DNA damage, neuronal and glial cell death and neurodegeneration

Apoptosis

Volumn 15, Issue 11, 2010, Pages 1371-1381

  Barzilai, Ari ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

A T Nijmegen Breakage Syndrome; Ataxia telangiectasia; DNA damage; DNA damage response; Glia; NBS; Neurodgeneration; Neurons

Indexed keywords

ATM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; GALACTOSYLCERAMIDE; MRE11 PROTEIN; MYELIN BASIC PROTEIN; NIBRIN;

ALZHEIMER DISEASE; ARTICLE; ATAXIA TELANGIECTASIA; BRAIN NERVE CELL; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DEATH; DNA DAMAGE; DNA REPAIR; GENE MUTATION; GENOMIC INSTABILITY; GLIA CELL; HUMAN; NERVE DEGENERATION; NIJMEGEN BREAKAGE SYNDROME; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SPINAL CORD INJURY;

ATAXIA TELANGIECTASIA;

EID: 78650033889     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0501-0     Document Type: Article

References (133)

1. CW Abner PJ McKinnon 2004 The DNA double-strand break response in the nervous system DNA Repair (Amst) 3 8-9 1141 1147 1:CAS:528:DC%2BD2cXmtVeqtLk%3D
2. A Barzilai S Biton Y Shiloh 2008 The role of the DNA damage response in neuronal development, organization and maintenance DNA Repair (Amst) 7 7 1010 1027 1:CAS:528:DC%2BD1cXnt1aksbg%3D
3. TT Su 2006 Cellular responses to DNA damage: one signal, multiple choices Annu Rev Genet 40 187 208 1:CAS:528:DC%2BD2sXnslKl 16805666
4. BB Zhou SJ Elledge 2000 The DNA damage response: putting checkpoints in perspective Nature 408 6811 433 439 1:CAS:528:DC%2BD3cXos1Srsb0%3D 11100718
5. G Iliakis, et al. 2003 DNA damage checkpoint control in cells exposed to ionizing radiation Oncogene 22 37 5834 5847 1:CAS:528:DC%2BD3sXmslemt7c%3D 12947390
6. Y Shiloh 2003 ATM and related protein kinases: safeguarding genome integrity Nat Rev Cancer 3 3 155 168 1:CAS:528:DC%2BD3sXhsFGhtr4%3D 12612651
7. Y Andegeko, et al. 2001 Nuclear retention of ATM at sites of DNA double strand breaks J Biol Chem 276 41 38224 38230 1:CAS:528:DC%2BD3MXotFOqsr4%3D 11454856
8. CJ Bakkenist MB Kastan 2003 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 421 6922 499 506 1:CAS:528:DC%2BD3sXntFSqsQ%3D%3D 12556884
9. T Uziel, et al. 2003 Requirement of the MRN complex for ATM activation by DNA damage EMBO J 22 20 5612 5621 1:CAS:528:DC%2BD3sXot1Cqsrw%3D 14532133
10. Meyn MS, Khanna KK, Young D, Wang W (2003) Nuclear dynamics of ATM following DNA damage, International A-T workshop. Abstract book
11. EU Kurz SP Lees-Miller 2004 DNA damage-induced activation of ATM and ATM-dependent signaling pathways DNA Repair (Amst) 3 8-9 889 900 1:CAS:528:DC%2BD2cXmtVeqsbY%3D
12. RA DiTullio Jr, et al. 2002 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer Nat Cell Biol 4 12 998 1002 1:CAS:528:DC%2BD38XptFKmtLs%3D 12447382
13. O Fernandez-Capetillo, et al. 2002 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 Nat Cell Biol 4 12 993 997 1:CAS:528:DC%2BD38XptFKmt7k%3D 12447390
14. B Wang, et al. 2002 53BP1, a mediator of the DNA damage checkpoint Science 298 5597 1435 1438 1:CAS:528:DC%2BD38Xos1WntrY%3D 12364621
