NLRC5 limits the activation of inflammatory pathways

Journal of Immunology

Volumn 185, Issue 3, 2010, Pages 1681-1691

  Benko, Szilvia ^a   Magalhaes, Joao G ^a   Philpott, Dana J ^a   Girardin, Stephen E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CYTOKINE RESPONSE MODIFIER A; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR C5; POLYINOSINIC POLYCYTIDYLIC ACID; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AUTACOID; NLRC5 PROTEIN, HUMAN; NLRC5 PROTEIN, MOUSE; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSOL; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; LYMPHOID CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION TERMINATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL STRAIN CACO 2; GENETICS; HELA CELL; IMMUNOLOGY; LEUKEMIA CELL LINE; MACROPHAGE; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; CACO-2 CELLS; CELL LINE; CELL LINE, TUMOR; HELA CELLS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-10; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR SEQUENCE DATA; SIGNAL TRANSDUCTION;

EID: 77956409550     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903900     Document Type: Article

References (24)

1. Fritz, J. H., and S. E. Girardin. 2005. How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals. J. Endotoxin Res. 11: 390-394.
2. Takeuchi, O., and S. Akira. 2008. MDA5/RIG-I and virus recognition. Curr. Opin. Immunol. 20: 17-22.
3. Ting, J. P., and B. K. Davis. 2005. CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu. Rev. Immunol. 23: 387-414.
4. Park, J. H., Y. G. Kim, C. McDonald, T. D. Kanneganti, M. Hasegawa, M. Body-Malapel, N. Inohara, and G. Núñez. 2007. RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J. Immunol. 178: 2380-2386.
5. Travassos, L. H., L. A. Carneiro, M. Ramjeet, S. Hussey, Y. G. Kim, J. G. Magalhães, L. Yuan, F. Soares, E. Chea, L. Le Bourhis, et al. 2010. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat. Immunol. 11: 55-62.
6. Tschopp, J., F. Martinon, and K. Burns. 2003. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 4: 95-104.
7. Listen, P., N. Roy, K. Tamai, C. Lefebvre, S. Baird, G. Cherton-Horvat, R. Farahani, M. McLean, J. E. Ikeda, A. MacKenzie, and R. G. Korneluk. 1996. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379: 349-353.
8. Sutterwala, F. S., and R. A. Flavell. 2009. NLRC4/IPAF: a CARD carrying member of the NLR family. Clin. Immunol. 130: 2-6.
9. Ting, J. P., and J. Trowsdale. 2002. Genetic control of MHC class II expression. Cell 109(Suppl.): S21-S33. (Pubitemid 34457849)
10. Geddes, K., J. G. Magalhães, and S. E. Girardin. 2009. Unleashing the therapeutic potential of NOD-like receptors. Nat. Rev. Drug Discov. 8: 465-479.
11. Reith,W., and B. Mach. 2001. The bare lymphocyte syndrome and the regulation of MHC expression. Annu. Rev. Immunol. 19: 331-373.
12. Steimle, V., C. A. Siegrist, A. Mottet, B. Lisowska-Grospierre, and B. Mach. 1994. Regulation of MHC class II expression by interferon-γ mediated by the transactivator gene CIITA. Science 265: 106-109. (Pubitemid 24253184)
13. Cressman, D. E., W. J. O'Connor, S. F. Greer, X. S. Zhu, and J. P. Ting. 2001. Mechanisms of nuclear import and export that control the subcellular localization of class II transactivator. J. Immunol. 167: 3626-3634.
14. Magalhaes, J. G., J. H. Fritz, L. Le Bourhis, G. Sellge, L. H. Travassos, T. Selvanantham, S. E. Girardin, J. L. Gommerman, and D. J. Philpott. 2008. Nod2-dependent Th2 polarization of antigen-specific immunity. J. Immunol. 181: 7925-7935.
15. Tattoli, I., L. A. Carneiro, M. Jéhanno, J. G. Magalhaes, Y. Shu, D. J. Philpott, D. Arnoult, and S. E. Girardin. 2008. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production. EMBO Rep. 9: 293-300.
16. Benko, S., J. Tozser, G. Miklossy, A. Varga, J. Kadas, A. Csutak, A. Berta, and E. Rajnavolgyi. 2008. Constitutive and UV-B modulated transcription of Nodlike receptors and their functional partners in human corneal epithelial cells. Mol. Vis. 14: 1575-1583.
17. Szanto, A., S. Benko, I. Szatmari, B. L. Balint, I. Furtos, R. Rühl, S. Molnar, L. Csiba, R. Garuti, S. Calandra, et al. 2004. Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages. Mol. Cell. Biol. 24: 8154-8166.
18. Williams, K. L., J. D. Lich, J. A. Duncan, W. Reed, P. Rallabhandi, C. Moore, S. Kurtz, V. M. Coffield, M. A. Accavitti-Loper, L. Su, et al. 2005. The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor α-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J. Biol. Chem. 280: 39914-39924.
19. Conti, B. J., B. K. Davis, J. Zhang, W. O'connor, Jr., K. L. Williams, and J. P. Ting. 2005. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J. Biol. Chem. 280: 18375-18385.
20. Rajasingh, J., E. Bord, C. Luedemann, J. Asai, H. Hamada, T. Thorne, G. Qin, D. Goukassian, Y. Zhu, D. W. Losordo, et al. 2006. IL-10-induced TNF-α mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J. 20: 2112-2114.
21. Williams, L. M., G. Ricchetti, U. Sarma, T. Smallie, and B. M. Foxwell. 2004. Interleukin-10 suppression of myeloid cell activation - a continuing puzzle. Immunology 113: 281-292.
22. Yao, Y., W. Li, M. H. Kaplan, and C. H. Chang. 2005. Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J. Exp. Med. 201: 1899-1903.
23. Cui, J., L. Zhu, X. Xia, H. Y. Wang, X. Legras, J. Hong, J. Ji, P. Shen, S. Zheng, Z. J. Chen, and R. F. Wang. 2010. NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways. Cell 141: 483-496.
24. Kuenzel, S., A. Till, M. Winkler, R. Häsler, S. Lipinski, S. Jung, J. Grötzinger, H. Fickenscher, S. Schreiber, and P. Rosenstiel. 2010. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. J. Immunol. 184: 1990-2000.