The Apoptosome Activates Caspase-9 by Dimerization

Molecular Cell

Volumn 22, Issue 2, 2006, Pages 269-275

  Pop, Cristina ^a   Timmer, John ^a   Sperandio, Sabina ^a   Salvesen, Guy S ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSOME; CASPASE 8; CASPASE 9; ENZYME PRECURSOR;

ALLOSTERISM; APICAL MEMBRANE; APOPTOSIS; ARTICLE; DIMERIZATION; ENZYME ACTIVATION; ENZYME STRUCTURE; GENETIC CONSERVATION; MOLECULAR MODEL; POLYMERIZATION; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 8; CASPASE 9; CASPASES; CATALYSIS; CELL LINE; CITRATES; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 33646024628     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.03.009     Document Type: Article

References (35)

1. Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., and Akey C.W. Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding and activation. Mol. Cell 9 (2002) 423-432
2. Baliga B.C., Read S.H., and Kumar S. The biochemical mechanism of caspase-2 activation. Cell Death Differ. 11 (2004) 1234-1241
3. Boatright K.M., and Salvesen G.S. Mechanisms of caspase activation. Curr. Opin. Cell Biol. 15 (2003) 725-731
4. Boatright K.M., Renatus M., Scott F.L., Sperandio S., Shin H., Pedersen I., Ricci J.-E., Edris W.A., Sutherlin D.P., Green D.R., and Salvesen G.S. A unified model for apical caspase activation. Mol. Cell 11 (2003) 529-541
5. Chao Y., Shiozaki E.N., Srinivasula S.M., Rigotti D.J., Fairman R., and Shi Y. Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. PLoS Biol. 3 (2005) e183 10.1371/journal.pbio.0030381
6. Debatin K.M., and Krammer P.H. Death receptors in chemotherapy and cancer. Oncogene 23 (2004) 2950-2966
7. Denault J.B., and Salvesen G.S. Caspases: keys in the ignition of cell death. Chem. Rev. 102 (2002) 4489-4500
8. Donepudi M., Mac Sweeney A., Briand C., and Gruetter M.G. Insights into the regulatory mechanism for caspase-8 activation. Mol. Cell 11 (2003) 543-549
9. Edelhoch H. Spectroscopic determination of tryptophan and tyrosine in proteins. Biochemistry 6 (1967) 1948-1954
10. Fuentes-Prior P., and Salvesen G.S. The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem. J. 384 (2004) 201-232
11. Jiang X., and Wang X. Cytochrome C-mediated apoptosis. Annu. Rev. Biochem. 73 (2004) 87-106
12. Khan A.R., and James M.N. Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes. Protein Sci. 7 (1998) 815-836
13. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
14. Muzio M., Stockwell B.R., Stennicke H.R., Salvesen G.S., and Dixit V.M. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273 (1998) 2926-2930
15. Pop C., Chen Y.R., Smith B., Bose K., Bobay B., Tripathy A., Franzen S., and Clark A.C. Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. Biochemistry 40 (2001) 14224-14235
16. Pop C., Feeney B., Tripathy A., and Clark A.C. Mutations in the procaspase-3 dimer interface affect the activity of the zymogen. Biochemistry 42 (2003) 12311-12320
17. Quan L.T., Caputo A., Bleackley R.C., Pickup D.J., and Salvesen G.S. Granzyme B is inhibited by the cowpox virus serpin CrmA. J. Biol. Chem. 270 (1995) 10377-10379
18. Renatus M., Stennicke H.R., Scott F.L., Liddington R.C., and Salvesen G.S. Dimer formation drives the activation of the cell death protease caspase 9. Proc. Natl. Acad. Sci. USA 98 (2001) 14250-14255
19. Riedl S.J., and Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat. Rev. Mol. Cell Biol. 5 (2004) 897-907
20. Riedl S.J., Li W., Chao Y., Schwarzenbacher R., and Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature 434 (2005) 926-933
21. Rodriguez J., and Lazebnik Y. Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev. 13 (1999) 3179-3184
22. Salvesen G.S., and Duckett C.S. IAP proteins: blocking the road to death's door. Nat. Rev. Mol. Cell Biol. 3 (2002) 401-410
23. Shi Y. Caspase activation: revisiting the induced proximity model. Cell 117 (2004) 855-858
24. Shiozaki E.N., Chai J., and Shi Y. Oligomerization and activation of caspase-9, induced by Apaf-1 CARD. Proc. Natl. Acad. Sci. USA 99 (2002) 4197-4202
25. Shiozaki E.N., Chai J., Rigotti D.J., Riedl S.J., Li P., Srinivasula S.M., Alnemri E.S., Fairman R., and Shi Y. Mechanism of XIAP-mediated inhibition of caspase-9. Mol. Cell 11 (2003) 519-527
26. Stennicke H.R., and Salvesen G.S. Caspases: preparation and characterization. Methods 17 (1999) 313-319
27. Stennicke H.R., Deveraux Q.L., Humke E.W., Reed J.C., Dixit V.M., and Salvesen G.S. Caspase-9 can be activated without proteolytic processing. J. Biol. Chem. 274 (1999) 8359-8362
28. Stennicke H.R., Ryan C.A., and Salvesen G.S. Reprieval from execution: The molecular basis of caspase inhibition. Trends Biochem. Sci. 27 (2002) 94-101
29. Sun C., Cai M., Meadows R.P., Xu N., Gunasekera A.H., Herrmann J., Wu J.C., and Fesik S.W. NMR structure and mutagenesis of the third BIR domain of the inhibitor of apoptosis protein XIAP. J. Biol. Chem. 275 (2000) 33777-33781
30. Talanian R.V., Dang L.C., Ferenz C.R., Hackett M.C., Mankovich J.A., Welch J.P., Wong W.W., and Brady K.D. Stability and oligomeric equilibria of refolded interleukin-1beta converting enzyme. J. Biol. Chem. 271 (1996) 21853-21858
31. Yan N., Jijie Chai J., Lee E.S., Gu L., Liu Q., He J., Wu J.-W., Kokel D., Li H., Hao Q., et al. Structure of the CED-4/CED-9 complex reveals insights into programmed cell death in Caenorhabditis elegans. Nature 437 (2005) 831-837
32. Yang J.K., Wang L., Zheng L., Wan F., Ahmed M., Lenardo M.J., and Wu H. Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Mol. Cell 20 (2005) 939-949
33. Yu X., Wang L., Acehan D., Wang X., and Akey C.W. Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer. J. Mol. Biol. 355 (2006) 577-589
34. Zhou Q., Snipas S., Orth K., Dixit V.M., and Salvesen G.S. Target protease specificity of the viral serpin CrmA: analysis of five caspases. J. Biol. Chem. 273 (1997) 7797-7800
35. Zou H., Li Y., Liu X., and Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274 (1999) 11549-11556