Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenesinfection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 22, 2009, Pages 9016-9020

  Yeretssian, Garabet ^a   Doiron, Karine ^a   Shao, Wei ^a   Leavitt, Blair R ^b   Hayden, Michael R ^b   Nicholson, Donald W ^c   Saleh, Maya ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Centre for Molecular Medicine and Therapeutics   (Canada)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Estrogen; Inflammatory caspase; Innate immunity; SNP

Indexed keywords

CASPASE 12; ESTRADIOL; ESTROGEN RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME REPRESSION; ESTRADIOL BLOOD LEVEL; ESTROGEN RESPONSIVE ELEMENT; FEMALE; GENE MAPPING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFECTION RESISTANCE; INFECTION SENSITIVITY; INNATE IMMUNITY; INTRON; LISTERIOSIS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN VARIANT; SEX DIFFERENCE; TRANSGENE;

ANIMALS; CASPASE 12; CHROMATIN IMMUNOPRECIPITATION; CODON, NONSENSE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, INNATE; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; MALE; MICE; MICE, TRANSGENIC; RNA STABILITY; SEX FACTORS;

LISTERIA; LISTERIA MONOCYTOGENES; MAMMALIA; MUS;

EID: 67049158196     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0813362106     Document Type: Article

References (26)

1. Petrilli V, Dostert C, Muruve DA, Tschopp J (2007) The inflammasome: A danger sensing complex triggering innate immunity. Curr Opin Immunol 19:615-622. (Pubitemid 350236810)
2. Shao W, et al. (2007) The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem 282:36321-36329.
3. Fantuzzi G, Dinarello CA (1999) Interleukin-18 and interleukin-1 beta: Two cytokine substrates for ICE (caspase-1). J Clin Immunol 19:1-11. (Pubitemid 29113328)
4. Keller M, Ruegg A, Werner S, Beer HD (2008) Active caspase-1 is a regulator of unconventional protein secretion. Cell 132:818-831. (Pubitemid 351312798)
5. Cookson BT, Brennan MA (2001) Pro-inflammatory programmed cell death. Trends Microbiol 9:113-114. (Pubitemid 32182347)
6. Labbé K, Saleh M (2008) Cell death in the host response to pathogens. Cell Death Differ 43:380-390.
7. Martinon F, Burns K, Tschopp J (2002) The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417-426. (Pubitemid 35007355)
8. Wang S, et al. (1998) Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92:501-509. (Pubitemid 28101113)
9. Saleh M, et al. (2006) Enhanced bacterial clearance and sepsis resistance in caspase-12 deficient mice. Nature 440:1064-1068.
10. Fischer H, Koenig U, Eckhart L, Tschachler E (2002) Human caspase 12 has acquired deleterious mutations. Biochem Biophys Res Commun 293:722-726. (Pubitemid 34687247)
11. Saleh M, et al. (2004) Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429:75-79. (Pubitemid 38620553)
12. Xue Y, et al. (2006) Spread of an inactive form of caspase-12 in humans is due to recent positive selection. Am J Hum Genet 78:659-670.
13. Edelson BT, Unanue ER (2002) MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol 169:3869-3875.
14. Opitz B, et al. (2006) Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J Immunol 176:484-490. (Pubitemid 43023294)
15. Warren SE, et al. (2008) Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J Immunol 180:7558-7564.
16. Leber JH, et al. (2008) Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen. PLoS Pathog 4:e6. (Pubitemid 351230894)
17. Terres G, Morrison SL, Habicht GS (1968) A quantitative difference in the immune response between male and female mice. Proc Soc Exp Biol Med 127:664-667.
18. Beery TA (2003) Sex differences in infection and sepsis. Crit Care Nurs Clin North Am 15:55-62. (Pubitemid 38608985)
19. Gellin BG, Broome CV (1989) Listeriosis. JAMA 261:1313-1320. (Pubitemid 19072225)
20. Pasche B, et al. (2005) Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production. Infect Immun 73:5952-5960. (Pubitemid 41193034)
21. Shyu AB, Wilkinson MF, van Hoof A (2008) Messenger RNA regulation: To translate or to degrade. EMBO J 27:471-481. (Pubitemid 351225677)
22. Chang YF, Imam JS, Wilkinson MF (2007) The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76:51-74.
23. Kalai M, et al. (2003) Regulation of the expression and processing of caspase-12. J Cell Biol 162:457-467. (Pubitemid 36988554)
24. Morell V (1995) Zeroing in on how hormones affect the immune system. Science 269:773-775.
25. Salem ML (2004) Estrogen, a double-edged sword: Modulation of TH1- and TH2- mediated inflammations by differential regulation of TH1/TH2 cytokine production. Curr Drug Targets Inflamm Allergy 3:97-104. (Pubitemid 38854894)
26. Carroll JS, et al. (2006) Genome-wide analysis of estrogen receptor binding sites. Nat Genet 38:1289-1297. (Pubitemid 44646291)