-
1
-
-
0027278557
-
Instability and decay of the primary structure of DNA
-
Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993; 362:709-15.
-
(1993)
Nature
, vol.362
, pp. 709-715
-
-
Lindahl, T.1
-
2
-
-
0037829284
-
Checkpoint signaling: Epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase
-
Abraham RT. Checkpoint signaling: Epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase. Bioessays 2003; 25:627-30.
-
(2003)
Bioessays
, vol.25
, pp. 627-630
-
-
Abraham, R.T.1
-
3
-
-
0344585940
-
The interacting pathways for prevention and repair of oxidative DNA damage
-
Slupphaug G, Kavli B, Krokan HE. The interacting pathways for prevention and repair of oxidative DNA damage. Mutat Res 2003; 531:231-51.
-
(2003)
Mutat Res
, vol.531
, pp. 231-251
-
-
Slupphaug, G.1
Kavli, B.2
Krokan, H.E.3
-
4
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15:2177-96.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
5
-
-
0036270993
-
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: Fail-safe protection against carcinogenesis
-
Bernstein C, Bernstein H, Payne CM, Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: Fail-safe protection against carcinogenesis. Mutat Res 2002; 511:145-78.
-
(2002)
Mutat Res
, vol.511
, pp. 145-178
-
-
Bernstein, C.1
Bernstein, H.2
Payne, C.M.3
Garewal, H.4
-
6
-
-
0034600975
-
Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells
-
Johnson RD, Jasin M. Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells. EMBO J 2000; 19:3398-407.
-
(2000)
EMBO J
, vol.19
, pp. 3398-3407
-
-
Johnson, R.D.1
Jasin, M.2
-
9
-
-
0037150731
-
The genetics of the E2F family of transcription factors: Shared functions and unique roles
-
DeGregori J. The genetics of the E2F family of transcription factors:Shared functions and unique roles. Biochim Biophys Acta 2002; 1602:131-50.
-
(2002)
Biochim Biophys Acta
, vol.1602
, pp. 131-150
-
-
DeGregori, J.1
-
10
-
-
0034636583
-
Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb
-
O'Connor DJ, Lu X. Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb. Oncogene 2000; 19:2369-76.
-
(2000)
Oncogene
, vol.19
, pp. 2369-2376
-
-
O'Connor, D.J.1
Lu, X.2
-
11
-
-
0032939925
-
Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
-
Blattner C, Sparks A, Lane D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol Cell Biol 1999; 19:3704-13.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3704-3713
-
-
Blattner, C.1
Sparks, A.2
Lane, D.3
-
12
-
-
0345299171
-
Increased levels of E2F-1-dependent DNA binding activity after UV- Or gamma-irradiation
-
Hofferer M, Wirbelauer C, Humar B, Krek W. Increased levels of E2F-1-dependent DNA binding activity after UV- or gamma-irradiation. Nucleic Acids Res 1999; 27:491-5.
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 491-495
-
-
Hofferer, M.1
Wirbelauer, C.2
Humar, B.3
Krek, W.4
-
13
-
-
0032622050
-
p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin
-
Meng RD, Phillips P, El-Deiry WS. p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin. Int J Oncol 1999; 14:5-14.
-
(1999)
Int J Oncol
, vol.14
, pp. 5-14
-
-
Meng, R.D.1
Phillips, P.2
El-Deiry, W.S.3
-
14
-
-
0034306996
-
The Rb/E2F pathway: Expanding roles and emerging paradigms
-
Harbour JW, Dean DC. The Rb/E2F pathway:Expanding roles and emerging paradigms. Genes Dev 2000; 14:2393-409.
-
(2000)
Genes Dev
, vol.14
, pp. 2393-2409
-
-
Harbour, J.W.1
Dean, D.C.2
-
15
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995; 81:323-30.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
16
-
-
0035829650
-
Regulation of neuronal survival and death by E2F-dependent gene repression and derepression
-
Liu DX, Greene LA. Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron 2001; 32:425-38.