15. Y Wang, et al. 2000 BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures Genes Dev 14 8 927 939 1:CAS:528:DC%2BD3cXivFyltrw%3D 10783165
16. D Cortez, et al. 1999 Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks Science 286 5442 1162 1166 1:CAS:528:DyaK1MXnt1Krsb4%3D 10550055
17. M Gatei, et al. 2000 Role for ATM in DNA damage-induced phosphorylation of BRCA1 Cancer Res 60 12 3299 3304 1:CAS:528:DC%2BD3cXktlyku7o%3D 10866324
18. M Gatei, et al. 2001 Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies J Biol Chem 276 20 17276 17280 1:CAS:528:DC%2BD3MXjvFGitLk%3D 11278964
19. A Barzilai 2007 The contribution of the DNA damage response to neuronal viability Antioxid Redox Signal 9 211 218 1:CAS:528:DC%2BD28Xht1yis7bK 17115940
20. Katyal S, McKinnon PJ (2007) DNA repair deficiency and neurodegeneration. Cell Cycle 6(19)
21. ML Fishel MR Vasko MR Kelley 2007 DNA repair in neurons: so if they don't divide what's to repair? Mutat Res 614 1-2 24 36 1:CAS:528:DC%2BD28Xhtlaqs7nK 16879837
22. L Weissman, et al. 2007 DNA repair, mitochondria, and neurodegeneration Neuroscience 145 4 1318 1329 1:CAS:528:DC%2BD2sXksVyjtLc%3D 17092652
23. B Halliwell 2006 Oxidative stress and neurodegeneration: where are we now? J Neurochem 97 6 1634 1658 1:CAS:528:DC%2BD28Xnt1Ons7g%3D 16805774
24. SP LeDoux, et al. 2007 Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults Neuroscience 145 4 1249 1259 1:CAS:528:DC%2BD2sXksVyjtL8%3D 17097236
25. SW Ryter, et al. 2007 Mechanisms of cell death in oxidative stress Antioxid Redox Signal 9 1 49 89 1:CAS:528:DC%2BD28Xht1Wqur3L 17115887
26. JH Hoeijmakers 2001 Genome maintenance mechanisms for preventing cancer Nature 411 6835 366 374 1:CAS:528:DC%2BD3MXktVSjs74%3D 11357144
27. CJ Bakkenist MB Kastan 2004 Initiating cellular stress responses Cell 118 1 9 17 1:CAS:528:DC%2BD2cXlvFejtb4%3D 15242640
28. AJ Callegari TJ Kelly 2007 Shedding light on the DNA damage checkpoint Cell Cycle 6 6 660 666 1:CAS:528:DC%2BD2sXnvFCltLo%3D 17387276
29. JE Eyfjord SK Bodvarsdottir 2005 Genomic instability and cancer: networks involved in response to DNA damage Mutat Res 592 1-2 18 28 1:CAS:528: DC%2BD2MXht1OmsLzP 16002101
30. M O'Driscoll PA Jeggo 2006 The role of double-strand break repair-insights from human genetics Nat Rev Genet 7 1 45 54 16369571
31. JC Harrison JE Haber 2006 Surviving the breakup: the DNA damage checkpoint Annu Rev Genet 40 209 235 1:CAS:528:DC%2BD2sXnslKk 16805667
32. MF Lavin Y Shiloh 1997 The genetic defect in ataxia-telangiectasia Annu Rev Immunol 15 177 202 1:CAS:528:DyaK2sXisVCntrg%3D 9143686
33. S Biton A Barzilai Y Shiloh 2008 The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle DNA Repair (Amst) 7 7 1028 1038 1:CAS:528:DC%2BD1cXnt1aksbk%3D
34. M Digweed A Reis K Sperling 1999 Nijmegen breakage syndrome: consequences of defective DNA double strand break repair Bioessays 21 8 649 656 1:STN:280:DyaK1MzmvFKgsg%3D%3D 10440861
35. H Tauchi, et al. 1999 Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1 Genomics 55 2 242 247 1:CAS:528:DyaK1MXhsVyntbw%3D 9933573
