Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons

Journal of Neuroscience

Volumn 17, Issue 23, 1997, Pages 8975-8983

  Park, David S ^a   Levine, Beth ^a   Ferrari, Giovanna ^b   Greene, Lloyd A ^a  

^a The New York Presbyterian Hospital   (United States)

^b FIDIA S P A   (Italy)

Author keywords

Apoptosis; CDK; Cell cycle; Cell death; Sindbis; Sympathetic neuron

Indexed keywords

CYCLIN DEPENDENT KINASE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATOR GENE; SINDBIS VIRUS; SUPERIOR CERVICAL GANGLION; SYMPATHETIC NERVE CELL;

EID: 0030694346     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-23-08975.1997     Document Type: Article

References (16)

1. Batistatou A, Greene LA (1993) Internucleosomal DNA cleavage and neuronal cell survival/death. J Cell Biol 122:523-532.
2. Batistatou A, Merry DE, Korsmeyer SJ, Greene LA (1993) Bcl-2 affects survival, but not neuronal differentiation of PC12 cells. J Neurosci 13:4422-4428.
3. Berry DE, Lu Y, Schimdt B, Falon PG, O'Connell C, Hu S-X, Xu H-J, Blanck G (1996) Retinoblastoma protein inhibits IFN induced apoptosis. Oncogene 12:1809-1819.
4. Brooks SF, Gibson LA, Rubin LL (1993) Apoptosis induced by NGF-withdrawal from differentiated PC12 cells involves activation of P34cdc2 kinase. Soc Neurosci Abstr 19:885.
5. Chellepan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR (1991) The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053-1061.
6. Cheng EHY, Levine B, Boise LH, Thompson CB, Hardwick JM (1996) Bax-independent inhibition of apoptosis by Bclx-L. Nature 379:554-556.
7. Deckworth TL, Elliot JL, Knudson CM, Johnson Jr EM, Snider WD, Korsmeyer SJ (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17:401-411.
8. Doree M, Galas S (1994) The cyclin-dependent protein kinases and the control of cell division. FASEB J 8:1114-1121.
9. Edwards SN, Buckmaster AE, Tolkovsky AM (1991) The death programme in cultured sympathetic neurones can be suppressed at the post-translational level by nerve growth factor, cyclic AMP, and depolarization. J Neurochem 57:2140-2143.
10. Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson Jr EM (1994) Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 127:1717-1727.
11. Fan G, Ma X, Kren BT, Steer CJ (1996) The retinoblastoma gene product inhibits TGF-b1 induced apoptosis in rat hepatocyte and human HuH-7 hepatoma cells. Oncogene 12:1909-1919.
12. Poluha W, Poluha DK, Chang B, Crosgie NE, Schonoff CM, Kilpatrick DL, Ross AH (1996) The cyclin-dependent kinase inhibitor p21waf1 is required for survival of differentiating neuroblastoma cells. Mol Cell Biol 16:1334-1341.
13. Rubin LL, Philpott KL, Brooks SF (1993) The molecular mechanisms of neuronal apoptosis. Curr Opin Neurobiol 3:391-394.
14. Rydel RE, Greene LA (1988) cAMP analogs promote survival and neurite outgrowth in cultures of sympathetic and sensory neurons independently of nerve growth factor. Proc Natl Acad Sci USA 85:1257-1261.
15. Schlesinger S (1993) Alphaviruses-vectors for the expression of heterologous genes. TIBTECH 11:18-22.
16. Xiong C, Levis R, Shen P, Schlesinger S, Rice CM, Huang HV (1989) Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science 243:1188-1191.