-
(2001)
Neuron
, vol.32
, pp. 425-438
-
-
Liu, D.X.1
Greene, L.A.2
-
17
-
-
0033796320
-
RB-dependent S-phase response to DNA damage
-
Knudsen KE, Booth D, Naderi S, Sever-Chroneos Z, Fribourg AP, Hunton IC, et al. RB-dependent S-phase response to DNA damage. Mol Cell Biol 2000; 20:7751-63.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 7751-7763
-
-
Knudsen, K.E.1
Booth, D.2
Naderi, S.3
Sever-Chroneos, Z.4
Fribourg, A.P.5
Hunton, I.C.6
-
18
-
-
0034949169
-
Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis
-
Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, et al. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis Mol Cell Biol 2001; 21:4684-99.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4684-4699
-
-
Ishida, S.1
Huang, E.2
Zuzan, H.3
Spang, R.4
Leone, G.5
West, M.6
-
19
-
-
85047699837
-
E2Fs up-regulate expression of genes Involved in DNA replication, DNA repair and mitosis
-
Polager S, Kalma Y, Berkovich E, Ginsberg D. E2Fs up-regulate expression of genes Involved in DNA replication, DNA repair and mitosis. Oncogene 2002; 21:437-46.
-
(2002)
Oncogene
, vol.21
, pp. 437-446
-
-
Polager, S.1
Kalma, Y.2
Berkovich, E.3
Ginsberg, D.4
-
21
-
-
0037448689
-
ATM is a target for positive regulation by E2F-1
-
Berkovich E, Ginsberg D. ATM is a target for positive regulation by E2F-1. Oncogene 2003; 22:161-7.
-
(2003)
Oncogene
, vol.22
, pp. 161-167
-
-
Berkovich, E.1
Ginsberg, D.2
-
22
-
-
2342640317
-
A new role for E2F-1 in checkpoint control
-
Stevens C, LaThangue NB. A new role for E2F-1 in checkpoint control. Cell Cycle 2003; 2:435-7.
-
(2003)
Cell Cycle
, vol.2
, pp. 435-437
-
-
Stevens, C.1
Lathangue, N.B.2
-
23
-
-
0037080674
-
Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis
-
Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev 2002; 16:235-44.
-
(2002)
Genes Dev
, vol.16
, pp. 235-244
-
-
Weinmann, A.S.1
Yan, P.S.2
Oberley, M.J.3
Huang, T.H.4
Farnham, P.J.5
-
24
-
-
0029011805
-
Cell cycle and apoptosis: Common pathways to life and death
-
King KL, Cidlowski JA. Cell cycle and apoptosis:Common pathways to life and death. J Cell Biochem 1995; 58:175-80.
-
(1995)
J Cell Biochem
, vol.58
, pp. 175-180
-
-
King, K.L.1
Cidlowski, J.A.2
-
25
-
-
0036897835
-
A revised picture of the E2F transcriptional network and RB function
-
Stevaux O, Dyson NJ. A revised picture of the E2F transcriptional network and RB function. Curr Opin Cell Biol 2002; 14:684-91.
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 684-691
-
-
Stevaux, O.1
Dyson, N.J.2
-
26
-
-
0033605576
-
c-Abl neutralizes the inhibitory effect of Mdm2 on p53
-
Sionov RV, Moallem E, Berger M, Kazaz A, Gerlitz O, Ben-Neriah Y, et al. c-Abl neutralizes the inhibitory effect of Mdm2 on p53. J Biol Chem 1999; 274:8371-4.
-
(1999)
J Biol Chem
, vol.274
, pp. 8371-8374
-
-
Sionov, R.V.1
Moallem, E.2
Berger, M.3
Kazaz, A.4
Gerlitz, O.5
Ben-Neriah, Y.6
-
27
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001; 268:2764-72.
-
(2001)
Eur J Biochem
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
28
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases:Safeguarding genome integrity. Nat Rev Cancer 2003; 3:155-68.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
29
-
-
0034641724
-
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
-
Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci USA 2000; 97:10389-94.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10389-10394
-
-
Matsuoka, S.1
Rotman, G.2
Ogawa, A.3
Shiloh, Y.4
Tamai, K.5
Elledge, S.J.6
-
30
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 2000; 287:1824-7.
