A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 22, 2008, Pages 7803-7808

  Hsu, Li Chung ^a,e   Ali, Syed R ^a   McGillivray, Shauna ^a   Tseng, Ping Hui ^a   Mariathasan, Sanjeev ^c   Humke, Eric W ^c   Eckmann, Lars ^a   Powell, Jonathan J ^d   Nizet, Victor ^a,b   Dixit, Vishva M ^c   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c GENENTECH INC   (United States)

^d MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Inflammasome; Lethal toxin; LPS

Indexed keywords

ANTHRAX TOXIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LEUCINE; MURAMYL DIPEPTIDE; PROTEIN; PROTEIN NALP1; APOPTOSIS REGULATORY PROTEIN; CARD15 PROTEIN, MOUSE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; NALP1 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK2 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL INFECTION; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; GEL FILTRATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; ANIMAL; ANTHRAX; CELL LINE; GEL CHROMATOGRAPHY; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; MICROBIOLOGY; MOUSE STRAIN; MUTATION; PROTEIN ANALYSIS;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS);

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTHRAX; APOPTOSIS REGULATORY PROTEINS; BACILLUS ANTHRACIS; CASPASE 1; CELL LINE; CHROMATOGRAPHY, GEL; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, INBRED STRAINS; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; PROTEIN INTERACTION MAPPING; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES;

EID: 45549093755     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802726105     Document Type: Article

References (42)

1. Martinon F, Tschopp J (2007) Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ 14:10-22.
2. Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7:31-40.
3. Dinarello CA (2002) The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 20:S1-13.
4. Dinarello CA (2004) Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res 10:201-222.
5. Schmitz J, et al. (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23:479-490.
6. Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417-426.
7. Martinon F, Agostini L, Meylan E, Tschopp J (2004) Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 14:1929-1934.
8. Mariathasan S, et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-218.
9. Mariathasan S, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440:228-232.
10. Eckmann L, Karin M (2005) NOD2 and Crohn's disease: loss or gain of function? Immunity 22:661-667.
11. Girardin SE, et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278:8869-8872.
12. Maeda S, et al. (2005) Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 307:734-738.
13. van Heel DA, et al. (2005) Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet 365:1794-1796.
14. Martinon F, Tschopp J (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561-574.
15. Baillie L (2001) The development of new vaccines against Bacillus anthracis. J Appl Microbiol 91:609-613.
16. Kobayashi KS, et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307:731-734.
17. Ashwood P, Thompson RP, Powell JJ (2007) Fine particles that adsorb lipopolysaccharide via bridging calcium cations may mimic bacterial pathogenicity towards cells. Exp Biol Med 232:107-117.
18. Evans SM, et al. (2002) The role of dietary microparticles and calcium in apoptosis and interleukin-1beta release of intestinal macrophages. Gastroenterology 123:1543-1553.
19. Greten FR, et al. (2007) NF-kappaB Is a Negative Regulator of IL-1beta Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKbeta. Cell 130:918-931.
20. Pan Q, et al. (2007) MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol 82:177-183.
21. Kuida K, et al. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267:2000-2003.
22. Ogura Y, et al. (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276:4812-4818.
23. Chin AI, et al. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416:190-194.
24. Tanabe T, et al. (2004) Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J 23:1587-1597.
25. Moffett P, Farnham G, Peart J, Baulcombe DC (2002) Interaction between domains of a plant NBS-LRR protein in disease resistance-related cell death. EMBO J 21:4511-4519.
26. Poyet JL, et al. (2001) Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J Biol Chem 276:28309-28313.
27. Faustin B, et al. (2007) Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell 25:713-724.
28. Boyden ED, Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38:240-244.
29. Park JM, Greten FR, Li ZW, Karin M (2002) Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297:2048-2051.
30. Ferwerda G, et al. (2008) Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta. Eur J Immunol 38:184-191.
31. Park JM, Ng VH, Maeda S, Rest RF, Karin M (2004) Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med 200:1647-1655.
32. Abbott DW, Wilkins A, Asara JM, Cantley LC (2004) The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol 14:2217-2227.
33. Butler M, Boyle JJ, Powell JJ, Playford RJ, Ghosh S (2007) Dietary microparticles implicated in Crohn's disease can impair macrophage phagocytic activity and act as adjuvants in the presence of bacterial stimuli. Inflamm Res 56:353-361.
34. Perregaux D, Gabel CA (1994) Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 269:15195-15203.
35. Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit VM (2000) ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell 103:99-111.
36. Fernandes-Alnemri T, et al. (2007) The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 14:1590-1604.
37. Muehlbauer SM, et al. (2007) Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis. Cell Cycle 6:758-766.
38. Park JM, et al. (2005) Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis-CREB and NF-kappaB as key regulators. Immunity 23:319-329.
39. Pellizzari R, Guidi-Rontani C, Vitale G, Mock M, Montecucco C (1999) Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha. FEBS Lett 462:199-204.
40. Netea MG, et al. (2005) NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype. Neth J Med 63:305-308.
41. Sutterwala FS, et al. (2006) Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24:317-327.
42. Janes BK, Stibitz S (2006) Routine markerless gene replacement in Bacillus anthracis. Infect Immun 74:1949-1953.