Role for ATM in DNA damage-induced phosphorylation of BRCA1

Cancer Research

Volumn 60, Issue 12, 2000, Pages 3299-3304

  Gatei, Magtouf ^b   Scott, Shaun P ^b   Filippovitch, Igor ^c   Soronika, Natasha ^c   Lavin, Martin F ^b   Weber, Barbara ^d   Khanna, Kum Kum ^a,b  

^a Bancroft Centre   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c INSTITUTE OF BIOPHYSICS   (Russian Federation)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; ATAXIA TELANGIECTASIA; BREAST CANCER; CANCER SUSCEPTIBILITY; CELL CYCLE; CEREBELLAR ATAXIA; CONTROLLED STUDY; DNA DAMAGE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IONIZING RADIATION; MOUSE; NONHUMAN; ONCOGENE; OVARY CANCER; PHOSPHORYLATION; PRIORITY JOURNAL; RADIOSENSITIVITY;

ATAXIA TELANGIECTASIA; BRCA1 PROTEIN; CELL CYCLE; CELL CYCLE PROTEINS; CELLS, CULTURED; CLONING, MOLECULAR; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; RECOMBINANT FUSION PROTEINS; SERINE; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0034125103     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Swift, M., Reitnauer, P. J., Morrell, D., and Chase, C. L. Breast and other cancers in families with ataxia-telangiectasia. N. Engl. J. Med., 316: 1289-1294, 1987.
2. Swift, M., Morrell, D., Massey, R. B., and Chase, C. L. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N. Engl. J. Med., 325: 1831-1836, 1991.
3. Easton, D. F. Cancer risks in A-T heterozygotes. Int. J. Radiat. Biol., 66: S177-S182, 1994.
4. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartiel, A., Gatti, R. A., Chessa, L., Sanal, O., Lavin, M. F., Jaspers, N. G. J., Taylor, M. R., Arletl, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S., and Shiloh, Y. A single ataxia telangiectasia gene with a product similar to Pl-3 kinase. Science (Washington DC), 268: 1749-1753, 1995.
5. Zakian, V. A. ATM-related genes: what do they tell us about functions of the human gene? Cell, 82: 685-687, 1995.
6. Lavin, M. F., Khanna, K. K., Beamish, H., Spring, K., Watters, D., and Shiloh, Y. Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase. Trends Biochem. Sci., 20: 382-383, 1995.
7. Khanna, K. K. ATM gene and cancer risk: a continuing debate, J. Natl. Cancer Inst., 92: 795-802, 2000.
8. Stankovic, T., Kidd, A. M., Sutcliffe, A., McGuire, G. M., Robinson, P., Weber, P., Bedenham, T., Bradwell, A. R., Easton, D. F., Lennox, G. G., Haites, N., Byrd, P. J., and Taylor, A. M. ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer. Am. J. Hum. Genet., 62: 334-345, 1998.
9. Lavin, M. F., and Khanna, K. K. ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia. Int. J. Radiat. Biol., 75: 1201-1214, 1999.
10. Khanna, K. K., Gatti, R., Concannon, P., Weemaes, C., Hoekstra, M. F., Lavin, M., and D'Andrea, A. Cellular responses to DNA damage and human chromosome instability syndromes. In: J. A. Nickloff and M. F. Hoekstra (eds.), DNA Damage and Repair, Vol. 2, pp. 395-442. Totowa, NJ: Humana Press, 1998.
11. Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., and Ziv, Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (Washington DC). 281: 1674-1677, 1998.
12. Canman, C. E., Lim, D. S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., and Siliciano, J. D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (Washington DC), 281: 1677-1679, 1998.
13. Khanna, K. K., Keating, K. E., Kozlov, S., Scott, S., Gatei, M., Hobson, K., Taya, Y., Gabrielli, B., Chan, D., Lees-Miller, S. P., and Lavin, M. F. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat. Genet., 20: 398-400, 1998.
14. Baskaran, R., Wood, L. D., Whitaker, L. L., Canman, C. E., Morgan, S. E., Xu, Y., Barlow, C., Baltimore, D., Wynshaw-Boris, A., Kastan, M. B., and Wang, J. Y. Ataxia telangiectasia mutant protein activates c-Ab1 tyrosine kinase in response to ionizing radiation. Nature (Lond.). 387: 516-519, 1997.
15. Gately, D. P., Hittle, J. C., Chan, G. K., and Yen, T. J. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Mol. Biol. Cell. 9: 2361-2374, 1998.
16. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C., Hattier, T., Phelps, R., Haugen-Strano, A., Katcher, H., Yakumo, K., Gholami, Z., Shaffer, D., Stone, S., Bayer, S., Wray, C., Bogden, R., Dayananth, P., Ward, J., Tonin, P., Narod, S., Bristow, P. K., Norris, F. H., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, C., Lewis, C., Neuhausen, S., Cannon-Albright, L., Goldgar, D., Wiseman, R., Kamb, A., and Skolnick, M. H. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (Washington DC), 266: 66-71, 1994.
17. Zhang, H., Tombline, G., and Weber, B. L. BRCA1, BRCA2, and DNA damage response: collision or collusion? Cell, 92: 433-436, 1998.
18. Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., and Livingston, D. M. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell, 90: 425-435, 1997.
19. Gowen, L. C., Johnson, B. L., Latour, A. M., Sulik, K. K., and Koller, B. H. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat. Genet., 12: 191-194, 1996.
20. Gowen, L. C., Avrutskaya, A. V., Latour, A. M., Koller, B. H., and Leadon, S. A. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science (Washington DC), 281: 1009-1012, 1998.
21. Moynahan, M. E., Chiu, J. W., Koller, B. H., and Jasin, M. Brca1 controls homology-directed DNA repair. Mol. Cell, 4: 511-518, 1999.
22. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell, 3: 389-395, 1999.
23. Zhang, H., Somasundaram, K., Peng, Y., Tian, H., Bi, D., Weber, B. L., and El-Deiry, W. S. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene, 16: 1713-1721, 1998.
24. Oakley, G. G., Zernik-Kobak, M., Carty, M. P., Khanna, K. K., Lavin, M. F., and Dixon, K. UV light induced modulation of RPA phosphorylation by expression of ATM protein. In: Eighth International Workshop on Ataxia-Telangiectasia, Las Vegas, 1999.
25. Kaufmann, W. K. Cell cycle checkpoints and DNA repair preserve the stability of the human genome. Cancer Metastasis Rev., 14: 31-41, 1995.
26. Khanna, K. K., and Lavin, M. F. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene, 8: 3307-3312, 1993.
27. Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., and Kastan, M. B. DNA damage induces phosphorylation of the ammo terminus of p53. Genes Dev., 11: 3471-3481, 1997.
28. Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S. Y., Taya, Y., Prives, C., and Abraham, R. T. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev., 13: 152-157, 1999.
29. Zhang, N., Chen, P., Khanna, K. K., Scott, S., Gatei, M, Kozlov, S., Watters, D., Spring, K., Yen, T., and Lavin, M. F. Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. Proc. Natl. Acad. Sci. USA, 94: 8021-8026, 1997.
30. Zhang, N., Chen, P., Gatei, M., Scott, S., Khanna, K. K., and Lavin, M. F. An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells. Oncogene, 17: 811-818, 1998.
31. Shafman, T., Khanna, K. K., Kedar, P., Spring, K., Kozlov, S., Yen, T., Hobson, K., Gatei, M., Zhang, N., Watters, D., Egerton, M., Shiloh, Y., Kharbanda, S., Kufe, D., and Lavin, M. F. Interaction between ATM protein and c-Ab1 in response to DNA damage. Nature (Lond.), 387: 520-523, 1997.
32. Yuille, M. A., and Coignet, L. J. The ataxia telangiectasia gene in familial and sporadic cancer. Recent Results Cancer Res., 154: 156-173, 1998.
33. Kinzler, K. W., and Vogelstein, B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature (Lond.), 386: 761-763, 1997.
34. Cortez, D., Wang, Y., Qin, J., and Elledge, S. J. Requirement of ATM-dependent phosphorylalion of brca1 in the DNA damage response to double-strand breaks. Science (Washington DC), 286: 1162-1166, 1999.
35. Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., and Scully, R. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell, 2: 317-328, 1998.
36. Zhong, Q., Chen, C. F., Li, S., Chen, Y., Wang, C. C., Xiao, J., Chen, P. L., Sharp, Z. D., and Lee, W. H. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science (Washington DC), 285: 747-750, 1999.