Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

Journal of Histochemistry and Cytochemistry

Volumn 55, Issue 5, 2007, Pages 443-452

  Kummer, J Alain ^a   Broekhuizen, Roel ^a   Everett, Helen ^b   Agostini, Laetitia ^b   Kuijk, Loes ^a   Martinon, Fabio ^b   Van Bruggen, Robin ^b   Tschopp, Jürg ^b,c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c Dept of Biochemistry ^*  (Switzerland)

Author keywords

Autoinflammatory disease; Inflammation; Mucosa

Indexed keywords

CYTOKINE; INFLAMMASOME PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MONOCLONAL ANTIBODY; MULTIPROTEIN COMPLEX; PROTEIN NALP1; PROTEIN NALP3; UNCLASSIFIED DRUG;

ARTICLE; AUTOINFLAMMATORY DISEASE; B LYMPHOCYTE; CELL NUCLEUS; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRYOPYRIN GENE; CYTOKINE PRODUCTION; CYTOPLASM; DENDRITIC CELL; ENZYME ACTIVATION; ESOPHAGUS MUCOSA; GENE; GENE MUTATION; GENITAL SYSTEM; GRANULOCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INNATE IMMUNITY; INTESTINE EPITHELIUM; LANGERHANS CELL; LUNG ALVEOLUS EPITHELIUM; MONOCYTE; MOUTH MUCOSA; MUCKLE WELLS SYNDROME; NERVE CELL; OROPHARYNX; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STOMACH EPITHELIUM; T LYMPHOCYTE; TESTIS; UTERINE CERVIX EPITHELIUM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIBODIES, MONOCLONAL; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CELL LINE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFLAMMATION; ORGAN SPECIFICITY;

EID: 34247574122     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/jhc.6A7101.2006     Document Type: Article

References (34)

1. Aganna E, Martinon F, Hawkins PN, Ross JB, Swan DC, Booth DR, Lachmann HJ, et al. (2002) Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum 46:2445-2452
2. Agostini L, Martinon F, Burns K, McDermott EM, Hawkins PN, Tschopp J (2004) NALP3 forms an IL-1β processing inflammasome with increased activity in Muckle-Wells auto-inflammatory disorder. Immunity 20:319-325
3. Allan SM, Tyrrell PJ, Rothwell NJ (2005) Interleukin-1 and neuronal injury. Nat Rev Immunol 5:629-640
4. Anderson JP, Mueller JL, Rosengren S, Boyle DL, Schaner P, Cannon SB, Goodyear CS, et al. (2004) Structural, expression, and evolutionary analysis of mouse CIAS1. Gene 338:25-34
5. Boyden ED, Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38:240-244
6. Chu ZL, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, et al. (2001) A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J Biol Chem 276:9239-9245
7. Dinarello CA (1998) Interleukin-1β, interleukin-18, and the interleukin-1β converting enzyme. Ann NY Acad Sci 856:1-11
8. Emsley HC, Smith CJ, Georgiou RF, Vail A, Hopkins SJ, Rothwell NJ, Tyrrell PJ (2005) A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. J Neurol Neurosurg Psychiatry 76:1366-1372
9. Goldbach-Mansky R, Dailey NJ, Canna SW, Gelabert A, Jones J, Rubin BI, Kim HJ, et al. (2006) Neonatal-onset multisystem inflammatory disease responsive to interleukin-1β inhibition. N Engl J Med 355:581-592
10. Harton JA, Linhoff MW, Zhang J, Ting JP (2002) Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J Immunol 169:4088-4093
11. Hawkins PN, Lachmann HJ, Aganna E, McDermott MF (2004) Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 50:607-612
12. Hlaing T, Guo RF, Dilley KA, Loussia JM, Morrish TA, Shi MM, Vincenz C, et al. (2001) Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J Biol Chem 276:9230-9238
13. Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29:301-305
14. Huleihel M, Lunenfeld E, Blindman A, Prinsloo I, Potashnik G (2003) Over expression of interleukin-1α, interleukin-1β and interleukin-1 receptor antagonist in testicular tissues from sexually immature mice as compared to adult mice. Eur Cytokine Netw 14:27-33
15. Inohara N, Chamaillard M, McDonald C, Nunez G (2005) NODLRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 74:355-383
16. Kanneganti TD, Ozoren N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, et al. (2006) Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440:233-236
17. Kastner DL (2005) Hereditary periodic fever syndromes. Hematol Am Soc Hematol Educ Program 22:74-81
18. LeibundGut-Landmann S, Waldburger JM, Krawczyk M, Otten LA, Suter T, Fontana A, Acha-Orbea H, et al. (2004) Mini-review: specificity and expression of CIITA, the master regulator of MHC class II genes. Eur J Immunol 34:1513-1525
19. Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-218
20. Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440:228-232
21. Martinon F, Agostini L, Meylan E, Tschopp J (2004) Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 14:1929-1934
22. Martinon F, Burns K, Tschopp J (2002) The inflammasome. A molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol Cell 10:417-426
23. Martinon F, Hofmann K, Tschopp J (2001) The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol 10:R118-120
24. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-241
25. Martinon F, Tschopp J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26:447-454
26. Masumoto J, Taniguchi S, Nakayama J, Shiohara M, Hidaka E, Katsuyama T, Murase S, et al. (2001) Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues. J Histochem Cytochem 49:1269-1275
27. Molofsky AB, Byrne BG, Whitfield NN, Madigan CA, Fuse ET, Tateda K, Swanson MS (2006) Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J Exp Med 203:1093-1104
28. O'Connor W Jr, Harton JA, Zhu X, Linhoff MW, Ting JP (2003) Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J Immunol 171:6329-6333
29. Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE (2006) Flagellin-deficient Legionella mutants evade caspase-1-and NAIP5-mediated macrophage immunity. PLoS Pathog 2:e18. Published online March 17, 2006 (DOI: 10.1371/journal.ppat.0020018)
30. Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, et al. (2006) Critical role for NALP3/CIAS1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24:317-327
31. Ting J, Davis B (2005) CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu Rev Immunol 23:387-414
32. Tschopp J, Martinon F, Burns K (2003) NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol 4:95-104
33. Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, et al. (2004) ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells 9:1055-1067
34. Yao J, Keri JE, Taffs RE, Colton CA (1992) Characterization of interleukin-1 production by microglia in culture. Brain Res 591:88-93