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
Wakeham, A.4
Ruland, J.5
Yoshida, H.6
-
31
-
-
0028960617
-
E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
-
Kowalik TF, DeGregori J, Schwarz JK, Nevins JR. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol 1995; 69:2491-500.
-
(1995)
J Virol
, vol.69
, pp. 2491-2500
-
-
Kowalik, T.F.1
DeGregori, J.2
Schwarz, J.K.3
Nevins, J.R.4
-
33
-
-
0028786545
-
Overexpression of the Bcl-2 protein increases the half-life of p21 Bax
-
Miyashita T, Kitada S, Krajewski S, Horne WA, Delia D, Reed JC. Overexpression of the Bcl-2 protein increases the half-life of p21 Bax. J Biol Chem 1995; 270:26049-52.
-
(1995)
J Biol Chem
, vol.270
, pp. 26049-26052
-
-
Miyashita, T.1
Kitada, S.2
Krajewski, S.3
Horne, W.A.4
Delia, D.5
Reed, J.C.6
-
34
-
-
0035889087
-
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
-
Fortin A, Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS, et al. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol 2001; 155:207-16.
-
(2001)
J Cell Biol
, vol.155
, pp. 207-216
-
-
Fortin, A.1
Cregan, S.P.2
MacLaurin, J.G.3
Kushwaha, N.4
Hickman, E.S.5
Thompson, C.S.6
-
35
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004; 303:1010-4.
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
-
37
-
-
0027078198
-
Genomic heterogeneity of DNA repair. Role in aging?
-
Hanawalt PC, Gee P, Ho L, Hsu RK, Kane CJ. Genomic heterogeneity of DNA repair. Role in aging? Ann N Y Acad Sci 1992; 663:17-25.
-
(1992)
Ann N Y Acad Sci
, vol.663
, pp. 17-25
-
-
Hanawalt, P.C.1
Gee, P.2
Ho, L.3
Hsu, R.K.4
Kane, C.J.5
-
38
-
-
0034283878
-
Linking DNA damage and neurodegeneration
-
Rolig RL, McKinnon PJ. Linking DNA damage and neurodegeneration. Trends Neuroscie 2000; 23:417-24.
-
(2000)
Trends Neuroscie
, vol.23
, pp. 417-424
-
-
Rolig, R.L.1
McKinnon, P.J.2
-
39
-
-
0034335375
-
Brain atrophy and neuronal loss in alcoholism: A role for DNA damage?
-
Brooks PJ. Brain atrophy and neuronal loss in alcoholism: A role for DNA damage? Neurochem Int 2000; 37:403-12.
-
(2000)
Neurochem Int
, vol.37
, pp. 403-412
-
-
Brooks, P.J.1
-
40
-
-
0031975026
-
Response of postmitotic neurons to X-irradiation: Implications for the role of DNA damage in neuronal apoptosis
-
Gobbel GT, Bellinzona M, Vogt AR, Gupta N, Fike JR, Chan PH. Response of postmitotic neurons to X-irradiation:Implications for the role of DNA damage in neuronal apoptosis. J Neurosci 1998; 18:147-55.
-
(1998)
J Neurosci
, vol.18
, pp. 147-155
-
-
Gobbel, G.T.1
Bellinzona, M.2
Vogt, A.R.3
Gupta, N.4
Fike, J.R.5
Chan, P.H.6
-
41
-
-
0029738086
-
Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: Evidence for cell cycle-independent toxicity
-
Morris EJ, Geller HM. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I:Evidence for cell cycle-independent toxicity. J Cell Biol 1996; 134, 757-70.
-
(1996)
J Cell Biol
, vol.134
, pp. 757-770
-
-
Morris, E.J.1
Geller, H.M.2
-
42
-
-
0030633568
-
RecA protein: Structure, function, and role in recombinational DNA repair
-
Roca AI, Cox MM. RecA protein:Structure, function, and role in recombinational DNA repair. Prog Nucleic Acid Res Mol Biol 1997; 56:129-223.
