondrial apoptosis pathway. Nat Cell Biol 6: 121–128
11. Seth RB, Sun L, Ea CK, Chen ZJ (2005) Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF‐κB and IRF3. Cell 122: 669–682