Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation

Infection and Immunity

Volumn 75, Issue 3, 2007, Pages 1484-1492

  Dorfleutner, Andrea ^a   Bryan, Nicole B ^a   Talbott, Siera J ^a   Funya, Kristin N ^a   Rellick, Stephanie L ^a   Reed, John C ^b   Shi, Xianglin ^c   Rojanasakul, Yon ^d   Flynn, Daniel C ^a   Stehlik, Christian ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^d WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CELL PROTEIN; DEATH RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN ASC; PROTEIN CATERPILLER; PROTEIN CPOP1; PROTEIN CPOP2; PROTEIN NALP; PROTEIN PAN; PROTEIN PYPAF; PYRIN DOMAIN PROTEIN; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; CARRIER PROTEINS; CELL LINE; CYTOSKELETAL PROTEINS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; JURKAT CELLS; MOLECULAR SEQUENCE DATA; TRANSCRIPTION FACTORS;

EID: 33847730763     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01315-06     Document Type: Article

References (36)

1. Agostini, L., F. Martinon, K. Burns, M. F. McDermott, P. N. Hawkins, and J. Tschopp. 2004. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20:319-325.
2. Bruey, J. M., N. Bruey-Sedano, R. Newman, S. Chandler, C. Stehlik, and J. C. Reed. 2004. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. J. Biol. Chem. 279:51897-51907.
3. Brydges, S., and D. L. Kastner. 2006. The systemic autoinflammatory diseases: inborn errors of the innate immune system. Curr. Top. Microbiol. Immunol. 305:127-160.
4. Condorelli, G., G. Vigliotta, A. Cafieri, A. Trencia, P. Andalo, F. Oriente, C. Miele, M. Caruso, P. Formisano, and F. Beguinot. 1999. PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induccd apoptosis. Oncogene 18:4409-4415.
5. Conway, K. E., B. B. McConnell, C. E. Bowring, C. D. Donald, S. T. Warren, and P. M. Vertino. 2000. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res. 60:6236-6242.
6. Dinarello, C. A. 2005. Blocking IL-1 in systemic inflammation. J. Exp. Med. 201:1355-1359.
7. Dinarello, C. A. 1998. Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann. N. Y. Acad. Sci. 856:1-11.
8. 7a. Dorfleutner, A., S. J. Talbott, N. B. Bryan, K. N. Funya, J. C. Reed, X. Shi, D. C. Flynn, Y. Rojanasakul, and C. Stehlik. Poxvirus PYRIN-only proteins are modulators of the host immune response. Virus Genes, in press.
9. Dowds, T. A., J. Masumoto, L. Zhu, N. Inohara, and G. Nunez. 2004. Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J. Biol. Chem. 279:21924-21928.
10. Druilhe, A., S. M. Srinivasula, M. Razmara, M. Ahmad, and E. S. Alnemri. 2001. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ. 8:649-657.
11. Fantuzzi, G., and C. A. Dinarello. 1999. Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1). J. Clin. Immunol. 19:1-11.
12. Humke, E. W., S. K. Shriver, M. A. Starovasnik, W. J. Fairbrother, and V. M. Dixit. 2000. ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell 103:99-111.
13. Inohara, N., and G. Nunez. 2003. NODS: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3:371-381.
14. Johnston, J. B., J. W. Barrett, S. H. Nazarian, M. Goodwin, D. Ricuttio, G. Wang, and G. McFadden. 2005. A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection. Immunity 23:587-598.
15. Kanneganti, T. D., M. Body-Malapel, A. Amer, J. H. Park, J. Whitfield, L. Franchi, Z. F. Taraporewala, D. Miller, J. T. Patton, N. Inohara, and G. Nunez. 2006. Critical role for cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J. Biol. Chem. 48: 36560-36568.
16. Kanneganti, T. D., N. Ozoren, M. Body-Malapel, A. Amer, J. H. Park, L. Franchi, J. Whitfield, W. Barchet, M. Colonna, P. Vandenabeele, J. Bertin, A. Coyle, E. P. Grant, S. Akira, and G. Nunez. 2006. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440:232-236.