36. I van der Burgt, et al. 1996 Nijmegen breakage syndrome J Med Genet 33 2 153 156 8929954
37. D D'Amours SP Jackson 2002 The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling Nat Rev Mol Cell Biol 3 5 317 327 11988766
38. V Dumon-Jones, et al. 2003 Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis Cancer Res 63 21 7263 7269 1:CAS:528:DC%2BD3sXovVGltrc%3D 14612522
39. J Zhu, et al. 2001 Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice Curr Biol 11 2 105 109 1:CAS:528:DC%2BD3MXhtVSgtbY%3D 11231126
40. R Waltes, et al. 2009 Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder Am J Hum Genet 84 5 605 616 1:CAS:528: DC%2BD1MXmvFCmurw%3D 19409520
41. GS Stewart, et al. 1999 The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder Cell 99 6 577 587 1:CAS:528:DC%2BD3cXitVKi 10612394
42. D Delia M Piane G Buscemi C Savio S Palmeri P Lulli L Carlessi E Fontanella L Chessa 2004 Mre11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangicetasia like disorder Hum Mol Genet 13 18 2155 2163 1:CAS:528:DC%2BD2cXnsVyis78%3D 15269180
43. H Korr, et al. 2001 Neuron loss during early adulthood following prenatal low-dose X-irradiation in the mouse brain Int J Radiat Biol 77 5 567 580 1:CAS:528:DC%2BD3MXjsFCltbg%3D 11382335
44. K Ito, et al. 2007 Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes J Immunol 178 1 103 110 1:CAS:528:DC%2BD2sXnsl2j 17182545
45. F Coppedè L Migliore 2010 DNA repair in premature aging disorders and neurodegeneration Curr Aging Sci 3 1 3 19 20298165
46. KW Caldecott 2004 DNA single-strand breaks and neurodegeneration DNA Repair (Amst) 3 8-9 875 882 1:CAS:528:DC%2BD2cXmtVeqsbg%3D
47. TB Kirkwood SN Austad 2000 Why do we age? Nature 408 6809 233 238 1:CAS:528:DC%2BD3cXotFGltL0%3D 11089980
48. BP Rutten H Korr HW Steinbusch C Schmitz 2003 The aging brain: Accumulation of DNA damage or neuron loss? Mech Ageing Dev 124 349 355 12663133
49. JH Morrison PR Hof 2002 Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease Prog Brain Res 136 467 486 1:CAS:528:DC%2BD38XlsVKmsr4%3D 12143403
50. BP Rutten, et al. 2003 The aging brain: less neurons could be better Mech Ageing Dev 124 3 349 355 12663133
51. BS Mandavilli KS Rao 1996 Neurons in the cerebral cortex are most susceptible to DNA-damage in aging rat brain Biochem Mol Biol Int 40 3 507 514 1:CAS:528:DyaK28XmsFygu78%3D 8908359
52. T Lu, et al. 2004 Gene regulation and DNA damage in the ageing human brain Nature 429 6994 883 891 1:CAS:528:DC%2BD2cXltVKltLY%3D 15190254
53. CW Cotman JH Su 1996 Mechanisms of neuronal death in Alzheimer's disease Brain Pathol 6 4 493 506 1:STN:280:DyaK2s%2FpvFOmsg%3D%3D 8944319
54. RF Itzhaki 1994 Possible factors in the etiology of Alzheimer's disease Mol Neurobiol 9 1-3 1 13 1:CAS:528:DyaK2MXjtV2gt7g%3D 7888085
55. JH Robbins 1987 Parkinson's disease, twins, and the DNA-damage hypothesis Ann Neurol 21 4 412 1:STN:280:DyaL2s3htFyjsw%3D%3D 3579227
56. HK Edelberg JY Wei 1996 The biology of Alzheimer's disease Mech Ageing Dev 91 2 95 114 1:CAS:528:DyaK28XntVGjsL8%3D 8905608
