Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3

Journal of Immunology

Volumn 181, Issue 1, 2008, Pages 17-21

  Li, Hanfen ^a   Willingham, Stephen B ^b   Ting, Jenny P Y ^b   Re, Fabio ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM HYDROXIDE; ALUMINUM PHOSPHATE; ALUMINUM POTASSIUM SULFATE; CHITOSAN; CRYOPYRIN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 33; ALUMINUM DERIVATIVE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; PHOSPHATE;

ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ARTICLE; CYTOKINE RELEASE; DENDRITIC CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; ANIMAL; CELL CULTURE; CELL LINE; DRUG EFFECT; GENETICS; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOUSE; MOUSE MUTANT; RNA INTERFERENCE;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM COMPOUNDS; ALUMINUM HYDROXIDE; ANIMALS; CARRIER PROTEINS; CELL LINE; CELLS, CULTURED; HUMANS; IMMUNE SYSTEM; INFLAMMATION; MICE; MICE, KNOCKOUT; PHOSPHATES; RNA INTERFERENCE;

EID: 47849087075     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.1.17     Document Type: Article

References (28)

1. Gupta, R. K., E. H. Relyveld, E. B. Lindblad, B. Bizzini, S. Ben-Efraim, and C. K. Gupta. 1993. Adjuvants - a balance between toxicity and adjuvanticity. Vaccine 11: 293-306.
2. Sun, H., K. G. Pollock, and J. M. Brewer. 2003. Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro. Vaccine 21:849-855.
3. McKee, A. S., M. W. Munks, and P. Marrack. 2007. How do adjuvants work? Important considerations for new generation adjuvants. Immunity 27:687-690.
4. Ramanathan, V. D., P. Badenoch-Jones, and J. L Turk. 1979. Complement activation by aluminium and zirconium compounds. Immunology 37: 881-888.
5. White, R. G., A. H. Coons, and J. M. Connolly. 1955. Studies on antibody production. III. The alum granuloma. J. Exp. Med. 102: 73-82.
6. Jordan, M. B., D. M. Mills, J. Kappler, P. Marrack, and J. C. Cambier. 2004. Promotion of B cell immune responses via an alum-induced myeloid cell population. Science 304: 1803-1810.
7. Wang, H. B., and P. F. Weller. 2008. Pivotal advance: eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production. J. Leukocyte Biol. 83: 817-821.
8. Li, H., S. Nookala, and F. Re. 2007. Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1β and IL-18 release. J. Immunol. 178: 5271-5276.
9. Dinarello, C. A. 2006. Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. Am. J. Clin. Nutr. 83:447S-455S.
10. + T cells. J. Immunol. 162: 3256-3262.
11. + T cells. J. Immunol. 159: 591-598.
12. Schmitz, J., A. Owyang, E. Oldham, Y. Song, E. Murphy, T. K. McCIanahan, G. Zurawski, M. Moshrefi, J. Qin, X. Li, et al. 2005. IL-33, an interleukin-I-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23: 479-490.
13. Ogura, Y., F. S. Sutterwala, and R. A. Flavell. 2006. The inflammasome: first line of the immune response to cell stress. Cell 126: 659-662.
14. Agostini, L., F. Martinon, K. Burns, M. F. McDermott, P. N. Hawkins, and J. Tschopp. 2004. NALP3 forms an IL-1 β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20: 319-325.
15. Mariathasan, S., K. Newton, D. M. Monack, D. Vucic, D. M. French, W. P. Lee, M. Roose-Girma, S. Erickson, and V. M. Dixit. 2004. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430: 215-218.
16. Mariathasan, S., D. S. Weiss, K. Newton, J. McBride, K. O'Rourke, M. Roose-Girma, W. P. Lee, Y. Weinrauch, D. M. Monack, and V. M. Dixit. 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-232.
17. Franchi, L., A. Amer, M. Body-Malapel, T. D. Kanneganti, N. Ozoren, R. Jagirdar, N. Inohara, P. Vandenabeele, J. Bertin, A. Coyle, et al. 2006. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages. Nat. Immunol. 7: 576-582.
18. Miao, E. A., C. M. Alpuche-Aranda, M. Dors, A. E. Clark, M. W. Bader, S. I. Miller, and A. Aderem. 2006. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf. Nat. Immunol. 7: 569-575.
19. Taxman, D. J., J. Zhang, C. Champagne, D. T. Bergstralh, H. A. Iocca, J. D. Lich, and J. P. Ting. 2006. Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways. J. Immunol. 177: 4252-4256.
20. Xiang, S. D., A. Scholzen, G. Minigo, C. David, V. Apostolopoulos, P. L. Mottram, and M. Plebanski. 2006. Pathogen recognition and development of particulate vaccines: does size matter? Methods 40: 1-9.
21. Kool, M., T. Soullie, M. van Nimwegen, M. A. Willart, F. Muskens, S. Jung, H. C. Hoogsteden, H. Hammad, and B. N. Lambrecht. 2008. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J. Exp. Med 205: 869.
22. Martinon, F., V. Petrilli, A. Mayor, A. Tardivel, and J. Tschopp. 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237.
23. Shi, Y., J. E. Evans, and K. L. Rock. 2003. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425: 516.
24. Schnare, M., G. M. Barton, A. C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2001. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2: 947-950.
25. Gavin, A. L., K. Hoebe, B. Duong, T. Ota, C. Martin, B. Beutler, and D. Nemazee. 2006. Adjuvant-enhanced antibody responses in the absence of Toll-like receptor signaling. Science 314: 1936-1933.
26. Huber, M., H. U. Beuscher, P. Rohwer, R. Kurrle, M. Rollinghoff, and M. Lohoff. 1998. Costimulation via TCR and IL-1 receptor reveals a novel IL-1α-mediated au-tocrine pathway of Th2 cell proliferation. J. Immunol. 160: 4242-4247.
27. Nakae, S., Y. Komiyama, H. Yokoyama, A. Nambu, M. Umeda, M. Iwase, I. Homma, K. Sudo, R. Horai, M. Asano, and Y. Iwakura. 2003. IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int. Immunol. 15: 483-490.
28. Pollock, K. G., M. Conacher, X. Q. Wei, J. Alexander, and J. M. Brewer. 2003. In-terleukin-18 plays a role in both the alum-induced T helper 2 response and the T helper 1 response induced by alum-adsorbed interleukin-12. Immunology 108: 137-143.