17. Krueger, A., I. Schmitz, S. Baumann, P. H. Krammer, and S. Kirchhoff. 2001. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J. Biol. Chem. 276:20633-20640.
18. Lamkanfi, M., G. Denecker, M. Kalai, K. D'Hondt, A. Meeus, W. Declercq, X. Saelens, and P. Vandenabeele. 2004. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. J. Biol. Chem. 279:51729-51738.
19. Lee, S.-H., C. Stehlik, and J. C. Reed. 2001. COP, a CARD-containing protein and inhibitor of pro-interleukin-1b processing. J. Biol. Chem. 276: 34495-34500.
20. Liepinsh, E., R. Barbais, E. Dahl, A. Sharipo, E. Staub, and G. Otting. 2003. The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition. J. Mol. Biol. 332:1155-1163.
21. Mariathasan, S., K. Newton, D. M. Monack, D. Vucic, D. M. French, W. P. Lee, M. Roose-Girma, S. Erickson, and V. M. Dixit. 2004. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-218.
22. Mariathasan, S., D. S. Weiss, K. Newton, J. McBride, K. O'Rourke, M. Roose-Girma, W. P. Lee, Y. Weinrauch, D. M. Monack, and V. M. Dixit. 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440:228-232.
23. Martinon, F., K. Burns, and J. Tschopp. 2002. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10:417-426.
24. Martinon, F., V. Petrilli, A. Mayor, A. Tardivel, and J. Tschopp. 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-241.
25. Masumoto, J., S. Taniguchi, K. Ayukawa, H. Sarvotham, T. Kishino, N. Niikawa, E. Hidaka, T. Katsuyama, T. Higuchi, and J. Sagara. 1999. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J. Biol. Chem. 274:33835-33838.
26. Moss, B., and J. L. Shisler. 2001. Immunology 101 at poxvirus U: immune evasion genes. Semin. Immunol. 13:59-66.
27. Schmitz, J., A. Owyang, E. Oldham, Y. Song, E. Murphy, T. K. McClanahan, G. Zurawski, M. Moshrefi, J. Qin, X. Li, D. M. Gorman, J. F. Bazan, and R. A. Kastelein. 2005. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23:479-490.
28. Seet, B. T., J. B. Johnston, C. R. Brunetti, J. W. Barrett, H. Everett, C. Cameron, J. Sypula, S. H. Nazarian, A. Lucas, and G. McFadden. 2003. Poxviruses and immune evasion. Annu. Rev. Immunol. 21:377-423.
29. Stehlik, C., L. Florentino, A. Dorfleutner, J. M. Bruey, E. M. Ariza, J. Sagara, and J. C. Reed. 2002. The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J. Exp. Med. 196:1605-1615.
30. Stehlik, C., M. Krajewska, K. Welsh, S. Krajewski, A. Godzik, and J. C. Reed. 2003. The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappaB and pro-caspase-1 regulation. Biochem. J. 373:101-113.
31. Stehlik, C., S. H. Lee, A. Dorfleutner, A. Stassinopoulos, J. Sagara, and J. C. Reed. 2003. Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation. J. Immunol. 171:6154-6163.
32. Stehlik, C., and J. C. Reed. 2004. The PYRIN connection: novel players in innate immunity and inflammation. J. Exp. Med. 200:551-558.
33. Sutterwala, F. S., Y. Ogura, M. Szczepanik, M. Lara-Tejero, G. S. Lichtenberger, E. P. Grant, J. Bertin, A. J. Coyle, J. E. Galan, P. W. Askenase, and R. A. Flavell. 2006. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24:317-327.
34. Ting, J. P., and B. K. Davis. 2005. CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu. Rev. Immunol. 23: 387-414.
35. Tschopp, J., F. Martinon, and K. Burns. 2003. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 4:95-104.
36. Yamamoto, M, K. Yaginuma, H. Tsutsui, J. Sagara, X. Guan, E. Seki, K. Yasuda, M. Yamamoto, S. Akira, K. Nakanishi, T. Noda, and S. Taniguchi. 2004. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells 9:1055-1067.