G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis

Journal of Neuroscience

Volumn 17, Issue 4, 1997, Pages 1256-1270

  Park, David S ^a   Morris, Erick J ^b   Greene, Lloyd A ^a   Geller, Herbert M ^b  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

apoptosis; camptothecin; cell cycle; cyclin dependent kinases; cysteine proteases; DNA damage

Indexed keywords

ACETYLCYSTEINE; APHIDICOLIN; CAMPTOTHECIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DEFEROXAMINE; DNA; FLAVOPIRIDOL; MIMOSINE; NERVE GROWTH FACTOR; OLOMOUCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL CYCLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS INHIBITION; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NONHUMAN; PREVENTION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE;

EID: 0031016498     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-04-01256.1997     Document Type: Article

References (25)

1. Aller P, Rius C, Mata F, Zorrilla A, Cabanas C, Bellon T, Bernabeu C (1992) Camptothecin induces differentiation and stimulates the expression of differentiation-related genes in U-937 human promonocytic leukemia cells. Cancer Res 52:1245-1251.
2. Batistatou A, Greene LA (1993) Internucleosomal DNA cleavage and neuronal cell survival/death. J Cell Biol 122:523-532.
3. Brooks SF, Gibson LA, Rubin LL (1993) Apoptosis induced by NGF-withdrawal from differentiated PC12 cells involves activation of P34cdc2 kinase. Soc Neurosci Abstr 1:885.
4. Chen X, Bargonetti J, Prives C (1995) P53, through 21 (WAF/CIP1), induces cyclin Dl synthesis. Cancer Res 55:4257-4263.
5. Cheng B, Mattson MP (1991) NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron 7:1031-1041.
6. D'Arpa P, Beardmore C, Liu LF (1990) Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res 50:6919-6924.
7. Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM (1994) Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 127:1717-1727.
8. Farinelli SE, Greene LA (1996) Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. J Neurosci 16:1150-1162.
9. Ferrari G, Greene LA (1994) Proliferative inhibition by dominant-negative Ras rescues naive and neuronally-differentiated PC12 cells from apoptotic death. EMBO J 13:5922-5928.
10. Ferrari G, Yan CYI, Greene LA (1995) N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 15:2857-2866.
11. Filgueira de Azevedo W, Mueller-Dieckmann H-J, Schulze-Gahmen U, Worland PJ, Sausville E, Kim S-H (1996) Structural basis for specificity and potency of a flavanoid inhibitor of human CDK2, a cell cycle kinase. Proc Natl Acad Sci USA 93:2735-2740.
12. Freeman RF, Estus S, Johnson Jr EM (1994) Analysis of cell-related gene expression in postmitotic neurons: selective induction of cyclin Dl during programmed cell death. Neuron 12:343-355.
13. Ganeshaguru K, Hoffbrand AV, Grady RW, Cerami A (1980) Effects of various iron chelating agents on DNA synthesis in human cells. Biochem Pharmacol 29:1275-1279.
14. Gao CY, Zalenka PS (1995) Induction of cyclin B and HI kinase activity in apoptotic PC12 cells. Exp Cell Res 219:612-618.
15. Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2428.
16. Greene LA, Farinelli SE, Yan CYI, Ferrari G (1995) On the mechanisms by which neurotrophic factors regulate neuronal survival and cell death. In: Death in the nervous system (Ibanez CF, Fuxe K, Hokfelt T, Jornvall H, Olson L, Ottosen D, eds), pp 55-67. Oxford: Pergammon.
17. Ham J, Babji C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, Rubin LL (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14:927-939.
18. Hoang AT, Cohen KJ, Barrett JF, Bergstrom DA, Dang CV (1994) Participation of cyclin A in Myc-induced apoptosis. Proc Natl Acad Sci USA 91:6875-6879.
19. Horwitz S, Chang C-K, Grollman AP (1971) Studies on camptothecin. I. Effects on nucleic acid and protein synthesis. Mol Pharmacol 7:632-644.
20. Hsiang YH, Hertzberg R, Hecht S, Liu LF (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 260:14873-14878.
21. Hsiang YH, Lihou MG, Liu LF (1989) Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res 49:5077-5082.
22. Kaur G, Stetler-Stevenson M, Sebcrs S, Worland P, Sedlacek H, Myers C, Czech J, Naik R, Sausville E (1992) Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J Natl Cancer Inst 22:1736-1740.
23. Wallach PM, Love SR, Fiorica JV, Huffman MS, Flannery MT (1992) Erythromycin associated hearing loss in a patient with prior cisplatinum induced ototoxicity. J Fla Med Assoc 79:821-822.
24. Winkelman MD, Hines JD (1983) Cerebellar degeneration caused by high-dose cytosine arabinoside: a clinicopathological study. Ann Neurol 14:520-527.
25. Yan CYI, Ferrari G, Greene LA (1995) N-acetylcysteine-promoted survival of PC12 cells is glutathione-independent but transcription-dependent. J Biol Chem 270:26827-26832.