57. WR Markesbery MA Lovell 2006 DNA oxidation in Alzheimer's disease Antioxid Redox Signal 8 11-12 2039 2045 1:CAS:528:DC%2BD28XhtVKntb7N 17034348
58. RL Rolig PJ McKinnon 2000 Linking DNA damage and neurodegeneration Trends Neurosci 23 9 417 424 1:CAS:528:DC%2BD3cXlvFSqu70%3D 10941191
59. Y Lee PJ McKinnon 2007 Responding to DNA double strand breaks in the nervous system Neuroscience 145 1365 1374 1:CAS:528:DC%2BD2sXksVyjtbs%3D 16934412
60. VN Vyjayanti KS Rao 2006 DNA double strand break repair in brain: reduced NHEJ activity in aging rat neurons Neurosci Lett 393 1 18 22 1:CAS:528:DC%2BD2MXhtlSjs7fP 16226837
61. V Davydov LA Hansen DA Shackelford 2003 Is DNA repair compromised in Alzheimer's disease? Neurobiol Aging 24 7 953 968 1:CAS:528:DC%2BD3sXmsVeisL0%3D 12928056
62. E Jacobsen, et al. 2004 Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains Brain Res Mol Brain Res 128 1 1 7 1:CAS:528:DC%2BD2cXntFWrsLs%3D 15337312
63. E Adamec JP Vonsattel RA Nixon 1999 DNA strand breaks in Alzheimer's disease Brain Res 849 1-2 67 77 1:CAS:528:DyaK1MXnslyms7w%3D 10592288
64. ME Boerrigter JY Wei J Vijg 1992 DNA repair and Alzheimer's disease J Gerontol 47 6 B177 B184 1:STN:280:DyaK3s%2Fls1Wkuw%3D%3D 1430845
65. J Busser DS Geldmacher K Herrup 1998 Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain J Neurosci 18 8 2801 2807 1:CAS:528:DyaK1cXis1ejt70%3D 9525997
66. Z Nagy 2000 Cell cycle regulatory failure in neurones: causes and consequences Neurobiol Aging 21 6 761 769 1:CAS:528:DC%2BD3cXovFGqu74%3D 11124420
67. DA Shackelford 2006 DNA end joining activity is reduced in Alzheimer's disease Neurobiol Aging 27 4 596 605 1:CAS:528:DC%2BD28XitVCltr0%3D 15908050
68. JH Su G Deng CW Cotman 1997 Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain Brain Res 774 1-2 193 199 1:CAS:528:DyaK2sXntlCitb8%3D 9452208
69. Y Yang K Herrup 2007 Cell division in the CNS: protective response or lethal event in post-mitotic neurons? Biochim Biophys Acta 1772 4 457 466 1:CAS:528:DC%2BD2sXjtVahurc%3D 17158035
70. R Eilam, et al. 1998 Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice Proc Natl Acad Sci USA 95 21 12653 12656 1:CAS:528:DyaK1cXmsl2qu7w%3D 9770541
71. RE Shackelford, et al. 2003 Desferrioxamine treatment increases the genomic stability of Ataxia-telangiectasia cells DNA Repair (Amst) 2 9 971 981 1:CAS:528:DC%2BD3sXntVGhtL8%3D
72. RE Shackelford 2005 Pharmacologic manipulation of the ataxia-telangiectasia mutated gene product as an intervention in age-related disease Med Hypotheses 65 2 363 369 1:CAS:528:DC%2BD2MXks1Gntrc%3D 15922113
73. EB Becker A Bonni 2004 Cell cycle regulation of neuronal apoptosis in development and disease Prog Neurobiol 72 1 1 25 1:CAS:528:DC%2BD2cXhs12js7k%3D 15019174
74. Kruman II 2004 Why do neurons enter the cell cycle? Cell Cycle 3 6 769 773 1:CAS:528:DC%2BD2MXmtVCmsw%3D%3D 15136759
75. K Herrup, et al. 2004 Divide and die: cell cycle events as triggers of nerve cell death J Neurosci 24 42 9232 9239 1:CAS:528:DC%2BD2cXpsVWgsrs%3D 15496657
76. Kruman II, et al. 2004 Cell cycle activation linked to neuronal cell death initiated by DNA damage Neuron 41 4 549 561 1:CAS:528:DC%2BD2cXhvFOrsLg%3D 14980204