-
(1997)
Prog Nucleic Acid Res Mol Biol
, vol.56
, pp. 129-223
-
-
Roca, A.I.1
Cox, M.M.2
-
43
-
-
0033961277
-
Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression
-
Nouspikel T, Hanawalt PC. Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression. Mol Cell Biol 2000; 20:1562-70.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1562-1570
-
-
Nouspikel, T.1
Hanawalt, P.C.2
-
44
-
-
0025827017
-
Gene-specific DNA repair in terminally differentiating rat myoblasts
-
Ho L, Hanawalt PC. Gene-specific DNA repair in terminally differentiating rat myoblasts. Mutat Res 1991; 255:123-41.
-
(1991)
Mutat Res
, vol.255
, pp. 123-141
-
-
Ho, L.1
Hanawalt, P.C.2
-
45
-
-
0021905437
-
DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
-
Bohr VA, Smith CA, Okumoto DS, Hanawalt PC. DNA repair in an active gene:Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell 1985; 40:359-69.
-
(1985)
Cell
, vol.40
, pp. 359-369
-
-
Bohr, V.A.1
Smith, C.A.2
Okumoto, D.S.3
Hanawalt, P.C.4
-
46
-
-
0023663101
-
Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
-
Mellon I, Spivak G, Hanawalt PC. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell 1987; 51:241-9.
-
(1987)
Cell
, vol.51
, pp. 241-249
-
-
Mellon, I.1
Spivak, G.2
Hanawalt, P.C.3
-
47
-
-
0036712428
-
When machines get stuck-obstructed RNA polymerase II: Displacement, degradation or suicide
-
van den Boom V, Jaspers NG, Vermeulen W. When machines get stuck-obstructed RNA polymerase II:Displacement, degradation or suicide. Bioessays. 2002; 24:780-4.
-
(2002)
Bioessays
, vol.24
, pp. 780-784
-
-
Van Den Boom, V.1
Jaspers, N.G.2
Vermeulen, W.3
-
48
-
-
0036012794
-
DNA repair in terminally differentiated cells
-
Nouspikel T, Hanawalt PC. DNA repair in terminally differentiated cells. DNA Repair (Amst) 2002; 1:59-75.
-
(2002)
DNA Repair (Amst)
, vol.1
, pp. 59-75
-
-
Nouspikel, T.1
Hanawalt, P.C.2
-
49
-
-
0033590624
-
Inhibition of RNA polymerase II as a trigger for the p53 response
-
Ljungman M, Zhang F, Chen F, Rainbow AJ, McKay BC. Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene 1999; 18:583-92.
-
(1999)
Oncogene
, vol.18
, pp. 583-592
-
-
Ljungman, M.1
Zhang, F.2
Chen, F.3
Rainbow, A.J.4
McKay, B.C.5
-
50
-
-
0034329742
-
Apoptosis in neurodegenerative disorders
-
Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000; 1:120-9.
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 120-129
-
-
Mattson, M.P.1
-
51
-
-
0037417220
-
Apoptosis and caspases in neurodegenerative diseases
-
Friedlander RM. Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 2003; 348:1365-75.
-
(2003)
N Engl J Med
, vol.348
, pp. 1365-1375
-
-
Friedlander, R.M.1
-
52
-
-
0037366104
-
Oxidative stress, cell cycle, and neurodegeneration
-
Klein JA, Ackerman SL. Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest 2003; 111:785-93.
-
(2003)
J Clin Invest
, vol.111
, pp. 785-793
-
-
Klein, J.A.1
Ackerman, S.L.2
-
53
-
-
0035003439
-
Chemistry and biochemistry of oxidative stress in neurodegenerative disease
-
Sayre LM, Smith MA, Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 2001; 8:721-38.
