Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 10, 2009, Pages 3935-3940

  Faustin, Benjamin ^a   Chen, Ya ^a   Zhai, Dayong ^a   Le Negrate, Gaelle ^a   Lartigue, Lydia ^b   Satterthwait, Arnold ^a   Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Apoptosis; Innate immunity

Indexed keywords

ADENOSINE TRIPHOSPHATE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NLR FAMILY PYRIN DOMAIN CONTAINING PROTEIN 1; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; BINDING AFFINITY; CELL DAMAGE; CELL DEATH; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME KINETICS; ENZYMOLOGY; FLUORESCENCE POLARIZATION; IC 50; IMMUNOBLOTTING; INNATE IMMUNITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; BCL-X PROTEIN; CASPASE 1; ENZYME ACTIVATION; INFLAMMATION; KINETICS; PEPTIDES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62649092113     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809414106     Document Type: Article

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