77. DS Park, et al. 1997 G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis J Neurosci 17 4 1256 1270 1:CAS:528:DyaK2sXhtVGlurg%3D 9006970
78. DS Park, et al. 1998 Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents J Cell Biol 143 2 457 467 1:CAS:528:DyaK1cXmsl2gtbk%3D 9786955
79. DS Park, et al. 1998 Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress J Neurosci 18 3 830 840 1:CAS:528:DyaK1cXmtFGguw%3D%3D 9437005
80. MC Athanasiou, et al. 1998 The transcription factor E2F-1 in SV40 T antigen-induced cerebellar Purkinje cell degeneration Mol Cell Neurosci 12 1-2 16 28 1:CAS:528:DyaK1cXntlOns7c%3D 9770337
81. RM Feddersen, et al. 1992 Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice Neuron 9 5 955 966 1:CAS:528:DyaK3sXpvFGkug%3D%3D 1419002
82. RM Feddersen, et al. 1995 In vivo viability of postmitotic Purkinje neurons requires pRb family member function Mol Cell Neurosci 6 2 153 167 1:CAS:528:DyaK2MXmtlOgtLk%3D 7551567
83. N Heintz 1993 Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biochem Sci 18 5 157 159 1:STN:280:DyaK3szhvVartA%3D%3D 8328013
84. S Bauer PH Patterson 2005 The cell cycle-apoptosis connection revisited in the adult brain J Cell Biol 171 4 641 650 1:CAS:528:DC%2BD2MXht1KgtL3M 16291699
85. A Copani, et al. 2001 Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path? Trends Neurosci 24 1 25 31 1:CAS:528:DC%2BD3MXktl2rtQ%3D%3D 11163884
86. GU Hoglinger, et al. 2007 The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease Proc Natl Acad Sci USA 104 9 3585 3590 17360686
87. D Alvira, et al. 2007 Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons Neuroscience 146 1 350 365 1:CAS:528:DC%2BD2sXkslais7g%3D 17343987
88. A Shirvan, et al. 1997 Induction of mitosis-related genes during dopamine-triggered apoptosis in sympathetic neurons J Neural Transm Suppl 50 67 78 1:STN:280:DyaK2s7ptFKrtQ%3D%3D 9120426
89. A Shirvan, et al. 1997 Two waves of cyclin B and proliferating cell nuclear antigen expression during dopamine-triggered neuronal apoptosis J Neurochem 69 2 539 549 1:CAS:528:DyaK2sXkvFGktLc%3D 9231711
90. K Herrup JC Busser 1995 The induction of multiple cell cycle events precedes target-related neuronal death Development 121 8 2385 2395 1:CAS:528:DyaK2MXnsFSgsr8%3D 7671804
91. J Padmanabhan K Brown ML Shelanski 2007 Cell cycle inhibition and retinoblastoma protein overexpression prevent Purkinje cell death in organotypic slice cultures Dev Neurobiol 67 6 818 826 1:CAS:528:DC%2BD2sXmt1Sqs74%3D 17443827
92. J Rashidian GO Iyirhiaro DS Park 2007 Cell cycle machinery and stroke Biochim Biophys Acta 1772 4 484 493 1:CAS:528:DC%2BD2sXjtVahu7w%3D 17241774
93. KR Byrnes BA Stoica S Fricke S Di Giovanni AI Faden 2007 Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury Brain 130 2977 2992 17690131
94. KR Byrnes AI Faden 2007 Role of cell cycle proteins in CNS injury Neurochem Res 32 1799 1807 1:CAS:528:DC%2BD2sXhtVGmsLzI 17404835
95. R Bowser MA Smith 2002 Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle J Alzheimers Dis 4 3 249 254 1:CAS:528: DC%2BD38XmtFWitr8%3D 12226545