-
(2001)
Curr Med Chem
, vol.8
, pp. 721-738
-
-
Sayre, L.M.1
Smith, M.A.2
Perry, G.3
-
54
-
-
0028180518
-
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
-
Hensley K, Carney JM, Mattson MP, Aksenova M, Harris M, Wu JF, et al. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease. Proc Natl Acad Sci USA 1994; 91:3270-4.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3270-3274
-
-
Hensley, K.1
Carney, J.M.2
Mattson, M.P.3
Aksenova, M.4
Harris, M.5
Wu, J.F.6
-
55
-
-
0035370304
-
New insights into progressive supranuclear palsy
-
Albers DS, Augood SJ. New insights into progressive supranuclear palsy. Trends Neurosci 2001; 24:347-53.
-
(2001)
Trends Neurosci
, vol.24
, pp. 347-353
-
-
Albers, D.S.1
Augood, S.J.2
-
56
-
-
0029751104
-
Oxidative stress and the pathogenesis of Parkinson's disease
-
Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996; 47:S161-70.
-
(1996)
Neurology
, vol.47
-
-
Jenner, P.1
Olanow, C.W.2
-
57
-
-
0035033411
-
Oxidative stress and neurodegeneration in prion diseases
-
Kim JI, Choi SI, Kim NH, Jin JK, Choi EK, Carp RI, et al. Oxidative stress and neurodegeneration in prion diseases. Ann N Y Acad Sci 2001; 928:182-6.
-
(2001)
Ann N Y Acad Sci
, vol.928
, pp. 182-186
-
-
Kim, J.I.1
Choi, S.I.2
Kim, N.H.3
Jin, J.K.4
Choi, E.K.5
Carp, R.I.6
-
58
-
-
0031754202
-
Increased nuclear DNA oxidation in the brain in Alzheimer's disease
-
Gabbita SP, Lovell MA, Markesbery WR. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J Neurochem 1998; 71:2034-40.
-
(1998)
J Neurochem
, vol.71
, pp. 2034-2040
-
-
Gabbita, S.P.1
Lovell, M.A.2
Markesbery, W.R.3
-
59
-
-
0036733355
-
The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
-
Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 2002; 54:375-429.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 375-429
-
-
Virag, L.1
Szabo, C.2
-
60
-
-
0025973703
-
Chemical determination of free radical-induced damage to DNA
-
Dizdaroglu M. Chemical determination of free radical-induced damage to DNA. Free Radic Biol Med 1991; 10:225-42.
-
(1991)
Free Radic Biol Med
, vol.10
, pp. 225-242
-
-
Dizdaroglu, M.1
-
62
-
-
0030806869
-
DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology
-
Lucassen PJ, Chung WC, Kamphorst W, Swaab DF. DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology. J Neuropathol Exp Neurol. 1997; 56:887-900.
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, pp. 887-900
-
-
Lucassen, P.J.1
Chung, W.C.2
Kamphorst, W.3
Swaab, D.F.4
-
64
-
-
1342333775
-
Cell cycle activation linked to neuronal cell death initiated by DNA damage
-
Kruman II, Wersto RP, Cardozo-Pelaez F, Smilenov L, Chan SL, Chrest FJ, et al. Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron 2004; 41:549-61.
-
(2004)
Neuron
, vol.41
, pp. 549-561
-
-
Kruman, I.I.1
Wersto, R.P.2
Cardozo-Pelaez, F.3
Smilenov, L.4
Chan, S.L.5
Chrest, F.J.6
-
65
-
-
0036942993
-
Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain
-
Iida T, Furuta A, Nishioka K, Nakabeppu Y, Iwaki T. Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain. Acta Neuropathol (Berl) 2002; 103:20-5.
-
(2002)
Acta Neuropathol (Berl)
, vol.103
, pp. 20-25
-
-
Iida, T.1
Furuta, A.2
Nishioka, K.3
Nakabeppu, Y.4
Iwaki, T.5
-
66
-
-
0032462852
-
Can oxidative DNA damage be used as a biomarker of cancer risk in humans. Problems, resolutions and preliminary results from nutritional supplementation studies
-
Halliwell B. Can oxidative DNA damage be used as a biomarker of cancer risk in humans. Problems, resolutions and preliminary results from nutritional supplementation studies. Free Radic Res 1998; 29:469-86.
