Pure hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid

Journal of Immunology

Volumn 183, Issue 8, 2009, Pages 5208-5220

  Griffith, Jason W ^a   Sun, Tiffany ^a   McIntosh, Michael T ^a   Bucala, Richard ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; CRYOPYRIN; GAMMA INTERFERON; HEMOZOIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; URIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; SCHIZONT; SIGNAL TRANSDUCTION; SYNTHESIS;

ALLOPURINOL; ANIMALS; CARRIER PROTEINS; CHEMOKINE CCL2; CHEMOKINE CXCL1; CYTOSKELETAL PROTEINS; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEMEPROTEINS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MACROPHAGES; MALARIA, FALCIPARUM; MICE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PLASMODIUM FALCIPARUM; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA; URIC ACID;

EID: 74049105256     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0713552     Document Type: Article

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