96. A McShea AF Wahl MA Smith 1999 Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease Med Hypotheses 52 6 525 527 1:CAS:528:DyaK1MXltlOiur0%3D 10459833
97. MD Nguyen, et al. 2003 Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1 J Neurosci 23 6 2131 2140 1:CAS:528:DC%2BD3sXlsV2qsbg%3D 12657672
98. S Di Giovanni, et al. 2003 Gene profiling in spinal cord injury shows role of cell cycle in neuronal death Ann Neurol 53 4 454 468 1:CAS:528:DC%2BD3sXjtFGitbY%3D 12666113
99. CY Kuan, et al. 2004 Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain J Neurosci 24 47 10763 10772 1:CAS:528:DC%2BD2cXhtVKls7zP 15564594
100. DX Liu LA Greene 2001 Neuronal apoptosis at the G1/S cell cycle checkpoint Cell Tissue Res 305 2 217 228 1:CAS:528:DC%2BD3MXltVGitLg%3D 11545259
101. DS Park SE Farinelli LA Greene 1996 Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons J Biol Chem 271 14 8161 8169 8626506
102. DS Park, et al. 1997 Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons J Neurosci 17 23 8975 8983 1:CAS:528:DyaK2sXnsFWksrY%3D 9364045
103. O Kranenburg AJ van der Eb A Zantema 1996 Cyclin D1 is an essential mediator of apoptotic neuronal cell death EMBO J 15 1 46 54 1:CAS:528: DyaK28XlsVKhtw%3D%3D 8598205
104. Y Zhang, et al. 2006 The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin J Neurosci 26 34 8819 8828 1:CAS:528:DC%2BD28Xpt1Srs7w%3D 16928871
105. S Ranganathan R Bowser 2003 Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis Am J Pathol 162 3 823 835 1:CAS:528:DC%2BD3sXit1GksL8%3D 12598317
106. DS Smith, et al. 2000 Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway Cell Growth Differ 11 12 625 633 1:CAS:528:DC%2BD3MXitVGrtw%3D%3D 11149597
107. Y Yang DS Geldmacher K Herrup 2001 DNA replication precedes neuronal cell death in Alzheimer's disease J Neurosci 21 8 2661 2668 1:CAS:528: DC%2BD3MXjtVWku7s%3D 11306619
108. Y Yang K Herrup 2005 Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism J Neurosci 25 10 2522 2529 1:CAS:528:DC%2BD2MXis1ygsrc%3D 15758161
109. PJ McKinnon 2001 Ataxia telangiectasia: new neurons and ATM Trends Mol Med 7 6 233 234 1:CAS:528:DC%2BD3MXltVahu7w%3D 11378498
110. Y Lee PJ McKinnon 2000 ATM dependent apoptosis in the nervous system Apoptosis 5 6 523 529 1:CAS:528:DC%2BD3MXisV2lu74%3D 11303911
111. KH Herzog, et al. 1998 Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system Science 280 5366 1089 1091 1:CAS:528:DyaK1cXjt1egsbg%3D 9582124
112. JA Klein, et al. 2002 The harlequin mouse mutation downregulates apoptosis-inducing factor Nature 419 6905 367 374 1:CAS:528:DC%2BD38XntlGgsb8%3D 12353028
113. JW Husseman D Nochlin I Vincent 2000 Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases Neurobiol Aging 21 6 815 828 1:CAS:528:DC%2BD3cXovFGqu7s%3D 11124425
114. Y Konishi, et al. 2002 Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery Mol Cell 9 5 1005 1016 1:CAS:528: DC%2BD38XksFKjtLk%3D 12049737
115. I Vincent M Rosado P Davies 1996 Mitotic mechanisms in Alzheimer's disease? J Cell Biol 132 3 413 425 1:CAS:528:DyaK28XpsVejtw%3D%3D 8636218