-
(1998)
Free Radic Res
, vol.29
, pp. 469-486
-
-
Halliwell, B.1
-
67
-
-
0036469268
-
N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons
-
Wartiovaara K, Barnabe-Heider F, Miller FD, Kaplan DR. N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J Neurosci 2002; 22:815-24.
-
(2002)
J Neurosci
, vol.22
, pp. 815-824
-
-
Wartiovaara, K.1
Barnabe-Heider, F.2
Miller, F.D.3
Kaplan, D.R.4
-
68
-
-
0033635551
-
Mitotic activation: A convergent mechanism for a cohort of neurodegenerative diseases
-
Husseman JW, Nochlin D, Vincent I. Mitotic activation:A convergent mechanism for a cohort of neurodegenerative diseases. Neurobiol Aging 2000; 21:815-28.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 815-828
-
-
Husseman, J.W.1
Nochlin, D.2
Vincent, I.3
-
69
-
-
0027178335
-
Cell death and the cell cycle: A relationship between transformation and neurodegeneration?
-
Heintz N. Cell death and the cell cycle:A relationship between transformation and neurodegeneration? Trends Biochem Sci 1993; 18:157-9.
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 157-159
-
-
Heintz, N.1
-
70
-
-
0035818519
-
Chromosomal variation in neurons of the developing and adult mammalian nervous system
-
Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc Natl Acad Sci USA 2001; 98:13361-6.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13361-13366
-
-
Rehen, S.K.1
McConnell, M.J.2
Kaushal, D.3
Kingsbury, M.A.4
Yang, A.H.5
Chun, J.6
-
71
-
-
0029078677
-
The induction of multiple cell cycle events precedes target-related neuronal death
-
Herrup K, Busser JC. The induction of multiple cell cycle events precedes target-related neuronal death. Development 1995; 121:2385-95.
-
(1995)
Development
, vol.121
, pp. 2385-2395
-
-
Herrup, K.1
Busser, J.C.2
-
73
-
-
0035871660
-
DNA replication precedes neuronal cell death in Alzheimer's disease
-
Yang Y, Geldmacher DS, Herrup K. DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci 2001; 21:2661-8.
-
(2001)
J Neurosci
, vol.21
, pp. 2661-2668
-
-
Yang, Y.1
Geldmacher, D.S.2
Herrup, K.3
-
74
-
-
0036282745
-
Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery
-
Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell 2002; 9:1005-16.
-
(2002)
Mol Cell
, vol.9
, pp. 1005-1016
-
-
Konishi, Y.1
Lehtinen, M.2
Donovan, N.3
Bonni, A.4
-
75
-
-
0034730122
-
Cyclin-dependent kinases as a therapeutic target for stroke
-
Osuga H, Osuga S, Wang F, Fetni R, Hogan MJ, Slack Rs, et al. Cyclin-dependent kinases as a therapeutic target for stroke. Proc Natl Acad Sci USA 2000; 97:10254-9.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10254-10259
-
-
Osuga, H.1
Osuga, S.2
Wang, F.3
Fetni, R.4
Hogan, M.J.5
Slack, R.6
-
76
-
-
0035990906
-
Cyclin-dependent kinases as potential targets to improve stroke outcome
-
O'Hare M, Wang F, Park DS. Cyclin-dependent kinases as potential targets to improve stroke outcome. Pharmacol Ther 2002; 93:135-43.
-
(2002)
Pharmacol Ther
, vol.93
, pp. 135-143
-
-
O'Hare, M.1
Wang, F.2
Park, D.S.3
-
77
-
-
0037442820
-
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition
-
Rideout HJ, Wang Q, Park DS, Stefanis L. Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition. J Neurosci 2003; 23:1237-45.
-
(2003)
J Neurosci
, vol.23
, pp. 1237-1245
-
-
Rideout, H.J.1
Wang, Q.2
Park, D.S.3
Stefanis, L.4
-
79
-
-
0037224933
-
Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta
-
El-Khodor BF, Oo TF, Kholodilov N, Burke RE. Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta. Exp Neurol 2003; 179:17-27.
-
(2003)
Exp Neurol
, vol.179
, pp. 17-27
-
-
El-Khodor, B.F.1
Oo, T.F.2
Kholodilov, N.3
Burke, R.E.4
-
80
-
-
0035879076
-
Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death
-
Katchanov J, Harms C, Gertz K, Hauck L, Waeber C, Hirt L, et al. Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. J Neurosci 2001; 21:5045-53.
-
(2001)
J Neurosci
, vol.21
, pp. 5045-5053
-
-
Katchanov, J.1
Harms, C.2
Gertz, K.3
Hauck, L.4
Waeber, C.5
Hirt, L.6
-
81
-
-
0037444453
-
Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1
-
Nguyen MD, Boudreau M, Kriz J, Couillard-Despres S, Kaplan DR, Julien JP. Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. J Neurosci 2003; 23:2131-40.
-
(2003)
J Neurosci
, vol.23
, pp. 2131-2140
-
-
Nguyen, M.D.1
Boudreau, M.2
Kriz, J.3
Couillard-Despres, S.4
Kaplan, D.R.5
Julien, J.P.6
-
82
-
-
0032585817
-
Mechanisms of neuronal death in Down's syndrome
-
Nagy Z. Mechanisms of neuronal death in Down's syndrome. J Neural Transm Suppl 1999; 57:233-45.
-
(1999)
J Neural Transm Suppl
, vol.57
, pp. 233-245
-
-
Nagy, Z.1
-
83
-
-
1342284247
-
A. Inhibition of CDKs: A strategy for preventing kainic acid-induced apoptosis in neurons
-
Verdaguer E, Jorda EG, Stranges A, Canudas AM, Jimenez A, Sureda FX, et al. A. Inhibition of CDKs:A strategy for preventing kainic acid-induced apoptosis in neurons. Ann N Y Acad Sci 2003; 1010:671-4.
-
(2003)
Ann N Y Acad Sci
, vol.1010
, pp. 671-674
-
-
Verdaguer, E.1
Jorda, E.G.2
Stranges, A.3
Canudas, A.M.4
Jimenez, A.5
Sureda, F.X.6
-
84
-
-
0036968946
-
Niemann-Pick disease type C yields possible due for why cerebellar neurons do not form neurofibrillary tangles
-
Bu B, Klunemann H, Suzuki K, Li J, Bird T, Jin LW, et al. Niemann-Pick disease type C yields possible due for why cerebellar neurons do not form neurofibrillary tangles. Neurobiol Dis 2002; 11:285-97.
-
(2002)
Neurobiol Dis
, vol.11
, pp. 285-297
-
-
Bu, B.1
Klunemann, H.2
Suzuki, K.3
Li, J.4
Bird, T.5
Jin, L.W.6
-
85
-
-
1542381057
-
Cell cycle regulation of neuronal apoptosis in development and disease
-
Becker EB, Bonni A. Cell cycle regulation of neuronal apoptosis in development and disease. Prog Neurobiol 2004; 72:1-25.
-
(2004)
Prog Neurobiol
, vol.72
, pp. 1-25
-
-
Becker, E.B.1
Bonni, A.2
-
86
-
-
0030996226
-
A sequence in the N- Terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein a
-
Nagelhus TA, Haug T, Singh KK, Keshav KF, Skorpen F, Occerlei M, et al. A sequence in the N- terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A. J Biol Chem 1997; 272:6561-6.
-
(1997)
J Biol Chem
, vol.272
, pp. 6561-6566
-
-
Nagelhus, T.A.1
Haug, T.2
Singh, K.K.3
Keshav, K.F.4
Skorpen, F.5
Occerlei, M.6
-
87
-
-
0028986617
-
E2F-1 and a cyclin-like DNA repair enzyme, uracil-DNA glycosylase, provide evidence for an autoregulatory mechanism for transcription
-
Walsh MJ, Shue G, Spidoni K, Kapoor A. E2F-1 and a cyclin-like DNA repair enzyme, uracil-DNA glycosylase, provide evidence for an autoregulatory mechanism for transcription. J. Biol. Chem 1995; 270:5289-98.