116. T Arendt M Holzer U Gartner 1998 Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease J Neural Transm 105 8-9 949 960 1:CAS:528:DyaK1MXhsVOluw%3D%3D 9869328
117. T Arendt, et al. 1996 Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease Neuroreport 7 18 3047 3049 1:STN:280: DyaK2s7ms1ertA%3D%3D 9116237
118. CT McMurray 2005 To die or not to die: DNA repair in neurons Mutat Res 577 1-2 260 274 1:CAS:528:DC%2BD2MXosVegsr0%3D 15921706
119. T Nouspikel PC Hanawalt 2000 Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression Mol Cell Biol 20 5 1562 1570 1:CAS:528: DC%2BD3cXhtF2ntro%3D 10669734
120. T Nouspikel PC Hanawalt 2002 DNA repair in terminally differentiated cells DNA Repair (Amst) 1 1 59 75 1:CAS:528:DC%2BD38XhsVans74%3D
121. D Merlo, et al. 2005 DNA repair in post-mitotic neurons: a gene-trapping strategy Cell Death Differ 12 3 307 309 1:CAS:528:DC%2BD2MXhtlSrt70%3D 15665815
122. TH Krishna, et al. 2005 Reduced DNA gap repair in aging rat neuronal extracts and its restoration by DNA polymerase beta and DNA-ligase J Neurochem 92 4 818 823 1:CAS:528:DC%2BD2MXhs1KqtLw%3D 15686483
123. KS Rao VV Annapurna NS Raji 2001 DNA polymerase-beta may be the main player for defective DNA repair in aging rat neurons Ann N Y Acad Sci 928 113 120 1:STN:280:DC%2BD38%2FmvF2qug%3D%3D 11795502
124. KS Rao, et al. 2000 Loss of base excision repair in aging rat neurons and its restoration by DNA polymerase beta Brain Res Mol Brain Res 85 1-2 251 259 1:CAS:528:DC%2BD3MXnvFyi 11146128
125. A Copani, et al. 2006 DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid J Neurosci 26 43 10949 10957 1:CAS:528: DC%2BD28XhtFymsLjN 17065437
126. H Imai, et al. 2002 Specific expression of the cell cycle regulation proteins, GADD34 and PCNA, in the peri-infarct zone after focal cerebral ischaemia in the rat Eur J Neurosci 15 12 1929 1936 1:STN:280: DC%2BD38vgsFWktg%3D%3D 12099899
127. DA Shackelford, et al. 1999 Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion J Neurosci 19 12 4727 4738 1:CAS:528:DyaK1MXjvVCkt74%3D 10366606
128. GD Amromin E Boder R Teplitz 1979 Ataxia-telangiectasia with a 32 year survival. A clinicopathological report J Neuropathol Exp Neurol 38 6 621 643 1:STN:280:DyaL3c%2Fps1WmtQ%3D%3D 533861
129. RO Kuljis, et al. 1997 Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia Proc Natl Acad Sci USA 94 23 12688 12693 1:CAS:528:DyaK2sXns1yltbk%3D 9356511
130. N Liu, et al. 2005 ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes Lab Invest 85 12 1471 1480 1:CAS:528:DC%2BD2MXht1aqsrzJ 16189515
131. J Kim PK Wong 2009 Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes J Biol Chem 284 21 14396 14404 1:CAS:528:DC%2BD1MXlvV2ju7Y%3D 19321450
132. EC Gosink MJ Chong PJ McKinnon 1999 Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity Cancer Res 59 20 5294 5298 1:CAS:528:DyaK1MXmvFelsbk%3D 10537312
133. Y Assaf, et al. 2008 MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome Exp Neurol 209 1 181 191 1:CAS:528: DC%2BD1cXivFejtw%3D%3D 17976584