-
(1995)
J Biol Chem
, vol.270
, pp. 5289-5298
-
-
Walsh, M.J.1
Shue, G.2
Spidoni, K.3
Kapoor, A.4
-
88
-
-
0037179691
-
The harlequin mouse mutation downregulates apoptosis-inducing factor
-
Sep 26
-
Klein JA, Longo-Guess CM, Rossmann MP, Seburn KL, Hurd RE, Frankel WN, et al. The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature Sep 26 2002; 419:367-74.
-
(2002)
Nature
, vol.419
, pp. 367-374
-
-
Klein, J.A.1
Longo-Guess, C.M.2
Rossmann, M.P.3
Seburn, K.L.4
Hurd, R.E.5
Frankel, W.N.6
-
89
-
-
0034655373
-
Apoptosis or senescence-like growth arrest: Influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts
-
Chen QM, Liu J, Merrett JB. Apoptosis or senescence-like growth arrest:Influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem J 2000; 347:543-51.
-
(2000)
Biochem J
, vol.347
, pp. 543-551
-
-
Chen, Q.M.1
Liu, J.2
Merrett, J.B.3
-
90
-
-
85078513502
-
DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis
-
Huang X, Traganos F, Darzynkiewicz Z. DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis. Cell Cycle 2003; 2:614-9.
-
(2003)
Cell Cycle
, vol.2
, pp. 614-619
-
-
Huang, X.1
Traganos, F.2
Darzynkiewicz, Z.3
-
91
-
-
0036900066
-
Genetic and environmental factors in cancer and neurodegenerative diseases
-
Migliore L, Coppede F. Genetic and environmental factors in cancer and neurodegenerative diseases. Mutat Res 2002; 512:135-53.
-
(2002)
Mutat Res
, vol.512
, pp. 135-153
-
-
Migliore, L.1
Coppede, F.2
-
92
-
-
0031663617
-
ATM: From gene to function
-
Rotman G, Shiloh Y. ATM:From gene to function. Hum Mol Genet 1998; 7:1555-63.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 1555-1563
-
-
Rotman, G.1
Shiloh, Y.2
-
93
-
-
0033516991
-
Targeting in double-strand breaks to replicating DNA identifies a subpathway of DSB repair that is defective ataxia-telangiectasia cells
-
Johnson RT, Gotoh E, Mullinger AM, Ryan AJ, Shiloh Y, Ziv Y, et al. Targeting in double-strand breaks to replicating DNA identifies a subpathway of DSB repair that is defective ataxia-telangiectasia cells. Biochem Biophys Res Commun 1999; 261:317-25.
-
(1999)
Biochem Biophys Res Commun
, vol.261
, pp. 317-325
-
-
Johnson, R.T.1
Gotoh, E.2
Mullinger, A.M.3
Ryan, A.J.4
Shiloh, Y.5
Ziv, Y.6
-
94
-
-
0032524070
-
Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
-
Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 1998; 280:1089-91.
-
(1998)
Science
, vol.280
, pp. 1089-1091
-
-
Herzog, K.H.1
Chong, M.J.2
Kapsetaki, M.3
Morgan, J.I.4
McKinnon, P.J.5
-
95
-
-
0034681136
-
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system
-
Chong MJ, Murray MR, Gosink EC, Russell HR, Srinivasan A, Kapsetaki M, et al. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci USA 2000; 97:889-94.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 889-894
-
-
Chong, M.J.1
Murray, M.R.2
Gosink, E.C.3
Russell, H.R.4
Srinivasan, A.5
Kapsetaki, M.6
-
96
-
-
0037428712
-
Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein
-
Macleod MR, Ramage L, McGregor A, Seekl JR. Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein. Neuroreport 2003; 14:215-7.
-
(2003)
Neuroreport
, vol.14
, pp. 215-217
-
-
Macleod, M.R.1
Ramage, L.2
McGregor, A.3
Seekl, J.R.4
|